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Robert Andrew Peterfreund, M.D., PH.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Peterfreund RA. Intravenous administration of medications during an anesthetic: a deceptively simple process. J Clin Monit Comput. 2019 May 28. PMID: 31134475.
    Citations:    
  2. Dineen J, Maus DC, Muzyka I, See RB, Cahill DP, Carter BS, Curry WT, Jones PS, Nahed BV, Peterfreund RA, Simon MV. Factors that modify the risk of intraoperative seizures triggered by electrical stimulation during supratentorial functional mapping. Clin Neurophysiol. 2019 Jun; 130(6):1058-1065. PMID: 30930194.
    Citations:    
  3. Lewis LD, Piantoni G, Peterfreund RA, Eskandar EN, Harrell PG, Akeju O, Aglio LS, Cash SS, Brown EN, Mukamel EA, Purdon PL. A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans. Elife. 2018 08 10; 7. PMID: 30095069.
    Citations:    Fields:    Translation:Humans
  4. Kim UR, Peterfreund RA, Lovich MA. Drug Infusion Systems: Technologies, Performance, and Pitfalls. Anesth Analg. 2017 05; 124(5):1493-1505. PMID: 28212219.
    Citations:    Fields:    Translation:Humans
  5. Parker MJ, Lovich MA, Tsao AC, Deng H, Houle T, Peterfreund RA. Novel Pump Control Technology Accelerates Drug Delivery Onset in a Model of Pediatric Drug Infusion. Anesth Analg. 2017 04; 124(4):1129-1134. PMID: 28181934.
    Citations:    Fields:    Translation:Humans
  6. Pezone MJ, Peterfreund RA, Maslov MY, Govindaswamy RR, Lovich MA. Infusion System Architecture Impacts the Ability of Intensive Care Nurses to Maintain Hemodynamic Stability in a Living Swine Simulator. Anesthesiology. 2016 May; 124(5):1077-85. PMID: 26933793.
    Citations: 1     Fields:    Translation:HumansAnimals
  7. Lovich MA, Pezone MJ, Maslov MY, Murray MR, Wakim MG, Peterfreund RA. Infusion system carrier flow perturbations and dead-volume: large effects on drug delivery in vitro and hemodynamic responses in a swine model. Anesth Analg. 2015 Jun; 120(6):1255-63. PMID: 25811259.
    Citations: 1     Fields:    Translation:Animals
  8. Parker MJ, Lovich MA, Tsao AC, Wei AE, Wakim MG, Maslov MY, Tsukada H, Peterfreund RA. Computer control of drug delivery by continuous intravenous infusion: bridging the gap between intended and actual drug delivery. Anesthesiology. 2015 Mar; 122(3):647-58. PMID: 25419684.
    Citations: 1     Fields:    Translation:Animals
  9. Walcott BP, Khanna A, Yanamadala V, Coumans JV, Peterfreund RA. Cost analysis of spinal and general anesthesia for the surgical treatment of lumbar spondylosis. J Clin Neurosci. 2015 Mar; 22(3):539-43. PMID: 25510535.
    Citations:    Fields:    Translation:Humans
  10. McCarty LK, Saddawi-Konefka D, Gargan LM, Driscoll WD, Walsh JL, Peterfreund RA. Application of process improvement principles to increase the frequency of complete airway management documentation. Anesthesiology. 2014 Dec; 121(6):1166-74. PMID: 25299742.
    Citations: 1     Fields:    Translation:Humans
  11. Lovich MA, Wakim MG, Wei A, Parker MJ, Maslov MY, Pezone MJ, Tsukada H, Peterfreund RA. Drug infusion system manifold dead-volume impacts the delivery response time to changes in infused medication doses in vitro and also in vivo in anesthetized swine. Anesth Analg. 2013 Dec; 117(6):1313-8. PMID: 24257380.
    Citations: 2     Fields:    Translation:Animals
  12. Lewis LD, Ching S, Weiner VS, Peterfreund RA, Eskandar EN, Cash SS, Brown EN, Purdon PL. Local cortical dynamics of burst suppression in the anaesthetized brain. Brain. 2013 Sep; 136(Pt 9):2727-37. PMID: 23887187.
    Citations: 26     Fields:    Translation:Humans
  13. Mirzakhani H, Nozari A, Ehrenfeld JM, Peterfreund R, Szabo M, Walsh JL, Jiang Y, Sandberg W, Rosow C, Wang J. Case report: profound hypotension after anesthetic induction with propofol in patients treated with rifampin. Anesth Analg. 2013 Jul; 117(1):61-4. PMID: 23687230.
    Citations:    Fields:    Translation:Humans
  14. Peterfreund RA, Philip JH. Critical parameters in drug delivery by intravenous infusion. Expert Opin Drug Deliv. 2013 Aug; 10(8):1095-108. PMID: 23565777.
    Citations: 4     Fields:    Translation:Humans
  15. Pierce ET, Kumar V, Zheng H, Peterfreund RA. Medication and volume delivery by gravity-driven micro-drip intravenous infusion: potential variations during "wide-open" flow. Anesth Analg. 2013 Mar; 116(3):614-8. PMID: 23400996.
    Citations:    Fields:    Translation:Humans
  16. Peterfreund RA, Luman E, Martuza RL. Anesthesia for suboccipital craniotomy in a patient with lymphangioleiomyomatosis: a case report. Case Rep Pulmonol. 2012; 2012:804789. PMID: 22934225.
    Citations:    
  17. Tsao AC, Lovich MA, Parker MJ, Zheng H, Peterfreund RA. Delivery interaction between co-infused medications: an in vitro modeling study of microinfusion. Paediatr Anaesth. 2013 Jan; 23(1):33-9. PMID: 22712626.
    Citations: 1     Fields:    
  18. Lee SL, Peterfreund RA. Visual vignette. Subglottic tracheal stenosis. Endocr Pract. 2012 May-Jun; 18(3):428. PMID: 22592054.
    Citations:    Fields:    Translation:Humans
  19. Ehrenfeld JM, Henneman JP, Peterfreund RA, Sheehan TD, Xue F, Spring S, Sandberg WS. Ongoing professional performance evaluation (OPPE) using automatically captured electronic anesthesia data. Jt Comm J Qual Patient Saf. 2012 Feb; 38(2):73-80. PMID: 22372254.
    Citations: 4     Fields:    Translation:Humans
  20. Peterfreund RA, Driscoll WD, Walsh JL, Subramanian A, Anupama S, Weaver M, Morris T, Arnholz S, Zheng H, Pierce ET, Spring SF. Evaluation of a mandatory quality assurance data capture in anesthesia: a secure electronic system to capture quality assurance information linked to an automated anesthesia record. Anesth Analg. 2011 May; 112(5):1218-25. PMID: 21415434.
    Citations: 5     Fields:    Translation:Humans
  21. Ma H, Lovich MA, Peterfreund RA. Quantitative analysis of continuous intravenous infusions in pediatric anesthesia: safety implications of dead volume, flow rates, and fluid delivery. Paediatr Anaesth. 2011 Jan; 21(1):78-86. PMID: 21155930.
    Citations: 2     Fields:    Translation:Humans
  22. Nahed BV, Walcott BP, Ortman AJ, Kahle KT, Aghi M, Peterfreund RA, Coumans JV. Interval, acute onset airway obstruction associated with a fracture of the C4 vertebra in a patient with ankylosing spondylitis. J Clin Neurosci. 2010 Aug; 17(8):1085-8. PMID: 20580996.
    Citations:    Fields:    Translation:Humans
  23. Peterfreund RA, Akhtar S. How sweet it is . . . (or isn't)! Anesth Analg. 2010 Apr 01; 110(4):979-81. PMID: 20357141.
    Citations: 1     Fields:    Translation:Humans
  24. Moss DR, Bartels K, Peterfreund GL, Lovich MA, Sims NM, Peterfreund RA. An in vitro analysis of central venous drug delivery by continuous infusion: the effect of manifold design and port selection. Anesth Analg. 2009 Nov; 109(5):1524-9. PMID: 19843791.
    Citations: 2     Fields:    
  25. Bartels K, Moss DR, Peterfreund RA. An analysis of drug delivery dynamics via a pediatric central venous infusion system: quantification of delays in achieving intended doses. Anesth Analg. 2009 Oct; 109(4):1156-61. PMID: 19762743.
    Citations: 5     Fields:    Translation:Humans
  26. Chen D, Lee SL, Peterfreund RA. New therapeutic agents for diabetes mellitus: implications for anesthetic management. Anesth Analg. 2009 Jun; 108(6):1803-10. PMID: 19448205.
    Citations: 1     Fields:    Translation:HumansAnimals
  27. Lovich MA, Peterfreund GL, Sims NM, Peterfreund RA. Central venous catheter infusions: a laboratory model shows large differences in drug delivery dynamics related to catheter dead volume. Crit Care Med. 2007 Dec; 35(12):2792-8. PMID: 18074479.
    Citations: 6     Fields:    Translation:Humans
  28. Lovich MA, Peterfreund GL, Sims NM, Peterfreund RA. Central venous catheter infusions: A laboratory model shows large differences in drug delivery dynamics related to catheter dead volume* Crit Care Med. 2007 Oct 23. PMID: 18090364.
    Citations:    
  29. Driscoll WD, Columbia MA, Peterfreund RA. Awareness during general anesthesia: analysis of contributing causes aided by automatic data capture. J Neurosurg Anesthesiol. 2007 Oct; 19(4):268-72. PMID: 17893580.
    Citations: 1     Fields:    Translation:Humans
  30. Peterfreund RA, Wargo JA. Errant central line placement. J Clin Anesth. 2007 Sep; 19(6):479-81. PMID: 17967683.
    Citations: 1     Fields:    Translation:Humans
  31. Driscoll WD, Columbia MA, Peterfreund RA. An observational study of anesthesia record completeness using an anesthesia information management system. Anesth Analg. 2007 Jun; 104(6):1454-61, table of contents. PMID: 17513641.
    Citations: 7     Fields:    Translation:Humans
  32. Lovich MA, Kinnealley ME, Sims NM, Peterfreund RA. The delivery of drugs to patients by continuous intravenous infusion: modeling predicts potential dose fluctuations depending on flow rates and infusion system dead volume. Anesth Analg. 2006 Apr; 102(4):1147-53. PMID: 16551914.
    Citations: 7     Fields:    Translation:Humans
  33. Lovich MA, Doles J, Peterfreund RA. The impact of carrier flow rate and infusion set dead-volume on the dynamics of intravenous drug delivery. Anesth Analg. 2005 Apr; 100(4):1048-55. PMID: 15781520.
    Citations: 6     Fields:    
  34. Mashour GA, Peterfreund RA. Spinal anesthesia and Ogilvie's syndrome. J Clin Anesth. 2005 Mar; 17(2):122-3. PMID: 15809128.
    Citations: 2     Fields:    Translation:Humans
  35. Yu L, Frith MC, Suzuki Y, Peterfreund RA, Gearan T, Sugano S, Schwarzschild MA, Weng Z, Fink JS, Chen JF. Characterization of genomic organization of the adenosine A2A receptor gene by molecular and bioinformatics analyses. Brain Res. 2004 Mar 12; 1000(1-2):156-73. PMID: 15053963.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  36. Firth PG, Tsuruta Y, Kamath Y, Dzik WH, Ogilvy CS, Peterfreund RA. Transfusion-related acute lung injury or acute chest syndrome of sickle cell disease? - A case report. Can J Anaesth. 2003 Nov; 50(9):895-9. PMID: 14617585.
    Citations:    Fields:    Translation:Humans
  37. Chandrasekhar S, Peterfreund RA. Horner's syndrome following very low concentration bupivacaine infusion for labor epidural analgesia. J Clin Anesth. 2003 May; 15(3):217-9. PMID: 12770660.
    Citations: 5     Fields:    Translation:Humans
  38. Wallington CL, Peters DM, Gelb CR, Peterfreund RA. Orphanin FQ/nociceptin and mu-opioid receptor mRNA levels in human SH-SY5Y neuroblastoma cells: effects of activating the cAMP-PKA signal transduction pathway. Brain Res. 2002 Jul 19; 944(1-2):73-81. PMID: 12106667.
    Citations:    Fields:    Translation:HumansCells
  39. Fitzsimons MG, Peterfreund RA, Raines DE. Aprotinin administration and pulmonary thromboembolism during orthotopic liver transplantation: report of two cases. Anesth Analg. 2001 Jun; 92(6):1418-21. PMID: 11375816.
    Citations: 5     Fields:    Translation:Humans
  40. Firth PG, Peterfreund RA. Management of multiple intracranial aneurysms: neuroanesthetic considerations of sickle cell disease. J Neurosurg Anesthesiol. 2000 Oct; 12(4):366-71. PMID: 11147387.
    Citations: 1     Fields:    
  41. Fulling PD, Peterfreund RA. Alkalinization and precipitation characteristics of 0.2% ropivacaine. Reg Anesth Pain Med. 2000 Sep-Oct; 25(5):518-21. PMID: 11009239.
    Citations: 3     Fields:    Translation:HumansCells
  42. Salim H, Ferré S, Dalal A, Peterfreund RA, Fuxe K, Vincent JD, Lledo PM. Activation of adenosine A1 and A2A receptors modulates dopamine D2 receptor-induced responses in stably transfected human neuroblastoma cells. J Neurochem. 2000 Jan; 74(1):432-9. PMID: 10617149.
    Citations: 16     Fields:    Translation:HumansCells
  43. Dull RO, Peterfreund RA. Variations in the composition of spinal anesthetic solutions: the effects of drug addition order and preparation methods. Anesth Analg. 1998 Dec; 87(6):1326-30. PMID: 9842821.
    Citations:    Fields:    
  44. Peters DM, Gies EK, Gelb CR, Peterfreund RA. Agonist-induced desensitization of A2B adenosine receptors. Biochem Pharmacol. 1998 Mar 15; 55(6):873-82. PMID: 9586960.
    Citations: 5     Fields:    Translation:AnimalsCells
  45. Gies EK, Peters DM, Gelb CR, Knag KM, Peterfreund RA. Regulation of mu opioid receptor mRNA levels by activation of protein kinase C in human SH-SY5Y neuroblastoma cells. Anesthesiology. 1997 Nov; 87(5):1127-38. PMID: 9366465.
    Citations: 3     Fields:    Translation:HumansCells
  46. Peterfreund RA, Gies EK, Fink JS. Protein kinase C regulates adenosine A2a receptor mRNA expression in SH-SY5Y cells. Eur J Pharmacol. 1997 Oct 01; 336(1):71-80. PMID: 9384256.
    Citations: 1     Fields:    Translation:HumansCells
  47. Willsey DB, Peterfreund RA. Compartment syndrome of the upper arm after pressurized infiltration of intravenous fluid. J Clin Anesth. 1997 Aug; 9(5):428-30. PMID: 9257213.
    Citations: 7     Fields:    Translation:Humans
  48. Qvist J, Peterfreund RA, Perlmutter GS. Transient compartment syndrome of the forearm after attempted radial artery cannulation. Anesth Analg. 1996 Jul; 83(1):183-5. PMID: 8659734.
    Citations: 6     Fields:    Translation:Humans
  49. Peterfreund RA, MacCollin M, Gusella J, Fink JS. Characterization and expression of the human A2a adenosine receptor gene. J Neurochem. 1996 Jan; 66(1):362-8. PMID: 8522976.
    Citations: 9     Fields:    Translation:HumansCells
  50. Peterfreund RA, Kosofsky BE, Fink JS. Cellular localization of dopamine D2 receptor messenger RNA in the rat trigeminal ganglion. Anesth Analg. 1995 Dec; 81(6):1181-5. PMID: 7486101.
    Citations: 1     Fields:    Translation:AnimalsCells
  51. Hess D, Fisher D, Peterfreund RA, Kacmarek RM. The delivery of aerosolized steroids from MDIs with nozzle extensions: quantitative laboratory evaluation of a method to improve aerosol delivery to intubated patients. Intensive Care Med. 1995 Nov; 21(11):945-51. PMID: 8636529.
    Citations:    Fields:    Translation:Humans
  52. MacCollin M, Peterfreund R, MacDonald M, Fink JS, Gusella J. Mapping of a human A2a adenosine receptor (ADORA2) to chromosome 22. Genomics. 1994 Mar 15; 20(2):332-3. PMID: 8020991.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  53. Peterfreund RA, Niven RW, Kacmarek RM. Syringe-actuated metered dose inhalers: a quantitative laboratory evaluation of albuterol delivery through nozzle extensions. Anesth Analg. 1994 Mar; 78(3):554-8. PMID: 8109777.
    Citations: 2     Fields:    Translation:Humans
  54. Niven RW, Kacmarek RM, Brain JD, Peterfreund RA. Small bore nozzle extensions to improve the delivery efficiency of drugs from metered dose inhalers: laboratory evaluation. Am Rev Respir Dis. 1993 Jun; 147(6 Pt 1):1590-4. PMID: 8503573.
    Citations: 3     Fields:    Translation:Humans
  55. Fink JS, Weaver DR, Rivkees SA, Peterfreund RA, Pollack AE, Adler EM, Reppert SM. Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatum. Brain Res Mol Brain Res. 1992 Jul; 14(3):186-95. PMID: 1279342.
    Citations: 116     Fields:    Translation:AnimalsCells
  56. Peterfreund RA, Datta S, Ostheimer GW. pH adjustment of local anesthetic solutions with sodium bicarbonate: laboratory evaluation of alkalinization and precipitation. Reg Anesth. 1989 Nov-Dec; 14(6):265-70. PMID: 2562097.
    Citations: 5     Fields:    
  57. Peterfreund RA, Vale WW. Local anesthetics inhibit veratridine-induced secretion of calcitonin gene-related peptide (CGRP) from cultured rat trigeminal ganglion cells. Brain Res. 1986 Aug 13; 380(1):159-61. PMID: 3489500.
    Citations:    Fields:    Translation:AnimalsCells
  58. Peterfreund RA, Sawchenko PE, Vale W. Thyroid hormones reversibly suppress somatostatin secretion and immunoreactivity in cultured neocortical cells. Brain Res. 1985 Mar 04; 328(2):259-70. PMID: 2859080.
    Citations: 1     Fields:    Translation:Animals
  59. Peterfreund RA, Vale WW. Somatostatin secretion from the hypothalamus. Adv Exp Med Biol. 1985; 188:183-200. PMID: 2863930.
    Citations:    Fields:    Translation:AnimalsCells
  60. Peterfreund RA, Vale WW. Somatostatin analogs inhibit somatostatin secretion from cultured hypothalamus cells. Neuroendocrinology. 1984 Nov; 39(5):397-402. PMID: 6151126.
    Citations: 4     Fields:    Translation:AnimalsCells
  61. Peterfreund RA, Vale WW. Picrotoxinin and phorbol-12-myristate-13-acetate stimulate the secretion of multiple forms of somatostatin from cultured rat brain cells. J Neurochem. 1984 Jul; 43(1):126-30. PMID: 6726241.
    Citations: 1     Fields:    Translation:AnimalsCells
  62. Mason RT, Peterfreund RA, Sawchenko PE, Corrigan AZ, Rivier JE, Vale WW. Release of the predicted calcitonin gene-related peptide from cultured rat trigeminal ganglion cells. Nature. 1984 Apr 12-18; 308(5960):653-5. PMID: 6369148.
    Citations: 34     Fields:    Translation:AnimalsCells
  63. Peterfreund RA, Vale WW. Phorbol diesters stimulate somatostatin secretion from cultured brain cells. Endocrinology. 1983 Jul; 113(1):200-8. PMID: 6407821.
    Citations: 4     Fields:    Translation:AnimalsCells
  64. Peterfreund RA, Vale WW. Ovine corticotropin-releasing factor stimulates somatostatin secretion from cultured brain cells. Endocrinology. 1983 Apr; 112(4):1275-8. PMID: 6131810.
    Citations: 5     Fields:    Translation:Animals
  65. Peterfreund RA, Vale WW. Muscarinic cholinergic stimulation of somatostatin secretion from long term dispersed cell cultures of fetal rat hypothalamus: inhibition by gamma-aminobutyric acid and serotonin. Endocrinology. 1983 Feb; 112(2):526-34. PMID: 6129132.
    Citations: 3     Fields:    Translation:AnimalsCells
  66. Shoemaker WJ, Peterfreund RA, Vale W. Methodological considerations in culturing peptidergic neurons. Methods Enzymol. 1983; 103:347-62. PMID: 6321891.
    Citations: 1     Fields:    Translation:AnimalsCells
  67. Peterfreund RA, Vale W. High molecular weight somatostatin secretion by cultured rat brain cells. Brain Res. 1982 May 13; 239(2):463-77. PMID: 6124303.
    Citations: 5     Fields:    Translation:AnimalsCells
  68. Trotta PP, Peterfreund RA, Schonberg R, Balis ME. Rabbit adenosine deaminase conversion proteins. Purification and characterization. Biochemistry. 1979 Jul 10; 18(14):2953-9. PMID: 465449.
    Citations: 1     Fields:    Translation:Animals
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.