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Robert Andrew Peterfreund, M.D., Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gibson LE, Knudsen AS, Arney D, Deng H, Sims NM, Peterfreund RA. Correction to: Lag times to steady state drug delivery by continuous intravenous infusion: direct comparison of peristaltic and syringe pump performance identifies contributions from infusion system dead volume and pump startup characteristics. J Clin Monit Comput. 2022 Aug; 36(4):1235-1236. PMID: 34989950.
    Citations:    Fields:    
  2. Tsao AC, Parker MJ, Lovich MA, Suja VC, Deng H, Houle T, Peterfreund RA. Initiation of an Emulsion Microinfusion: Flow Direction Influences Delivery Onset Rate. Eur J Pharm Sci. 2022 May 01; 172:106154. PMID: 35227840.
    Citations:    Fields:    Translation:Humans
  3. Gibson LE, Knudsen AS, Arney D, Deng H, Sims NM, Peterfreund RA. Lag times to steady state drug delivery by continuous intravenous infusion: direct comparison of peristaltic and syringe pump performance identifies contributions from infusion system dead volume and pump startup characteristics. J Clin Monit Comput. 2022 10; 36(5):1489-1498. PMID: 34878612.
    Citations:    Fields:    
  4. Stipp MM, Nanda P, Coumans JV, Peterfreund RA. Direct Visualization of the Dural Puncture Site During Lumbar Spine Surgery Performed Under Spinal Anesthesia: A Case Report. A A Pract. 2021 Feb 11; 15(2):e01397. PMID: 33577173.
    Citations: 1     Fields:    Translation:Humans
  5. Lu SY, LaMuraglia GM, Burki FP, See RB, Peterfreund RA. Ipsilateral Vocal Cord Monitoring for Carotid Endarterectomy and Concurrent Contralateral Vocal Cord Paralysis: A Case Report. A A Pract. 2020 Oct; 14(12):e01331. PMID: 33094950.
    Citations:    Fields:    Translation:Humans
  6. Deng H, Coumans JV, Anderson R, Houle TT, Peterfreund RA. Spinal anesthesia for lumbar spine surgery correlates with fewer total medications and less frequent use of vasoactive agents: A single center experience. PLoS One. 2019; 14(6):e0217939. PMID: 31194777; PMCID: PMC6563985.
    Citations: 1     Fields:    Translation:Humans
  7. Peterfreund RA. Intravenous administration of medications during an anesthetic: a deceptively simple process. J Clin Monit Comput. 2019 08; 33(4):547-548. PMID: 31134475.
    Citations:    Fields:    Translation:Humans
  8. Dineen J, Maus DC, Muzyka I, See RB, Cahill DP, Carter BS, Curry WT, Jones PS, Nahed BV, Peterfreund RA, Simon MV. Factors that modify the risk of intraoperative seizures triggered by electrical stimulation during supratentorial functional mapping. Clin Neurophysiol. 2019 06; 130(6):1058-1065. PMID: 30930194.
    Citations: 1     Fields:    Translation:Humans
  9. Lewis LD, Piantoni G, Peterfreund RA, Eskandar EN, Harrell PG, Akeju O, Aglio LS, Cash SS, Brown EN, Mukamel EA, Purdon PL. A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans. Elife. 2018 08 10; 7. PMID: 30095069.
    Citations: 9     Fields:    Translation:Humans
  10. Kim UR, Peterfreund RA, Lovich MA. Drug Infusion Systems: Technologies, Performance, and Pitfalls. Anesth Analg. 2017 05; 124(5):1493-1505. PMID: 28212219.
    Citations: 4     Fields:    Translation:Humans
  11. Parker MJ, Lovich MA, Tsao AC, Deng H, Houle T, Peterfreund RA. Novel Pump Control Technology Accelerates Drug Delivery Onset in a Model of Pediatric Drug Infusion. Anesth Analg. 2017 04; 124(4):1129-1134. PMID: 28181934.
    Citations:    Fields:    Translation:Humans
  12. Pezone MJ, Peterfreund RA, Maslov MY, Govindaswamy RR, Lovich MA. Infusion System Architecture Impacts the Ability of Intensive Care Nurses to Maintain Hemodynamic Stability in a Living Swine Simulator. Anesthesiology. 2016 May; 124(5):1077-85. PMID: 26933793.
    Citations: 1     Fields:    Translation:HumansAnimals
  13. Lovich MA, Pezone MJ, Maslov MY, Murray MR, Wakim MG, Peterfreund RA. Infusion system carrier flow perturbations and dead-volume: large effects on drug delivery in vitro and hemodynamic responses in a swine model. Anesth Analg. 2015 Jun; 120(6):1255-63. PMID: 25811259.
    Citations: 1     Fields:    Translation:Animals
  14. Parker MJ, Lovich MA, Tsao AC, Wei AE, Wakim MG, Maslov MY, Tsukada H, Peterfreund RA. Computer control of drug delivery by continuous intravenous infusion: bridging the gap between intended and actual drug delivery. Anesthesiology. 2015 Mar; 122(3):647-58. PMID: 25419684.
    Citations: 1     Fields:    Translation:Animals
  15. Walcott BP, Khanna A, Yanamadala V, Coumans JV, Peterfreund RA. Cost analysis of spinal and general anesthesia for the surgical treatment of lumbar spondylosis. J Clin Neurosci. 2015 Mar; 22(3):539-43. PMID: 25510535.
    Citations: 6     Fields:    Translation:Humans
  16. McCarty LK, Saddawi-Konefka D, Gargan LM, Driscoll WD, Walsh JL, Peterfreund RA. Application of process improvement principles to increase the frequency of complete airway management documentation. Anesthesiology. 2014 Dec; 121(6):1166-74. PMID: 25299742.
    Citations: 1     Fields:    Translation:Humans
  17. Lovich MA, Wakim MG, Wei A, Parker MJ, Maslov MY, Pezone MJ, Tsukada H, Peterfreund RA. Drug infusion system manifold dead-volume impacts the delivery response time to changes in infused medication doses in vitro and also in vivo in anesthetized swine. Anesth Analg. 2013 Dec; 117(6):1313-8. PMID: 24257380.
    Citations: 2     Fields:    Translation:Animals
  18. Lewis LD, Ching S, Weiner VS, Peterfreund RA, Eskandar EN, Cash SS, Brown EN, Purdon PL. Local cortical dynamics of burst suppression in the anaesthetized brain. Brain. 2013 Sep; 136(Pt 9):2727-37. PMID: 23887187; PMCID: PMC3754454.
    Citations: 52     Fields:    Translation:Humans
  19. Mirzakhani H, Nozari A, Ehrenfeld JM, Peterfreund R, Szabo M, Walsh JL, Jiang Y, Sandberg W, Rosow C, Wang J. Case report: profound hypotension after anesthetic induction with propofol in patients treated with rifampin. Anesth Analg. 2013 Jul; 117(1):61-4. PMID: 23687230.
    Citations: 1     Fields:    Translation:Humans
  20. Peterfreund RA, Philip JH. Critical parameters in drug delivery by intravenous infusion. Expert Opin Drug Deliv. 2013 Aug; 10(8):1095-108. PMID: 23565777.
    Citations: 15     Fields:    Translation:Humans
  21. Pierce ET, Kumar V, Zheng H, Peterfreund RA. Medication and volume delivery by gravity-driven micro-drip intravenous infusion: potential variations during "wide-open" flow. Anesth Analg. 2013 Mar; 116(3):614-8. PMID: 23400996.
    Citations: 1     Fields:    Translation:Humans
  22. Peterfreund RA, Luman E, Martuza RL. Anesthesia for suboccipital craniotomy in a patient with lymphangioleiomyomatosis: a case report. Case Rep Pulmonol. 2012; 2012:804789. PMID: 22934225.
    Citations: 1     
  23. Tsao AC, Lovich MA, Parker MJ, Zheng H, Peterfreund RA. Delivery interaction between co-infused medications: an in vitro modeling study of microinfusion. Paediatr Anaesth. 2013 Jan; 23(1):33-9. PMID: 22712626.
    Citations: 2     Fields:    
  24. Lee SL, Peterfreund RA. Visual vignette. Subglottic tracheal stenosis. Endocr Pract. 2012 May-Jun; 18(3):428. PMID: 22592054.
    Citations:    Fields:    Translation:Humans
  25. Ehrenfeld JM, Henneman JP, Peterfreund RA, Sheehan TD, Xue F, Spring S, Sandberg WS. Ongoing professional performance evaluation (OPPE) using automatically captured electronic anesthesia data. Jt Comm J Qual Patient Saf. 2012 Feb; 38(2):73-80. PMID: 22372254.
    Citations: 5     Fields:    Translation:Humans
  26. Peterfreund RA, Driscoll WD, Walsh JL, Subramanian A, Anupama S, Weaver M, Morris T, Arnholz S, Zheng H, Pierce ET, Spring SF. Evaluation of a mandatory quality assurance data capture in anesthesia: a secure electronic system to capture quality assurance information linked to an automated anesthesia record. Anesth Analg. 2011 May; 112(5):1218-25. PMID: 21415434.
    Citations: 8     Fields:    Translation:Humans
  27. Ma H, Lovich MA, Peterfreund RA. Quantitative analysis of continuous intravenous infusions in pediatric anesthesia: safety implications of dead volume, flow rates, and fluid delivery. Paediatr Anaesth. 2011 Jan; 21(1):78-86. PMID: 21155930.
    Citations: 3     Fields:    Translation:Humans
  28. Nahed BV, Walcott BP, Ortman AJ, Kahle KT, Aghi M, Peterfreund RA, Coumans JV. Interval, acute onset airway obstruction associated with a fracture of the C4 vertebra in a patient with ankylosing spondylitis. J Clin Neurosci. 2010 Aug; 17(8):1085-8. PMID: 20580996.
    Citations:    Fields:    Translation:Humans
  29. Peterfreund RA, Akhtar S. How sweet it is . . . (or isn't)! Anesth Analg. 2010 Apr 01; 110(4):979-81. PMID: 20357141.
    Citations: 1     Fields:    Translation:Humans
  30. Moss DR, Bartels K, Peterfreund GL, Lovich MA, Sims NM, Peterfreund RA. An in vitro analysis of central venous drug delivery by continuous infusion: the effect of manifold design and port selection. Anesth Analg. 2009 Nov; 109(5):1524-9. PMID: 19843791.
    Citations: 3     Fields:    
  31. Bartels K, Moss DR, Peterfreund RA. An analysis of drug delivery dynamics via a pediatric central venous infusion system: quantification of delays in achieving intended doses. Anesth Analg. 2009 Oct; 109(4):1156-61. PMID: 19762743.
    Citations: 9     Fields:    Translation:Humans
  32. Chen D, Lee SL, Peterfreund RA. New therapeutic agents for diabetes mellitus: implications for anesthetic management. Anesth Analg. 2009 Jun; 108(6):1803-10. PMID: 19448205.
    Citations: 1     Fields:    Translation:HumansAnimals
  33. Lovich MA, Peterfreund GL, Sims NM, Peterfreund RA. Central venous catheter infusions: a laboratory model shows large differences in drug delivery dynamics related to catheter dead volume. Crit Care Med. 2007 Dec; 35(12):2792-8. PMID: 18074479.
    Citations: 9     Fields:    Translation:Humans
  34. Lovich MA, Peterfreund GL, Sims NM, Peterfreund RA. Central venous catheter infusions: A laboratory model shows large differences in drug delivery dynamics related to catheter dead volume* Crit Care Med. 2007 Oct 23. PMID: 18090364.
  35. Driscoll WD, Columbia MA, Peterfreund RA. Awareness during general anesthesia: analysis of contributing causes aided by automatic data capture. J Neurosurg Anesthesiol. 2007 Oct; 19(4):268-72. PMID: 17893580.
    Citations: 3     Fields:    Translation:Humans
  36. Peterfreund RA, Wargo JA. Errant central line placement. J Clin Anesth. 2007 Sep; 19(6):479-81. PMID: 17967683.
    Citations: 1     Fields:    Translation:Humans
  37. Driscoll WD, Columbia MA, Peterfreund RA. An observational study of anesthesia record completeness using an anesthesia information management system. Anesth Analg. 2007 Jun; 104(6):1454-61, table of contents. PMID: 17513641.
    Citations: 11     Fields:    Translation:Humans
  38. Lovich MA, Kinnealley ME, Sims NM, Peterfreund RA. The delivery of drugs to patients by continuous intravenous infusion: modeling predicts potential dose fluctuations depending on flow rates and infusion system dead volume. Anesth Analg. 2006 Apr; 102(4):1147-53. PMID: 16551914.
    Citations: 11     Fields:    Translation:Humans
  39. Lovich MA, Doles J, Peterfreund RA. The impact of carrier flow rate and infusion set dead-volume on the dynamics of intravenous drug delivery. Anesth Analg. 2005 Apr; 100(4):1048-1055. PMID: 15781520.
    Citations: 11     Fields:    
  40. Mashour GA, Peterfreund RA. Spinal anesthesia and Ogilvie's syndrome. J Clin Anesth. 2005 Mar; 17(2):122-3. PMID: 15809128.
    Citations: 2     Fields:    Translation:Humans
  41. Yu L, Frith MC, Suzuki Y, Peterfreund RA, Gearan T, Sugano S, Schwarzschild MA, Weng Z, Fink JS, Chen JF. Characterization of genomic organization of the adenosine A2A receptor gene by molecular and bioinformatics analyses. Brain Res. 2004 Mar 12; 1000(1-2):156-73. PMID: 15053963.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  42. Firth PG, Tsuruta Y, Kamath Y, Dzik WH, Ogilvy CS, Peterfreund RA. Transfusion-related acute lung injury or acute chest syndrome of sickle cell disease? - A case report. Can J Anaesth. 2003 Nov; 50(9):895-9. PMID: 14617585.
    Citations: 1     Fields:    Translation:Humans
  43. Chandrasekhar S, Peterfreund RA. Horner's syndrome following very low concentration bupivacaine infusion for labor epidural analgesia. J Clin Anesth. 2003 May; 15(3):217-9. PMID: 12770660.
    Citations: 6     Fields:    Translation:Humans
  44. Wallington CL, Peters DM, Gelb CR, Peterfreund RA. Orphanin FQ/nociceptin and mu-opioid receptor mRNA levels in human SH-SY5Y neuroblastoma cells: effects of activating the cAMP-PKA signal transduction pathway. Brain Res. 2002 Jul 19; 944(1-2):73-81. PMID: 12106667.
    Citations:    Fields:    Translation:HumansCells
  45. Fitzsimons MG, Peterfreund RA, Raines DE. Aprotinin administration and pulmonary thromboembolism during orthotopic liver transplantation: report of two cases. Anesth Analg. 2001 Jun; 92(6):1418-21. PMID: 11375816.
    Citations: 6     Fields:    Translation:Humans
  46. Firth PG, Peterfreund RA. Management of multiple intracranial aneurysms: neuroanesthetic considerations of sickle cell disease. J Neurosurg Anesthesiol. 2000 Oct; 12(4):366-71. PMID: 11147387.
    Citations: 2     Fields:    
  47. Fulling PD, Peterfreund RA. Alkalinization and precipitation characteristics of 0.2% ropivacaine. Reg Anesth Pain Med. 2000 Sep-Oct; 25(5):518-21. PMID: 11009239.
    Citations: 6     Fields:    Translation:HumansCells
  48. Salim H, Ferré S, Dalal A, Peterfreund RA, Fuxe K, Vincent JD, Lledo PM. Activation of adenosine A1 and A2A receptors modulates dopamine D2 receptor-induced responses in stably transfected human neuroblastoma cells. J Neurochem. 2000 Jan; 74(1):432-9. PMID: 10617149.
    Citations: 21     Fields:    Translation:HumansCells
  49. Dull RO, Peterfreund RA. Variations in the composition of spinal anesthetic solutions: the effects of drug addition order and preparation methods. Anesth Analg. 1998 Dec; 87(6):1326-30. PMID: 9842821.
    Citations:    Fields:    
  50. Peters DM, Gies EK, Gelb CR, Peterfreund RA. Agonist-induced desensitization of A2B adenosine receptors. Biochem Pharmacol. 1998 Mar 15; 55(6):873-82. PMID: 9586960.
    Citations: 5     Fields:    Translation:AnimalsCells
  51. Gies EK, Peters DM, Gelb CR, Knag KM, Peterfreund RA. Regulation of mu opioid receptor mRNA levels by activation of protein kinase C in human SH-SY5Y neuroblastoma cells. Anesthesiology. 1997 Nov; 87(5):1127-38. PMID: 9366465.
    Citations: 3     Fields:    Translation:HumansCells
  52. Peterfreund RA, Gies EK, Fink JS. Protein kinase C regulates adenosine A2a receptor mRNA expression in SH-SY5Y cells. Eur J Pharmacol. 1997 Oct 01; 336(1):71-80. PMID: 9384256.
    Citations: 2     Fields:    Translation:HumansCells
  53. Willsey DB, Peterfreund RA. Compartment syndrome of the upper arm after pressurized infiltration of intravenous fluid. J Clin Anesth. 1997 Aug; 9(5):428-30. PMID: 9257213.
    Citations: 10     Fields:    Translation:Humans
  54. Qvist J, Peterfreund RA, Perlmutter GS. Transient compartment syndrome of the forearm after attempted radial artery cannulation. Anesth Analg. 1996 Jul; 83(1):183-5. PMID: 8659734.
    Citations: 6     Fields:    Translation:Humans
  55. Peterfreund RA, MacCollin M, Gusella J, Fink JS. Characterization and expression of the human A2a adenosine receptor gene. J Neurochem. 1996 Jan; 66(1):362-8. PMID: 8522976.
    Citations: 18     Fields:    Translation:HumansCells
  56. Peterfreund RA, Kosofsky BE, Fink JS. Cellular localization of dopamine D2 receptor messenger RNA in the rat trigeminal ganglion. Anesth Analg. 1995 Dec; 81(6):1181-5. PMID: 7486101.
    Citations: 2     Fields:    Translation:AnimalsCells
  57. Hess D, Fisher D, Peterfreund RA, Kacmarek RM. The delivery of aerosolized steroids from MDIs with nozzle extensions: quantitative laboratory evaluation of a method to improve aerosol delivery to intubated patients. Intensive Care Med. 1995 Nov; 21(11):945-51. PMID: 8636529.
    Citations:    Fields:    Translation:Humans
  58. MacCollin M, Peterfreund R, MacDonald M, Fink JS, Gusella J. Mapping of a human A2a adenosine receptor (ADORA2) to chromosome 22. Genomics. 1994 Mar 15; 20(2):332-3. PMID: 8020991.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  59. Peterfreund RA, Niven RW, Kacmarek RM. Syringe-actuated metered dose inhalers: a quantitative laboratory evaluation of albuterol delivery through nozzle extensions. Anesth Analg. 1994 Mar; 78(3):554-8. PMID: 8109777.
    Citations: 3     Fields:    Translation:Humans
  60. Niven RW, Kacmarek RM, Brain JD, Peterfreund RA. Small bore nozzle extensions to improve the delivery efficiency of drugs from metered dose inhalers: laboratory evaluation. Am Rev Respir Dis. 1993 Jun; 147(6 Pt 1):1590-4. PMID: 8503573.
    Citations: 3     Fields:    Translation:Humans
  61. Fink JS, Weaver DR, Rivkees SA, Peterfreund RA, Pollack AE, Adler EM, Reppert SM. Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatum. Brain Res Mol Brain Res. 1992 Jul; 14(3):186-95. PMID: 1279342.
    Citations: 152     Fields:    Translation:AnimalsCells
  62. Peterfreund RA, Datta S, Ostheimer GW. pH adjustment of local anesthetic solutions with sodium bicarbonate: laboratory evaluation of alkalinization and precipitation. Reg Anesth. 1989 Nov-Dec; 14(6):265-70. PMID: 2562097.
    Citations: 6     Fields:    
  63. Peterfreund RA, Vale WW. Local anesthetics inhibit veratridine-induced secretion of calcitonin gene-related peptide (CGRP) from cultured rat trigeminal ganglion cells. Brain Res. 1986 Aug 13; 380(1):159-61. PMID: 3489500.
    Citations:    Fields:    Translation:AnimalsCells
  64. Peterfreund RA, Sawchenko PE, Vale W. Thyroid hormones reversibly suppress somatostatin secretion and immunoreactivity in cultured neocortical cells. Brain Res. 1985 Mar 04; 328(2):259-70. PMID: 2859080.
    Citations: 1     Fields:    Translation:Animals
  65. Peterfreund RA, Vale WW. Somatostatin secretion from the hypothalamus. Adv Exp Med Biol. 1985; 188:183-200. PMID: 2863930.
    Citations:    Fields:    Translation:AnimalsCells
  66. Peterfreund RA, Vale WW. Somatostatin analogs inhibit somatostatin secretion from cultured hypothalamus cells. Neuroendocrinology. 1984 Nov; 39(5):397-402. PMID: 6151126.
    Citations: 7     Fields:    Translation:AnimalsCells
  67. Peterfreund RA, Vale WW. Picrotoxinin and phorbol-12-myristate-13-acetate stimulate the secretion of multiple forms of somatostatin from cultured rat brain cells. J Neurochem. 1984 Jul; 43(1):126-30. PMID: 6726241.
    Citations: 1     Fields:    Translation:AnimalsCells
  68. Mason RT, Peterfreund RA, Sawchenko PE, Corrigan AZ, Rivier JE, Vale WW. Release of the predicted calcitonin gene-related peptide from cultured rat trigeminal ganglion cells. Nature. 1984 Apr 12-18; 308(5960):653-5. PMID: 6369148.
    Citations: 45     Fields:    Translation:AnimalsCells
  69. Peterfreund RA, Vale WW. Phorbol diesters stimulate somatostatin secretion from cultured brain cells. Endocrinology. 1983 Jul; 113(1):200-8. PMID: 6407821.
    Citations: 4     Fields:    Translation:AnimalsCells
  70. Peterfreund RA, Vale WW. Ovine corticotropin-releasing factor stimulates somatostatin secretion from cultured brain cells. Endocrinology. 1983 Apr; 112(4):1275-8. PMID: 6131810.
    Citations: 8     Fields:    Translation:Animals
  71. Peterfreund RA, Vale WW. Muscarinic cholinergic stimulation of somatostatin secretion from long term dispersed cell cultures of fetal rat hypothalamus: inhibition by gamma-aminobutyric acid and serotonin. Endocrinology. 1983 Feb; 112(2):526-34. PMID: 6129132.
    Citations: 3     Fields:    Translation:AnimalsCells
  72. Shoemaker WJ, Peterfreund RA, Vale W. Methodological considerations in culturing peptidergic neurons. Methods Enzymol. 1983; 103:347-62. PMID: 6321891.
    Citations: 1     Fields:    Translation:AnimalsCells
  73. Peterfreund RA, Vale W. High molecular weight somatostatin secretion by cultured rat brain cells. Brain Res. 1982 May 13; 239(2):463-77. PMID: 6124303.
    Citations: 6     Fields:    Translation:AnimalsCells
  74. Trotta PP, Peterfreund RA, Schonberg R, Balis ME. Rabbit adenosine deaminase conversion proteins. Purification and characterization. Biochemistry. 1979 Jul 10; 18(14):2953-9. PMID: 465449.
    Citations: 1     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.