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Thomas T. Simopoulos, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Orhurhu V, Olusunmade M, Urits I, Viswanath O, Peck J, Orhurhu MS, Adekoya P, Hirji S, Sampson J, Simopoulos T, Gill J. Trends of opioid use disorder amongst hospitalized patients with chronic pain. Pain Pract. 2019 May 11. PMID: 31077526.
    Citations:    
  2. Kaye AD, Jones MR, Viswanath O, Candido KD, Boswell MV, Soin A, Sanapati M, Harned ME, Simopoulos TT, Diwan S, Albers SL, Datta S, Falco FJ, Manchikanti L. ASIPP Guidelines for Sedation and Fasting Status of Patients Undergoing Interventional Pain Management Procedures. Pain Physician. 2019 May; 22(3):201-207. PMID: 31151329.
    Citations:    
  3. Jones MR, Novitch MB, Sarrafpour S, Ehrhardt KP, Scott BB, Orhurhu V, Viswanath O, Kaye AD, Gill J, Simopoulos TT. Government Legislation in Response to the Opioid Epidemic. Curr Pain Headache Rep. 2019 May 01; 23(6):40. PMID: 31044343.
    Citations:    
  4. Simopoulos T, Aner M, Sharma S, Ghosh P, Gill JS. Explantation of Percutaneous Spinal Cord Stimulator Devices: A Retrospective Descriptive Analysis of a Single-Center 15-Year Experience. Pain Med. 2019 Mar 19. PMID: 30889248.
    Citations:    
  5. Gill JS, Asgerally A, Simopoulos TT. High-Frequency Spinal Cord Stimulation at 10 kHz for the Treatment of Complex Regional Pain Syndrome: A Case Series of Patients With or Without Previous Spinal Cord Stimulator Implantation. Pain Pract. 2019 03; 19(3):289-294. PMID: 30365222.
    Citations:    Fields:    
  6. Kaye AD, Manchikanti L, Novitch MB, Mungrue IN, Anwar M, Jones MR, Helander EM, Cornett EM, Eng MR, Grider JS, Harned ME, Benyamin RM, Swicegood JR, Simopoulos TT, Abdi S, Urman RD, Deer TR, Bakhit C, Sanapati M, Atluri S, Pasupuleti R, Soin A, Diwan S, Vallejo R, Candido KD, Knezevic NN, Beall D, Albers SL, Latchaw RE, Prabhakar H, Hirsch JA. Responsible, Safe, and Effective Use of Antithrombotics and Anticoagulants in Patients Undergoing Interventional Techniques: American Society of Interventional Pain Physicians (ASIPP) Guidelines. Pain Physician. 2019 01; 22(1S):S75-S128. PMID: 30717501.
    Citations:    
  7. Viswanath O, Petro J, Asgerally A, Simopoulos TT. Letter to the Editor: Don't Believe Everything You Read: Perspectives from Your New Pain Physician. Pain Physician. 2018 05; 21(3):E281-E283. PMID: 29871383.
    Citations:    Fields:    
  8. Jones MR, Viswanath O, Peck J, Kaye AD, Gill JS, Simopoulos TT. A Brief History of the Opioid Epidemic and Strategies for Pain Medicine. Pain Ther. 2018 Jun; 7(1):13-21. PMID: 29691801.
    Citations:    
  9. Simopoulos T, Sharma S, Aner M, Gill JS. The Long-Term Durability of Multilumen Concentric Percutaneous Spinal Cord Stimulator Leads. Pain Pract. 2018 09; 18(7):845-849. PMID: 29363873.
    Citations:    Fields:    
  10. Simopoulos T, Leffler D, Barnett S, Campbell D, Lian SJ, Gill JS. Prospective Assessment of Pain and Comfort in Chronic Pain Patients Undergoing Interventional Pain Management Procedures. Pain Med. 2018 02 01; 19(2):336-347. PMID: 28431040.
    Citations:    Fields:    
  11. Simopoulos T, Yong RJ, Gill JS. Treatment of Chronic Refractory Neuropathic Pelvic Pain with High-Frequency 10-kilohertz Spinal Cord Stimulation. Pain Pract. 2018 07; 18(6):805-809. PMID: 29106051.
    Citations:    Fields:    
  12. Gill J, Simopoulos T. Reliability and Accuracy of MRI Laminar Angle Measurements to Determine Intraprocedural Contralateral Oblique View Angle for Cervical or Thoracic Interlaminar Epidural Steroid Injections-Safety Before Accuracy. Pain Med. 2017 11 01; 18(11):2256-2257. PMID: 28591865.
    Citations:    Fields:    
  13. Simopoulos T, Sharma S, Aner M, Gill JS. A Temporary vs. Permanent Anchored Percutaneous Lead Trial of Spinal Cord Stimulation: A Comparison of Patient Outcomes and Adverse Events. Neuromodulation. 2018 Jul; 21(5):508-512. PMID: 28901641.
    Citations:    Fields:    Translation:Humans
  14. Helm Ii S, Simopoulos TT, Stojanovic M, Abdi S, El Terany MA. Effectiveness of Thermal Annular Procedures in Treating Discogenic Low Back Pain. Pain Physician. 2017 09; 20(6):447-470. PMID: 28934777.
    Citations:    Fields:    Translation:Humans
  15. Bendel MA, O'Brien T, Hoelzer BC, Deer TR, Pittelkow TP, Costandi S, Walega DR, Azer G, Hayek SM, Wang Z, Eldrige JS, Qu W, Rosenow JM, Falowski SM, Neuman SA, Moeschler SM, Wassef C, Kim C, Niazi T, Saifullah T, Yee B, Kim C, Oryhan CL, Warren DT, Lerman I, Mora R, Hanes M, Simopoulos T, Sharma S, Gilligan C, Grace W, Ade T, Mekhail NA, Hunter JP, Choi D, Choi DY. Spinal Cord Stimulator Related Infections: Findings From a Multicenter Retrospective Analysis of 2737 Implants. Neuromodulation. 2017 Aug; 20(6):553-557. PMID: 28726312.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  16. Gill J, Nagda J, Aner M, Simopoulos T. Cervical Epidural Contrast Spread Patterns in Fluoroscopic Antero-Posterior, Lateral, and Contralateral Oblique View: A Three-Dimensional Analysis. Pain Med. 2017 06 01; 18(6):1027-1039. PMID: 28339542.
    Citations:    Fields:    Translation:Humans
  17. Hoelzer BC, Bendel MA, Deer TR, Eldrige JS, Walega DR, Wang Z, Costandi S, Azer G, Qu W, Falowski SM, Neuman SA, Moeschler SM, Wassef C, Kim C, Niazi T, Saifullah T, Yee B, Kim C, Oryhan CL, Rosenow JM, Warren DT, Lerman I, Mora R, Hayek SM, Hanes M, Simopoulos T, Sharma S, Gilligan C, Grace W, Ade T, Mekhail NA, Hunter JP, Choi D, Choi DY. Spinal Cord Stimulator Implant Infection Rates and Risk Factors: A Multicenter Retrospective Study. Neuromodulation. 2017 Aug; 20(6):558-562. PMID: 28493599.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  18. Gill JS, Simopoulos TT. Optimal Angle of Contralateral Oblique View in Cervical Interlaminar Epidural Injections: Safety or Precision? Pain Physician. 2017 03; 20(3):E478-E479. PMID: 28339454.
    Citations:    Fields:    Translation:Humans
  19. Spinner D, Aner M, Paul G, Simopoulos T, Gill J. Percutaneous Translaminar Facet Cyst Rupture and Epidural Access-Description of a Novel Technique. Pain Med. 2017 03 01; 18(3):410-413. PMID: 28395102.
    Citations:    Fields:    Translation:Humans
  20. Gill JS, Simopoulos TT. Reliability and Safety of Contra-Lateral Oblique View for Interlaminar Epidural Needle Placement: Standardization of the Appropriate Angle. Pain Physician. 2017 03; 20(3):E469. PMID: 28339450.
    Citations:    Fields:    Translation:Humans
  21. Manchikanti L, Kaye AM, Knezevic NN, McAnally H, Slavin K, Trescot AM, Blank S, Pampati V, Abdi S, Grider JS, Kaye AD, Manchikanti KN, Cordner H, Gharibo CG, Harned ME, Albers SL, Atluri S, Aydin SM, Bakshi S, Barkin RL, Benyamin RM, Boswell MV, Buenaventura RM, Calodney AK, Cedeno DL, Datta S, Deer TR, Fellows B, Galan V, Grami V, Hansen H, Helm Ii S, Justiz R, Koyyalagunta D, Malla Y, Navani A, Nouri KH, Pasupuleti R, Sehgal N, Silverman SM, Simopoulos TT, Singh V, Solanki DR, Staats PS, Vallejo R, Wargo BW, Watanabe A, Hirsch JA. Responsible, Safe, and Effective Prescription of Opioids for Chronic Non-Cancer Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines. Pain Physician. 2017 02; 20(2S):S3-S92. PMID: 28226332.
    Citations: 16     Fields:    Translation:Humans
  22. Simopoulos TT, Sharma S, Aner M, Gill JS. The Incidence and Management of Postdural Puncture Headache in Patients Undergoing Percutaneous Lead Placement for Spinal Cord Stimulation. Neuromodulation. 2016 Oct; 19(7):738-743. PMID: 27172329.
    Citations:    Fields:    Translation:Humans
  23. Gill JS, Stojanovic M, Simopoulos TT. In Defense of the Meticulous: A Case Against Ambiguity, and a Time to Standardize. Pain Physician. 2016 05; 19(4):E657-8. PMID: 27228534.
    Citations:    Fields:    Translation:Humans
  24. Gill JS, Simopoulos T. The Devil Is in the Details. Anesthesiology. 2016 Jan; 124(1):241. PMID: 26669991.
    Citations:    Fields:    Translation:HumansAnimals
  25. Gill JS, Nagda JV, Aner MM, Keel JC, Simopoulos TT. Contralateral Oblique View Is Superior to the Lateral View for Lumbar Epidural Access. Pain Med. 2016 05; 17(5):839-50. PMID: 26814266.
    Citations:    Fields:    Translation:Humans
  26. Simopoulos TT, Rosa H, Wootton J, Eichman DS, Gill JS. A Survey of Spinal Cord Stimulator Use by Chronic Pain Patients While Driving. Neuromodulation. 2016 Jul; 19(5):487-91. PMID: 26559374.
    Citations:    Fields:    Translation:Humans
  27. Simopoulos TT, Manchikanti L, Gupta S, Aydin SM, Kim CH, Solanki D, Nampiaparampil DE, Singh V, Staats PS, Hirsch JA. Systematic Review of the Diagnostic Accuracy and Therapeutic Effectiveness of Sacroiliac Joint Interventions. Pain Physician. 2015 Sep-Oct; 18(5):E713-56. PMID: 26431129.
    Citations: 6     Fields:    Translation:Humans
  28. Boswell MV, Manchikanti L, Kaye AD, Bakshi S, Gharibo CG, Gupta S, Jha SS, Nampiaparampil DE, Simopoulos TT, Hirsch JA. A Best-Evidence Systematic Appraisal of the Diagnostic Accuracy and Utility of Facet (Zygapophysial) Joint Injections in Chronic Spinal Pain. Pain Physician. 2015 Jul-Aug; 18(4):E497-533. PMID: 26218947.
    Citations: 4     Fields:    Translation:Humans
  29. Manchikanti L, Nampiaparampil DE, Manchikanti KN, Falco FJ, Singh V, Benyamin RM, Kaye AD, Sehgal N, Soin A, Simopoulos TT, Bakshi S, Gharibo CG, Gilligan CJ, Hirsch JA. Comparison of the efficacy of saline, local anesthetics, and steroids in epidural and facet joint injections for the management of spinal pain: A systematic review of randomized controlled trials. Surg Neurol Int. 2015; 6(Suppl 4):S194-235. PMID: 26005584.
    Citations: 12     
  30. Gill JS, Aner M, Nagda JV, Jyotsna N, Keel JC, Simopoulos TT. Contralateral oblique view is superior to lateral view for interlaminar cervical and cervicothoracic epidural access. Pain Med. 2015 Jan; 16(1):68-80. PMID: 25220833.
    Citations: 2     Fields:    Translation:Humans
  31. Manchikanti L, Atluri S, Candido KD, Boswell MV, Simopoulos TT, Grider JS, Falco FJ, Hirsch JA. Zohydro approval by food and drug administration: controversial or frightening? Pain Physician. 2014 Jul-Aug; 17(4):E437-50. PMID: 25054396.
    Citations: 6     Fields:    Translation:HumansPHPublic Health
  32. Manchikanti L, Hirsch JA, Heavner JE, Cohen SP, Benyamin RM, Sehgal N, Falco FJ, Vallejo R, Onyewu O, Zhu J, Kaye AD, Boswell MV, Helm S, Candido KD, Diwan S, Simopoulos TT, Singh V, Pampati V, Racz GB, Raj PP. Development of an interventional pain management specific instrument for methodologic quality assessment of nonrandomized studies of interventional techniques. Pain Physician. 2014 May-Jun; 17(3):E291-317. PMID: 24850112.
    Citations: 2     Fields:    Translation:Humans
  33. Jang SS, Arle JE, Gill JS, Simopoulos TT. Case series on variable presentation of ligamentum flavum stimulation following percutaneous cylindrical spinal cord stimulator lead implants. Pain Physician. 2014 May-Jun; 17(3):E397-403. PMID: 24850121.
    Citations:    Fields:    Translation:Humans
  34. Chaudhry ZA, Najib U, Bajwa ZH, Jacobs WC, Sheikh J, Simopoulos TT. Detailed analysis of allergic cutaneous reactions to spinal cord stimulator devices. J Pain Res. 2013; 6:617-23. PMID: 23946668.
    Citations:    
  35. Gill J, Aner M, Simopoulos T. Intricacies of the contralateral oblique view for interlaminar epidural access. Pain Med. 2013 Aug; 14(8):1265-6. PMID: 23659540.
    Citations: 1     Fields:    Translation:Humans
  36. Simopoulos TT, Gill JS. Magnetic resonance imaging of the lumbar spine in a patient with a spinal cord stimulator. Pain Physician. 2013 May-Jun; 16(3):E295-300. PMID: 23703428.
    Citations: 1     Fields:    Translation:Humans
  37. Manchikanti L, Abdi S, Atluri S, Benyamin RM, Boswell MV, Buenaventura RM, Bryce DA, Burks PA, Caraway DL, Calodney AK, Cash KA, Christo PJ, Cohen SP, Colson J, Conn A, Cordner H, Coubarous S, Datta S, Deer TR, Diwan S, Falco FJ, Fellows B, Geffert S, Grider JS, Gupta S, Hameed H, Hameed M, Hansen H, Helm S, Janata JW, Justiz R, Kaye AD, Lee M, Manchikanti KN, McManus CD, Onyewu O, Parr AT, Patel VB, Racz GB, Sehgal N, Sharma ML, Simopoulos TT, Singh V, Smith HS, Snook LT, Swicegood JR, Vallejo R, Ward SP, Wargo BW, Zhu J, Hirsch JA. An update of comprehensive evidence-based guidelines for interventional techniques in chronic spinal pain. Part II: guidance and recommendations. Pain Physician. 2013 Apr; 16(2 Suppl):S49-283. PMID: 23615883.
    Citations: 56     Fields:    Translation:Humans
  38. Slavin KV, Vaisman J, Pollack KL, Simopoulos TT, Kowlowitz E, Weinand ME, Norregaard TV. Treatment of chronic, intractable pain with a conventional implantable pulse generator: a meta-analysis of 4 clinical studies. Clin J Pain. 2013 Jan; 29(1):78-85. PMID: 22751030.
    Citations:    Fields:    Translation:Humans
  39. Falco FJ, Manchikanti L, Datta S, Sehgal N, Geffert S, Onyewu O, Singh V, Bryce DA, Benyamin RM, Simopoulos TT, Vallejo R, Gupta S, Ward SP, Hirsch JA. An update of the systematic assessment of the diagnostic accuracy of lumbar facet joint nerve blocks. Pain Physician. 2012 Nov-Dec; 15(6):E869-907. PMID: 23159979.
    Citations: 7     Fields:    Translation:Humans
  40. Hansen H, Manchikanti L, Simopoulos TT, Christo PJ, Gupta S, Smith HS, Hameed H, Cohen SP. A systematic evaluation of the therapeutic effectiveness of sacroiliac joint interventions. Pain Physician. 2012 May-Jun; 15(3):E247-78. PMID: 22622913.
    Citations: 15     Fields:    Translation:Humans
  41. Simopoulos TT, Manchikanti L, Singh V, Gupta S, Hameed H, Diwan S, Cohen SP. A systematic evaluation of prevalence and diagnostic accuracy of sacroiliac joint interventions. Pain Physician. 2012 May-Jun; 15(3):E305-44. PMID: 22622915.
    Citations: 17     Fields:    Translation:Humans
  42. Simopoulos TT, Nagda J, Aner MM. Percutaneous radiofrequency lesioning of the suprascapular nerve for the management of chronic shoulder pain: a case series. J Pain Res. 2012; 5:91-7. PMID: 22570561.
    Citations: 2     
  43. Rhame EE, Debonet AF, Simopoulos TT. Ultrasonographic guidance and characterization of cryoanalgesic lesions in treating a case of refractory sural neuroma. Case Rep Anesthesiol. 2011; 2011:691478. PMID: 22606391.
    Citations: 1     
  44. Nagda JV, Davis CW, Bajwa ZH, Simopoulos TT. Retrospective review of the efficacy and safety of repeated pulsed and continuous radiofrequency lesioning of the dorsal root ganglion/segmental nerve for lumbar radicular pain. Pain Physician. 2011 Jul-Aug; 14(4):371-6. PMID: 21785480.
    Citations: 8     Fields:    Translation:Humans
  45. Bernardini DJ, Pratt SD, Takoudes TC, Simopoulos TT. Spinal cord stimulation and the pregnant patient-specific considerations for management: A case series and review of the literature. Neuromodulation. 2010 Oct; 13(4):270-4. PMID: 21992881.
    Citations: 3     Fields:    
  46. Simopoulos T, Bajwa Z, Lantz G, Lee S, Burstein R. Implanted auriculotemporal nerve stimulator for the treatment of refractory chronic migraine. Headache. 2010 Jun; 50(6):1064-9. PMID: 20618819.
    Citations: 6     Fields:    Translation:Humans
  47. Lowry AM, Simopoulos TT. Spinal cord stimulation for the treatment of chronic knee pain following total knee replacement. Pain Physician. 2010 May-Jun; 13(3):251-6. PMID: 20495589.
    Citations: 3     Fields:    Translation:Humans
  48. Gerszten PC, Smuck M, Rathmell JP, Simopoulos TT, Bhagia SM, Mocek CK, Crabtree T, Bloch DA. Plasma disc decompression compared with fluoroscopy-guided transforaminal epidural steroid injections for symptomatic contained lumbar disc herniation: a prospective, randomized, controlled trial. J Neurosurg Spine. 2010 Apr; 12(4):357-71. PMID: 20201654.
    Citations: 7     Fields:    Translation:Humans
  49. Bajwa ZH, Simopoulos TT, Pal J, Kraemer JJ, Chopra P, Nagda JV, Najib U, Celestin J, Sial K, Ahmad B, Warfield C, Steinman TI, Wootton J. Low and therapeutic doses of antidepressants are associated with similar response in the context of multimodal treatment of pain. Pain Physician. 2009 Sep-Oct; 12(5):893-900. PMID: 19787016.
    Citations: 5     Fields:    Translation:Humans
  50. Simopoulos TT, Kraemer JJ, Glazer P, Bajwa ZH. Vertebral osteomyelitis: a potentially catastrophic outcome after lumbar epidural steroid injection. Pain Physician. 2008 Sep-Oct; 11(5):693-7. PMID: 18850035.
    Citations: 6     Fields:    Translation:Humans
  51. Ramanavarapu V, Simopoulos TT. Pulsed radiofrequency of lumbar dorsal root ganglia for chronic post-amputation stump pain. Pain Physician. 2008 Jul-Aug; 11(4):561-6. PMID: 18690285.
    Citations: 5     Fields:    Translation:Humans
  52. Simopoulos TT, Kraemer J, Nagda JV, Aner M, Bajwa ZH. Response to pulsed and continuous radiofrequency lesioning of the dorsal root ganglion and segmental nerves in patients with chronic lumbar radicular pain. Pain Physician. 2008 Mar-Apr; 11(2):137-44. PMID: 18354708.
    Citations: 14     Fields:    Translation:HumansCTClinical Trials
  53. Elkersh MA, Simopoulos TT, Bajwa ZH. Fundamentals of interventional pain medicine. Neurologist. 2005 Sep; 11(5):285-93. PMID: 16148735.
    Citations: 2     Fields:    Translation:HumansAnimals
  54. Simopoulos TT, Malik AB, Sial KA, Elkersh M, Bajwa ZH. Radiofrequency lesioning of the L2 ramus communicans in managing discogenic low back pain. Pain Physician. 2005 Jan; 8(1):61-5. PMID: 16850044.
    Citations: 2     Fields:    
  55. Hosny A, Simopoulos T, Collins B. Response of intractable post herpetic neuralgia to intrathecal baclofen. Pain Physician. 2004 Jul; 7(3):345-7. PMID: 16858473.
    Citations: 2     Fields:    
  56. Elkersh MA, Simopoulos TT, Malik AB, Cho EH, Bajwa ZH. Epidural clonidine relieves intractable neuropathic itch associated with herpes zoster-related pain. Reg Anesth Pain Med. 2003 Jul-Aug; 28(4):344-6. PMID: 12945030.
    Citations: 5     Fields:    Translation:Humans
  57. Simopoulos TT, Smith HS, Peeters-Asdourian C, Stevens DS. Use of meperidine in patient-controlled analgesia and the development of a normeperidine toxic reaction. Arch Surg. 2002 Jan; 137(1):84-8. PMID: 11772223.
    Citations: 2     Fields:    Translation:Humans
  58. Simopoulos T, Peeters-Asdourian C. Pneumocephalus after cervical epidural steroid injection. Anesth Analg. 2001 Jun; 92(6):1576-7. PMID: 11375849.
    Citations: 8     Fields:    Translation:Humans
  59. Simopoulos TT, Jencks WP. Alkaline phosphatase is an almost perfect enzyme. Biochemistry. 1994 Aug 30; 33(34):10375-80. PMID: 8068674.
    Citations: 12     Fields:    Translation:Cells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.