Harvard Catalyst Profiles

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Myra Ann Lipes, M.D.

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Mentoring
Determining the role of dopamine signaling pathways in conferring immune privilege to surrogate beta cells
Summer, 06/16/14 - 08/08/14

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK103609 (LIPES, MYRA A) Dec 1, 2015 - Nov 30, 2018
    NIH/NIDDK
    Cardiac Autoantibodies as Biomarkers for Heart Disease in Type 1 Diabetes
    Role: Principal Investigator
  2. R01DK072090 (LIPES, MYRA A) Aug 1, 2005 - May 31, 2011
    NIH/NIDDK
    Autoimmune Mechanisms in the Progression of CVD in Type 1 Diabetes
    Role: Principal Investigator
  3. R01HL077554 (LIPES, MYRA A) Jul 15, 2004 - May 31, 2010
    NIH/NHLBI
    Molecular Mechanisms of Autoimmune Heart Disease
    Role: Principal Investigator
  4. R01DK064568 (LIPES, MYRA A) Sep 30, 2002 - Aug 31, 2006
    NIH/NIDDK
    A cell-based glucose sensing and insulin delivery system
    Role: Principal Investigator
  5. P01DK053087 (WEIR, GORDON CAMPBELL) Feb 15, 1998 - Nov 30, 2003
    NIH/NIDDK
    ISLET XENOTRANSPLANTATION--GENETIC APPROACHES TO PROBLEM
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Sousa GR, Pober D, Galderisi A, Lv H, Yu L, Pereira AC, Doria A, Kosiborod M, Lipes MA. Glycemic Control, Cardiac Autoimmunity, and Long-Term Risk of Cardiovascular Disease in Type 1 Diabetes Mellitus: A DCCT/EDIC Cohort-Based Study. Circulation. 2018 Nov 26. PMID: 30586738.
    View in: PubMed
  2. Lipes MA, Galderisi A. Cardiac autoimmunity as a novel biomarker, mediator, and therapeutic target of heart disease in type 1 diabetes. Curr Diab Rep. 2015 May; 15(5):30. PMID: 25821130; PMCID: PMC4376963.
  3. Lv H, Lipes MA. Role of impaired central tolerance to a-myosin in inflammatory heart disease. Trends Cardiovasc Med. 2012 Jul; 22(5):113-7. PMID: 22902177; PMCID: PMC3472104.
  4. Gottumukkala RV, Lv H, Cornivelli L, Wagers AJ, Kwong RY, Bronson R, Stewart GC, Schulze PC, Chutkow W, Wolpert HA, Lee RT, Lipes MA. Myocardial infarction triggers chronic cardiac autoimmunity in type 1 diabetes. Sci Transl Med. 2012 Jun 13; 4(138):138ra80. PMID: 22700956; PMCID: PMC4303259.
  5. Lv H, Havari E, Pinto S, Gottumukkala RV, Cornivelli L, Raddassi K, Matsui T, Rosenzweig A, Bronson RT, Smith R, Fletcher AL, Turley SJ, Wucherpfennig K, Kyewski B, Lipes MA. Impaired thymic tolerance to a-myosin directs autoimmunity to the heart in mice and humans. J Clin Invest. 2011 Apr; 121(4):1561-73. PMID: 21436590; PMCID: PMC3069776.
  6. Stewart GC, Lopez-Molina J, Gottumukkala RV, Rosner GF, Anello MS, Hecht JL, Winters GL, Padera RF, Baughman KL, Lipes MA. Myocardial parvovirus B19 persistence: lack of association with clinicopathologic phenotype in adults with heart failure. Circ Heart Fail. 2011 Jan; 4(1):71-8. PMID: 21097605; PMCID: PMC3047418.
  7. Jasinski JM, Yu L, Nakayama M, Li MM, Lipes MA, Eisenbarth GS, Liu E. Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout. Diabetes. 2006 Jul; 55(7):1978-84. PMID: 16804066.
    View in: PubMed
  8. Medarova Z, Bonner-Weir S, Lipes M, Moore A. Imaging beta-cell death with a near-infrared probe. Diabetes. 2005 Jun; 54(6):1780-8. PMID: 15919800.
    View in: PubMed
  9. Jaeckel E, Lipes MA, von Boehmer H. Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes. Nat Immunol. 2004 Oct; 5(10):1028-35. PMID: 15378058.
    View in: PubMed
  10. Havari E, Lennon-Dumenil AM, Klein L, Neely D, Taylor JA, McInerney MF, Wucherpfennig KW, Lipes MA. Expression of the B7.1 costimulatory molecule on pancreatic beta cells abrogates the requirement for CD4 T cells in the development of type 1 diabetes. J Immunol. 2004 Jul 15; 173(2):787-96. PMID: 15240665.
    View in: PubMed
  11. Taylor JA, Havari E, McInerney MF, Bronson R, Wucherpfennig KW, Lipes MA. A spontaneous model for autoimmune myocarditis using the human MHC molecule HLA-DQ8. J Immunol. 2004 Feb 15; 172(4):2651-8. PMID: 14764740.
    View in: PubMed
  12. Wolpert HA, Faradji RN, Bonner-Weir S, Lipes MA. Metabolic decompensation in pump users due to lispro insulin precipitation. BMJ. 2002 May 25; 324(7348):1253. PMID: 12028980; PMCID: PMC113278.
  13. Moore A, Sun PZ, Cory D, Högemann D, Weissleder R, Lipes MA. MRI of insulitis in autoimmune diabetes. Magn Reson Med. 2002 Apr; 47(4):751-8. PMID: 11948737.
    View in: PubMed
  14. Faradji RN, Havari E, Chen Q, Gray J, Tornheim K, Corkey BE, Mulligan RC, Lipes MA. Glucose-induced toxicity in insulin-producing pituitary cells that coexpress GLUT2 and glucokinase. Implications for metabolic engineering. J Biol Chem. 2001 Sep 28; 276(39):36695-702. PMID: 11443115.
    View in: PubMed
  15. Kessler BM, Lennon-Duménil AM, Shinohara ML, Lipes MA, Ploegh HL. LMP2 expression and proteasome activity in NOD mice. Nat Med. 2000 Oct; 6(10):1064; author reply 1065-6. PMID: 11017111.
    View in: PubMed
  16. Koya D, Dennis JW, Warren CE, Takahara N, Schoen FJ, Nishio Y, Nakajima T, Lipes MA, King GL. Overexpression of core 2 N-acetylglycosaminyltransferase enhances cytokine actions and induces hypertrophic myocardium in transgenic mice. FASEB J. 1999 Dec; 13(15):2329-37. PMID: 10593880.
    View in: PubMed
  17. Lipes MA, Davalli AM, Cooper EM. Genetic engineering of insulin expression in nonislet cells: implications for beta-cell replacement therapy for insulin-dependent diabetes mellitus. Acta Diabetol. 1997 Mar; 34(1):2-5. PMID: 9134049.
    View in: PubMed
  18. Lipes MA, Cooper EM, Skelly R, Rhodes CJ, Boschetti E, Weir GC, Davalli AM. Insulin-secreting non-islet cells are resistant to autoimmune destruction. Proc Natl Acad Sci U S A. 1996 Aug 06; 93(16):8595-600. PMID: 8710916.
    View in: PubMed
  19. Patti ME, Sun XJ, Bruening JC, Araki E, Lipes MA, White MF, Kahn CR. 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice. J Biol Chem. 1995 Oct 20; 270(42):24670-3. PMID: 7559579.
    View in: PubMed
  20. Araki E, Lipes MA, Patti ME, Brüning JC, Haag B, Johnson RS, Kahn CR. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature. 1994 Nov 10; 372(6502):186-90. PMID: 7526222.
    View in: PubMed
  21. Lipes MA, Rosenzweig A, Tan KN, Tanigawa G, Seidman JG, Eisenbarth GS. Response. Science. 1993 Dec 03; 262(5139):1584. PMID: 17829386.
    View in: PubMed
  22. Kriauciunas KM, Goldstein BJ, Lipes MA, Kahn CR. Modulation of expression of insulin and IGF-I receptor by Epstein-Barr virus and its gene products LMP and EBNA-2 in lymphocyte cell lines. J Cell Physiol. 1993 Mar; 154(3):486-95. PMID: 8382208.
    View in: PubMed
  23. Lipes MA, Rosenzweig A, Tan KN, Tanigawa G, Ladd D, Seidman JG, Eisenbarth GS. Progression to diabetes in nonobese diabetic (NOD) mice with transgenic T cell receptors. Science. 1993 Feb 19; 259(5098):1165-9. PMID: 8267690.
    View in: PubMed
  24. Castaño L, Russo E, Zhou L, Lipes MA, Eisenbarth GS. Identification and cloning of a granule autoantigen (carboxypeptidase-H) associated with type I diabetes. J Clin Endocrinol Metab. 1991 Dec; 73(6):1197-201. PMID: 1955501.
    View in: PubMed
  25. Lipes MA, Eisenbarth GS. Transgenic mouse models of type I diabetes. Diabetes. 1990 Aug; 39(8):879-84. PMID: 2197138.
    View in: PubMed
  26. Lipes MA, Napolitano M, Jeang KT, Chang NT, Leonard WJ. Identification, cloning, and characterization of an immune activation gene. Proc Natl Acad Sci U S A. 1988 Dec; 85(24):9704-8. PMID: 2462251; PMCID: PMC282843.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.