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Matthew Macleod Heeney, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Heeney MM, Berhe S, Campagna DR, Oved JH, Kurre P, Shaw PJ, Teo J, Shanap MA, Hassab HM, Glader BE, Shah S, Yoshimi A, Ameri A, Antin JH, Boudreaux J, Briones M, Dickerson KE, Fernandez CV, Farah R, Hasle H, Keel SB, Olson TS, Powers JM, Rose MJ, Shimamura A, Bottomley SS, Fleming MD. SLC25A38 congenital sideroblastic anemia: Phenotypes and genotypes of 31 individuals from 24 families, including 11 novel mutations, and a review of the literature. Hum Mutat. 2021 Nov; 42(11):1367-1383. PMID: 34298585.
    Citations:    Fields:    
  2. Harris EM, Vilk E, Heeney MM, Solodiuk J, Greco C, Archer NM. A systematic review of ketamine for the management of vaso-occlusive pain in sickle cell disease. Pediatr Blood Cancer. 2021 Jul; 68(7):e28989. PMID: 33788404.
    Citations:    Fields:    
  3. Esrick EB, Lehmann LE, Biffi A, Achebe M, Brendel C, Ciuculescu MF, Daley H, MacKinnon B, Morris E, Federico A, Abriss D, Boardman K, Khelladi R, Shaw K, Negre H, Negre O, Nikiforow S, Ritz J, Pai SY, London WB, Dansereau C, Heeney MM, Armant M, Manis JP, Williams DA. Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease. N Engl J Med. 2021 01 21; 384(3):205-215. PMID: 33283990.
    Citations: 30     Fields:    Translation:HumansCellsCTClinical Trials
  4. Meier ER, Creary SE, Heeney MM, Dong M, Appiah-Kubi AO, Nelson SC, Niss O, Piccone C, Quarmyne MO, Quinn CT, Saving KL, Scott JP, Talati R, Latham TS, Pfeiffer A, Shook LM, Vinks AA, Lane A, McGann PT. Hydroxyurea Optimization through Precision Study (HOPS): study protocol for a randomized, multicenter trial in children with sickle cell anemia. Trials. 2020 Nov 27; 21(1):983. PMID: 33246482.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  5. Crispin A, Guo C, Chen C, Campagna DR, Schmidt PJ, Lichtenstein D, Cao C, Sendamarai AK, Hildick-Smith GJ, Huston NC, Boudreaux J, Bottomley SS, Heeney MM, Paw BH, Fleming MD, Ducamp S. Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia. J Clin Invest. 2020 10 01; 130(10):5245-5256. PMID: 32634119.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  6. Daak AA, Lopez-Toledano MA, Heeney MM. Biochemical and therapeutic effects of Omega-3 fatty acids in sickle cell disease. Complement Ther Med. 2020 Aug; 52:102482. PMID: 32951732.
    Citations: 1     Fields:    Translation:Humans
  7. Brucker WJ, Croteau SE, Prensner JR, Cullion K, Heeney MM, Lo J, McAlvin JB, Peeler K, Shah N, Yee CSK, Berry GT, Bodamer O. An emerging role for endothelial barrier support therapy for congenital disorders of glycosylation. J Inherit Metab Dis. 2020 07; 43(4):880-890. PMID: 32064623.
    Citations: 5     Fields:    Translation:HumansCells
  8. Inusa BPD, Colombatti R, Rees DC, Heeney MM, Hoppe CC, Ogutu B, Hassab HM, Zhou C, Yao S, Brown PB, Heath LE, Jakubowski JA, Abboud MR. Geographic Differences in Phenotype and Treatment of Children with Sickle Cell Anemia from the Multinational DOVE Study. J Clin Med. 2019 Nov 17; 8(11). PMID: 31744266.
    Citations: 3     
  9. Heeney MM, Abboud MR, Amilon C, Andersson M, Githanga J, Inusa B, Kanter J, Leonsson-Zachrisson M, Michelson AD, Berggren AR. Ticagrelor versus placebo for the reduction of vaso-occlusive crises in pediatric sickle cell disease: Rationale and design of a randomized, double-blind, parallel-group, multicenter phase 3 study (HESTIA3). Contemp Clin Trials. 2019 10; 85:105835. PMID: 31446143.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  10. Tripodi SI, Shamberger RC, Heeney MM, Tubman VN. Clinical and laboratory outcomes following total or partial splenectomy in patients with hereditary spherocytosis. Pediatr Hematol Oncol. 2019 Sep; 36(6):382-389. PMID: 31347415.
    Citations: 1     Fields:    Translation:Humans
  11. Donado C, Solodiuk J, Rangel SJ, Nelson CP, Heeney MM, Mahan ST, Ullrich C, Tsegaye B, Berde CB. Patient- and Nurse-Controlled Analgesia: 22-Year Experience in a Pediatric Hospital. Hosp Pediatr. 2019 02; 9(2):129-133. PMID: 30655310.
    Citations: 1     Fields:    Translation:Humans
  12. Esrick EB, Manis JP, Daley H, Baricordi C, Trébéden-Negre H, Pierciey FJ, Armant M, Nikiforow S, Heeney MM, London WB, Biasco L, Asmal M, Williams DA, Biffi A. Successful hematopoietic stem cell mobilization and apheresis collection using plerixafor alone in sickle cell patients. Blood Adv. 2018 10 09; 2(19):2505-2512. PMID: 30282642.
    Citations: 14     Fields:    Translation:HumansCells
  13. Kopel LS, Klings ES, Monuteaux MC, Gaffin JM, Heeney MM, Phipatanakul W. Bronchodilator Use for Acute Chest Syndrome Among Large Pediatric Hospitals in North America. Clin Pediatr (Phila). 2018 12; 57(14):1630-1637. PMID: 30173539.
    Citations:    Fields:    Translation:Humans
  14. Daak AA, Dampier CD, Fuh B, Kanter J, Alvarez OA, Black LV, McNaull MA, Callaghan MU, George A, Neumayr L, Hilliard LM, Sancilio F, Rabinowicz AL, Heeney MM. Double-blind, randomized, multicenter phase 2 study of SC411 in children with sickle cell disease (SCOT trial). Blood Adv. 2018 08 14; 2(15):1969-1979. PMID: 30097463.
    Citations: 10     Fields:    Translation:HumansCellsCTClinical Trials
  15. Riley LG, Heeney MM, Rudinger-Thirion J, Frugier M, Campagna DR, Zhou R, Hale GA, Hilliard LM, Kaplan JA, Kwiatkowski JL, Sieff CA, Steensma DP, Rennings AJ, Simons A, Schaap N, Roodenburg RJ, Kleefstra T, Arenillas L, Fita-Torró J, Ahmed R, Abboud M, Bechara E, Farah R, Tamminga RYJ, Bottomley SS, Sanchez M, Huls G, Swinkels DW, Christodoulou J, Fleming MD. The phenotypic spectrum of germline YARS2 variants: from isolated sideroblastic anemia to mitochondrial myopathy, lactic acidosis and sideroblastic anemia 2. Haematologica. 2018 12; 103(12):2008-2015. PMID: 30026338.
    Citations: 7     Fields:    Translation:Humans
  16. Berhe S, Heeney MM, Campagna DR, Thompson JF, White EJ, Ross T, Peake RWA, Hanrahan JD, Rodriguez V, Renaud DL, Patnaik MS, Chang E, Bottomley SS, Fleming MD. Recurrent heteroplasmy for the MT-ATP6 p.Ser148Asn (m.8969G>A) mutation in patients with syndromic congenital sideroblastic anemia of variable clinical severity. Haematologica. 2018 12; 103(12):e561-e563. PMID: 30006447.
    Citations: 1     Fields:    Translation:Humans
  17. Heeney MM, Guo D, De Falco L, Campagna DR, Olbina G, Kao PP, Schmitz-Abe K, Rahimov F, Gutschow P, Westerman K, Ostland V, Jackson T, Klaassen RJ, Markianos K, Finberg KE, Iolascon A, Westerman M, London WB, Fleming MD. Normalizing hepcidin predicts TMPRSS6 mutation status in patients with chronic iron deficiency. Blood. 2018 07 26; 132(4):448-452. PMID: 29895660.
    Citations: 6     Fields:    Translation:Humans
  18. Zaidi AU, Heeney MM. A Scientific Renaissance: Novel Drugs in Sickle Cell Disease. Pediatr Clin North Am. 2018 06; 65(3):445-464. PMID: 29803276.
    Citations:    Fields:    Translation:Humans
  19. Ballas SK, Zeidan AM, Duong VH, DeVeaux M, Heeney MM. The effect of iron chelation therapy on overall survival in sickle cell disease and ß-thalassemia: A systematic review. Am J Hematol. 2018 07; 93(7):943-952. PMID: 29635754.
    Citations: 7     Fields:    Translation:Humans
  20. Lesmana H, Dyer L, Li X, Denton J, Griffiths J, Chonat S, Seu KG, Heeney MM, Zhang K, Hopkin RJ, Kalfa TA. Alu element insertion in PKLR gene as a novel cause of pyruvate kinase deficiency in Middle Eastern patients. Hum Mutat. 2018 03; 39(3):389-393. PMID: 29288557.
    Citations: 2     Fields:    Translation:HumansCells
  21. Field JJ, Majerus E, Gordeuk VR, Gowhari M, Hoppe C, Heeney MM, Achebe M, George A, Chu H, Sheehan B, Puligandla M, Neuberg D, Lin G, Linden J, Nathan DG. Randomized phase 2 trial of regadenoson for treatment of acute vaso-occlusive crises in sickle cell disease. Blood Adv. 2017 Sep 12; 1(20):1645-1649. PMID: 29296811.
    Citations: 17     Fields:    
  22. Heath LE, Heeney MM, Hoppe CC, Adjei S, Agbenyega T, Badr M, Masera N, Zhou C, Brown PB, Jakubowski JA, Dampier C. Successful utilization of an electronic pain diary in a multinational phase 3 interventional study of pediatric sickle cell anemia. Clin Trials. 2017 Dec; 14(6):563-571. PMID: 28743191.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  23. Smith ER, Heeney M, Scott RM. Sickle Cell Disease. N Engl J Med. 2017 07 20; 377(3):304. PMID: 28727407.
    Citations:    Fields:    Translation:Humans
  24. Nassin ML, Vergilio JA, Heeney MM, LaBelle JL. Neonatal anemia: Revisiting the enigmatic pyknocyte. Am J Hematol. 2017 Jul; 92(7):717-721. PMID: 28335086.
    Citations:    Fields:    Translation:Humans
  25. Jakubowski JA, Hoppe CC, Zhou C, Smith BE, Brown PB, Heath LE, Inusa B, Rees DC, Small DS, Gupta N, Yao S, Heeney M, Kanter J. Real-time dose adjustment using point-of-care platelet reactivity testing in a double-blind study of prasugrel in children with sickle cell anaemia. Thromb Haemost. 2017 02 28; 117(3):580-588. PMID: 27929203.
    Citations: 4     Fields:    Translation:HumansCellsCTClinical Trials
  26. Cattivelli K, Campagna DR, Schmitz-Abe K, Heeney MM, Yaish HM, Caruso Brown AE, Kearney S, Walkovich K, Markianos K, Fleming MD, Neufeld EJ. Ringed sideroblasts in ß-thalassemia. Pediatr Blood Cancer. 2017 05; 64(5). PMID: 27808451.
    Citations:    Fields:    Translation:HumansCells
  27. Brendel C, Guda S, Renella R, Bauer DE, Canver MC, Kim YJ, Heeney MM, Klatt D, Fogel J, Milsom MD, Orkin SH, Gregory RI, Williams DA. Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype. J Clin Invest. 2016 10 03; 126(10):3868-3878. PMID: 27599293.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  28. Lichtenstein DA, Crispin AW, Sendamarai AK, Campagna DR, Schmitz-Abe K, Sousa CM, Kafina MD, Schmidt PJ, Niemeyer CM, Porter J, May A, Patnaik MM, Heeney MM, Kimmelman A, Bottomley SS, Paw BH, Markianos K, Fleming MD. A recurring mutation in the respiratory complex 1 protein NDUFB11 is responsible for a novel form of X-linked sideroblastic anemia. Blood. 2016 10 13; 128(15):1913-1917. PMID: 27488349.
    Citations: 12     Fields:    Translation:HumansCells
  29. Heeney MM, Hoppe CC, Rees DC. Prasugrel for Sickle Cell Vaso-Occlusive Events. N Engl J Med. 2016 07 14; 375(2):185-6. PMID: 27410930.
    Citations: 2     Fields:    Translation:Humans
  30. Tubman VN, Marshall R, Jallah W, Guo D, Ma C, Ohene-Frempong K, London WB, Heeney MM. Newborn Screening for Sickle Cell Disease in Liberia: A Pilot Study. Pediatr Blood Cancer. 2016 Apr; 63(4):671-6. PMID: 26739520.
    Citations: 18     Fields:    Translation:HumansPHPublic Health
  31. Heeney MM, Hoppe CC, Abboud MR, Inusa B, Kanter J, Ogutu B, Brown PB, Heath LE, Jakubowski JA, Zhou C, Zamoryakhin D, Agbenyega T, Colombatti R, Hassab HM, Nduba VN, Oyieko JN, Robitaille N, Segbefia CI, Rees DC. A Multinational Trial of Prasugrel for Sickle Cell Vaso-Occlusive Events. N Engl J Med. 2016 Feb 18; 374(7):625-35. PMID: 26644172.
    Citations: 43     Fields:    Translation:HumansCTClinical Trials
  32. Ware RE, Davis BR, Schultz WH, Brown RC, Aygun B, Sarnaik S, Odame I, Fuh B, George A, Owen W, Luchtman-Jones L, Rogers ZR, Hilliard L, Gauger C, Piccone C, Lee MT, Kwiatkowski JL, Jackson S, Miller ST, Roberts C, Heeney MM, Kalfa TA, Nelson S, Imran H, Nottage K, Alvarez O, Rhodes M, Thompson AA, Rothman JA, Helton KJ, Roberts D, Coleman J, Bonner MJ, Kutlar A, Patel N, Wood J, Piller L, Wei P, Luden J, Mortier NA, Stuber SE, Luban NLC, Cohen AR, Pressel S, Adams RJ. Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial. Lancet. 2016 Feb 13; 387(10019):661-670. PMID: 26670617.
    Citations: 110     Fields:    Translation:HumansCTClinical Trials
  33. Englum BR, Rothman J, Leonard S, Reiter A, Thornburg C, Brindle M, Wright N, Heeney MM, Jason Smithers C, Brown RL, Kalfa T, Langer JC, Cada M, Oldham KT, Scott JP, St Peter SD, Sharma M, Davidoff AM, Nottage K, Bernabe K, Wilson DB, Dutta S, Glader B, Crary SE, Dassinger MS, Dunbar L, Islam S, Kumar M, Rescorla F, Bruch S, Campbell A, Austin M, Sidonio R, Blakely ML, Rice HE. Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia. J Pediatr Surg. 2016 Jan; 51(1):122-7. PMID: 26613837.
    Citations: 10     Fields:    Translation:Humans
  34. Schmitz-Abe K, Ciesielski SJ, Schmidt PJ, Campagna DR, Rahimov F, Schilke BA, Cuijpers M, Rieneck K, Lausen B, Linenberger ML, Sendamarai AK, Guo C, Hofmann I, Newburger PE, Matthews D, Shimamura A, Snijders PJ, Towne MC, Niemeyer CM, Watson HG, Dziegiel MH, Heeney MM, May A, Bottomley SS, Swinkels DW, Markianos K, Craig EA, Fleming MD. Congenital sideroblastic anemia due to mutations in the mitochondrial HSP70 homologue HSPA9. Blood. 2015 Dec 17; 126(25):2734-8. PMID: 26491070.
    Citations: 22     Fields:    Translation:HumansCells
  35. Hoppe CC, Styles L, Heath LE, Zhou C, Jakubowski JA, Winters KJ, Brown PB, Rees DC, Heeney MM. Design of the DOVE (Determining Effects of Platelet Inhibition on Vaso-Occlusive Events) trial: A global Phase 3 double-blind, randomized, placebo-controlled, multicenter study of the efficacy and safety of prasugrel in pediatric patients with sickle cell anemia utilizing a dose titration strategy. Pediatr Blood Cancer. 2016 Feb; 63(2):299-305. PMID: 26402148.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  36. Wood JC, Pressel S, Rogers ZR, Odame I, Kwiatkowski JL, Lee MT, Owen WC, Cohen AR, St Pierre T, Heeney MM, Schultz WH, Davis BR, Ware RE. Liver iron concentration measurements by MRI in chronically transfused children with sickle cell anemia: baseline results from the TWiTCH trial. Am J Hematol. 2015 Sep; 90(9):806-10. PMID: 26087998.
    Citations: 11     Fields:    Translation:HumansCTClinical Trials
  37. Aygun B, Mortier NA, Kesler K, Lockhart A, Schultz WH, Cohen AR, Alvarez O, Rogers ZR, Kwiatkowski JL, Miller ST, Sylvestre P, Iyer R, Lane PA, Ware RE. Therapeutic phlebotomy is safe in children with sickle cell anaemia and can be effective treatment for transfusional iron overload. Br J Haematol. 2015 Apr; 169(2):262-6. PMID: 25612463.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  38. Styles L, Heiselman D, Heath LE, Moser BA, Small DS, Jakubowski JA, Zhou C, Redding-Lallinger R, Heeney MM, Quinn CT, Rana SR, Kanter J, Winters KJ. Prasugrel in children with sickle cell disease: pharmacokinetic and pharmacodynamic data from an open-label, adaptive-design, dose-ranging study. J Pediatr Hematol Oncol. 2015 Jan; 37(1):1-9. PMID: 25493452.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  39. Rice HE, Englum BR, Rothman J, Leonard S, Reiter A, Thornburg C, Brindle M, Wright N, Heeney MM, Smithers C, Brown RL, Kalfa T, Langer JC, Cada M, Oldham KT, Scott JP, St Peter S, Sharma M, Davidoff AM, Nottage K, Bernabe K, Wilson DB, Dutta S, Glader B, Crary SE, Dassinger MS, Dunbar L, Islam S, Kumar M, Rescorla F, Bruch S, Campbell A, Austin M, Sidonio R, Blakely ML. Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry. Am J Hematol. 2015 Mar; 90(3):187-92. PMID: 25382665.
    Citations: 6     Fields:    Translation:HumansCells
  40. Heeney MM. Iron clad: iron homeostasis and the diagnosis of hereditary iron overload. Hematology Am Soc Hematol Educ Program. 2014 Dec 05; 2014(1):202-9. PMID: 25696856.
    Citations: 2     Fields:    Translation:Humans
  41. Chakraborty PK, Schmitz-Abe K, Kennedy EK, Mamady H, Naas T, Durie D, Campagna DR, Lau A, Sendamarai AK, Wiseman DH, May A, Jolles S, Connor P, Powell C, Heeney MM, Giardina PJ, Klaassen RJ, Kannengiesser C, Thuret I, Thompson AA, Marques L, Hughes S, Bonney DK, Bottomley SS, Wynn RF, Laxer RM, Minniti CP, Moppett J, Bordon V, Geraghty M, Joyce PB, Markianos K, Rudner AD, Holcik M, Fleming MD. Mutations in TRNT1 cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD). Blood. 2014 Oct 30; 124(18):2867-71. PMID: 25193871.
    Citations: 60     Fields:    Translation:HumansCells
  42. Heeney MM, Cohen AR. Iron disorders. Hematol Oncol Clin North Am. 2014 Aug; 28(4):ix-x. PMID: 25064712.
    Citations:    Fields:    Translation:Humans
  43. Helton KJ, Adams RJ, Kesler KL, Lockhart A, Aygun B, Driscoll C, Heeney MM, Jackson SM, Krishnamurti L, Miller ST, Sarnaik SA, Schultz WH, Ware RE. Magnetic resonance imaging/angiography and transcranial Doppler velocities in sickle cell anemia: results from the SWiTCH trial. Blood. 2014 Aug 07; 124(6):891-8. PMID: 24914136.
    Citations: 34     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
  44. Heeney MM, Finberg KE. Iron-refractory iron deficiency anemia (IRIDA). Hematol Oncol Clin North Am. 2014 Aug; 28(4):637-52, v. PMID: 25064705.
    Citations: 19     Fields:    Translation:Humans
  45. Campagna DR, de Bie CI, Schmitz-Abe K, Sweeney M, Sendamarai AK, Schmidt PJ, Heeney MM, Yntema HG, Kannengiesser C, Grandchamp B, Niemeyer CM, Knoers NV, Swart S, Marron G, van Wijk R, Raymakers RA, May A, Markianos K, Bottomley SS, Swinkels DW, Fleming MD. X-linked sideroblastic anemia due to ALAS2 intron 1 enhancer element GATA-binding site mutations. Am J Hematol. 2014 Mar; 89(3):315-9. PMID: 24166784.
    Citations: 21     Fields:    Translation:HumansCells
  46. Ogunlesi F, Heeney MM, Koumbourlis AC. Systemic corticosteroids in acute chest syndrome: friend or foe? Paediatr Respir Rev. 2014 Mar; 15(1):24-7. PMID: 24268617.
    Citations: 5     Fields:    Translation:Humans
  47. Alvarez O, Yovetich NA, Scott JP, Owen W, Miller ST, Schultz W, Lockhart A, Aygun B, Flanagan J, Bonner M, Mueller BU, Ware RE. Pain and other non-neurological adverse events in children with sickle cell anemia and previous stroke who received hydroxyurea and phlebotomy or chronic transfusions and chelation: results from the SWiTCH clinical trial. Am J Hematol. 2013 Nov; 88(11):932-8. PMID: 23861242.
    Citations: 16     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
  48. Baskin MN, Goh XL, Heeney MM, Harper MB. Bacteremia risk and outpatient management of febrile patients with sickle cell disease. Pediatrics. 2013 Jun; 131(6):1035-41. PMID: 23669523.
    Citations: 17     Fields:    Translation:Humans
  49. Wiseman DH, May A, Jolles S, Connor P, Powell C, Heeney MM, Giardina PJ, Klaassen RJ, Chakraborty P, Geraghty MT, Major-Cook N, Kannengiesser C, Thuret I, Thompson AA, Marques L, Hughes S, Bonney DK, Bottomley SS, Fleming MD, Wynn RF. A novel syndrome of congenital sideroblastic anemia, B-cell immunodeficiency, periodic fevers, and developmental delay (SIFD). Blood. 2013 Jul 04; 122(1):112-23. PMID: 23553769.
    Citations: 32     Fields:    Translation:HumansCells
  50. Frelinger AL, Jakubowski JA, Brooks JK, Carmichael SL, Berny-Lang MA, Barnard MR, Heeney MM, Michelson AD. Platelet activation and inhibition in sickle cell disease (pains) study. Platelets. 2014; 25(1):27-35. PMID: 23469943.
    Citations: 15     Fields:    Translation:HumansCells
  51. Chawla A, Sprinz PG, Welch J, Heeney M, Usmani N, Pashankar F, Kavanagh P. Weight status of children with sickle cell disease. Pediatrics. 2013 Apr; 131(4):e1168-73. PMID: 23460681.
    Citations: 7     Fields:    Translation:Humans
  52. Strouse JJ, Heeney MM. Hydroxyurea for the treatment of sickle cell disease: efficacy, barriers, toxicity, and management in children. Pediatr Blood Cancer. 2012 Aug; 59(2):365-71. PMID: 22517797.
    Citations: 27     Fields:    Translation:Humans
  53. Ware RE, Helms RW. Stroke With Transfusions Changing to Hydroxyurea (SWiTCH). Blood. 2012 Apr 26; 119(17):3925-32. PMID: 22318199.
    Citations: 85     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
  54. McCarville MB, Rogers ZR, Sarnaik S, Scott P, Aygun B, Hilliard L, Lee MT, Kalinyak K, Owen W, Garro J, Schultz W, Yovetich N, Ware RE. Effects of chronic transfusions on abdominal sonographic abnormalities in children with sickle cell anemia. J Pediatr. 2012 Feb; 160(2):281-285.e1. PMID: 21907352.
    Citations: 3     Fields:    Translation:Humans
  55. Stewart AK, Shmukler BE, Vandorpe DH, Rivera A, Heneghan JF, Li X, Hsu A, Karpatkin M, O'Neill AF, Bauer DE, Heeney MM, John K, Kuypers FA, Gallagher PG, Lux SE, Brugnara C, Westhoff CM, Alper SL. Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S. Am J Physiol Cell Physiol. 2011 Dec; 301(6):C1325-43. PMID: 21849667.
    Citations: 8     Fields:    Translation:HumansCells
  56. Sobota A, Graham DA, Neufeld EJ, Heeney MM. Thirty-day readmission rates following hospitalization for pediatric sickle cell crisis at freestanding children's hospitals: risk factors and hospital variation. Pediatr Blood Cancer. 2012 Jan; 58(1):61-5. PMID: 21674766.
    Citations: 17     Fields:    Translation:Humans
  57. Sobota A, Neufeld EJ, Sprinz P, Heeney MM. Transition from pediatric to adult care for sickle cell disease: results of a survey of pediatric providers. Am J Hematol. 2011 Jun; 86(6):512-5. PMID: 21594889.
    Citations: 16     Fields:    Translation:Humans
  58. Vichinsky E, Bernaudin F, Forni GL, Gardner R, Hassell K, Heeney MM, Inusa B, Kutlar A, Lane P, Mathias L, Porter J, Tebbi C, Wilson F, Griffel L, Deng W, Giannone V, Coates T. Long-term safety and efficacy of deferasirox (Exjade) for up to 5 years in transfusional iron-overloaded patients with sickle cell disease. Br J Haematol. 2011 Aug; 154(3):387-97. PMID: 21592110.
    Citations: 13     Fields:    Translation:HumansCTClinical Trials
  59. Heeney MM. Rudolph’s Pediatrics (Rudolph AM, Rudolph C, First L, Lister G, Gershon AA. Editors). Anemia: Definition, Pathophysiology and Classification. 2011.
  60. Heeney MM. Rudolph’s Pediatrics. Iron Deficiency Anemia: Definition, Pathophysiology and Classification. 2011.
  61. Soranzo N, Sanna S, Wheeler E, Gieger C, Radke D, Dupuis J, Bouatia-Naji N, Langenberg C, Prokopenko I, Stolerman E, Sandhu MS, Heeney MM, Devaney JM, Reilly MP, Ricketts SL, Stewart AF, Voight BF, Willenborg C, Wright B, Altshuler D, Arking D, Balkau B, Barnes D, Boerwinkle E, Böhm B, Bonnefond A, Bonnycastle LL, Boomsma DI, Bornstein SR, Böttcher Y, Bumpstead S, Burnett-Miller MS, Campbell H, Cao A, Chambers J, Clark R, Collins FS, Coresh J, de Geus EJ, Dei M, Deloukas P, Döring A, Egan JM, Elosua R, Ferrucci L, Forouhi N, Fox CS, Franklin C, Franzosi MG, Gallina S, Goel A, Graessler J, Grallert H, Greinacher A, Hadley D, Hall A, Hamsten A, Hayward C, Heath S, Herder C, Homuth G, Hottenga JJ, Hunter-Merrill R, Illig T, Jackson AU, Jula A, Kleber M, Knouff CW, Kong A, Kooner J, Köttgen A, Kovacs P, Krohn K, Kühnel B, Kuusisto J, Laakso M, Lathrop M, Lecoeur C, Li M, Li M, Loos RJ, Luan J, Lyssenko V, Mägi R, Magnusson PK, Mälarstig A, Mangino M, Martínez-Larrad MT, März W, McArdle WL, McPherson R, Meisinger C, Meitinger T, Melander O, Mohlke KL, Mooser VE, Morken MA, Narisu N, Nathan DM, Nauck M, O'Donnell C, Oexle K, Olla N, Pankow JS, Payne F, Peden JF, Pedersen NL, Peltonen L, Perola M, Polasek O, Porcu E, Rader DJ, Rathmann W, Ripatti S, Rocheleau G, Roden M, Rudan I, Salomaa V, Saxena R, Schlessinger D, Schunkert H, Schwarz P, Seedorf U, Selvin E, Serrano-Ríos M, Shrader P, Silveira A, Siscovick D, Song K, Spector TD, Stefansson K, Steinthorsdottir V, Strachan DP, Strawbridge R, Stumvoll M, Surakka I, Swift AJ, Tanaka T, Teumer A, Thorleifsson G, Thorsteinsdottir U, Tönjes A, Usala G, Vitart V, Völzke H, Wallaschofski H, Waterworth DM, Watkins H, Wichmann HE, Wild SH, Willemsen G, Williams GH, Wilson JF, Winkelmann J, Wright AF, Zabena C, Zhao JH, Epstein SE, Erdmann J, Hakonarson HH, Kathiresan S, Khaw KT, Roberts R, Samani NJ, Fleming MD, Sladek R, Abecasis G, Boehnke M, Froguel P, Groop L, McCarthy MI, Kao WH, Florez JC, Uda M, Wareham NJ, Barroso I, Meigs JB. Common variants at 10 genomic loci influence hemoglobin A1(C) levels via glycemic and nonglycemic pathways. Diabetes. 2010 Dec; 59(12):3229-39. PMID: 20858683.
    Citations: 195     Fields:    Translation:Humans
  62. George M, Heeney MM, Woolf AD. Encephalopathy from lead poisoning masquerading as a flu-like syndrome in an autistic child. Pediatr Emerg Care. 2010 May; 26(5):370-3. PMID: 20453792.
    Citations: 5     Fields:    Translation:Humans
  63. Anderson DS, Heeney MM, Roth U, Menzel C, Fleming MD, Steen H. High-throughput matrix-assisted laser desorption ionization-time-of-flight mass spectrometry method for quantification of hepcidin in human urine. Anal Chem. 2010 Feb 15; 82(4):1551-5. PMID: 20102179.
    Citations: 7     Fields:    Translation:Humans
  64. Grace RF, Su H, Sena L, Poussaint TY, Heeney MM, Gutierrez A. Resolution of cerebral artery stenosis in a child with sickle cell anemia treated with hydroxyurea. Am J Hematol. 2010 Feb; 85(2):135-7. PMID: 20052745.
    Citations: 1     Fields:    Translation:Humans
  65. Heeney MM, Ware RE. Hydroxyurea for children with sickle cell disease. Hematol Oncol Clin North Am. 2010 Feb; 24(1):199-214. PMID: 20113903.
    Citations: 23     Fields:    Translation:Humans
  66. Ballas SK, Lieff S, Benjamin LJ, Dampier CD, Heeney MM, Hoppe C, Johnson CS, Rogers ZR, Smith-Whitley K, Wang WC, Telen MJ. Definitions of the phenotypic manifestations of sickle cell disease. Am J Hematol. 2010 Jan; 85(1):6-13. PMID: 19902523.
    Citations: 101     Fields:    Translation:Humans
  67. Sobota A, Graham DA, Heeney MM, Neufeld EJ. Corticosteroids for acute chest syndrome in children with sickle cell disease: variation in use and association with length of stay and readmission. Am J Hematol. 2010 Jan; 85(1):24-8. PMID: 19957348.
    Citations: 20     Fields:    Translation:Humans
  68. Smith ER, McClain CD, Heeney M, Scott RM. Pial synangiosis in patients with moyamoya syndrome and sickle cell anemia: perioperative management and surgical outcome. Neurosurg Focus. 2009 Apr; 26(4):E10. PMID: 19335126.
    Citations: 15     Fields:    Translation:Humans
  69. Morrissey LK, Shea JO, Kalish LA, Weiner DL, Branowicki P, Heeney MM. Clinical practice guideline improves the treatment of sickle cell disease vasoocclusive pain. Pediatr Blood Cancer. 2009 Mar; 52(3):369-72. PMID: 19023890.
    Citations: 11     Fields:    Translation:Humans
  70. Steinberg MH. Ohene-Frempong K. Heeney MM. Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management (Steinberg MH, Forget BG, Higgs DR, Weatherall DJ. Editors). Clinical and Pathophysiological Aspects of Sickle Cell Anemia. 2009; 437-496.
  71. Hettmer S, Heeney MM. Cefepime-induced neutropenia in a teenager. Pediatr Blood Cancer. 2008 Nov; 51(5):715-6. PMID: 18623224.
    Citations: 1     Fields:    Translation:HumansCells
  72. Finberg KE, Heeney MM, Campagna DR, Aydinok Y, Pearson HA, Hartman KR, Mayo MM, Samuel SM, Strouse JJ, Markianos K, Andrews NC, Fleming MD. Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). Nat Genet. 2008 May; 40(5):569-71. PMID: 18408718.
    Citations: 219     Fields:    Translation:HumansCells
  73. Heeney MM, Ware RE. Hydroxyurea for children with sickle cell disease. Pediatr Clin North Am. 2008 Apr; 55(2):483-501, x. PMID: 18381097.
    Citations: 31     Fields:    Translation:Humans
  74. Aygun B, McMurray MA, Schultz WH, Kwiatkowski JL, Hilliard L, Alvarez O, Heeney M, Kalinyak K, Lee MT, Miller S, Helms RW, Ware RE. Chronic transfusion practice for children with sickle cell anaemia and stroke. Br J Haematol. 2009 May; 145(4):524-8. PMID: 19344396.
    Citations: 8     Fields:    Translation:Humans
  75. Dover GJ. Heeney MM. Nathan and Oski’s Hematology of Infancy and Childhood (Nathan DG, Orkin SH, Ginsburg D, Look AT. Editors). Sickle Cell Disease. 2008; 949-1014.
  76. Mazumdar M, Heeney MM, Sox CM, Lieu TA. Preventing stroke among children with sickle cell anemia: an analysis of strategies that involve transcranial Doppler testing and chronic transfusion. Pediatrics. 2007 Oct; 120(4):e1107-16. PMID: 17768181.
    Citations: 8     Fields:    Translation:HumansPHPublic Health
  77. Tubman VN, Bennett CM, Luo HY, Chui DH, Heeney MM. Sickle cell disease caused by Hb S/Québec-CHORI: treatment with hydroxyurea and response. Pediatr Blood Cancer. 2007 Aug; 49(2):207-10. PMID: 17551985.
    Citations:    Fields:    Translation:Humans
  78. Masiello D, Heeney MM, Adewoye AH, Eung SH, Luo HY, Steinberg MH, Chui DH. Hemoglobin SE disease: a concise review. Am J Hematol. 2007 Jul; 82(7):643-9. PMID: 17278112.
    Citations: 9     Fields:    Translation:Humans
  79. Tubman VN, Smoot L, Heeney MM. Acquired immune cytopenias post-cardiac transplantation respond to rituximab. Pediatr Blood Cancer. 2007 Mar; 48(3):339-44. PMID: 16435382.
    Citations: 5     Fields:    Translation:HumansCells
  80. Heeney MM. Management of Sickle Cell Disease,. Comprehensive Pediatric Hospital Medicine (Zaoutis LD, Chiang VW). 2007; 731-737.
  81. Duncan C. Heeney MM. Hematologic Disorders. Manual of Pediatric Therapeutics (Greenes DS, Graeff JW.). 2007; 466-499.
  82. Luo HY, Heeney M, Wang WC, Eung SH, Ware RE, Steinberg MH, Chui DH. Hemoglobinopathies mimicking Hb S/beta-thalassemia: Hb S/S with alpha-thalassemia and Hb S/Volga. Am J Hematol. 2006 May; 81(5):361-5. PMID: 16628724.
    Citations: 1     Fields:    Translation:Humans
  83. Heeney MM. Risk of cholelithiasis in sickle cell anemia. Haematologica. 2005 Feb; 90(2):147. PMID: 15713573.
    Citations: 1     Fields:    Translation:HumansCells
  84. Heeney MM, Andrews NC. Iron homeostasis and inherited iron overload disorders: an overview. Hematol Oncol Clin North Am. 2004 Dec; 18(6):1379-403, ix. PMID: 15511621.
    Citations: 12     Fields:    Translation:Humans
  85. Heeney MM, Whorton MR, Howard TA, Johnson CA, Ware RE. Chemical and functional analysis of hydroxyurea oral solutions. J Pediatr Hematol Oncol. 2004 Mar; 26(3):179-84. PMID: 15125610.
    Citations: 19     Fields:    Translation:Humans
  86. Heeney MM, Zimmerman SA, Ware RE. Childhood autoimmune cytopenia secondary to unsuspected common variable immunodeficiency. J Pediatr. 2003 Nov; 143(5):662-5. PMID: 14615742.
    Citations: 8     Fields:    Translation:Humans
  87. Heeney MM, Howard TA, Zimmerman SA, Ware RE. UGT1A promoter polymorphisms influence bilirubin response to hydroxyurea therapy in sickle cell anemia. J Lab Clin Med. 2003 Apr; 141(4):279-82. PMID: 12677174.
    Citations: 5     Fields:    Translation:HumansCellsCTClinical Trials
  88. Heeney MM, Ormsbee SM, Moody MA, Howard TA, DeCastro CM, Ware RE. Increased expression of anti-apoptosis genes in peripheral blood cells from patients with paroxysmal nocturnal hemoglobinuria. Mol Genet Metab. 2003 Apr; 78(4):291-4. PMID: 12706380.
    Citations: 3     Fields:    Translation:HumansCells
  89. Heeney MM. Ware RE. . Newborn Screening for Hemoglobinopathies. Practical Algorithms in Pediatric Hematology Oncology (Sills R.). 2003.
  90. Heeney MM. Ware RE. Diagnostic Approach to Sickle Hemoglobinopathies. Practical Algorithms in Pediatric Hematology-Oncology (Sills R). 2003.
  91. Ware RE. Heeney MM. Pickens CV. DeCastro CM. Howard TA. A multi-step model for the pathogenesis and evolution of PNH. Paroxysmal Nocturnal Hemoglobinuria (PNH) and Related Disorders. 2003; 41-54.
  92. Heeney MM, Delgrosso K, Robinson R, Johnson CA, Daeschner CW, Campbell TA, Surrey S, Ware RE. Interpretation of fetal hemoglobin only on newborn screening for hemoglobinopathy. J Pediatr Hematol Oncol. 2002 Aug-Sep; 24(6):499-502. PMID: 12218602.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  93. Zhang XL, Seong R, Piracha R, Larijani M, Heeney M, Parnes JR, Chamberlain JW. Distinct stage-specific cis-active transcriptional mechanisms control expression of T cell coreceptor CD8 alpha at double- and single-positive stages of thymic development. J Immunol. 1998 Sep 01; 161(5):2254-66. PMID: 9725219.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  94. Kushida MM, Dey A, Zhang XL, Campbell J, Heeney M, Carlyle J, Ganguly S, Ozato K, Vasavada H, Chamberlain JW. A 150-base pair 5' region of the MHC class I HLA-B7 gene is sufficient to direct tissue-specific expression and locus control region activity: the alpha site determines efficient expression and in vivo occupancy at multiple cis-active sites throughout this region. J Immunol. 1997 Nov 15; 159(10):4913-29. PMID: 9366417.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  95. "Retrospective Assessment of Utilisation and Effect on Management of Echocardiography in Patients with Suspected Mitral Valve Prolapse" . Supervisor: D. Isaac, MD Year II Research Elective, Faculty of Medicine, University of Calgary, Calgary, AB . 1996.
  96. "The Mechanisms of Scaphoid Fracture and Relation to Hand of Dominance, Activity During Injury, and Anatomical Site of Fracture: A Retrospective Analysis" . Year I Research Elective, Faculty of Medicine, University of Calgary, Calgary, AB. 1995.
  97. "Distinct Regulatory Mechanisms Control CD8 Expression in CD4+/CD8+ Thymocytes vs. CD4-/CD8- in vivo". Oral Presentation, Hospital for Sick Children Research Institute, Toronto, ON. 1992.
  98. "Renal Expression of Urokinase-type Plasminogen Activator is Decreased in Experimental Nephrosis.". Oral Presentation, Hospital for Sick Children Research Institute, Toronto, ON. 1991.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.