Harvard Catalyst Profiles

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Jing Ni, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kabraji S, Ni J, Sammons S, Li T, Van Swearingen AED, Wang Y, Pereslete A, Hsu L, DiPiro PJ, Lascola C, Moore H, Hughes M, Raghavendra AS, Gule-Monroe M, Murthy RK, Winer EP, Anders CK, Zhao JJ, Lin NU. Preclinical and Clinical Efficacy of Trastuzumab Deruxtecan in Breast Cancer Brain Metastases. Clin Cancer Res. 2023 Jan 04; 29(1):174-182. PMID: 36074155; PMCID: PMC9811155.
    Citations: 2     Fields:    Translation:Humans
  2. Barrows RD, Jeffries DE, Vishe M, Tukachinsky H, Zheng SL, Li F, Ma Z, Li X, Jin S, Song H, Zhang R, Zhang S, Ni J, Luan H, Wen L, Rongshan Y, Ying C, Shair MD. Potent Uncompetitive Inhibitors of Nicotinamide N-Methyltransferase (NNMT) as In Vivo Chemical Probes. J Med Chem. 2022 11 10; 65(21):14642-14654. PMID: 36288465.
    Citations: 1     Fields:    Translation:Cells
  3. Ni J, Kabraji S, Xie S, Wang Y, Pan P, He X, Liu Z, Leone JP, Long HW, Brown MA, Winer EP, Dillon DAR, Lin NU, Zhao JJ. p16INK4A-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases. Nat Commun. 2022 03 18; 13(1):1473. PMID: 35304445; PMCID: PMC8933392.
    Citations:    Fields:    Translation:Humans
  4. Xie S, Ni J, Guo H, Luu V, Wang Y, Zhao JJ, Roberts TM. The role of the PIK3CA gene in the development and aging of the brain. Sci Rep. 2021 01 11; 11(1):291. PMID: 33431926.
    Citations: 1     Fields:    Translation:Animals
  5. Xie S, Ni J, McFaline-Figueroa JR, Wang Y, Bronson RT, Ligon KL, Wen PY, Roberts TM, Zhao JJ. Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas. Cell Rep. 2020 09 29; 32(13):108196. PMID: 32997991.
    Citations: 5     Fields:    Translation:HumansAnimals
  6. Bhola PD, Ahmed E, Guerriero JL, Sicinska E, Su E, Lavrova E, Ni J, Chipashvili O, Hagan T, Pioso MS, McQueeney K, Ng K, Aguirre AJ, Cleary JM, Cocozziello D, Sotayo A, Ryan J, Zhao JJ, Letai A. High-throughput dynamic BH3 profiling may quickly and accurately predict effective therapies in solid tumors. Sci Signal. 2020 06 16; 13(636). PMID: 32546544; PMCID: PMC8023011.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  7. Liu Z, Wang Y, Kabraji S, Xie S, Pan P, Liu Z, Ni J, Zhao JJ. Improving orthotopic mouse models of patient-derived breast cancer brain metastases by a modified intracarotid injection method. Sci Rep. 2019 01 24; 9(1):622. PMID: 30679540.
    Citations: 9     Fields:    Translation:HumansAnimals
  8. Pal S, Kozono D, Yang X, Fendler W, Fitts W, Ni J, Alberta JA, Zhao J, Liu KX, Bian J, Truffaux N, Weiss WA, Resnick AC, Bandopadhayay P, Ligon KL, DuBois SG, Mueller S, Chowdhury D, Haas-Kogan DA. Dual HDAC and PI3K Inhibition Abrogates NF?B- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas. Cancer Res. 2018 07 15; 78(14):4007-4021. PMID: 29760046; PMCID: PMC6294442.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  9. Kabraji S, Ni J, Lin NU, Xie S, Winer EP, Zhao JJ. Drug Resistance in HER2-Positive Breast Cancer Brain Metastases: Blame the Barrier or the Brain? Clin Cancer Res. 2018 04 15; 24(8):1795-1804. PMID: 29437794; PMCID: PMC5899637.
    Citations: 35     Fields:    Translation:HumansAnimals
  10. Zheng S, Sun Z, Ni J, Li Z, Sha Y, Zhang T, Qiao S, Zhao G, Song Z. mGluR6 regulates keratinocyte phagocytosis by modulating CaM KII/ERK/MLC signalling pathway. Exp Dermatol. 2016 11; 25(11):909-911. PMID: 27246800.
    Citations: 1     Fields:    Translation:HumansCells
  11. Cizmecioglu O, Ni J, Xie S, Zhao JJ, Roberts TM. Rac1-mediated membrane raft localization of PI3K/p110ß is required for its activation by GPCRs or PTEN loss. Elife. 2016 10 04; 5. PMID: 27700986.
    Citations: 15     Fields:    Translation:AnimalsCells
  12. Ferguson FM, Ni J, Zhang T, Tesar B, Sim T, Kim ND, Deng X, Brown JR, Zhao JJ, Gray NS. Discovery of a Series of 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-ones as Selective PI3K-d/? Inhibitors. ACS Med Chem Lett. 2016 Oct 13; 7(10):908-912. PMID: 27774127; PMCID: PMC5066161.
    Citations: 4     
  13. Ni J, Xie S, Ramkissoon SH, Luu V, Sun Y, Bandopadhayay P, Beroukhim R, Roberts TM, Stiles CD, Segal RA, Ligon KL, Hahn WC, Zhao JJ. Tyrosine receptor kinase B is a drug target in astrocytomas. Neuro Oncol. 2017 01; 19(1):22-30. PMID: 27402815; PMCID: PMC5193024.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  14. Ni J, Ramkissoon SH, Xie S, Goel S, Stover DG, Guo H, Luu V, Marco E, Ramkissoon LA, Kang YJ, Hayashi M, Nguyen QD, Ligon AH, Du R, Claus EB, Alexander BM, Yuan GC, Wang ZC, Iglehart JD, Krop IE, Roberts TM, Winer EP, Lin NU, Ligon KL, Zhao JJ. Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases. Nat Med. 2016 07; 22(7):723-6. PMID: 27270588; PMCID: PMC4938731.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  15. Ni J, Cerwenka A. STAT5 Loss Awakens the Dark Force in Natural Killer Cells. Cancer Discov. 2016 Apr; 6(4):347-9. PMID: 27045017.
    Citations: 2     Fields:    Translation:HumansCells
  16. Roy A, Skibo J, Kalume F, Ni J, Rankin S, Lu Y, Dobyns WB, Mills GB, Zhao JJ, Baker SJ, Millen KJ. Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy. Elife. 2015 Dec 03; 4. PMID: 26633882; PMCID: PMC4744197.
    Citations: 39     Fields:    Translation:HumansAnimals
  17. Roy A, Ni J, Skibo J, Rankin S, Dobyns WB, Kalume F, Baker SJ, Zhao J, Millen KJ. Modeling human PIK3CA-related congenital brain overgrowth and epilepsy in mice. Int J Dev Neurosci. 2015 Dec; 47(Pt A):46. PMID: 26531452.
  18. Yuzugullu H, Baitsch L, Von T, Steiner A, Tong H, Ni J, Clayton LK, Bronson R, Roberts TM, Gritsman K, Zhao JJ. A PI3K p110ß-Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis. Nat Commun. 2015 Oct 07; 6:8501. PMID: 26442967.
    Citations: 24     Fields:    Translation:AnimalsCells
  19. Liu Q, Boudot A, Ni J, Hennessey T, Beauparlant SL, Rajabi HN, Zahnow C, Ewen ME. Cyclin D1 and C/EBPß LAP1 operate in a common pathway to promote mammary epithelial cell differentiation. Mol Cell Biol. 2014 Aug; 34(16):3168-79. PMID: 24912680.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  20. Ni J, Miller M, Stojanovic A, Garbi N, Cerwenka A. Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors. J Exp Med. 2012 Dec 17; 209(13):2351-65. PMID: 23209317.
    Citations: 171     Fields:    Translation:HumansAnimalsCells
  21. Ni J, Liu Q, Xie S, Carlson C, Von T, Vogel K, Riddle S, Benes C, Eck M, Roberts T, Gray N, Zhao J. Functional characterization of an isoform-selective inhibitor of PI3K-p110ß as a potential anticancer agent. Cancer Discov. 2012 May; 2(5):425-33. PMID: 22588880.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  22. Liu Q, Kirubakaran S, Hur W, Niepel M, Westover K, Thoreen CC, Wang J, Ni J, Patricelli MP, Vogel K, Riddle S, Waller DL, Traynor R, Sanda T, Zhao Z, Kang SA, Zhao J, Look AT, Sorger PK, Sabatini DM, Gray NS. Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics. J Biol Chem. 2012 Mar 23; 287(13):9742-9752. PMID: 22223645; PMCID: PMC3322972.
    Citations: 53     Fields:    Translation:HumansCells
  23. Xie S, Ni J, Lee YF, Liu S, Li G, Shyr CR, Chang C. Increased acetylation in the DNA-binding domain of TR4 nuclear receptor by the coregulator ARA55 leads to suppression of TR4 transactivation. J Biol Chem. 2011 Jun 17; 286(24):21129-36. PMID: 21515881.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  24. Xie S, Lee YF, Kim E, Chen LM, Ni J, Fang LY, Liu S, Lin SJ, Abe J, Berk B, Ho FM, Chang C. TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13353-8. PMID: 19666541.
    Citations: 48     Fields:    Translation:AnimalsCells
  25. Ni J, Mai T, Pang ST, Haque I, Huang K, DiMaggio MA, Xie S, James NS, Kasi D, Chemler SR, Yeh S. In vitro and in vivo anticancer effects of the novel vitamin E ether analogue RRR-alpha-tocopheryloxybutyl sulfonic acid in prostate cancer. Clin Cancer Res. 2009 Feb 01; 15(3):898-906. PMID: 19188160.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  26. Ni J, Wen X, Yao J, Chang HC, Yin Y, Zhang M, Xie S, Chen M, Simons B, Chang P, di Sant'Agnese A, Messing EM, Yeh S. Tocopherol-associated protein suppresses prostate cancer cell growth by inhibition of the phosphoinositide 3-kinase pathway. Cancer Res. 2005 Nov 01; 65(21):9807-16. PMID: 16267002.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  27. Yang L, Xie S, Jamaluddin MS, Altuwaijri S, Ni J, Kim E, Chen YT, Hu YC, Wang L, Chuang KH, Wu CT, Chang C. Induction of androgen receptor expression by phosphatidylinositol 3-kinase/Akt downstream substrate, FOXO3a, and their roles in apoptosis of LNCaP prostate cancer cells. J Biol Chem. 2005 Sep 30; 280(39):33558-65. PMID: 16061480.
    Citations: 62     Fields:    Translation:HumansCells
  28. Xie S, Lin HK, Ni J, Yang L, Wang L, di Sant'Agnese PA, Chang C. Regulation of interleukin-6-mediated PI3K activation and neuroendocrine differentiation by androgen signaling in prostate cancer LNCaP cells. Prostate. 2004 Jun 15; 60(1):61-7. PMID: 15129430.
    Citations: 19     Fields:    Translation:HumansCells
  29. Hu YC, Yeh S, Yeh SD, Sampson ER, Huang J, Li P, Hsu CL, Ting HJ, Lin HK, Wang L, Kim E, Ni J, Chang C. Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. J Biol Chem. 2004 Aug 06; 279(32):33438-46. PMID: 15166229.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  30. Yang L, Yeh SD, Xie S, Altuwaijri S, Ni J, Hu YC, Chen YT, Bao BY, Su CH, Chang C. Androgen suppresses PML protein expression in prostate cancer CWR22R cells. Biochem Biophys Res Commun. 2004 Jan 30; 314(1):69-75. PMID: 14715247.
    Citations: 8     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.