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Anna Christina Muriel, M.D.


Available: 01/10/22, Expires: 12/01/22

Acute Lymphoblastic Leukemia (ALL) is the most common childhood cancer and requires two to three years of treatment with corticosteroids every few weeks to achieve very high survival rates. Steroids are an essential component of curative ALL treatment and yet have significant neuropsychiatric side effects that decrease quality of life for children with cancer and their families. Steroids can cause irritability, insomnia, increased appetite, behavior problems, and aggression, which are extremely challenging for children and families. Periodic behavioral issues disrupt children's schooling, family life, and social development. Identifying and measuring these symptoms is a first step in supporting families and alleviating this source of distress. There is no standardized questionnaire to help patients and oncology teams identify and measure these emotional and behavioral symptoms. This study will use focus groups and written input from parents and oncology staff to develop a validated questionnaire of steroid induced mood symptoms. Qualitative focus group data will be analyzed to determine the most common and challenging symptoms observed by parents and staff. These qualitative themes will then be used to create a standardized questionnaire to identify symptoms and measure their intensity. Such a questionnaire would help families and oncology staff better understand these side effects and access appropriate support and interventions to improve quality of life for children and their families during treatment for childhood leukemia. Students would have the opportunity to collaborate with the study team and the Data Survey Core at DFCI in collecting and analyzing qualitative data from focus groups and learn the steps in measure development. They would also have an opportunity to do some clinical shadowing and understand more about the management of the emotional and behavioral side effects of cancer treatment in youth.

Caregiver Medical Traumatic Stress in Newly Diagnosed Pediatric Cancer Patients: Associated Psychosocial Variables and Implications
Summer, 07/01/13 - 08/16/13

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03CA126394 (MURIEL, ANNA C) Sep 27, 2006 - Aug 31, 2009
    A Study of Distress and Parenting Concerns Among Adults with Cancer
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Park EM, Wang M, Bowers SM, Muriel AC, Rauch PK, Edwards T, Yi SM, Daniel B, Hanson LC, Song MK. Adaptation and Psychometric Evaluation of the Parenting Concerns Questionnaire-Advanced Disease. Am J Hosp Palliat Care. 2022 Aug; 39(8):918-925. PMID: 34619978.
    Citations:    Fields:    Translation:Humans
  2. Zheng DJ, Umaretiya PJ, Schwartz ER, Al-Sayegh H, Raphael JL, van Litsenburg RRL, Ma C, Muriel AC, Bona K. Disparities in pediatric psychosocial oncology utilization. Pediatr Blood Cancer. 2021 11; 68(11):e29342. PMID: 34519425; PMCID: PMC8463506.
    Citations:    Fields:    Translation:Humans
  3. Morris SE, Tarquini SJ, Yusufov M, Adolf E, Amonoo HL, Bain PA, Borstelmann NA, Braun IM, Hughes T, Muriel AC, Northman LM, Peteet JR, Poort H, Russ-Carbin A, Pirl WF. Burnout in psychosocial oncology clinicians: A systematic review. Palliat Support Care. 2021 04; 19(2):223-234. PMID: 32895081.
    Citations: 1     Fields:    Translation:Humans
  4. Muriel AC, Burgers DE, Treyball AN, Vrooman LM, Adolf E, Samsel C. Risk factors for steroid-induced affective disorder in children with leukemia. Pediatr Blood Cancer. 2021 05; 68(5):e28847. PMID: 33305874.
    Citations: 1     Fields:    Translation:Humans
  5. Muriel AC. Pediatric psychosocial oncology in the COVID 19 era: Patterns of use, challenges, and lessons learned. Psychooncology. 2020 09; 29(9):1436-1438. PMID: 32779807; PMCID: PMC7404651.
    Citations: 2     Fields:    
  6. Isaac EI, Sivagnanalingam U, Meisman AR, Wetherington Donewar C, Ewing LJ, Katz ER, Muriel AC, Rohan JM. Longitudinal Patterns of Social Problem-Solving Skills in an Ethnically Diverse Sample of Pediatric Patients with Cancer and their Caregivers. Int J Environ Res Public Health. 2020 02 29; 17(5). PMID: 32121378.
    Citations: 1     Fields:    Translation:Humans
  7. Pariseau EM, Chevalier L, Muriel AC, Long KA. Parental awareness of sibling adjustment: Perspectives of parents and siblings of children with cancer. J Fam Psychol. 2020 Sep; 34(6):698-708. PMID: 31829671.
    Citations: 3     Fields:    Translation:Humans
  8. Muriel AC, Moore CW, Beiser M, Park ER, Lim CT, Rauch P. What do surviving children wish for from a dying parent? A qualitative exploration. Death Stud. 2020; 44(5):319-327. PMID: 30623743.
    Citations:    Fields:    Translation:Humans
  9. Park EM, Stephenson EM, Moore CW, Deal AM, Muriel AC. Parental psychological distress and cancer stage: a comparison of adults with metastatic and non-metastatic cancer. Support Care Cancer. 2019 Jul; 27(7):2443-2451. PMID: 30368671.
    Citations: 1     Fields:    Translation:Humans
  10. Kazak AE, Scialla MA, Patenaude AF, Canter K, Muriel AC, Kupst MJ, Chen FF, Wiener L. The multidisciplinary pediatric psycho-oncology workforce: A national report on supervision for staff and training opportunities. Psychooncology. 2018 12; 27(12):2802-2808. PMID: 30242934; PMCID: PMC6715455.
    Citations:    Fields:    Translation:Humans
  11. Samsel C, Kearney J, Meadows AL, Abrams A, Hirst JM, Muriel AC. Reply to: Comment on: Olanzapine for chemotherapy-induced nausea: Lessons learned from child and adolescent psychiatry. Pediatr Blood Cancer. 2019 01; 66(1):e27490. PMID: 30270495.
    Citations:    Fields:    Translation:Humans
  12. Arruda-Colli MNF, Bedoya SZ, Muriel A, Pelletier W, Wiener L. In good times and in bad: what strengthens or challenges a parental relationship during a child's cancer trajectory? J Psychosoc Oncol. 2018 Sep-Oct; 36(5):635-648. PMID: 30862312; PMCID: PMC6645386.
    Citations:    Fields:    Translation:Humans
  13. Zheng DJ, Shyr D, Ma C, Muriel AC, Wolfe J, Bona K. Feasibility of systematic poverty screening in a pediatric oncology referral center. Pediatr Blood Cancer. 2018 12; 65(12):e27380. PMID: 30069999; PMCID: PMC6193823.
    Citations: 5     Fields:    Translation:Humans
  14. Muriel AC, Tarquini S, Morris SE. The "Liaison" in Consultation-Liaison Psychiatry: Helping Medical Staff Cope with Pediatric Death. Child Adolesc Psychiatr Clin N Am. 2018 10; 27(4):591-598. PMID: 30219220.
    Citations:    Fields:    Translation:Humans
  15. Long KA, Pariseau EM, Muriel AC, Chu A, Kazak AE, Alderfer MA. Development of a Psychosocial Risk Screener for Siblings of Children With Cancer: Incorporating the Perspectives of Parents. J Pediatr Psychol. 2018 07 01; 43(6):693-701. PMID: 29617821.
    Citations: 3     Fields:    Translation:Humans
  16. Samsel C, Kearney J, Meadows AL, Abrams A, Hirst JM, Muriel AC. Olanzapine for chemotherapy-induced nausea: Lessons learned from child and adolescent psychiatry. Pediatr Blood Cancer. 2018 Oct; 65(10):e27289. PMID: 29932280.
    Citations: 1     Fields:    Translation:Humans
  17. Northman L, Morris M, Loucas C, Ross S, Muriel AC, Guo D, London WB, Manley P, Ullrich NJ. The Effectiveness of a Hospital-Based School Liaison Program: A Comparative Study of Parental Perception of School Supports for Children With Pediatric Cancer and Neurofibromatosis Type 1. J Pediatr Oncol Nurs. 2018 Jul/Aug; 35(4):276-286. PMID: 29600747.
    Citations: 2     Fields:    Translation:Humans
  18. Manso L, Pineda R, Huertas B, Fernández-Rivas M, Diéguez MC, Cerecedo I, Muriel A, Fernández FB, DunnGalvin A, Antolín-Amérigo D, De la Hoz B. Validation of the Spanish Version of the Food Allergy Quality of Life Questionnaire-Parent Form (S-FAQLQ-PF). J Investig Allergol Clin Immunol. 2017; 27(6):363-369. PMID: 28656900.
    Citations:    Fields:    Translation:HumansPHPublic Health
  19. Loucas CA, Brand SR, Bedoya SZ, Muriel AC, Wiener L. Preparing youth with cancer for amputation: A systematic review. J Psychosoc Oncol. 2017 Jul-Aug; 35(4):483-493. PMID: 28318419; PMCID: PMC5554078.
    Citations: 1     Fields:    Translation:Humans
  20. Rohan JM, Fukuda T, Alderfer MA, Wetherington Donewar C, Ewing L, Katz ER, Muriel AC, Vinks AA, Drotar D. Measuring Medication Adherence in Pediatric Cancer: An Approach to Validation. J Pediatr Psychol. 2017 Mar 01; 42(2):232-244. PMID: 27189694.
    Citations: 11     Fields:    Translation:Humans
  21. Wiener L, Battles H, Zadeh S, Pelletier W, Arruda-Colli MNF, Muriel AC. The perceived influence of childhood cancer on the parents' relationship. Psychooncology. 2017 Dec; 26(12):2109-2117. PMID: 27859953.
    Citations: 11     Fields:    Translation:Humans
  22. Samsel C, Muriel AC. Risk factors and treatment for steroid-related mood and behavior symptoms in preschool children with leukemia: A case series. Pediatr Blood Cancer. 2017 02; 64(2):343-345. PMID: 27615378.
    Citations:    Fields:    Translation:Humans
  23. Muriel AC, Wolfe J, Block SD. Pediatric Palliative Care and Child Psychiatry: A Model for Enhancing Practice and Collaboration. J Palliat Med. 2016 Oct; 19(10):1032-1038. PMID: 27551812.
    Citations:    Fields:    
  24. Liptak C, Brinkman T, Bronson A, Delaney B, Chordas C, Brand S, Patenaude AF, Muriel AC, Manley P. A social program for adolescent and young adult survivors of pediatric brain tumors: The power of a shared medical experience. J Psychosoc Oncol. 2016 Nov-Dec; 34(6):493-511. PMID: 27541834.
    Citations: 1     Fields:    Translation:Humans
  25. Inhestern L, Bultmann JC, Beierlein V, Möller B, Romer G, Muriel AC, Moore CW, Koch U, Bergelt C. Psychometric properties of the Parenting Concerns Questionnaire in cancer survivors with minor and young adult children. Psychooncology. 2016 09; 25(9):1092-8. PMID: 26677091.
    Citations: 5     Fields:    Translation:Humans
  26. Steele AC, Mullins LL, Mullins AJ, Muriel AC. Psychosocial Interventions and Therapeutic Support as a Standard of Care in Pediatric Oncology. Pediatr Blood Cancer. 2015 Dec; 62 Suppl 5:S585-618. PMID: 26700919.
    Citations: 30     Fields:    Translation:Humans
  27. Kearney JA, Salley CG, Muriel AC. Standards of Psychosocial Care for Parents of Children With Cancer. Pediatr Blood Cancer. 2015 Dec; 62 Suppl 5:S632-83. PMID: 26700921; PMCID: PMC5066591.
    Citations: 68     Fields:    Translation:Humans
  28. Park EM, Deal AM, Check DK, Hanson LC, Reeder-Hayes KE, Mayer DK, Yopp JM, Song MK, Muriel AC, Rosenstein DL. Parenting concerns, quality of life, and psychological distress in patients with advanced cancer. Psychooncology. 2016 08; 25(8):942-8. PMID: 26282575.
    Citations: 21     Fields:    Translation:Humans
  29. Moore CW, Rauch PK, Baer L, Pirl WF, Muriel AC. Parenting changes in adults with cancer. Cancer. 2015 Oct 01; 121(19):3551-7. PMID: 26094587; PMCID: PMC4575606.
    Citations: 17     Fields:    Translation:Humans
  30. Rohan JM, Drotar D, Alderfer M, Donewar CW, Ewing L, Katz ER, Muriel A. Electronic monitoring of medication adherence in early maintenance phase treatment for pediatric leukemia and lymphoma: identifying patterns of nonadherence. J Pediatr Psychol. 2015 Jan-Feb; 40(1):75-84. PMID: 24365698.
    Citations: 13     Fields:    Translation:Humans
  31. Brinkman TM, Zhang N, Recklitis CJ, Kimberg C, Zeltzer LK, Muriel AC, Stovall M, Srivastava DK, Sklar CA, Robison LL, Krull KR. Suicide ideation and associated mortality in adult survivors of childhood cancer. Cancer. 2014 Jan 15; 120(2):271-7. PMID: 24122148; PMCID: PMC3947253.
    Citations: 28     Fields:    Translation:Humans
  32. Brinkman TM, Zhu L, Zeltzer LK, Recklitis CJ, Kimberg C, Zhang N, Muriel AC, Stovall M, Srivastava DK, Robison LL, Krull KR. Longitudinal patterns of psychological distress in adult survivors of childhood cancer. Br J Cancer. 2013 Sep 03; 109(5):1373-81. PMID: 23880828.
    Citations: 45     Fields:    Translation:Humans
  33. Brinkman TM, Liptak CC, Delaney BL, Chordas CA, Muriel AC, Manley PE. Suicide ideation in pediatric and adult survivors of childhood brain tumors. J Neurooncol. 2013 Jul; 113(3):425-32. PMID: 23624716.
    Citations: 20     Fields:    Translation:Humans
  34. Muriel AC, Moore CW, Baer L, Park ER, Kornblith AB, Pirl W, Prigerson H, Ing J, Rauch PK. Measuring psychosocial distress and parenting concerns among adults with cancer: the Parenting Concerns Questionnaire. Cancer. 2012 Nov 15; 118(22):5671-8. PMID: 22517236; PMCID: PMC3422599.
    Citations: 26     Fields:    Translation:Humans
  35. Diéguez MC, Cerecedo I, Muriel A, Losada A, García E, Lázaro M, de la Hoz B. Adaptation and validation of the Spanish version of the Quality Of Life in Latex Allergy questionnaire (QOLLA). J Investig Allergol Clin Immunol. 2011; 21(4):283-9. PMID: 21721374.
    Citations:    Fields:    Translation:Humans
  36. Anna Muriel MD, Colette Case CCLS, Barbara Sourkes PhD. Children’s Voices: The Experience of Patients and their Siblings. Textbook of Interdisciplinary Pediatric Palliative Care, Joanne Wolfe, Pamela Hinds and Barbara Sourkes Eds . 2010.
  37. Fawzi MC, Betancourt TS, Marcelin L, Klopner M, Munir K, Muriel AC, Oswald C, Mukherjee JS. Depression and post-traumatic stress disorder among Haitian immigrant students: implications for access to mental health services and educational programming. BMC Public Health. 2009 Dec 22; 9:482. PMID: 20028506.
    Citations: 8     Fields:    Translation:Humans
  38. Anna Muriel. Parenting Concerns among Adults with Cancer: Preliminary Results. Proceedings of the 56th Annual Meeting of the Academy of Psychosomatic Medicine. 2009.
  39. Muriel AC, Hwang VS, Kornblith A, Greer J, Greenberg DB, Temel J, Schapira L, Pirl W. Management of psychosocial distress by oncologists. Psychiatr Serv. 2009 Aug; 60(8):1132-4. PMID: 19648204.
    Citations: 14     Fields:    Translation:Humans
  40. Nilsson ME, Maciejewski PK, Zhang B, Wright AA, Trice ED, Muriel AC, Friedlander RJ, Fasciano KM, Block SD, Prigerson HG. Mental health, treatment preferences, advance care planning, location, and quality of death in advanced cancer patients with dependent children. Cancer. 2009 Jan 15; 115(2):399-409. PMID: 19110677; PMCID: PMC2630701.
    Citations: 41     Fields:    Translation:Humans
  41. Muriel AC, and Rauch PK, MD . Talking with families and children about the death of a parent . Oxford Textbook of Palliative Care, Hanks G, Cherny N, Christakis N, Fallon M, Kaasa S, Portenoy R Eds. 2009.
  42. Muriel AC, Moore CW, Villanueva JJ, Rauch PK. A Pilot Study of Distres and Parenting Concerns among Adults with Cancer. Proceedings of the 55th annual meeting of the Academy of Psychosomatic Medicine. 2008.
  43. Muriel AC. Transition from pediatric to adult systems of care for chronic illness: challenges and useful approaches. Proceedings of the 55th annual meeting of the Academy of Psychosomatic Medicine. 2008.
  44. Nilsson ME, Maciejewski PK, Zhang B, Wright AA, Trice ED, Muriel A, Friedlander R, Block SD, Prigerson HG. Mental health, treatment preferences, advance care planning, and location and quality of death in advanced cancer patients with dependent children. J Clin Oncol. 2008 May 20; 26(15_suppl):9517. PMID: 27948255.
  45. Pirl WF, Muriel AC, Hwang V, Kornblith A, Greer J, Donelan K, Greenberg DB, Temel J, Schapira L. Screening for Psycosocial Distress: A Survey of Oncologists. Journal of Supportive Oncology. 2007; 5(10):499-504.
  46. Pirl WF, Muriel A, Hwang V, Kornblith A, Greer J, Donelan K, Greenberg DB, Temel J, Schapira L. Screening for psychosocial distress: a national survey of oncologists. J Support Oncol. 2007 Nov-Dec; 5(10):499-504. PMID: 18240673.
    Citations: 38     Fields:    Translation:Humans
  47. Pirl WF, Muriel A, Schapia L, Hwang V, Moore C, Temel J, Kornblith A, Holland JC. Statewide survey on the management of psychosocial distress by oncologists. J Clin Oncol. 2006 Jun 20; 24(18_suppl):8601. PMID: 27954479.
  48. Rauch PK and Muriel, AC. Raising an Emotionally Healthy Child When a Parent is Sick. 2006.
  49. Muriel AC, Rauch PK. Supporting parents with cancer: Screening and psycho-education. Quick Reference for Oncology Clinicians: The Psychiatric and Psychological Dimensions of Cancer Symptom Management. Holland JC, Greenberg DB, Hughes MK (Eds.). 2006.
  50. Simon NM, Pollack MH, Fischmann D, Perlman CA, Muriel AC, Moore CW, Nierenberg AA, Shear MK. Complicated grief and its correlates in patients with bipolar disorder. J Clin Psychiatry. 2005 Sep; 66(9):1105-10. PMID: 16187766.
    Citations: 27     Fields:    Translation:Humans
  51. Huskamp HA, Deverka PA, Epstein AM, Epstein RS, McGuigan KA, Muriel AC, Frank RG. Impact of 3-tier formularies on drug treatment of attention-deficit/hyperactivity disorder in children. Arch Gen Psychiatry. 2005 Apr; 62(4):435-41. PMID: 15809411; PMCID: PMC1403292.
    Citations: 23     Fields:    Translation:Humans
  52. Muriel AC, Messner E. Dealing with the rigors of psychiatric practice. The Ten-Minute Guide to Psychiatric Diagnosis and Treatment. Stern TA. (Ed.). 2005.
  53. Pirl W, Muriel AC, Beiser M, Moore CW. Differences between primary care and oncology providers in managing depression. Academy of Psychosomatic Medicine. 2005; 46(2):164.
  54. Moore CW, Muriel AC, Pirl WF, Beiser ME, Rauch PK. Adult cancer patients as parents: What do oncologists and primary care providers know?. American Psychosocial Oncology Society. 2005.
  55. Muriel AC, Beiser, ME, Durant S, Moore CW, Swick S, Rauch PK. Referrals to a new consultation service for parents with cancer. Psychosomatics. 2005; 46(2):178.
  56. Jellinek MS, Abraham ME, Muriel AC, Swick SS. Managed health care and child mental health services: Where is Horton to hear the Who's?. Current Pediatric Reviews. 2005; 1(1):31-37.
  57. Anna C. Muriel, MD. Parents with Cancer: How to Help Children Cope with a Parent's Terminal Illness. Journal of the American Academy of Child & Adolescent Psychiatry. 2005; 98.
  58. Muriel AC. Learning to bear witness. J Palliat Med. 2004 Oct; 7(5):720-2. PMID: 15588367.
    Citations:    Fields:    Translation:Humans
  59. Abrams A, Muriel AC, Rauch PK. Consultation with children. MGH Handbook of General Hospital Psychiatry. Stern TA, Fricchione GL, Cassem NH, Jellinek MS, Rosenbaum JF. (Eds.). 2004.
  60. Greenberg D, Vitagliano H, Pirl W, Abrams A, Muriel AC, Rauch PK. The evolution of the psychiatric role in oncology. MGH Handbook of General Hospital Psychiatry. Stern TA, Fricchione GL, Cassem NH, Jellinek MS, Rosenbaum JF (Eds.). 2004.
  61. Muriel AC. . Delivering the news. Facing Cancer: A Complete Guide for People with Cancer, their Families, and Caregivers. Stern TA, Sekeres MA (Eds.). 2004.
  62. Rauch PK, Muriel AC. The importance of parenting concerns among patients with cancer. Crit Rev Oncol Hematol. 2004 Jan; 49(1):37-42. PMID: 14734153.
    Citations: 12     Fields:    Translation:Humans
  63. Muriel AC, Rauch PK. Suggestions for patients on how to talk with children about a parent's cancer. J Support Oncol. 2003 Jul-Aug; 1(2):143-5. PMID: 15352659.
    Citations: 4     Fields:    Translation:Humans
  64. Rauch PK, Muriel AC, Cassem NH. Parents with cancer: who's looking after the children? J Clin Oncol. 2003 May 01; 21(9 Suppl):117s-121s. PMID: 12743216.
    Citations: 6     Fields:    Translation:Humans
  65. Muriel AC, Rauch PK. . A pilot parent guidance program for parents with cancer. Psycho-Oncology. 2003; 12(4):supplement: S151.
  66. Rauch PK, Muriel AC, Cassem NH. Parents with cancer: who's looking after the children? J Clin Oncol. 2002 Nov 01; 20(21):4399-402. PMID: 12409342.
    Citations: 12     Fields:    Translation:Humans
  67. Muriel AC, Bostic JQ, Dolan J. Juvenile mood disorders. Primary Care Handbook of Child Mental Health. 2002.
  68. Bostic JQ, Muriel AC, Hack S, Weinstein S, Herzog D. Anorexia nervosa in a 7-year-old girl. J Dev Behav Pediatr. 1997 Oct; 18(5):331-3. PMID: 9349976.
    Citations: 1     Fields:    Translation:Humans
  69. Mullen MK, Coll CG, Vohr BR, Muriel AC, Oh W. Mother-infant feeding interaction in full-term small-for-gestational-age infants. J Pediatr. 1988 Jan; 112(1):143-8. PMID: 3335952.
    Citations: 1     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.