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Stephan Kissler, Ph.D.

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Overview
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Stephan Kissler investigates immune mechanisms relevant to autoimmunity with a particular focus on type 1 diabetes (T1D). The Kissler laboratory models gene variations associated with human T1D in mouse models to study the function of genes that modify the risk of disease. The knowledge gained from these studies will facilitate the rational design of immune therapies aiming to prevent or halt autoimmunity.

Research
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01DK120445 (KISSLER, STEPHAN) Sep 30, 2018 - Feb 28, 2025
    NIH
    Functional Validation of Gene Modifications that Protect Beta Cells against Autoimmunity Identified by Genome-Wide CRISPR Cas9 Screening
    Role: Principal Investigator
  2. R56DK109954 (KISSLER, STEPHAN) Jul 7, 2016 - Jun 30, 2017
    NIH
    Genetic Modifiers of MHC Class II Presentation in Autoimmune Diabetes
    Role: Principal Investigator
  3. R21AI122110 (KISSLER, STEPHAN) Jan 1, 2016 - Dec 31, 2017
    NIH
    Immune regulatory function of CD5
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Stewart T, Bode K, Kissler S, Yi P. Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice. J Vis Exp. 2022 11 18; (189). PMID: 36468712.
    Citations:    Fields:    Translation:AnimalsCells
  2. Schuster C, Kiaf B, Hatzihristidis T, Ruckdeschel A, Nieves-Bonilla J, Ishikawa Y, Zhao B, Zheng P, Love PE, Kissler S. CD5 Controls Gut Immunity by Shaping the Cytokine Profile of Intestinal T Cells. Front Immunol. 2022; 13:906499. PMID: 35720357; PMCID: PMC9201032.
    Citations:    Fields:    Translation:Animals
  3. Kissler S. Toward a precision medicine approach for autoimmunity. Proc Natl Acad Sci U S A. 2022 05 10; 119(19):e2204841119. PMID: 35522710; PMCID: PMC9171808.
    Citations:    Fields:    
  4. Kissler S. Genetic Modifiers of Thymic Selection and Central Tolerance in Type 1 Diabetes. Front Immunol. 2022; 13:889856. PMID: 35464420; PMCID: PMC9021641.
    Citations:    Fields:    Translation:HumansCells
  5. Cai EP, Ishikawa Y, Zhang W, Leite NC, Li J, Hou S, Kiaf B, Hollister-Lock J, Yilmaz NK, Schiffer CA, Melton DA, Kissler S, Yi P. Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes. Nat Metab. 2020 09; 2(9):934-945. PMID: 32719542.
    Citations: 14     Fields:    Translation:AnimalsCells
  6. Haeger A, Alexander S, Vullings M, Kaiser FMP, Veelken C, Flucke U, Koehl GE, Hirschberg M, Flentje M, Hoffman RM, Geissler EK, Kissler S, Friedl P. Collective cancer invasion forms an integrin-dependent radioresistant niche. J Exp Med. 2020 01 06; 217(1). PMID: 31658985; PMCID: PMC7037234.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  7. Shi X, Shao F, Li Z, Kang L, Liu J, Kissler S, Zhou Z, Jia L, Zheng P. Regulation of B cell homeostasis by Ptpn22 contributes to type 1 diabetes in NOD mice. Endocrine. 2020 03; 67(3):535-543. PMID: 31732921.
    Citations: 1     Fields:    Translation:AnimalsCells
  8. Gaglia J, Kissler S. Anti-CD3 Antibody for the Prevention of Type 1 Diabetes: A Story of Perseverance. Biochemistry. 2019 10 08; 58(40):4107-4111. PMID: 31523950.
    Citations: 7     Fields:    Translation:HumansAnimals
  9. Nieves-Bonilla JM, Kiaf B, Schuster C, Kissler S. The type 1 diabetes candidate gene Dexi does not affect disease risk in the nonobese diabetic mouse model. Genes Immun. 2020 01; 21(1):71-77. PMID: 31435002.
    Citations: 2     Fields:    Translation:Animals
  10. Dirice E, Kahraman S, De Jesus DF, El Ouaamari A, Basile G, Baker RL, Yigit B, Piehowski PD, Kim MJ, Dwyer AJ, Ng RWS, Schuster C, Vethe H, Martinov T, Ishikawa Y, Teo AKK, Smith RD, Hu J, Haskins K, Serwold T, Qian WJ, Fife BT, Kissler S, Kulkarni RN. Increased ß-cell proliferation before immune cell invasion prevents progression of type 1 diabetes. Nat Metab. 2019 05; 1(5):509-518. PMID: 31423480.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  11. Duke-Cohan JS, Ishikawa Y, Yoshizawa A, Choi YI, Lee CN, Acuto O, Kissler S, Reinherz EL. Regulation of thymocyte trafficking by Tagap, a GAP domain protein linked to human autoimmunity. Sci Signal. 2018 06 12; 11(534). PMID: 29895617; PMCID: PMC6393939.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  12. Schuster C, Jonas F, Zhao F, Kissler S. Peripherally induced regulatory T cells contribute to the control of autoimmune diabetes in the NOD mouse model. Eur J Immunol. 2018 07; 48(7):1211-1216. PMID: 29604048; PMCID: PMC6033626.
    Citations: 10     Fields:    Translation:AnimalsCells
  13. Thelin MA, Kissler S, Vigneault F, Watters AL, White D, Koshy ST, Vermillion SA, Mooney DJ, Serwold T, Ali OA. In Vivo Enrichment of Diabetogenic T Cells. Diabetes. 2017 08; 66(8):2220-2229. PMID: 28396510; PMCID: PMC5521861.
    Citations: 7     Fields:    Translation:AnimalsCells
  14. Caballero-Franco C, Kissler S. The autoimmunity-associated gene RGS1 affects the frequency of T follicular helper cells. Genes Immun. 2016 06; 17(4):228-38. PMID: 27029527; PMCID: PMC4892947.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  15. Nowakowska DJ, Kissler S. Ptpn22 Modifies Regulatory T Cell Homeostasis via GITR Upregulation. J Immunol. 2016 Mar 01; 196(5):2145-52. PMID: 26810223; PMCID: PMC4761465.
    Citations: 8     Fields:    Translation:AnimalsCells
  16. Chaudhari SM, Sluimer JC, Koch M, Theelen TL, Manthey HD, Busch M, Caballero-Franco C, Vogel F, Cochain C, Pelisek J, Daemen MJ, Lutz MB, Görlach A, Kissler S, Hermanns HM, Zernecke A. Deficiency of HIF1a in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in Mice. Arterioscler Thromb Vasc Biol. 2015 Nov; 35(11):2316-25. PMID: 26404487; PMCID: PMC4618712.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  17. Schuster C, Gerold KD, Schober K, Probst L, Boerner K, Kim MJ, Ruckdeschel A, Serwold T, Kissler S. The Autoimmunity-Associated Gene CLEC16A Modulates Thymic Epithelial Cell Autophagy and Alters T Cell Selection. Immunity. 2015 May 19; 42(5):942-52. PMID: 25979422.
    Citations: 45     Fields:    Translation:AnimalsCells
  18. Zheng P, Kissler S. PTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a loss-of-function variant. Diabetes. 2013 Mar; 62(3):896-904. PMID: 23193190; PMCID: PMC3581188.
    Citations: 36     Fields:    Translation:AnimalsCells
  19. Joseph J, Bittner S, Kaiser FM, Wiendl H, Kissler S. IL-17 silencing does not protect nonobese diabetic mice from autoimmune diabetes. J Immunol. 2012 Jan 01; 188(1):216-21. PMID: 22116823.
    Citations: 30     Fields:    Translation:AnimalsCells
  20. Kissler S. From genome-wide association studies to etiology: probing autoimmunity genes by RNAi. Trends Mol Med. 2011 Nov; 17(11):634-40. PMID: 21783421.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  21. Gerold KD, Zheng P, Rainbow DB, Zernecke A, Wicker LS, Kissler S. The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function. Diabetes. 2011 Jul; 60(7):1955-63. PMID: 21602513; PMCID: PMC3121435.
    Citations: 41     Fields:    Translation:AnimalsCells
  22. Acharya M, Mukhopadhyay S, Païdassi H, Jamil T, Chow C, Kissler S, Stuart LM, Hynes RO, Lacy-Hulbert A. av Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice. J Clin Invest. 2010 Dec; 120(12):4445-52. PMID: 21099114; PMCID: PMC2993596.
    Citations: 51     Fields:    Translation:AnimalsCells
  23. Beyersdorf N, Braun A, Vögtle T, Varga-Szabo D, Galdos RR, Kissler S, Kerkau T, Nieswandt B. STIM1-independent T cell development and effector function in vivo. J Immunol. 2009 Mar 15; 182(6):3390-7. PMID: 19265116.
    Citations: 42     Fields:    Translation:AnimalsCells
  24. Kissler S. Studying autoimmunity by in vivo RNA interference. Methods Mol Biol. 2009; 555:109-18. PMID: 19495691.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  25. Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M, Galuppo P, Just S, Rottbauer W, Frantz S, Castoldi M, Soutschek J, Koteliansky V, Rosenwald A, Basson MA, Licht JD, Pena JT, Rouhanifard SH, Muckenthaler MU, Tuschl T, Martin GR, Bauersachs J, Engelhardt S. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature. 2008 Dec 18; 456(7224):980-4. PMID: 19043405.
    Citations: 1001     Fields:    Translation:HumansAnimalsCells
  26. Kissler S, Stern P, Takahashi K, Hunter K, Peterson LB, Wicker LS. In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes. Nat Genet. 2006 Apr; 38(4):479-83. PMID: 16550170.
    Citations: 60     Fields:    Translation:Animals
  27. Dillon CP, Sandy P, Nencioni A, Kissler S, Rubinson DA, Van Parijs L. Rnai as an experimental and therapeutic tool to study and regulate physiological and disease processes. Annu Rev Physiol. 2005; 67:147-73. PMID: 15709955.
    Citations: 32     Fields:    Translation:HumansAnimals
  28. Kissler S, Van Parijs L. Exploring the genetic basis of disease using RNA interference. Expert Rev Mol Diagn. 2004 Sep; 4(5):645-51. PMID: 15347258.
    Citations:    Fields:    Translation:AnimalsCells
  29. Nencioni A, Sandy P, Dillon C, Kissler S, Blume-Jensen P, Van Parijs L. RNA interference for the identification of disease-associated genes. Curr Opin Mol Ther. 2004 Apr; 6(2):136-40. PMID: 15195924.
    Citations: 2     Fields:    Translation:HumansAnimals
  30. Kissler S, Lu L, Cantor H. Thymic selection can compensate for mutations affecting T cell activation and generate a normal T cell repertoire in mutant mice. Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):210-4. PMID: 14694195; PMCID: PMC314164.
    Citations:    Fields:    Translation:AnimalsCells
  31. Kissler S, Anderton SM, Wraith DC. Cross-reactivity and T-cell receptor antagonism of myelin basic protein-reactive T cells is modulated by the activation state of the antigen presenting cell. J Autoimmun. 2002 Dec; 19(4):183-93. PMID: 12473239.
    Citations: 3     Fields:    Translation:AnimalsCells
  32. Ye Q, Press B, Kissler S, Yang XF, Lu L, Bassing CH, Sleckman BP, Jansson M, Panoutsakopoulou V, Trimble LA, Alt FW, Cantor H. T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice. J Exp Med. 2002 Jul 01; 196(1):87-95. PMID: 12093873; PMCID: PMC2194014.
    Citations: 6     Fields:    Translation:AnimalsCells
  33. Kissler S, Anderton SM, Wraith DC. Antigen-presenting cell activation: a link between infection and autoimmunity? J Autoimmun. 2001 May; 16(3):303-8. PMID: 11334496.
    Citations: 8     Fields:    Translation:AnimalsCells
  34. Anderton SM, Kissler S, Lamont AG, Wraith DC. Therapeutic potential of TCR antagonists is determined by their ability to modulate a diverse repertoire of autoreactive T cells. Eur J Immunol. 1999 06; 29(6):1850-7. PMID: 10382747.
    Citations: 6     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.