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profileShin-Young Park, PH.D.

TitleInstructor in Pediatrics
InstitutionBoston Children's Hospital
DepartmentPediatrics
AddressChildren's Hospital
Transfusion Med/Lab Med, Enders 828
320 Longwood Ave
Boston MA 02115
Phone617/919-2694
Fax617/730-0218
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P01HL095489     (SILBERSTEIN, LESLIE ERIC)Apr 1, 2009 - Mar 31, 2021
NIH/NHLBI
Molecular Mechanisms of Blood Cell Transfusion
Role: Co-Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bajrami B, Zhu H, Kwak HJ, Mondal S, Hou Q, Geng G, Karatepe K, Zhang YC, Nombela-Arrieta C, Park SY, Loison F, Sakai J, Xu Y, Silberstein LE, Luo HR. G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling. J Exp Med. 2016 Sep 19; 213(10):1999-2018. PMID: 27551153; PMCID: PMC5030805 [Available on 03/19/17].
  2. Ciuculescu MF, Park SY, Canty K, Mathieu R, Silberstein LE, Williams DA. Perivascular deletion of murine Rac reverses the ratio of marrow arterioles and sinusoid vessels and alters hematopoiesis in vivo. Blood. 2015 May 14; 125(20):3105-13. PMID: 25824687; PMCID: PMC4432004.
  3. Kwak HJ, Liu P, Bajrami B, Xu Y, Park SY, Nombela-Arrieta C, Mondal S, Sun Y, Zhu H, Chai L, Silberstein LE, Cheng T, Luo HR. Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis. Immunity. 2015 Jan 20; 42(1):159-71. PMID: 25579427; PMCID: PMC4303526.
  4. Kumar L, Chou J, Yee CS, Borzutzky A, Vollmann EH, von Andrian UH, Park SY, Hollander G, Manis JP, Poliani PL, Geha RS. Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function. J Exp Med. 2014 May 05; 211(5):929-42. PMID: 24752297; PMCID: PMC4010910.
  5. Nombela-Arrieta C, Pivarnik G, Winkel B, Canty KJ, Harley B, Mahoney JE, Park SY, Lu J, Protopopov A, Silberstein LE. Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment. Nat Cell Biol. 2013 May; 15(5):533-43. PMID: 23624405; PMCID: PMC4156024.
  6. Mollova M, Bersell K, Walsh S, Savla J, Das LT, Park SY, Silberstein LE, Dos Remedios CG, Graham D, Colan S, Kühn B. Cardiomyocyte proliferation contributes to heart growth in young humans. Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):1446-51. PMID: 23302686; PMCID: PMC3557060.
  7. Park SY, Wolfram P, Canty K, Harley B, Nombela-Arrieta C, Pivarnik G, Manis J, Beggs HE, Silberstein LE. Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments. J Immunol. 2013 Feb 01; 190(3):1094-102. PMID: 23264658; PMCID: PMC3552136.
  8. Kim H, Taghados SJ, Fischer K, Maeng LS, Park S, Yoo SS. Noninvasive transcranial stimulation of rat abducens nerve by focused ultrasound. Ultrasound Med Biol. 2012 Sep; 38(9):1568-75. PMID: 22763009; PMCID: PMC3428140.
  9. Yang PS, Kim H, Lee W, Bohlke M, Park S, Maher TJ, Yoo SS. Transcranial focused ultrasound to the thalamus is associated with reduced extracellular GABA levels in rats. Neuropsychobiology. 2012; 65(3):153-60. PMID: 22378299.
    View in: PubMed
  10. Lu J, Sun Y, Nombela-Arrieta C, Du KP, Park SY, Chai L, Walkley C, Luo HR, Silberstein LE. Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion. Exp Hematol. 2012 Apr; 40(4):307-17.e3. PMID: 22155722; PMCID: PMC3307834.
  11. Yoo SS, Kim H, Min BK, Franck E, Park S. Transcranial focused ultrasound to the thalamus alters anesthesia time in rats. Neuroreport. 2011 Oct 26; 22(15):783-7. PMID: 21876461; PMCID: PMC3174273.
  12. Jia Y, Loison F, Hattori H, Li Y, Erneux C, Park SY, Gao C, Chai L, Silberstein LE, Schurmans S, Luo HR. Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4739-44. PMID: 18339802; PMCID: PMC2290809.
  13. Le Y, Zhu BM, Harley B, Park SY, Kobayashi T, Manis JP, Luo HR, Yoshimura A, Hennighausen L, Silberstein LE. SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis. Immunity. 2007 Nov; 27(5):811-23. PMID: 18031698.
    View in: PubMed
  14. Glodek AM, Le Y, Dykxhoorn DM, Park SY, Mostoslavsky G, Mulligan R, Lieberman J, Beggs HE, Honczarenko M, Silberstein LE. Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells. Leukemia. 2007 Aug; 21(8):1723-32. PMID: 17568820.
    View in: PubMed
  15. Park SY, Li H, Avraham S. RAFTK/Pyk2 regulates EGF-induced PC12 cell spreading and movement. Cell Signal. 2007 Feb; 19(2):289-300. PMID: 16945503.
    View in: PubMed
  16. Park SY, Schinkmann KA, Avraham S. RAFTK/Pyk2 mediates LPA-induced PC12 cell migration. Cell Signal. 2006 Jul; 18(7):1063-71. PMID: 16199135.
    View in: PubMed
  17. Jiang S, Avraham HK, Park SY, Kim TA, Bu X, Seng S, Avraham S. Process elongation of oligodendrocytes is promoted by the Kelch-related actin-binding protein Mayven. J Neurochem. 2005 Mar; 92(5):1191-203. PMID: 15715669.
    View in: PubMed
  18. Park SY, Avraham HK, Avraham S. RAFTK/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent manner. J Biol Chem. 2004 Aug 06; 279(32):33315-22. PMID: 15166227.
    View in: PubMed
  19. McShan GD, Zagozdzon R, Park SY, Zrihan-Licht S, Fu Y, Avraham S, Avraham H. Csk homologous kinase associates with RAFTK/Pyk2 in breast cancer cells and negatively regulates its activation and breast cancer cell migration. Int J Oncol. 2002 Jul; 21(1):197-205. PMID: 12063569.
    View in: PubMed
  20. Koziak K, Kaczmarek E, Park SY, Fu Y, Avraham S, Avraham H. RAFTK/Pyk2 involvement in platelet activation is mediated by phosphoinositide 3-kinase. Br J Haematol. 2001 Jul; 114(1):134-40. PMID: 11472358.
    View in: PubMed
  21. Park SY, Avraham H, Avraham S. Characterization of the tyrosine kinases RAFTK/Pyk2 and FAK in nerve growth factor-induced neuronal differentiation. J Biol Chem. 2000 Jun 30; 275(26):19768-77. PMID: 10764815.
    View in: PubMed
  22. Avraham H, Park SY, Schinkmann K, Avraham S. RAFTK/Pyk2-mediated cellular signalling. Cell Signal. 2000 Mar; 12(3):123-33. PMID: 10704819.
    View in: PubMed
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