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Binglan Yu, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21HL130956 (YU, BINGLAN) Aug 1, 2016 - Jul 31, 2019
    Producing Nitric Oxide by Pulsed Electrical Discharge in Air for Inhalation Therapy
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Goto S, Grange RMH, Pinciroli R, Rosales IA, Li R, Boerboom SL, Ostrom KF, Marutani E, Wanderley HV, Bagchi A, Colvin RB, Berra L, Minaeva O, Goldstein LE, Malhotra R, Zapol WM, Ichinose F, Yu B. Electronic cigarette vaping with aged coils causes acute lung injury in mice. Arch Toxicol. 2022 12; 96(12):3363-3371. PMID: 36195745.
    Citations:    Fields:    Translation:Animals
  2. Nakagawa A, Cooper MK, Kost-Alimova M, Berstler J, Yu B, Berra L, Klings ES, Huang MS, Heeney MM, Bloch DB, Zapol WM. High-Throughput Assay to Screen Small Molecules for Their Ability to Prevent Sickling of Red Blood Cells. ACS Omega. 2022 Apr 26; 7(16):14009-14016. PMID: 35559170; PMCID: PMC9089379.
    Citations: 1     
  3. Di Fenza R, Yu B, Carroll RW, Berra L. Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds. J Vis Exp. 2022 02 16; (180). PMID: 35253799.
    Citations:    Fields:    
  4. Gianni S, Fenza RD, Morais CCA, Fakhr BS, Mueller AL, Yu B, Carroll RW, Ichinose F, Zapol WM, Berra L. High-Dose Nitric Oxide From Pressurized Cylinders and Nitric Oxide Produced by an Electric Generator From Air. Respir Care. 2022 02; 67(2):201-208. PMID: 34413210.
    Citations: 3     Fields:    Translation:HumansCells
  5. Gianni S, Morais CCA, Larson G, Pinciroli R, Carroll R, Yu B, Zapol WM, Berra L. Ideation and assessment of a nitric oxide delivery system for spontaneously breathing subjects. Nitric Oxide. 2020 11 01; 104-105:29-35. PMID: 32835810.
    Citations: 9     Fields:    Translation:Humans
  6. Yu B, Zadek F, Fischbach A, Wiegand SB, Berra L, Bloch DB, Zapol WM. Intratracheal injection of nitric oxide, generated from air by pulsed electrical discharge, for the treatment of pulmonary hypertension in awake ambulatory lambs. Nitric Oxide. 2020 04 01; 97:11-15. PMID: 31982629.
    Citations: 1     Fields:    Translation:Animals
  7. Yu B, Zapol WM, Berra L. Electrically generated nitric oxide from air: a safe and economical treatment for pulmonary hypertension. Intensive Care Med. 2019 11; 45(11):1612-1614. PMID: 31451859.
    Citations:    Fields:    Translation:Humans
  8. Hayashida K, Miyazaki Y, Yu B, Silverman MG, Pinciroli R, Berra L, Malhotra R, Donnino MW, Ichinose F. Depletion of Vascular Nitric Oxide Contributes to Poor Outcomes after Cardiac Arrest. Am J Respir Crit Care Med. 2019 05 15; 199(10):1288-1290. PMID: 30785772; PMCID: PMC6519855.
    Citations: 2     Fields:    Translation:Humans
  9. Yu B, Ichinose F, Bloch DB, Zapol WM. Inhaled nitric oxide. Br J Pharmacol. 2019 01; 176(2):246-255. PMID: 30288739; PMCID: PMC6295404.
    Citations: 26     Fields:    Translation:HumansAnimals
  10. Seidelmann SB, Feofanova E, Yu B, Franceschini N, Claggett B, Kuokkanen M, Puolijoki H, Ebeling T, Perola M, Salomaa V, Shah A, Coresh J, Selvin E, MacRae CA, Cheng S, Boerwinkle E, Solomon SD. Genetic Variants in SGLT1, Glucose Tolerance, and Cardiometabolic Risk. J Am Coll Cardiol. 2018 10 09; 72(15):1763-1773. PMID: 30286918; PMCID: PMC6403489.
    Citations: 27     Fields:    Translation:Humans
  11. Chen B, Li Y, Yu B, Zhang Z, Brommer B, Williams PR, Liu Y, Hegarty SV, Zhou S, Zhu J, Guo H, Lu Y, Zhang Y, Gu X, He Z. Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations. Cell. 2018 07 26; 174(3):521-535.e13. PMID: 30033363.
    Citations: 61     Fields:    Translation:AnimalsCells
  12. Liu ES, Thoonen R, Petit E, Yu B, Buys ES, Scherrer-Crosbie M, Demay MB. Increased Circulating FGF23 Does Not Lead to Cardiac Hypertrophy in the Male Hyp Mouse Model of XLH. Endocrinology. 2018 05 01; 159(5):2165-2172. PMID: 29635291; PMCID: PMC5915960.
    Citations: 25     Fields:    Translation:Animals
  13. Nakagawa A, Ferrari M, Schleifer G, Cooper MK, Liu C, Yu B, Berra L, Klings ES, Safo RS, Chen Q, Musayev FN, Safo MK, Abdulmalik O, Bloch DB, Zapol WM. A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells. Mol Pharm. 2018 05 07; 15(5):1954-1963. PMID: 29634905; PMCID: PMC5942180.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  14. Yu B, Ferrari M, Schleifer G, Blaesi AH, Wepler M, Zapol WM, Bloch DB. Development of a portable mini-generator to safely produce nitric oxide for the treatment of infants with pulmonary hypertension. Nitric Oxide. 2018 05 01; 75:70-76. PMID: 29486304.
    Citations: 3     Fields:    Translation:Animals
  15. Zapol WM, Charles HC, Martin AR, Sá RC, Yu B, Ichinose F, MacIntyre N, Mammarappallil J, Moon R, Chen JZ, Geier ET, Darquenne C, Prisk GK, Katz I. Pulmonary Delivery of Therapeutic and Diagnostic Gases. J Aerosol Med Pulm Drug Deliv. 2018 04; 31(2):78-87. PMID: 29451844; PMCID: PMC6421997.
    Citations: 1     Fields:    Translation:Humans
  16. Wang X, Liu Y, Li X, Zhang Z, Yang H, Zhang Y, Williams PR, Alwahab NSA, Kapur K, Yu B, Zhang Y, Chen M, Ding H, Gerfen CR, Wang KH, He Z. Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills. Cell. 2017 Oct 05; 171(2):440-455.e14. PMID: 28942925.
    Citations: 63     Fields:    Translation:Animals
  17. Muenster S, Lieb WS, Fabry G, Allen KN, Kamat SS, Guy AH, Dordea AC, Teixeira L, Tainsh RE, Yu B, Zhu W, Ashpole NE, Malhotra R, Brouckaert P, Bloch DB, Scherrer-Crosbie M, Stamer WD, Kuehn MH, Pasquale LR, Buys ES. The Ability of Nitric Oxide to Lower Intraocular Pressure Is Dependent on Guanylyl Cyclase. Invest Ophthalmol Vis Sci. 2017 09 01; 58(11):4826-4835. PMID: 28973329; PMCID: PMC5624778.
    Citations: 12     Fields:    Translation:Animals
  18. Liu Y, Wang X, Li W, Zhang Q, Li Y, Zhang Z, Zhu J, Chen B, Williams PR, Zhang Y, Yu B, Gu X, He Z. A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions. Neuron. 2017 Aug 16; 95(4):817-833.e4. PMID: 28817801.
    Citations: 71     Fields:    Translation:AnimalsCells
  19. Seidelmann SB, Vardeny O, Claggett B, Yu B, Shah AM, Ballantyne CM, Selvin E, MacRae CA, Boerwinkle E, Solomon SD. An NPPB Promoter Polymorphism Associated With Elevated N-Terminal pro-B-Type Natriuretic Peptide and Lower Blood Pressure, Hypertension, and Mortality. J Am Heart Assoc. 2017 Mar 24; 6(4). PMID: 28341776; PMCID: PMC5533018.
    Citations: 27     Fields:    Translation:HumansCells
  20. Graw JA, Yu B, Rezoagli E, Warren HS, Buys ES, Bloch DB, Zapol WM. Endothelial dysfunction inhibits the ability of haptoglobin to prevent hemoglobin-induced hypertension. Am J Physiol Heart Circ Physiol. 2017 Jun 01; 312(6):H1120-H1127. PMID: 28314763; PMCID: PMC5495929.
    Citations: 13     Fields:    Translation:Animals
  21. Muenster S, Beloiartsev A, Yu B, Du E, Abidi S, Dao M, Fabry G, Graw JA, Wepler M, Malhotra R, Fernandez BO, Feelisch M, Bloch KD, Bloch DB, Zapol WM. Exposure of Stored Packed Erythrocytes to Nitric Oxide Prevents Transfusion-associated Pulmonary Hypertension. Anesthesiology. 2016 11; 125(5):952-963. PMID: 27517645; PMCID: PMC5069190.
    Citations: 5     Fields:    Translation:AnimalsCells
  22. Berra L, Rodriguez-Lopez J, Rezoagli E, Yu B, Fisher DF, Semigran MJ, Bloch DB, Channick RN, Zapol WM. Electric Plasma-generated Nitric Oxide: Hemodynamic Effects in Patients with Pulmonary Hypertension. Am J Respir Crit Care Med. 2016 11 01; 194(9):1168-1170. PMID: 27797618; PMCID: PMC5114452.
    Citations: 6     Fields:    Translation:Humans
  23. Yu B, Blaesi AH, Casey N, Raykhtsaum G, Zazzeron L, Jones R, Morrese A, Dobrynin D, Malhotra R, Bloch DB, Goldstein LE, Zapol WM. Detection and removal of impurities in nitric oxide generated from air by pulsed electrical discharge. Nitric Oxide. 2016 11 30; 60:16-23. PMID: 27592386.
    Citations: 6     Fields:    Translation:AnimalsCellsPHPublic Health
  24. O'Rourke C, Shelton G, Hutcheson JD, Burke MF, Martyn T, Thayer TE, Shakartzi HR, Buswell MD, Tainsh RE, Yu B, Bagchi A, Rhee DK, Wu C, Derwall M, Buys ES, Yu PB, Bloch KD, Aikawa E, Bloch DB, Malhotra R. Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation. J Vis Exp. 2016 05 31; (111). PMID: 27284788.
    Citations: 9     Fields:    Translation:HumansAnimals
  25. Yu B, Muenster S, Blaesi AH, Bloch DB, Zapol WM. Producing nitric oxide by pulsed electrical discharge in air for portable inhalation therapy. Sci Transl Med. 2015 Jul 01; 7(294):294ra107. PMID: 26136478.
    Citations: 20     Fields:    Translation:Animals
  26. Wang X, Wang X, Wang W, Zhang J, Wang J, Wang C, Lv M, Zuo T, Liu D, Zhang H, Wu J, Yu B, Kong W, Wu H, Yu X. Both Rbx1 and Rbx2 exhibit a functional role in the HIV-1 Vif-Cullin5 E3 ligase complex in vitro. Biochem Biophys Res Commun. 2015 Jun 12; 461(4):624-9. PMID: 25912140.
    Citations: 6     Fields:    Translation:HumansCells
  27. Deng L, Shang L, Bai S, Chen J, He X, Martin-Trevino R, Chen S, Li XY, Meng X, Yu B, Wang X, Liu Y, McDermott SP, Ariazi AE, Ginestier C, Ibarra I, Ke J, Luther T, Clouthier SG, Xu L, Shan G, Song E, Yao H, Hannon GJ, Weiss SJ, Wicha MS, Liu S. MicroRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development. Cancer Res. 2014 Nov 15; 74(22):6648-60. PMID: 25217527.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  28. Yu B, Chen X, Li S, Liu Y, Jacques-Tiura AJ, Yan H. Acculturative stress and influential factors among international students in China: a structural dynamic perspective. PLoS One. 2014; 9(4):e96322. PMID: 24788357; PMCID: PMC4005751.
    Citations: 11     Fields:    Translation:Humans
  29. Kida K, Shirozu K, Yu B, Mandeville JB, Bloch KD, Ichinose F. Beneficial effects of nitric oxide on outcomes after cardiac arrest and cardiopulmonary resuscitation in hypothermia-treated mice. Anesthesiology. 2014 Apr; 120(4):880-9. PMID: 24496125; PMCID: PMC4346787.
    Citations: 22     Fields:    Translation:Animals
  30. Zhou GL, Beloiartsev A, Yu B, Baron DM, Zhou W, Niedra R, Lu N, Tainsh LT, Zapol WM, Seed B, Bloch KD. Deletion of the murine cytochrome P450 Cyp2j locus by fused BAC-mediated recombination identifies a role for Cyp2j in the pulmonary vascular response to hypoxia. PLoS Genet. 2013 Nov; 9(11):e1003950. PMID: 24278032; PMCID: PMC3836722.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  31. Protti A, Dong X, Andia ME, Yu B, Dokukina K, Chaubey S, Phinikaridou A, Vizcay-Barrena G, Taupitz M, Botnar RM, Shah AM. Assessment of inflammation with a very small iron-oxide particle in a murine model of reperfused myocardial infarction. J Magn Reson Imaging. 2014 Mar; 39(3):598-608. PMID: 24006053.
    Citations: 5     Fields:    Translation:Animals
  32. Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerte' M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR. Soluble Guanylate Cyclase a1-Deficient Mice: a novel murine model for Primary Open Angle Glaucoma. Ann Neurosci. 2013 Apr; 20(2):65-6. PMID: 25206015.
    Citations: 1     
  33. Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerté M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR. Soluble guanylate cyclase a1-deficient mice: a novel murine model for primary open angle glaucoma. PLoS One. 2013; 8(3):e60156. PMID: 23527308.
    Citations: 33     Fields:    Translation:AnimalsCells
  34. Beloiartsev A, Baron DM, Yu B, Bloch KD, Zapol WM. Hemoglobin infusion does not alter murine pulmonary vascular tone. Nitric Oxide. 2013 Apr 01; 30:1-8. PMID: 23313572.
    Citations: 2     Fields:    Translation:Animals
  35. Lei C, Yu B, Shahid M, Beloiartsev A, Bloch KD, Zapol WM. Inhaled nitric oxide attenuates the adverse effects of transfusing stored syngeneic erythrocytes in mice with endothelial dysfunction after hemorrhagic shock. Anesthesiology. 2012 Dec; 117(6):1190-202. PMID: 23168426; PMCID: PMC3852861.
    Citations: 20     Fields:    Translation:AnimalsCells
  36. Yu B, Morales JF, O'Rourke SM, Tatsuno GP, Berman PW. Glycoform and net charge heterogeneity in gp120 immunogens used in HIV vaccine trials. PLoS One. 2012; 7(8):e43903. PMID: 22928048.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  37. Berra L, Coppadoro A, Yu B, Lei C, Spagnolli E, Steinbicker AU, Bloch KD, Lin T, Sammy FY, Warren HS, Fernandez BO, Feelisch M, Dzik WH, Stowell CP, Zapol WM. Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers. Anesthesiology. 2012 Jul; 117(1):56-63. PMID: 22531338; PMCID: PMC3980575.
    Citations: 21     Fields:    Translation:Humans
  38. Yu B, Zhou S, Wang Y, Qian T, Ding G, Ding F, Gu X. miR-221 and miR-222 promote Schwann cell proliferation and migration by targeting LASS2 after sciatic nerve injury. J Cell Sci. 2012 Jun 01; 125(Pt 11):2675-83. PMID: 22393241.
    Citations: 57     Fields:    Translation:AnimalsCells
  39. Baron DM, Yu B, Lei C, Bagchi A, Beloiartsev A, Stowell CP, Steinbicker AU, Malhotra R, Bloch KD, Zapol WM. Pulmonary hypertension in lambs transfused with stored blood is prevented by breathing nitric oxide. Anesthesiology. 2012 Mar; 116(3):637-47. PMID: 22293717; PMCID: PMC3293704.
    Citations: 34     Fields:    Translation:Animals
  40. Yu B, Lei C, Baron DM, Steinbicker AU, Bloch KD, Zapol WM. Diabetes augments and inhaled nitric oxide prevents the adverse hemodynamic effects of transfusing syngeneic stored blood in mice. Transfusion. 2012 Jul; 52(7):1410-22. PMID: 22233290.
    Citations: 27     Fields:    Translation:AnimalsCells
  41. Lui FE, Yu B, Baron DM, Lei C, Zapol WM, Kluger R. Hemodynamic responses to a hemoglobin bis-tetramer and its polyethylene glycol conjugate. Transfusion. 2012 May; 52(5):974-82. PMID: 22070638.
    Citations: 1     Fields:    Translation:Animals
  42. Yu B, Zhou S, Wang Y, Ding G, Ding F, Gu X. Profile of microRNAs following rat sciatic nerve injury by deep sequencing: implication for mechanisms of nerve regeneration. PLoS One. 2011; 6(9):e24612. PMID: 21931774.
    Citations: 41     Fields:    Translation:Animals
  43. Yu B, Zhou S, Qian T, Wang Y, Ding F, Gu X. Altered microRNA expression following sciatic nerve resection in dorsal root ganglia of rats. Acta Biochim Biophys Sin (Shanghai). 2011 Nov; 43(11):909-15. PMID: 21908854.
    Citations: 24     Fields:    Translation:AnimalsCells
  44. Yu B, Shahid M, Egorina EM, Sovershaev MA, Raher MJ, Lei C, Wu MX, Bloch KD, Zapol WM. Endothelial dysfunction enhances vasoconstriction due to scavenging of nitric oxide by a hemoglobin-based oxygen carrier. Anesthesiology. 2010 Mar; 112(3):586-94. PMID: 20179495; PMCID: PMC2829726.
    Citations: 29     Fields:    Translation:Animals
  45. Yu B, Bloch KD, Zapol WM. Hemoglobin-based red blood cell substitutes and nitric oxide. Trends Cardiovasc Med. 2009 Apr; 19(3):103-7. PMID: 19679268.
    Citations: 12     Fields:    Translation:HumansAnimals
  46. Yu B, Volpato GP, Chang K, Bloch KD, Zapol WM. Prevention of the pulmonary vasoconstrictor effects of HBOC-201 in awake lambs by continuously breathing nitric oxide. Anesthesiology. 2009 Jan; 110(1):113-22. PMID: 19104178; PMCID: PMC2704389.
    Citations: 15     Fields:    Translation:Animals
  47. Yu B, Raher MJ, Volpato GP, Bloch KD, Ichinose F, Zapol WM. Inhaled nitric oxide enables artificial blood transfusion without hypertension. Circulation. 2008 Apr 15; 117(15):1982-90. PMID: 18391111; PMCID: PMC2733227.
    Citations: 52     Fields:    Translation:Animals
  48. Volpato GP, Searles R, Yu B, Scherrer-Crosbie M, Bloch KD, Ichinose F, Zapol WM. Inhaled hydrogen sulfide: a rapidly reversible inhibitor of cardiac and metabolic function in the mouse. Anesthesiology. 2008 Apr; 108(4):659-68. PMID: 18362598; PMCID: PMC2838418.
    Citations: 51     Fields:    Translation:Animals
  49. Yu B, Liu Z, Chang TM. Polyhemoglobin with different percentage of tetrameric hemoglobin and effects on vasoactivity and electrocardiogram. Artif Cells Blood Substit Immobil Biotechnol. 2006; 34(2):159-73. PMID: 16537172.
    Citations: 8     Fields:    Translation:Animals
  50. Yu B, Swi Chang TM. In vitro and in vivo effects of polyhaemoglobin-tyrosinase on murine B16F10 melanoma. Melanoma Res. 2004 Jun; 14(3):197-202. PMID: 15179188.
    Citations: 7     Fields:    Translation:AnimalsCells
  51. Yu B, Chang TM. Polyhemoglobin-tyrosinase, an oxygen carrier with murine B16F10 melanoma suppression properties: a preliminary report. Artif Cells Blood Substit Immobil Biotechnol. 2004 May; 32(2):293-302. PMID: 15274434.
    Citations:    Fields:    Translation:Animals
  52. Yu B, Chang TM. Effects of long-term oral administration of polymeric microcapsules containing tyrosinase on maintaining decreased systemic tyrosine levels in rats. J Pharm Sci. 2004 Apr; 93(4):831-7. PMID: 14999721.
    Citations: 1     Fields:    Translation:Animals
  53. Yu B, Chang TM. Effects of combined oral administration and intravenous injection on maintaining decreased systemic tyrosine levels in rats. Artif Cells Blood Substit Immobil Biotechnol. 2004 Feb; 32(1):129-48. PMID: 15027806.
    Citations:    Fields:    Translation:Animals
  54. Yu B, Chang TMS. In vitro and in vivo enzyme studies of polyhemoglobin-tyrosinase. Biotechnology and BioengineeringIn. 2004; 86(7):835-841.
  55. Yu B, Chang TM. In vitro enzyme kinetics of microencapsulated tyrosinase. Artif Cells Blood Substit Immobil Biotechnol. 2002 Sep-Nov; 30(5-6):533-46. PMID: 12537404.
    Citations:    Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.