Harvard Catalyst Profiles

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Roslyn W. Orkin, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. S10RR006352 (ORKIN, ROSLYN W) May 16, 1991 - May 15, 1992
    Role: Principal Investigator
  2. R01HL037676 (ORKIN, ROSLYN W) Sep 30, 1986 - Feb 28, 1991
    Role: Principal Investigator
  3. R01AR025527 (ORKIN, ROSLYN W) Apr 1, 1979 - Dec 31, 1993
    Role: Principal Investigator
  4. R01AM025527 (ORKIN, ROSLYN W) Apr 1, 1979 - Dec 31, 1987
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Casey PJ, Dattilo JB, Dai G, Albert JA, Tsukurov OI, Orkin RW, Gertler JP, Abbott WM. The effect of combined arterial hemodynamics on saphenous venous endothelial nitric oxide production. J Vasc Surg. 2001 Jun; 33(6):1199-205. PMID: 11389418.
    Citations: 10     Fields:    Translation:HumansCells
  2. Grabowski EF, Reininger AJ, Petteruti PG, Tsukurov O, Orkin RW. Shear stress decreases endothelial cell tissue factor activity by augmenting secretion of tissue factor pathway inhibitor. Arterioscler Thromb Vasc Biol. 2001 Jan; 21(1):157-62. PMID: 11145948.
    Citations: 8     Fields:    Translation:Humans
  3. Dai G, Tsukurov O, Orkin RW, Abbott WM, Kamm RD, Gertler JP. An in vitro cell culture system to study the influence of external pneumatic compression on endothelial function. J Vasc Surg. 2000 Nov; 32(5):977-87. PMID: 11054230.
    Citations: 3     Fields:    Translation:HumansCells
  4. Grabowski EF, Carter CA, Tsukurov O, Conroy N, Hsu CY, Abbott WM, Ingelfinger JR, Orkin RW. Comparison of human umbilical vein and adult saphenous vein endothelial cells: implications for newborn hemostasis and for laboratory models of endothelial cell function. J Pediatr Hematol Oncol. 2000 May-Jun; 22(3):266-8. PMID: 10864062.
    Citations:    Fields:    Translation:HumansCells
  5. Tsukurov OI, Kwolek CJ, L'Italien GJ, Benbrahim A, Milinazzo BB, Conroy NE, Gertler JP, Orkin RW, Abbott WM. The response of adult human saphenous vein endothelial cells to combined pressurized pulsatile flow and cyclic strain, in vitro. Ann Vasc Surg. 2000 May; 14(3):260-7. PMID: 10796958.
    Citations: 4     Fields:    Translation:Humans
  6. Grabowski EF, Carter CA, Ingelfinger JR, Tsukurov O, Conroy N, Abbott WM, Orkin RW. Comparison of tissue factor pathway in human umbilical vein and adult saphenous vein endothelial cells: implications for newborn hemostasis and for laboratory models of endothelial cell function. Pediatr Res. 1999 Dec; 46(6):742-7. PMID: 10590033.
    Citations: 1     Fields:    Translation:HumansCells
  7. Morgan BA, Orkin RW, Noramly S, Perez A. Stage-specific effects of sonic hedgehog expression in the epidermis. Dev Biol. 1998 Sep 01; 201(1):1-12. PMID: 9733569.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  8. Benbrahim A, L'Italien GJ, Kwolek CJ, Petersen MJ, Milinazzo B, Gertler JP, Abbott WM, Orkin RW. Characteristics of vascular wall cells subjected to dynamic cyclic strain and fluid shear conditions in vitro. J Surg Res. 1996 Oct; 65(2):119-27. PMID: 8903457.
    Citations: 1     Fields:    Translation:HumansCells
  9. Benbrahim A, L'Italien GJ, Milinazzo BB, Warnock DF, Dhara S, Gertler JP, Orkin RW, Abbott WM. A compliant tubular device to study the influences of wall strain and fluid shear stress on cells of the vascular wall. J Vasc Surg. 1994 Aug; 20(2):184-94. PMID: 8040941.
    Citations: 5     Fields:    Translation:Animals
  10. Petersen MJ, Abbott WM, H'Doubler PB, L'Italien GJ, Hoppel BE, Rosen BR, Fallon JT, Orkin RW. Hemodynamics and aneurysm development in vascular allografts. J Vasc Surg. 1993 Dec; 18(6):955-63; discussion 963-4. PMID: 8264052.
    Citations: 1     Fields:    Translation:Animals
  11. Gertler JP, Perry L, L'Italien G, Chung-Welch N, Cambria RP, Orkin R, Abbott WM. Ambient oxygen tension modulates endothelial fibrinolysis. J Vasc Surg. 1993 Dec; 18(6):939-45; discussion 945-6. PMID: 8264050.
    Citations: 12     Fields:    Translation:HumansCells
  12. Petersen MJ, Hoppel BE, Megerman J, Orkin RW, Rosen BR, Abbott WM. Magnetic resonance imaging of small arteries. J Surg Res. 1992 Oct; 53(4):391-5. PMID: 1405619.
    Citations:    Fields:    Translation:Animals
  13. McGuire PG, Orkin RW. Urokinase activity in the developing avian heart: a spatial and temporal analysis. Dev Dyn. 1992 Jan; 193(1):24-33. PMID: 1540703.
    Citations: 4     Fields:    Translation:AnimalsCells
  14. H'Doubler PB, Peterson M, Shek W, Auchincloss H, Abbott WM, Orkin RW. Spontaneously hypertensive and Wistar Kyoto rats are genetically disparate. Lab Anim Sci. 1991 Oct; 41(5):471-3. PMID: 1666150.
    Citations: 7     Fields:    Translation:Animals
  15. McGuire PG, Brocks DG, Killen PD, Orkin RW. Increased deposition of basement membrane macromolecules in specific vessels of the spontaneously hypertensive rat. Am J Pathol. 1989 Aug; 135(2):291-9. PMID: 2675615; PMCID: PMC1879927.
    Citations: 1     Fields:    Translation:Animals
  16. McGuire PG, Castellot JJ, Orkin RW. Size-dependent hyaluronate degradation by cultured cells. J Cell Physiol. 1987 Nov; 133(2):267-76. PMID: 3680390.
    Citations: 15     Fields:    Translation:AnimalsCells
  17. McGuire PG, Orkin RW. Isolation of rat aortic endothelial cells by primary explant techniques and their phenotypic modulation by defined substrata. Lab Invest. 1987 Jul; 57(1):94-105. PMID: 3298852.
    Citations: 35     Fields:    Translation:AnimalsCells
  18. Orkin RW, Knudson W, Toole BP. Loss of hyaluronate-dependent coat during myoblast fusion. Dev Biol. 1985 Feb; 107(2):527-30. PMID: 3972168.
    Citations: 6     Fields:    Translation:AnimalsCells
  19. Bernanke DH, Orkin RW. Hyaluronidase activity in embryonic chick heart muscle and cushion tissue and cells. Dev Biol. 1984 Dec; 106(2):351-9. PMID: 6500178.
    Citations: 4     Fields:    Translation:AnimalsCells
  20. Bernanke DH, Orkin RW. Hyaluronate binding and degradation by cultured embryonic chick cardiac cushion and myocardial cells. Dev Biol. 1984 Dec; 106(2):360-7. PMID: 6209180.
    Citations:    Fields:    Translation:AnimalsCells
  21. Heathcote JG, Bruns RR, Orkin RW. Biosynthesis of sulphated macromolecules by rabbit lens epithelium. II. Relationship to basement membrane formation. J Cell Biol. 1984 Sep; 99(3):861-9. PMID: 6236228; PMCID: PMC2113412.
    Citations: 2     Fields:    Translation:AnimalsCells
  22. Heathcote JG, Orkin RW. Biosynthesis of sulphated macromolecules by rabbit lens epithelium. I. Identification of the major macromolecules synthesized by lens epithelial cells in vitro. J Cell Biol. 1984 Sep; 99(3):852-60. PMID: 6470043; PMCID: PMC2113408.
    Citations: 3     Fields:    Translation:AnimalsCells
  23. Wright TC, Orkin RW, Destrempes M, Kurnit DM. Increased adhesiveness of Down syndrome fetal fibroblasts in vitro. Proc Natl Acad Sci U S A. 1984 Apr; 81(8):2426-30. PMID: 6232609; PMCID: PMC345073.
    Citations: 11     Fields:    Translation:HumansCells
  24. Orkin RW, Underhill CB, Toole BP. Hyaluronate degradation in 3T3 and simian virus-transformed 3T3 cells. J Biol Chem. 1982 May 25; 257(10):5821-6. PMID: 6279615.
    Citations: 7     Fields:    Translation:AnimalsCells
  25. Grant ME, Heathcote JG, Orkin RW. Current concepts of basement-membrane structure and function. Biosci Rep. 1981 Nov; 1(11):819-42. PMID: 7030429.
    Citations: 11     Fields:    Translation:HumansAnimals
  26. Orkin RW, Toole BP. Chick embryo fibroblasts produce two forms of hyaluronidase. J Cell Biol. 1980 May; 85(2):248-57. PMID: 7372707; PMCID: PMC2110628.
    Citations: 3     Fields:    Translation:AnimalsCells
  27. Orkin RW, Toole BP. Isolation and characterization of hyaluronidase from cultures of chick embryo skin- and muscle-derived fibroblasts. J Biol Chem. 1980 Feb 10; 255(3):1036-42. PMID: 7356648.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  28. Orkin RW, Toole BP. Hyaluronidase activity and hyaluronate content of the developing chick embryo heart. Dev Biol. 1978 Oct; 66(2):308-20. PMID: 29813.
    Citations: 9     Fields:    Translation:Animals
  29. Orkin RW, Jackson G, Toole BP. Hyaluronidase activity in cultured chick embryo skin fibroblasts. Biochem Biophys Res Commun. 1977 Jul 11; 77(1):132-8. PMID: 19016.
    Citations: 2     Fields:    Translation:AnimalsCells
  30. Orkin RW, Williams BR, Cranley RE, Poppke DC, Brown KS. Defects in the cartilaginous growth plates of brachymorphic mice. J Cell Biol. 1977 May; 73(2):287-99. PMID: 67117; PMCID: PMC2109918.
    Citations: 10     Fields:    Translation:AnimalsCells
  31. Orkin RW, Gehron P, McGoodwin EB, Martin GR, Valentine T, Swarm R. A murine tumor producing a matrix of basement membrane. J Exp Med. 1977 Jan 01; 145(1):204-20. PMID: 830788; PMCID: PMC2180589.
    Citations: 146     Fields:    Translation:Animals
  32. Toole BP, Okayama M, Orkin RW, Yoshimura M, Muto M, Kaji A. Developmental roles of hyaluronate and chondroitin sulfate proteoglycans. Soc Gen Physiol Ser. 1977; 32:139-54. PMID: 333591.
    Citations: 9     Fields:    Translation:Animals
  33. Orkin RW, Pratt RM, Martin GR. Undersulfated chondroitin sulfate in the cartilage matrix of brachymorphic mice. Dev Biol. 1976 May; 50(1):82-94. PMID: 1269836.
    Citations: 24     Fields:    Translation:Animals
  34. Ketley JN, Orkin RW, Martin GR. Collagen in developing chick muscle in vivo and in vitro. Exp Cell Res. 1976 May; 99(2):261-8. PMID: 178511.
    Citations: 9     Fields:    Translation:Animals
  35. Hassel JR, Orkin RW. Synthesis and distribution of collagen in the rat palate during shelf elevation. Dev Biol. 1976 Mar; 49(1):80-8. PMID: 1254099.
    Citations: 6     Fields:    Translation:AnimalsCells
  36. Orkin RW, Pollard TD, Hay ED. SDS gel analysis of muscle proteins in embryonic cells. Dev Biol. 1973 Dec; 35(2):388-94. PMID: 4788228.
    Citations: 3     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.