Harvard Catalyst Profiles

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Brian Bacskai, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG061774 (GERASHCHENKO, DMITRY) Apr 15, 2019 - Jan 31, 2024
    NIH/NIA
    Slow-wave activity as a modifier of the progression of neurodegeneration in Alzheimer's disease
    Role: Co-Principal Investigator
  2. RF1NS110054 (BACSKAI, BRIAN J) Sep 30, 2018 - Aug 31, 2023
    NIH/NINDS
    Cerebral microvascular lesions and vascular and neuronal networks
    Role: Principal Investigator
  3. R01AG054598 (BACSKAI, BRIAN J) Mar 1, 2017 - Feb 28, 2022
    NIH/NIA
    The role of astrocytes in Alzheimer's disease pathogenesis
    Role: Principal Investigator
  4. R01NS096730 (GREENBERG, STEVEN M) Feb 1, 2016 - Jan 31, 2021
    NIH/NINDS
    CEREBRAL AMYLOID ANGIOPATHY AND MECHANISMS OF BRAIN AMYLOID ACCUMULATION
    Role: Principal Investigator
  5. R01AG044263 (BACSKAI, BRIAN J) Apr 15, 2015 - Mar 31, 2020
    NIH/NIA
    Molecular pathways leading to neurodegeneration in vivo
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Schlunk F, Böhm M, Boulouis G, Qin T, Arbel M, Tamim I, Fischer P, Bacskai BJ, Frosch MP, Endres M, Greenberg SM, Ayata C. Secondary Bleeding During Acute Experimental Intracerebral Hemorrhage. Stroke. 2019 May; 50(5):1210-1215. PMID: 31009358.
    Citations:    
  2. Freeze WM, Bacskai BJ, Frosch MP, Jacobs HIL, Backes WH, Greenberg SM, van Veluw SJ. Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy. Stroke. 2019 Feb; 50(2):328-335. PMID: 30661497.
    Citations:    Fields:    
  3. van Veluw SJ, Reijmer YD, van der Kouwe AJ, Charidimou A, Riley GA, Leemans A, Bacskai BJ, Frosch MP, Viswanathan A, Greenberg SM. Histopathology of diffusion imaging abnormalities in cerebral amyloid angiopathy. Neurology. 2019 Feb 26; 92(9):e933-e943. PMID: 30700595.
    Citations:    Fields:    
  4. Hou S, Bacskai BJ, Kumar A. The Resolution Matrix in Tomographic Multiplexing: Optimization of Inter-parameter Cross-talk, Relative Quantitation and Localization. IEEE Trans Biomed Eng. 2018 Dec 21. PMID: 30582520.
    Citations:    Fields:    
  5. Ji M, Arbel M, Zhang L, Freudiger CW, Hou SS, Lin D, Yang X, Bacskai BJ, Xie XS. Label-free imaging of amyloid plaques in Alzheimer's disease with stimulated Raman scattering microscopy. Sci Adv. 2018 Nov; 4(11):eaat7715. PMID: 30456301.
    Citations:    Fields:    
  6. Kelly P, Hudry E, Hou SS, Bacskai BJ. In Vivo Two Photon Imaging of Astrocytic Structure and Function in Alzheimer's Disease. Front Aging Neurosci. 2018; 10:219. PMID: 30072889.
    Citations:    
  7. Hierro-Bujalance C, Bacskai BJ, Garcia-Alloza M. In Vivo Imaging of Microglia With Multiphoton Microscopy. Front Aging Neurosci. 2018; 10:218. PMID: 30072888.
    Citations:    
  8. Funane T, Hou SS, Zoltowska KM, van Veluw SJ, Berezovska O, Kumar ATN, Bacskai BJ. Selective plane illumination microscopy (SPIM) with time-domain fluorescence lifetime imaging microscopy (FLIM) for volumetric measurement of cleared mouse brain samples. Rev Sci Instrum. 2018 May; 89(5):053705. PMID: 29864842.
    Citations:    Fields:    Translation:HumansAnimalsCells
  9. Wang X, Kastanenka KV, Arbel-Ornath M, Commins C, Kuzuya A, Lariviere AJ, Krafft GA, Hefti F, Jerecic J, Bacskai BJ. An acute functional screen identifies an effective antibody targeting amyloid-ß oligomers based on calcium imaging. Sci Rep. 2018 Mar 15; 8(1):4634. PMID: 29545579.
    Citations:    Fields:    
  10. Pagnier GJ, Kastanenka KV, Sohn M, Choi S, Choi SH, Soh H, Bacskai BJ. Novel botanical drug DA-9803 prevents deficits in Alzheimer's mouse models. Alzheimers Res Ther. 2018 01 29; 10(1):11. PMID: 29378621.
    Citations:    Fields:    
  11. Charidimou A, Boulouis G, Gurol ME, Ayata C, Bacskai BJ, Frosch MP, Viswanathan A, Greenberg SM. Emerging concepts in sporadic cerebral amyloid angiopathy. Brain. 2017 Jul 01; 140(7):1829-1850. PMID: 28334869.
    Citations: 9     Fields:    Translation:Humans
  12. Arbel-Ornath M, Hudry E, Boivin JR, Hashimoto T, Takeda S, Kuchibhotla KV, Hou S, Lattarulo CR, Belcher AM, Shakerdge N, Trujillo PB, Muzikansky A, Betensky RA, Hyman BT, Bacskai BJ. Soluble oligomeric amyloid-ß induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain. Mol Neurodegener. 2017 03 21; 12(1):27. PMID: 28327181.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  13. Maesako M, Horlacher J, Zoltowska KM, Kastanenka KV, Kara E, Svirsky S, Keller LJ, Li X, Hyman BT, Bacskai BJ, Berezovska O. Pathogenic PS1 phosphorylation at Ser367. Elife. 2017 01 30; 6. PMID: 28132667.
    Citations: 3     Fields:    Translation:AnimalsCells
  14. Kastanenka KV, Hou SS, Shakerdge N, Logan R, Feng D, Wegmann S, Chopra V, Hawkes JM, Chen X, Bacskai BJ. Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer's Disease. PLoS One. 2017; 12(1):e0170275. PMID: 28114405.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  15. Hou SS, Bacskai BJ, Kumar AT. Comparison of tomographic fluorescence spectral and lifetime multiplexing. Opt Lett. 2016 Nov 15; 41(22):5337-5340. PMID: 27842127.
    Citations:    Fields:    
  16. Kastanenka KV, Bussiere T, Shakerdge N, Qian F, Weinreb PH, Rhodes K, Bacskai BJ. Immunotherapy with Aducanumab Restores Calcium Homeostasis in Tg2576 Mice. J Neurosci. 2016 12 14; 36(50):12549-12558. PMID: 27810931.
    Citations: 9     Fields:    Translation:AnimalsCells
  17. Ramos-Rodriguez JJ, Spires-Jones T, Pooler AM, Lechuga-Sancho AM, Bacskai BJ, Garcia-Alloza M. Progressive Neuronal Pathology and Synaptic Loss Induced by Prediabetes and Type 2 Diabetes in a Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2017 07; 54(5):3428-3438. PMID: 27177549.
    Citations: 5     Fields:    Translation:AnimalsCells
  18. Hou SS, Bacskai BJ, Kumar AT. Optimal estimator for tomographic fluorescence lifetime multiplexing. Opt Lett. 2016 Apr 01; 41(7):1352-5. PMID: 27192234.
    Citations: 1     Fields:    
  19. Bakker EN, Bacskai BJ, Arbel-Ornath M, Aldea R, Bedussi B, Morris AW, Weller RO, Carare RO. Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases. Cell Mol Neurobiol. 2016 Mar; 36(2):181-94. PMID: 26993512.
    Citations: 44     Fields:    Translation:HumansAnimals
  20. Galea E, Morrison W, Hudry E, Arbel-Ornath M, Bacskai BJ, Gómez-Isla T, Stanley HE, Hyman BT. Topological analyses in APP/PS1 mice reveal that astrocytes do not migrate to amyloid-ß plaques. Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51):15556-61. PMID: 26644572.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  21. Chu W, Zhou D, Gaba V, Liu J, Li S, Peng X, Xu J, Dhavale D, Bagchi DP, d'Avignon A, Shakerdge NB, Bacskai BJ, Tu Z, Kotzbauer PT, Mach RH. Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for a-Synuclein Fibrils. J Med Chem. 2015 Aug 13; 58(15):6002-17. PMID: 26177091.
    Citations: 9     Fields:    
  22. Zhao L, Arbel-Ornath M, Wang X, Betensky RA, Greenberg SM, Frosch MP, Bacskai BJ. Matrix metalloproteinase 9-mediated intracerebral hemorrhage induced by cerebral amyloid angiopathy. Neurobiol Aging. 2015 Nov; 36(11):2963-2971. PMID: 26248866.
    Citations: 5     Fields:    Translation:HumansAnimals
  23. Lillis KP, Wang Z, Mail M, Zhao GQ, Berdichevsky Y, Bacskai B, Staley KJ. Evolution of Network Synchronization during Early Epileptogenesis Parallels Synaptic Circuit Alterations. J Neurosci. 2015 Jul 08; 35(27):9920-34. PMID: 26156993.
    Citations: 16     Fields:    Translation:AnimalsCells
  24. Eikermann-Haerter K, Arbel-Ornath M, Yalcin N, Yu ES, Kuchibhotla KV, Yuzawa I, Hudry E, Willard CR, Climov M, Keles F, Belcher AM, Sengul B, Negro A, Rosen IA, Arreguin A, Ferrari MD, van den Maagdenberg AM, Bacskai BJ, Ayata C. Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice. Ann Neurol. 2015 Aug; 78(2):193-210. PMID: 26032020.
    Citations: 5     Fields:    Translation:AnimalsCells
  25. Grishchuk Y, Sri S, Rudinskiy N, Ma W, Stember KG, Cottle MW, Sapp E, Difiglia M, Muzikansky A, Betensky RA, Wong AM, Bacskai BJ, Hyman BT, Kelleher RJ, Cooper JD, Slaugenhaupt SA. Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV. Acta Neuropathol Commun. 2014 Sep 09; 2:133. PMID: 25200117.
    Citations: 10     Fields:    Translation:AnimalsCells
  26. Glykys J, Dzhala V, Egawa K, Balena T, Saponjian Y, Kuchibhotla KV, Bacskai BJ, Kahle KT, Zeuthen T, Staley KJ. Response to comments on "Local impermeant anions establish the neuronal chloride concentration". Science. 2014 Sep 05; 345(6201):1130. PMID: 25190789.
    Citations: 4     Fields:    Translation:AnimalsCells
  27. Gu C, Chang J, Shchedrina VA, Pham VA, Hartwig JH, Suphamungmee W, Lehman W, Hyman BT, Bacskai BJ, Sever S. Regulation of dynamin oligomerization in cells: the role of dynamin-actin interactions and its GTPase activity. Traffic. 2014 Aug; 15(8):819-38. PMID: 24891099.
    Citations: 6     Fields:    Translation:AnimalsCells
  28. Guo Y, Yuan H, Claudio NM, Kura S, Shakerdge N, Mempel TR, Bacskai BJ, Josephson L. PEG-like nanoprobes: multimodal, pharmacokinetically and optically tunable nanomaterials. PLoS One. 2014; 9(4):e95406. PMID: 24781778.
    Citations: 2     Fields:    Translation:AnimalsCells
  29. Hou SS, Rice WL, Bacskai BJ, Kumar AT. Tomographic lifetime imaging using combined early- and late-arriving photons. Opt Lett. 2014 Mar 01; 39(5):1165-8. PMID: 24690697.
    Citations: 6     Fields:    
  30. Glykys J, Dzhala V, Egawa K, Balena T, Saponjian Y, Kuchibhotla KV, Bacskai BJ, Kahle KT, Zeuthen T, Staley KJ. Local impermeant anions establish the neuronal chloride concentration. Science. 2014 Feb 07; 343(6171):670-5. PMID: 24503855.
    Citations: 52     Fields:    Translation:AnimalsCells
  31. Kuchibhotla KV, Wegmann S, Kopeikina KJ, Hawkes J, Rudinskiy N, Andermann ML, Spires-Jones TL, Bacskai BJ, Hyman BT. Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):510-4. PMID: 24368848.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  32. Kopeikina KJ, Wegmann S, Pitstick R, Carlson GA, Bacskai BJ, Betensky RA, Hyman BT, Spires-Jones TL. Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. PLoS One. 2013; 8(11):e80834. PMID: 24278327.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  33. Xie H, Guan J, Borrelli LA, Xu J, Serrano-Pozo A, Bacskai BJ. Mitochondrial alterations near amyloid plaques in an Alzheimer's disease mouse model. J Neurosci. 2013 Oct 23; 33(43):17042-51. PMID: 24155308.
    Citations: 42     Fields:    Translation:AnimalsCells
  34. Neal KL, Shakerdge NB, Hou SS, Klunk WE, Mathis CA, Nesterov EE, Swager TM, McLean PJ, Bacskai BJ. Development and screening of contrast agents for in vivo imaging of Parkinson's disease. Mol Imaging Biol. 2013 Oct; 15(5):585-95. PMID: 23624948.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  35. Arbel-Ornath M, Hudry E, Eikermann-Haerter K, Hou S, Gregory JL, Zhao L, Betensky RA, Frosch MP, Greenberg SM, Bacskai BJ. Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer's disease mouse models. Acta Neuropathol. 2013 Sep; 126(3):353-64. PMID: 23818064.
    Citations: 45     Fields:    Translation:AnimalsCells
  36. Xie H, Hou S, Jiang J, Sekutowicz M, Kelly J, Bacskai BJ. Rapid cell death is preceded by amyloid plaque-mediated oxidative stress. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):7904-9. PMID: 23610434.
    Citations: 23     Fields:    Translation:AnimalsCells
  37. Garcia-Alloza M, Borrelli LA, Thyssen DH, Hickman SE, El Khoury J, Bacskai BJ. Four-dimensional microglia response to anti-Aß treatment in APP/PS1xCX3CR1/GFP mice. Intravital. 2013; 2(2). PMID: 28944103.
    Citations:    
  38. Ramos-Rodriguez JJ, Pacheco-Herrero M, Thyssen D, Murillo-Carretero MI, Berrocoso E, Spires-Jones TL, Bacskai BJ, Garcia-Alloza M. Rapid ß-amyloid deposition and cognitive impairment after cholinergic denervation in APP/PS1 mice. J Neuropathol Exp Neurol. 2013 Apr; 72(4):272-85. PMID: 23481704.
    Citations: 18     Fields:    Translation:AnimalsCells
  39. Gregory JL, Prada CM, Fine SJ, Garcia-Alloza M, Betensky RA, Arbel-Ornath M, Greenberg SM, Bacskai BJ, Frosch MP. Reducing available soluble ß-amyloid prevents progression of cerebral amyloid angiopathy in transgenic mice. J Neuropathol Exp Neurol. 2012 Nov; 71(11):1009-17. PMID: 23095848.
    Citations: 5     Fields:    Translation:Animals
  40. Hashimoto T, Serrano-Pozo A, Hori Y, Adams KW, Takeda S, Banerji AO, Mitani A, Joyner D, Thyssen DH, Bacskai BJ, Frosch MP, Spires-Jones TL, Finn MB, Holtzman DM, Hyman BT. Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid ß peptide. J Neurosci. 2012 Oct 24; 32(43):15181-92. PMID: 23100439.
    Citations: 49     Fields:    Translation:HumansCells
  41. Serrano-Pozo A, Mielke ML, Muzitansky A, Gómez-Isla T, Growdon JH, Bacskai BJ, Betensky RA, Frosch MP, Hyman BT. Stable size distribution of amyloid plaques over the course of Alzheimer disease. J Neuropathol Exp Neurol. 2012 Aug; 71(8):694-701. PMID: 22805771.
    Citations: 10     Fields:    Translation:Humans
  42. Nabuurs RJ, Rutgers KS, Welling MM, Metaxas A, de Backer ME, Rotman M, Bacskai BJ, van Buchem MA, van der Maarel SM, van der Weerd L. In vivo detection of amyloid-ß deposits using heavy chain antibody fragments in a transgenic mouse model for Alzheimer's disease. PLoS One. 2012; 7(6):e38284. PMID: 22675537.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  43. Wu HY, Hudry E, Hashimoto T, Uemura K, Fan ZY, Berezovska O, Grosskreutz CL, Bacskai BJ, Hyman BT. Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-ß revealed by a novel fluorescence resonance energy transfer assay. J Neurosci. 2012 Apr 11; 32(15):5298-309. PMID: 22496575.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  44. Hudry E, Wu HY, Arbel-Ornath M, Hashimoto T, Matsouaka R, Fan Z, Spires-Jones TL, Betensky RA, Bacskai BJ, Hyman BT. Inhibition of the NFAT pathway alleviates amyloid ß neurotoxicity in a mouse model of Alzheimer's disease. J Neurosci. 2012 Feb 29; 32(9):3176-92. PMID: 22378890.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  45. Lee JH, Bacskai BJ, Ayata C. Genetic animal models of cerebral vasculopathies. Prog Mol Biol Transl Sci. 2012; 105:25-55. PMID: 22137428.
    Citations: 4     Fields:    Translation:HumansAnimals
  46. Garcia-Alloza M, Gregory J, Kuchibhotla KV, Fine S, Wei Y, Ayata C, Frosch MP, Greenberg SM, Bacskai BJ. Cerebrovascular lesions induce transient ß-amyloid deposition. Brain. 2011 Dec; 134(Pt 12):3697-707. PMID: 22120142.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  47. Jones PB, Adams KW, Rozkalne A, Spires-Jones TL, Hshieh TT, Hashimoto T, von Armin CA, Mielke M, Bacskai BJ, Hyman BT. Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-ß in human Alzheimer brain. PLoS One. 2011 Jan 31; 6(1):e14586. PMID: 21297948.
    Citations: 28     Fields:    Translation:HumansCells
  48. Spires-Jones TL, de Calignon A, Meyer-Luehmann M, Bacskai BJ, Hyman BT. Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging. Methods. 2011 Mar; 53(3):201-7. PMID: 21163350.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  49. Dzhala VI, Kuchibhotla KV, Glykys JC, Kahle KT, Swiercz WB, Feng G, Kuner T, Augustine GJ, Bacskai BJ, Staley KJ. Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures. J Neurosci. 2010 Sep 01; 30(35):11745-61. PMID: 20810895.
    Citations: 52     Fields:    Translation:AnimalsCells
  50. Raymond SB, Boas DA, Bacskai BJ, Kumar AT. Lifetime-based tomographic multiplexing. J Biomed Opt. 2010 Jul-Aug; 15(4):046011. PMID: 20799813.
    Citations: 13     Fields:    Translation:Animals
  51. de Calignon A, Fox LM, Pitstick R, Carlson GA, Bacskai BJ, Spires-Jones TL, Hyman BT. Caspase activation precedes and leads to tangles. Nature. 2010 Apr 22; 464(7292):1201-4. PMID: 20357768.
    Citations: 177     Fields:    Translation:HumansAnimalsCells
  52. Wu HY, Hudry E, Hashimoto T, Kuchibhotla K, Rozkalne A, Fan Z, Spires-Jones T, Xie H, Arbel-Ornath M, Grosskreutz CL, Bacskai BJ, Hyman BT. Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation. J Neurosci. 2010 Feb 17; 30(7):2636-49. PMID: 20164348.
    Citations: 147     Fields:    Translation:HumansAnimalsCells
  53. Coma M, Serenó L, Da Rocha-Souto B, Scotton TC, España J, Sánchez MB, Rodríguez M, Agulló J, Guardia-Laguarta C, Garcia-Alloza M, Borrelli LA, Clarimón J, Lleó A, Bacskai BJ, Saura CA, Hyman BT, Gómez-Isla T. Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease. Neurobiol Dis. 2010 Jun; 38(3):482-91. PMID: 20149872.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  54. Rutgers KS, van Remoortere A, van Buchem MA, Verrips CT, Greenberg SM, Bacskai BJ, Frosch MP, van Duinen SG, Maat-Schieman ML, van der Maarel SM. Differential recognition of vascular and parenchymal beta amyloid deposition. Neurobiol Aging. 2011 Oct; 32(10):1774-83. PMID: 20015576.
    Citations: 8     Fields:    Translation:HumansCells
  55. Uemura K, Lill CM, Li X, Peters JA, Ivanov A, Fan Z, DeStrooper B, Bacskai BJ, Hyman BT, Berezovska O. Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio. PLoS One. 2009 Nov 18; 4(11):e7893. PMID: 19924286.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  56. Ran C, Xu X, Raymond SB, Ferrara BJ, Neal K, Bacskai BJ, Medarova Z, Moore A. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. J Am Chem Soc. 2009 Oct 28; 131(42):15257-61. PMID: 19807070.
    Citations: 40     Fields:    Translation:AnimalsCells
  57. Meyer-Luehmann M, Mielke M, Spires-Jones TL, Stoothoff W, Jones P, Bacskai BJ, Hyman BT. A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice. J Neurosci. 2009 Oct 07; 29(40):12636-40. PMID: 19812338.
    Citations: 22     Fields:    Translation:AnimalsCells
  58. Raymond SB, Kumar AT, Boas DA, Bacskai BJ. Optimal parameters for near infrared fluorescence imaging of amyloid plaques in Alzheimer's disease mouse models. Phys Med Biol. 2009 Oct 21; 54(20):6201-16. PMID: 19794239.
    Citations: 2     Fields:    Translation:HumansAnimals
  59. Glykys J, Dzhala VI, Kuchibhotla KV, Feng G, Kuner T, Augustine G, Bacskai BJ, Staley KJ. Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures. Neuron. 2009 Sep 10; 63(5):657-72. PMID: 19755108.
    Citations: 49     Fields:    Translation:AnimalsCells
  60. Stoothoff W, Jones PB, Spires-Jones TL, Joyner D, Chhabra E, Bercury K, Fan Z, Xie H, Bacskai B, Edd J, Irimia D, Hyman BT. Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport. J Neurochem. 2009 Oct; 111(2):417-27. PMID: 19686388.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  61. Kumar AT, Chung E, Raymond SB, van de Water JA, Shah K, Fukumura D, Jain RK, Bacskai BJ, Boas DA. Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast. Opt Lett. 2009 Jul 01; 34(13):2066-8. PMID: 19572001.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  62. Garcia-Alloza M, Subramanian M, Thyssen D, Borrelli LA, Fauq A, Das P, Golde TE, Hyman BT, Bacskai BJ. Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575. Mol Neurodegener. 2009 May 06; 4:19. PMID: 19419556.
    Citations: 24     Fields:    
  63. Garcia-Alloza M, Prada C, Lattarulo C, Fine S, Borrelli LA, Betensky R, Greenberg SM, Frosch MP, Bacskai BJ. Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice. J Neurochem. 2009 Jun; 109(6):1636-47. PMID: 19457117.
    Citations: 24     Fields:    Translation:HumansAnimals
  64. Kuchibhotla KV, Lattarulo CR, Hyman BT, Bacskai BJ. Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice. Science. 2009 Feb 27; 323(5918):1211-5. PMID: 19251629.
    Citations: 176     Fields:    Translation:HumansAnimalsCells
  65. Jiang Y, Borrelli L, Bacskai BJ, Kanaoka Y, Boyce JA. P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells. J Immunol. 2009 Jan 15; 182(2):1129-37. PMID: 19124756.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  66. Garcia-Alloza M, Borrelli LA, Hyman BT, Bacskai BJ. Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice. Neurobiol Aging. 2010 Dec; 31(12):2058-68. PMID: 19124175.
    Citations: 16     Fields:    Translation:Animals
  67. Koenigsknecht-Talboo J, Meyer-Luehmann M, Parsadanian M, Garcia-Alloza M, Finn MB, Hyman BT, Bacskai BJ, Holtzman DM. Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice. J Neurosci. 2008 Dec 24; 28(52):14156-64. PMID: 19109498.
    Citations: 58     Fields:    Translation:AnimalsCells
  68. Mandal AK, Jones PB, Bair AM, Christmas P, Miller D, Yamin TT, Wisniewski D, Menke J, Evans JF, Hyman BT, Bacskai B, Chen M, Lee DM, Nikolic B, Soberman RJ. The nuclear membrane organization of leukotriene synthesis. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20434-9. PMID: 19075240.
    Citations: 29     Fields:    Translation:AnimalsCells
  69. Spires-Jones TL, Mielke ML, Rozkalne A, Meyer-Luehmann M, de Calignon A, Bacskai BJ, Schenk D, Hyman BT. Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease. Neurobiol Dis. 2009 Feb; 33(2):213-20. PMID: 19028582.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  70. Stoothoff WH, Bacskai BJ, Hyman BT. Monitoring tau-tubulin interactions utilizing second harmonic generation in living neurons. J Biomed Opt. 2008 Nov-Dec; 13(6):064039. PMID: 19123685.
    Citations: 9     Fields:    Translation:AnimalsCells
  71. Kumar AT, Raymond SB, Dunn AK, Bacskai BJ, Boas DA. A time domain fluorescence tomography system for small animal imaging. IEEE Trans Med Imaging. 2008 Aug; 27(8):1152-63. PMID: 18672432.
    Citations: 35     Fields:    Translation:Animals
  72. Kuchibhotla KV, Goldman ST, Lattarulo CR, Wu HY, Hyman BT, Bacskai BJ. Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron. 2008 Jul 31; 59(2):214-25. PMID: 18667150.
    Citations: 187     Fields:    Translation:HumansAnimalsCells
  73. Raymond SB, Treat LH, Dewey JD, McDannold NJ, Hynynen K, Bacskai BJ. Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models. PLoS One. 2008 May 14; 3(5):e2175. PMID: 18478109.
    Citations: 59     Fields:    Translation:Animals
  74. Raymond SB, Skoch J, Hills ID, Nesterov EE, Swager TM, Bacskai BJ. Erratum to Smart optical probes for near-infrared fluorescence imaging of Alzheimer's disease pathology. Eur J Nucl Med Mol Imaging. 2008 May; 35(5):1032. PMID: 28289876.
    Citations:    Fields:    
  75. Kumar AT, Raymond SB, Bacskai BJ, Boas DA. Comparison of frequency-domain and time-domain fluorescence lifetime tomography. Opt Lett. 2008 Mar 01; 33(5):470-2. PMID: 18311295.
    Citations: 14     Fields:    
  76. Raymond SB, Skoch J, Hills ID, Nesterov EE, Swager TM, Bacskai BJ. Smart optical probes for near-infrared fluorescence imaging of Alzheimer's disease pathology. Eur J Nucl Med Mol Imaging. 2008 Mar; 35 Suppl 1:S93-8. PMID: 18236039.
    Citations: 26     Fields:    Translation:HumansAnimals
  77. Meyer-Luehmann M, Spires-Jones TL, Prada C, Garcia-Alloza M, de Calignon A, Rozkalne A, Koenigsknecht-Talboo J, Holtzman DM, Bacskai BJ, Hyman BT. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature. 2008 Feb 07; 451(7179):720-4. PMID: 18256671.
    Citations: 339     Fields:    Translation:AnimalsCells
  78. Spires-Jones TL, de Calignon A, Matsui T, Zehr C, Pitstick R, Wu HY, Osetek JD, Jones PB, Bacskai BJ, Feany MB, Carlson GA, Ashe KH, Lewis J, Hyman BT. In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. J Neurosci. 2008 Jan 23; 28(4):862-7. PMID: 18216194.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  79. Jones PB, Rozkalne A, Meyer-Luehmann M, Spires-Jones TL, Makarova A, Kumar AT, Berezovska O, Bacskai BB, Hyman BT. Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy. J Biomed Opt. 2008 Jan-Feb; 13(1):014008. PMID: 18315366.
    Citations: 4     Fields:    Translation:AnimalsCells
  80. Spires-Jones TL, Meyer-Luehmann M, Osetek JD, Jones PB, Stern EA, Bacskai BJ, Hyman BT. Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model. Am J Pathol. 2007 Oct; 171(4):1304-11. PMID: 17717139.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  81. Jiang Y, Borrelli LA, Kanaoka Y, Bacskai BJ, Boyce JA. CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. Blood. 2007 Nov 01; 110(9):3263-70. PMID: 17693579.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  82. Garcia-Alloza M, Ferrara BJ, Dodwell SA, Hickey GA, Hyman BT, Bacskai BJ. A limited role for microglia in antibody mediated plaque clearance in APP mice. Neurobiol Dis. 2007 Dec; 28(3):286-92. PMID: 17822910.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  83. Shin HK, Jones PB, Garcia-Alloza M, Borrelli L, Greenberg SM, Bacskai BJ, Frosch MP, Hyman BT, Moskowitz MA, Ayata C. Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy. Brain. 2007 Sep; 130(Pt 9):2310-9. PMID: 17638859.
    Citations: 52     Fields:    Translation:Animals
  84. Garcia-Alloza M, Borrelli LA, Rozkalne A, Hyman BT, Bacskai BJ. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J Neurochem. 2007 Aug; 102(4):1095-104. PMID: 17472706.
    Citations: 120     Fields:    Translation:AnimalsCells
  85. Bacskai BJ, Frosch MP, Freeman SH, Raymond SB, Augustinack JC, Johnson KA, Irizarry MC, Klunk WE, Mathis CA, Dekosky ST, Greenberg SM, Hyman BT, Growdon JH. Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Arch Neurol. 2007 Mar; 64(3):431-4. PMID: 17353389.
    Citations: 115     Fields:    Translation:Humans
  86. Prada CM, Garcia-Alloza M, Betensky RA, Zhang-Nunes SX, Greenberg SM, Bacskai BJ, Frosch MP. Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging. J Neurosci. 2007 Feb 21; 27(8):1973-80. PMID: 17314293.
    Citations: 22     Fields:    Translation:Animals
  87. Raymond SB, Skoch J, Bacskai BJ, Hynynen K. Modular design for in vivo optical imaging and ultrasound treatment in the murine brain. IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Feb; 54(2):431-4. PMID: 17328340.
    Citations: 3     Fields:    Translation:Animals
  88. Hillman EM, Devor A, Bouchard MB, Dunn AK, Krauss GW, Skoch J, Bacskai BJ, Dale AM, Boas DA. Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation. Neuroimage. 2007 Mar; 35(1):89-104. PMID: 17222567.
    Citations: 104     Fields:    Translation:Animals
  89. Kumar AT, Raymond SB, Boverman G, Boas DA, Bacskai BJ. Time resolved fluorescence tomography of turbid media based on lifetime contrast. Opt Express. 2006 Dec 11; 14(25):12255-70. PMID: 19529654.
    Citations: 26     Fields:    
  90. Garcia-Alloza M, Dodwell SA, Meyer-Luehmann M, Hyman BT, Bacskai BJ. Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model. J Neuropathol Exp Neurol. 2006 Nov; 65(11):1082-9. PMID: 17086105.
    Citations: 29     Fields:    Translation:AnimalsCells
  91. Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, Prada C, Greenberg SM, Bacskai BJ, Frosch MP. Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiol Dis. 2006 Dec; 24(3):516-24. PMID: 17029828.
    Citations: 178     Fields:    Translation:Animals
  92. Jones PB, Herl L, Berezovska O, Kumar AT, Bacskai BJ, Hyman BT. Time-domain fluorescent plate reader for cell based protein-protein interaction and protein conformation assays. J Biomed Opt. 2006 Sep-Oct; 11(5):054024. PMID: 17092173.
    Citations: 4     Fields:    Translation:Cells
  93. Sever S, Skoch J, Newmyer S, Ramachandran R, Ko D, McKee M, Bouley R, Ausiello D, Hyman BT, Bacskai BJ. Physical and functional connection between auxilin and dynamin during endocytosis. EMBO J. 2006 Sep 20; 25(18):4163-74. PMID: 16946707.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  94. Guo S, Wang S, Kim WJ, Lee SR, Frosch MP, Bacskai BJ, Greenberg SM, Lo EH. Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes. Brain Res. 2006 Sep 21; 1111(1):222-6. PMID: 16919608.
    Citations: 8     Fields:    Translation:AnimalsCells
  95. Raymond SB, Skoch J, Hynynen K, Bacskai BJ. Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo. J Cereb Blood Flow Metab. 2007 Feb; 27(2):393-403. PMID: 16685254.
    Citations: 47     Fields:    Translation:Animals
  96. Robbins EM, Betensky RA, Domnitz SB, Purcell SM, Garcia-Alloza M, Greenberg C, Rebeck GW, Hyman BT, Greenberg SM, Frosch MP, Bacskai BJ. Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease. J Neurosci. 2006 Jan 11; 26(2):365-71. PMID: 16407531.
    Citations: 33     Fields:    Translation:HumansAnimals
  97. Skoch J, Hyman BT, Bacskai BJ. Preclinical characterization of amyloid imaging probes with multiphoton microscopy. J Alzheimers Dis. 2006; 9(3 Suppl):401-7. PMID: 16914878.
    Citations: 4     Fields:    Translation:HumansAnimals
  98. Kumar AT, Skoch J, Bacskai BJ, Boas DA, Dunn AK. Fluorescence-lifetime-based tomography for turbid media. Opt Lett. 2005 Dec 15; 30(24):3347-9. PMID: 16389827.
    Citations: 23     Fields:    
  99. Nesterov EE, Skoch J, Hyman BT, Klunk WE, Bacskai BJ, Swager TM. In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers. Angew Chem Int Ed Engl. 2005 Aug 26; 44(34):5452-6. PMID: 16059955.
    Citations: 51     Fields:    Translation:AnimalsCells
  100. Spires TL, Meyer-Luehmann M, Stern EA, McLean PJ, Skoch J, Nguyen PT, Bacskai BJ, Hyman BT. Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J Neurosci. 2005 Aug 03; 25(31):7278-87. PMID: 16079410.
    Citations: 201     Fields:    Translation:AnimalsCells
  101. Xiang Z, Nesterov EE, Skoch J, Lin T, Hyman BT, Swager TM, Bacskai BJ, Reeves SA. Detection of myelination using a novel histological probe. J Histochem Cytochem. 2005 Dec; 53(12):1511-6. PMID: 16046669.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  102. Domnitz SB, Robbins EM, Hoang AW, Garcia-Alloza M, Hyman BT, Rebeck GW, Greenberg SM, Bacskai BJ, Frosch MP. Progression of cerebral amyloid angiopathy in transgenic mouse models of Alzheimer disease. J Neuropathol Exp Neurol. 2005 Jul; 64(7):588-94. PMID: 16042310.
    Citations: 23     Fields:    Translation:HumansAnimals
  103. Golde TE, Bacskai BJ. Bringing amyloid into focus. Nat Biotechnol. 2005 May; 23(5):552-4. PMID: 15877070.
    Citations: 3     Fields:    Translation:Animals
  104. Berezovska O, Lleo A, Herl LD, Frosch MP, Stern EA, Bacskai BJ, Hyman BT. Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein. J Neurosci. 2005 Mar 16; 25(11):3009-17. PMID: 15772361.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  105. von Arnim CA, Kinoshita A, Peltan ID, Tangredi MM, Herl L, Lee BM, Spoelgen R, Hshieh TT, Ranganathan S, Battey FD, Liu CX, Bacskai BJ, Sever S, Irizarry MC, Strickland DK, Hyman BT. The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate. J Biol Chem. 2005 May 06; 280(18):17777-85. PMID: 15749709.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  106. Brendza RP, Bacskai BJ, Cirrito JR, Simmons KA, Skoch JM, Klunk WE, Mathis CA, Bales KR, Paul SM, Hyman BT, Holtzman DM. Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice. J Clin Invest. 2005 Feb; 115(2):428-33. PMID: 15668737.
    Citations: 75     Fields:    Translation:AnimalsCells
  107. Sever S, Skoch J, Bacskai BJ, Newmyer SL. Assays and functional properties of auxilin-dynamin interactions. Methods Enzymol. 2005; 404:570-85. PMID: 16413301.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  108. Skoch J, Hickey GA, Kajdasz ST, Hyman BT, Bacskai BJ. In vivo imaging of amyloid-beta deposits in mouse brain with multiphoton microscopy. Methods Mol Biol. 2005; 299:349-63. PMID: 15980616.
    Citations: 23     Fields:    Translation:Animals
  109. Skoch J, Dunn A, Hyman BT, Bacskai BJ. Development of an optical approach for noninvasive imaging of Alzheimer's disease pathology. J Biomed Opt. 2005 Jan-Feb; 10(1):11007. PMID: 15847573.
    Citations: 7     Fields:    Translation:Animals
  110. Lleó A, Berezovska O, Herl L, Raju S, Deng A, Bacskai BJ, Frosch MP, Irizarry M, Hyman BT. Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation. Nat Med. 2004 Oct; 10(10):1065-6. PMID: 15448688.
    Citations: 62     Fields:    Translation:AnimalsCells
  111. Pasinelli P, Belford ME, Lennon N, Bacskai BJ, Hyman BT, Trotti D, Brown RH. Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria. Neuron. 2004 Jul 08; 43(1):19-30. PMID: 15233914.
    Citations: 126     Fields:    Translation:HumansAnimalsCells
  112. Stern EA, Bacskai BJ, Hickey GA, Attenello FJ, Lombardo JA, Hyman BT. Cortical synaptic integration in vivo is disrupted by amyloid-beta plaques. J Neurosci. 2004 May 12; 24(19):4535-40. PMID: 15140924.
    Citations: 74     Fields:    Translation:AnimalsCells
  113. Mandal AK, Skoch J, Bacskai BJ, Hyman BT, Christmas P, Miller D, Yamin TT, Xu S, Wisniewski D, Evans JF, Soberman RJ. The membrane organization of leukotriene synthesis. Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17):6587-92. PMID: 15084748.
    Citations: 19     Fields:    Translation:HumansCells
  114. Garcia-Alloza M, Bacskai BJ. Techniques for brain imaging in vivo. Neuromolecular Med. 2004; 6(1):65-78. PMID: 15781977.
    Citations: 5     Fields:    Translation:Humans
  115. Lombardo JA, Stern EA, McLellan ME, Kajdasz ST, Hickey GA, Bacskai BJ, Hyman BT. Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations. J Neurosci. 2003 Nov 26; 23(34):10879-83. PMID: 14645482.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  116. Ramdya P, Skoch J, Bacskai BJ, Hyman BT, Berezovska O. Activated Notch1 associates with a presenilin-1/gamma-secretase docking site. J Neurochem. 2003 Nov; 87(4):843-50. PMID: 14622115.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  117. Klunk WE, Engler H, Nordberg A, Bacskai BJ, Wang Y, Price JC, Bergström M, Hyman BT, Långström B, Mathis CA. Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography. Neuroimaging Clin N Am. 2003 Nov; 13(4):781-9, ix. PMID: 15024961.
    Citations: 17     Fields:    Translation:Humans
  118. Bacskai BJ, Hickey GA, Skoch J, Kajdasz ST, Wang Y, Huang GF, Mathis CA, Klunk WE, Hyman BT. Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12462-7. PMID: 14517353.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  119. Lennon NJ, Kho A, Bacskai BJ, Perlmutter SL, Hyman BT, Brown RH. Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. J Biol Chem. 2003 Dec 12; 278(50):50466-73. PMID: 14506282.
    Citations: 136     Fields:    Translation:AnimalsCells
  120. Bacskai BJ, Skoch J, Hickey GA, Allen R, Hyman BT. Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques. J Biomed Opt. 2003 Jul; 8(3):368-75. PMID: 12880341.
    Citations: 25     Fields:    Translation:AnimalsCells
  121. Berezovska O, Bacskai BJ, Hyman BT. Monitoring proteins in intact cells. Sci Aging Knowledge Environ. 2003 Jun 11; 2003(23):PE14. PMID: 12844526.
    Citations: 4     Fields:    Translation:HumansCells
  122. Berezovska O, Ramdya P, Skoch J, Wolfe MS, Bacskai BJ, Hyman BT. Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging. J Neurosci. 2003 Jun 01; 23(11):4560-6. PMID: 12805296.
    Citations: 24     Fields:    Translation:AnimalsCells
  123. Greenberg SM, Bacskai BJ, Hyman BT. Alzheimer disease's double-edged vaccine. Nat Med. 2003 Apr; 9(4):389-90. PMID: 12640449.
    Citations: 13     Fields:    Translation:HumansCells
  124. McLellan ME, Kajdasz ST, Hyman BT, Bacskai BJ. In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy. J Neurosci. 2003 Mar 15; 23(6):2212-7. PMID: 12657680.
    Citations: 45     Fields:    Translation:AnimalsCells
  125. D'Amore JD, Kajdasz ST, McLellan ME, Bacskai BJ, Stern EA, Hyman BT. In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories. J Neuropathol Exp Neurol. 2003 Feb; 62(2):137-45. PMID: 12578223.
    Citations: 44     Fields:    Translation:AnimalsCells
  126. Bacskai BJ, Hyman BT. Alzheimer's disease: what multiphoton microscopy teaches us. Neuroscientist. 2002 Oct; 8(5):386-90. PMID: 12374422.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  127. Bacskai BJ, Kajdasz ST, McLellan ME, Games D, Seubert P, Schenk D, Hyman BT. Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy. J Neurosci. 2002 Sep 15; 22(18):7873-8. PMID: 12223540.
    Citations: 108     Fields:    Translation:HumansAnimals
  128. Klunk WE, Bacskai BJ, Mathis CA, Kajdasz ST, McLellan ME, Frosch MP, Debnath ML, Holt DP, Wang Y, Hyman BT. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropathol Exp Neurol. 2002 Sep; 61(9):797-805. PMID: 12230326.
    Citations: 111     Fields:    Translation:AnimalsCells
  129. Bacskai BJ, Klunk WE, Mathis CA, Hyman BT. Imaging amyloid-beta deposits in vivo. J Cereb Blood Flow Metab. 2002 Sep; 22(9):1035-41. PMID: 12218409.
    Citations: 26     Fields:    Translation:Humans
  130. Kotilinek LA, Bacskai B, Westerman M, Kawarabayashi T, Younkin L, Hyman BT, Younkin S, Ashe KH. Reversible memory loss in a mouse transgenic model of Alzheimer's disease. J Neurosci. 2002 Aug 01; 22(15):6331-5. PMID: 12151510.
    Citations: 125     Fields:    Translation:Animals
  131. Mathis CA, Bacskai BJ, Kajdasz ST, McLellan ME, Frosch MP, Hyman BT, Holt DP, Wang Y, Huang GF, Debnath ML, Klunk WE. A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. Bioorg Med Chem Lett. 2002 Feb 11; 12(3):295-8. PMID: 11814781.
    Citations: 72     Fields:    Translation:AnimalsCells
  132. Christie R, Kimchi E, Kajdasz S, Bacskai B, Hyman BT. Multiphoton microscopy and amyloid angiopathy. Amyloid. 2001 Jul; 8 Suppl 1:48-50. PMID: 11676290.
    Citations: 5     Fields:    Translation:HumansAnimals
  133. Bacskai BJ, Kajdasz ST, Christie RH, Carter C, Games D, Seubert P, Schenk D, Hyman BT. Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat Med. 2001 Mar; 7(3):369-72. PMID: 11231639.
    Citations: 113     Fields:    Translation:AnimalsCells
  134. Kimchi EY, Kajdasz S, Bacskai BJ, Hyman BT. Analysis of cerebral amyloid angiopathy in a transgenic mouse model of Alzheimer disease using in vivo multiphoton microscopy. J Neuropathol Exp Neurol. 2001 Mar; 60(3):274-9. PMID: 11245211.
    Citations: 9     Fields:    Translation:Animals
  135. Christie RH, Bacskai BJ, Zipfel WR, Williams RM, Kajdasz ST, Webb WW, Hyman BT. Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy. J Neurosci. 2001 Feb 01; 21(3):858-64. PMID: 11157072.
    Citations: 58     Fields:    Translation:Animals
  136. Bacskai BJ, Xia MQ, Strickland DK, Rebeck GW, Hyman BT. The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors. Proc Natl Acad Sci U S A. 2000 Oct 10; 97(21):11551-6. PMID: 11016955.
    Citations: 54     Fields:    Translation:AnimalsCells
  137. Xia MQ, Bacskai BJ, Knowles RB, Qin SX, Hyman BT. Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer's disease. J Neuroimmunol. 2000 Aug 01; 108(1-2):227-35. PMID: 10900358.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  138. Grant ER, Bacskai BJ, Anegawa NJ, Pleasure DE, Lynch DR. Opposing contributions of NR1 and NR2 to protein kinase C modulation of NMDA receptors. J Neurochem. 1998 Oct; 71(4):1471-81. PMID: 9751180.
    Citations: 8     Fields:    Translation:HumansCells
  139. Grant ER, Bacskai BJ, Pleasure DE, Pritchett DB, Gallagher MJ, Kendrick SJ, Kricka LJ, Lynch DR. N-methyl-D-aspartate receptors expressed in a nonneuronal cell line mediate subunit-specific increases in free intracellular calcium. J Biol Chem. 1997 Jan 03; 272(1):647-56. PMID: 8995308.
    Citations: 11     Fields:    Translation:HumansCells
  140. Yoshioka A, Bacskai B, Pleasure D. Pathophysiology of oligodendroglial excitotoxicity. J Neurosci Res. 1996 Nov 15; 46(4):427-37. PMID: 8950702.
    Citations: 21     Fields:    Translation:AnimalsCells
  141. Bacskai BJ, Wallén P, Lev-Ram V, Grillner S, Tsien RY. Activity-related calcium dynamics in lamprey motoneurons as revealed by video-rate confocal microscopy. Neuron. 1995 Jan; 14(1):19-28. PMID: 7826636.
    Citations: 16     Fields:    Translation:AnimalsCells
  142. Ranganathan R, Bacskai BJ, Tsien RY, Zuker CS. Cytosolic calcium transients: spatial localization and role in Drosophila photoreceptor cell function. Neuron. 1994 Oct; 13(4):837-48. PMID: 7946332.
    Citations: 33     Fields:    Translation:AnimalsCells
  143. Civitelli R, Bacskai BJ, Mahaut-Smith MP, Adams SR, Avioli LV, Tsien RY. Single-cell analysis of cyclic AMP response to parathyroid hormone in osteoblastic cells. J Bone Miner Res. 1994 Sep; 9(9):1407-17. PMID: 7817824.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  144. Tsien RY, Bacskai BJ, Adams SR. FRET for studying intracellular signalling. Trends Cell Biol. 1993 Jul; 3(7):242-5. PMID: 14731760.
    Citations: 21     Fields:    
  145. Bacskai BJ, Hochner B, Mahaut-Smith M, Adams SR, Kaang BK, Kandel ER, Tsien RY. Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons. Science. 1993 Apr 09; 260(5105):222-6. PMID: 7682336.
    Citations: 109     Fields:    Translation:AnimalsCells
  146. Adams S, Bacskai B, Harootunian AT, Mahaut-Smith M, Sammak PJ, Taylor SS, Tsien RY. Imaging of cAMP signals and A-kinase translocation in single living cells. Adv Second Messenger Phosphoprotein Res. 1993; 28:167-70. PMID: 8398399.
    Citations: 1     Fields:    Translation:AnimalsCells
  147. Adams SR, Bacskai BJ, Hochner B, Kaang BK, Kandel ER, Mahaut-Smith M, Tsien RY. Confocal imaging of cAMP signals in Aplysia neurons. Jpn J Physiol. 1993; 43 Suppl 1:S91-3. PMID: 8271521.
    Citations:    Fields:    Translation:AnimalsCells
  148. Pizzonia JH, Gesek FA, Kennedy SM, Coutermarsh BA, Bacskai BJ, Friedman PA. Immunomagnetic separation, primary culture, and characterization of cortical thick ascending limb plus distal convoluted tubule cells from mouse kidney. In Vitro Cell Dev Biol. 1991 May; 27A(5):409-16. PMID: 1649164.
    Citations: 12     Fields:    Translation:AnimalsCells
  149. Bacskai BJ, Friedman PA. Activation of latent Ca2+ channels in renal epithelial cells by parathyroid hormone. Nature. 1990 Sep 27; 347(6291):388-91. PMID: 1699128.
    Citations: 21     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.