Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Stephan Kissler, Ph.D.

Title
Institution
Department
Address
Phone
Profile Picture

Overview
Stephan Kissler investigates immune mechanisms relevant to autoimmunity with a particular focus on type 1 diabetes (T1D). The Kissler laboratory models gene variations associated with human T1D in mouse models to study the function of genes that modify the risk of disease. The knowledge gained from these studies will facilitate the rational design of immune therapies aiming to prevent or halt autoimmunity.

Mentoring
Available: 11/01/18, Expires: 10/01/19

Our group aims to develop novel approaches to protecting insulin-producing beta cells in the pancreas to prevent or treat diabetes. We have performed a genome-scale CRISPR screen and have identified several candidate genes that can be targeted for protection. This project will focus on the mechanism by which one of the lead candidate genes makes beta cells resistant to dysfunction and cell death in diabetes.

Available: 10/02/18, Expires: 10/01/19

Our laboratory's research aims to understand defects in immune regulation that underlie autoimmunity. We are particularly interested in type 1 diabetes. Evidence from mouse models and human studies suggests that the gut microbiota modulates the risk of autoimmune diabetes. We recently discovered that a particular type of immune cell induced by gut microbes regulates autoimmunity in a mouse model for type 1 diabetes. This project will build on our initial discovery and aims to understand the mechanism by which these microbe-dependent immune cells regulate disease.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R56DK109954 (KISSLER, STEPHAN) Jul 7, 2016 - Jun 30, 2017
    NIH
    Genetic Modifiers of MHC Class II Presentation in Autoimmune Diabetes
    Role: Principal Investigator
  2. R21AI122110 (KISSLER, STEPHAN) Jan 1, 2016 - Aug 31, 2017
    NIH
    Immune regulatory function of CD5
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Duke-Cohan JS, Ishikawa Y, Yoshizawa A, Choi YI, Lee CN, Acuto O, Kissler S, Reinherz EL. Regulation of thymocyte trafficking by Tagap, a GAP domain protein linked to human autoimmunity. Sci Signal. 2018 Jun 12; 11(534). PMID: 29895617.
    View in: PubMed
  2. Schuster C, Jonas F, Zhao F, Kissler S. Peripherally induced regulatory T cells contribute to the control of autoimmune diabetes in the NOD mouse model. Eur J Immunol. 2018 Jul; 48(7):1211-1216. PMID: 29604048.
    View in: PubMed
  3. Thelin MA, Kissler S, Vigneault F, Watters AL, White D, Koshy ST, Vermillion SA, Mooney DJ, Serwold T, Ali OA. In Vivo Enrichment of Diabetogenic T Cells. Diabetes. 2017 08; 66(8):2220-2229. PMID: 28396510.
    View in: PubMed
  4. Caballero-Franco C, Kissler S. The autoimmunity-associated gene RGS1 affects the frequency of T follicular helper cells. Genes Immun. 2016 06; 17(4):228-38. PMID: 27029527; PMCID: PMC4892947 [Available on 09/30/16].
  5. Nowakowska DJ, Kissler S. Ptpn22 Modifies Regulatory T Cell Homeostasis via GITR Upregulation. J Immunol. 2016 Mar 01; 196(5):2145-52. PMID: 26810223; PMCID: PMC4761465 [Available on 03/01/17].
  6. Chaudhari SM, Sluimer JC, Koch M, Theelen TL, Manthey HD, Busch M, Caballero-Franco C, Vogel F, Cochain C, Pelisek J, Daemen MJ, Lutz MB, Görlach A, Kissler S, Hermanns HM, Zernecke A. Deficiency of HIF1a in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in Mice. Arterioscler Thromb Vasc Biol. 2015 Nov; 35(11):2316-25. PMID: 26404487; PMCID: PMC4618712 [Available on 11/01/16].
  7. Schuster C, Gerold KD, Schober K, Probst L, Boerner K, Kim MJ, Ruckdeschel A, Serwold T, Kissler S. The Autoimmunity-Associated Gene CLEC16A Modulates Thymic Epithelial Cell Autophagy and Alters T Cell Selection. Immunity. 2015 May 19; 42(5):942-52. PMID: 25979422; PMCID: PMC4439257.
  8. Zheng P, Kissler S. PTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a loss-of-function variant. Diabetes. 2013 Mar; 62(3):896-904. PMID: 23193190; PMCID: PMC3581188.
  9. Joseph J, Bittner S, Kaiser FM, Wiendl H, Kissler S. IL-17 silencing does not protect nonobese diabetic mice from autoimmune diabetes. J Immunol. 2012 Jan 01; 188(1):216-21. PMID: 22116823.
    View in: PubMed
  10. Kissler S. From genome-wide association studies to etiology: probing autoimmunity genes by RNAi. Trends Mol Med. 2011 Nov; 17(11):634-40. PMID: 21783421.
    View in: PubMed
  11. Gerold KD, Zheng P, Rainbow DB, Zernecke A, Wicker LS, Kissler S. The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function. Diabetes. 2011 Jul; 60(7):1955-63. PMID: 21602513.
    View in: PubMed
  12. Acharya M, Mukhopadhyay S, Païdassi H, Jamil T, Chow C, Kissler S, Stuart LM, Hynes RO, Lacy-Hulbert A. av Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice. J Clin Invest. 2010 Dec; 120(12):4445-52. PMID: 21099114; PMCID: PMC2993596.
  13. Beyersdorf N, Braun A, Vögtle T, Varga-Szabo D, Galdos RR, Kissler S, Kerkau T, Nieswandt B. STIM1-independent T cell development and effector function in vivo. J Immunol. 2009 Mar 15; 182(6):3390-7. PMID: 19265116.
    View in: PubMed
  14. Kissler S. Studying autoimmunity by in vivo RNA interference. Methods Mol Biol. 2009; 555:109-18. PMID: 19495691.
    View in: PubMed
  15. Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M, Galuppo P, Just S, Rottbauer W, Frantz S, Castoldi M, Soutschek J, Koteliansky V, Rosenwald A, Basson MA, Licht JD, Pena JT, Rouhanifard SH, Muckenthaler MU, Tuschl T, Martin GR, Bauersachs J, Engelhardt S. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature. 2008 Dec 18; 456(7224):980-4. PMID: 19043405.
    View in: PubMed
  16. Kissler S, Stern P, Takahashi K, Hunter K, Peterson LB, Wicker LS. In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes. Nat Genet. 2006 Apr; 38(4):479-83. PMID: 16550170.
    View in: PubMed
  17. Dillon CP, Sandy P, Nencioni A, Kissler S, Rubinson DA, Van Parijs L. Rnai as an experimental and therapeutic tool to study and regulate physiological and disease processes. Annu Rev Physiol. 2005; 67:147-73. PMID: 15709955.
    View in: PubMed
  18. Kissler S, Van Parijs L. Exploring the genetic basis of disease using RNA interference. Expert Rev Mol Diagn. 2004 Sep; 4(5):645-51. PMID: 15347258.
    View in: PubMed
  19. Nencioni A, Sandy P, Dillon C, Kissler S, Blume-Jensen P, Van Parijs L. RNA interference for the identification of disease-associated genes. Curr Opin Mol Ther. 2004 Apr; 6(2):136-40. PMID: 15195924.
    View in: PubMed
  20. Kissler S, Lu L, Cantor H. Thymic selection can compensate for mutations affecting T cell activation and generate a normal T cell repertoire in mutant mice. Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):210-4. PMID: 14694195; PMCID: PMC314164.
  21. Kissler S, Anderton SM, Wraith DC. Cross-reactivity and T-cell receptor antagonism of myelin basic protein-reactive T cells is modulated by the activation state of the antigen presenting cell. J Autoimmun. 2002 Dec; 19(4):183-93. PMID: 12473239.
    View in: PubMed
  22. Ye Q, Press B, Kissler S, Yang XF, Lu L, Bassing CH, Sleckman BP, Jansson M, Panoutsakopoulou V, Trimble LA, Alt FW, Cantor H. T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice. J Exp Med. 2002 Jul 01; 196(1):87-95. PMID: 12093873; PMCID: PMC2194014.
  23. Kissler S, Anderton SM, Wraith DC. Antigen-presenting cell activation: a link between infection and autoimmunity? J Autoimmun. 2001 May; 16(3):303-8. PMID: 11334496.
    View in: PubMed
  24. Anderton SM, Kissler S, Lamont AG, Wraith DC. Therapeutic potential of TCR antagonists is determined by their ability to modulate a diverse repertoire of autoreactive T cells. Eur J Immunol. 1999 06; 29(6):1850-7. PMID: 10382747.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Kissler's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (143)
Explore
_
Co-Authors (9)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.