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Robert Andrew Peterfreund, M.D., PH.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kim UR, Peterfreund RA, Lovich MA. Drug Infusion Systems: Technologies, Performance, and Pitfalls. Anesth Analg. 2017 05; 124(5):1493-1505. PMID: 28212219.
    View in: PubMed
  2. Parker MJ, Lovich MA, Tsao AC, Deng H, Houle T, Peterfreund RA. Novel Pump Control Technology Accelerates Drug Delivery Onset in a Model of Pediatric Drug Infusion. Anesth Analg. 2017 04; 124(4):1129-1134. PMID: 28181934.
    View in: PubMed
  3. Pezone MJ, Peterfreund RA, Maslov MY, Govindaswamy RR, Lovich MA. Infusion System Architecture Impacts the Ability of Intensive Care Nurses to Maintain Hemodynamic Stability in a Living Swine Simulator. Anesthesiology. 2016 May; 124(5):1077-85. PMID: 26933793.
    View in: PubMed
  4. Lovich MA, Pezone MJ, Maslov MY, Murray MR, Wakim MG, Peterfreund RA. Infusion system carrier flow perturbations and dead-volume: large effects on drug delivery in vitro and hemodynamic responses in a swine model. Anesth Analg. 2015 Jun; 120(6):1255-63. PMID: 25811259.
    View in: PubMed
  5. Parker MJ, Lovich MA, Tsao AC, Wei AE, Wakim MG, Maslov MY, Tsukada H, Peterfreund RA. Computer control of drug delivery by continuous intravenous infusion: bridging the gap between intended and actual drug delivery. Anesthesiology. 2015 Mar; 122(3):647-58. PMID: 25419684.
    View in: PubMed
  6. Walcott BP, Khanna A, Yanamadala V, Coumans JV, Peterfreund RA. Cost analysis of spinal and general anesthesia for the surgical treatment of lumbar spondylosis. J Clin Neurosci. 2015 Mar; 22(3):539-43. PMID: 25510535.
    View in: PubMed
  7. McCarty LK, Saddawi-Konefka D, Gargan LM, Driscoll WD, Walsh JL, Peterfreund RA. Application of process improvement principles to increase the frequency of complete airway management documentation. Anesthesiology. 2014 Dec; 121(6):1166-74. PMID: 25299742.
    View in: PubMed
  8. Lovich MA, Wakim MG, Wei A, Parker MJ, Maslov MY, Pezone MJ, Tsukada H, Peterfreund RA. Drug infusion system manifold dead-volume impacts the delivery response time to changes in infused medication doses in vitro and also in vivo in anesthetized swine. Anesth Analg. 2013 Dec; 117(6):1313-8. PMID: 24257380.
    View in: PubMed
  9. Lewis LD, Ching S, Weiner VS, Peterfreund RA, Eskandar EN, Cash SS, Brown EN, Purdon PL. Local cortical dynamics of burst suppression in the anaesthetized brain. Brain. 2013 Sep; 136(Pt 9):2727-37. PMID: 23887187; PMCID: PMC3754454.
  10. Mirzakhani H, Nozari A, Ehrenfeld JM, Peterfreund R, Szabo M, Walsh JL, Jiang Y, Sandberg W, Rosow C, Wang J. Case report: profound hypotension after anesthetic induction with propofol in patients treated with rifampin. Anesth Analg. 2013 Jul; 117(1):61-4. PMID: 23687230.
    View in: PubMed
  11. Peterfreund RA, Philip JH. Critical parameters in drug delivery by intravenous infusion. Expert Opin Drug Deliv. 2013 Aug; 10(8):1095-108. PMID: 23565777.
    View in: PubMed
  12. Pierce ET, Kumar V, Zheng H, Peterfreund RA. Medication and volume delivery by gravity-driven micro-drip intravenous infusion: potential variations during "wide-open" flow. Anesth Analg. 2013 Mar; 116(3):614-8. PMID: 23400996.
    View in: PubMed
  13. Peterfreund RA, Luman E, Martuza RL. Anesthesia for suboccipital craniotomy in a patient with lymphangioleiomyomatosis: a case report. Case Rep Pulmonol. 2012; 2012:804789. PMID: 22934225; PMCID: PMC3420421.
  14. Tsao AC, Lovich MA, Parker MJ, Zheng H, Peterfreund RA. Delivery interaction between co-infused medications: an in vitro modeling study of microinfusion. Paediatr Anaesth. 2013 Jan; 23(1):33-9. PMID: 22712626.
    View in: PubMed
  15. Lee SL, Peterfreund RA. Visual vignette. Subglottic tracheal stenosis. Endocr Pract. 2012 May-Jun; 18(3):428. PMID: 22592054.
    View in: PubMed
  16. Ehrenfeld JM, Henneman JP, Peterfreund RA, Sheehan TD, Xue F, Spring S, Sandberg WS. Ongoing professional performance evaluation (OPPE) using automatically captured electronic anesthesia data. Jt Comm J Qual Patient Saf. 2012 Feb; 38(2):73-80. PMID: 22372254.
    View in: PubMed
  17. Peterfreund RA, Driscoll WD, Walsh JL, Subramanian A, Anupama S, Weaver M, Morris T, Arnholz S, Zheng H, Pierce ET, Spring SF. Evaluation of a mandatory quality assurance data capture in anesthesia: a secure electronic system to capture quality assurance information linked to an automated anesthesia record. Anesth Analg. 2011 May; 112(5):1218-25. PMID: 21415434.
    View in: PubMed
  18. Ma H, Lovich MA, Peterfreund RA. Quantitative analysis of continuous intravenous infusions in pediatric anesthesia: safety implications of dead volume, flow rates, and fluid delivery. Paediatr Anaesth. 2011 Jan; 21(1):78-86. PMID: 21155930.
    View in: PubMed
  19. Nahed BV, Walcott BP, Ortman AJ, Kahle KT, Aghi M, Peterfreund RA, Coumans JV. Interval, acute onset airway obstruction associated with a fracture of the C4 vertebra in a patient with ankylosing spondylitis. J Clin Neurosci. 2010 Aug; 17(8):1085-8. PMID: 20580996.
    View in: PubMed
  20. Peterfreund RA, Akhtar S. How sweet it is . . . (or isn't)! Anesth Analg. 2010 Apr 01; 110(4):979-81. PMID: 20357141.
    View in: PubMed
  21. Moss DR, Bartels K, Peterfreund GL, Lovich MA, Sims NM, Peterfreund RA. An in vitro analysis of central venous drug delivery by continuous infusion: the effect of manifold design and port selection. Anesth Analg. 2009 Nov; 109(5):1524-9. PMID: 19843791.
    View in: PubMed
  22. Bartels K, Moss DR, Peterfreund RA. An analysis of drug delivery dynamics via a pediatric central venous infusion system: quantification of delays in achieving intended doses. Anesth Analg. 2009 Oct; 109(4):1156-61. PMID: 19762743.
    View in: PubMed
  23. Chen D, Lee SL, Peterfreund RA. New therapeutic agents for diabetes mellitus: implications for anesthetic management. Anesth Analg. 2009 Jun; 108(6):1803-10. PMID: 19448205.
    View in: PubMed
  24. Lovich MA, Peterfreund GL, Sims NM, Peterfreund RA. Central venous catheter infusions: a laboratory model shows large differences in drug delivery dynamics related to catheter dead volume. Crit Care Med. 2007 Dec; 35(12):2792-8. PMID: 18074479.
    View in: PubMed
  25. Lovich MA, Peterfreund GL, Sims NM, Peterfreund RA. Central venous catheter infusions: A laboratory model shows large differences in drug delivery dynamics related to catheter dead volume* Crit Care Med. 2007 Oct 23. PMID: 18090364.
    View in: PubMed
  26. Driscoll WD, Columbia MA, Peterfreund RA. Awareness during general anesthesia: analysis of contributing causes aided by automatic data capture. J Neurosurg Anesthesiol. 2007 Oct; 19(4):268-72. PMID: 17893580.
    View in: PubMed
  27. Peterfreund RA, Wargo JA. Errant central line placement. J Clin Anesth. 2007 Sep; 19(6):479-81. PMID: 17967683.
    View in: PubMed
  28. Driscoll WD, Columbia MA, Peterfreund RA. An observational study of anesthesia record completeness using an anesthesia information management system. Anesth Analg. 2007 Jun; 104(6):1454-61, table of contents. PMID: 17513641.
    View in: PubMed
  29. Lovich MA, Kinnealley ME, Sims NM, Peterfreund RA. The delivery of drugs to patients by continuous intravenous infusion: modeling predicts potential dose fluctuations depending on flow rates and infusion system dead volume. Anesth Analg. 2006 Apr; 102(4):1147-53. PMID: 16551914.
    View in: PubMed
  30. Lovich MA, Doles J, Peterfreund RA. The impact of carrier flow rate and infusion set dead-volume on the dynamics of intravenous drug delivery. Anesth Analg. 2005 Apr; 100(4):1048-55. PMID: 15781520.
    View in: PubMed
  31. Mashour GA, Peterfreund RA. Spinal anesthesia and Ogilvie's syndrome. J Clin Anesth. 2005 Mar; 17(2):122-3. PMID: 15809128.
    View in: PubMed
  32. Yu L, Frith MC, Suzuki Y, Peterfreund RA, Gearan T, Sugano S, Schwarzschild MA, Weng Z, Fink JS, Chen JF. Characterization of genomic organization of the adenosine A2A receptor gene by molecular and bioinformatics analyses. Brain Res. 2004 Mar 12; 1000(1-2):156-73. PMID: 15053963.
    View in: PubMed
  33. Firth PG, Tsuruta Y, Kamath Y, Dzik WH, Ogilvy CS, Peterfreund RA. Transfusion-related acute lung injury or acute chest syndrome of sickle cell disease? - A case report. Can J Anaesth. 2003 Nov; 50(9):895-9. PMID: 14617585.
    View in: PubMed
  34. Chandrasekhar S, Peterfreund RA. Horner's syndrome following very low concentration bupivacaine infusion for labor epidural analgesia. J Clin Anesth. 2003 May; 15(3):217-9. PMID: 12770660.
    View in: PubMed
  35. Wallington CL, Peters DM, Gelb CR, Peterfreund RA. Orphanin FQ/nociceptin and mu-opioid receptor mRNA levels in human SH-SY5Y neuroblastoma cells: effects of activating the cAMP-PKA signal transduction pathway. Brain Res. 2002 Jul 19; 944(1-2):73-81. PMID: 12106667.
    View in: PubMed
  36. Fitzsimons MG, Peterfreund RA, Raines DE. Aprotinin administration and pulmonary thromboembolism during orthotopic liver transplantation: report of two cases. Anesth Analg. 2001 Jun; 92(6):1418-21. PMID: 11375816.
    View in: PubMed
  37. Firth PG, Peterfreund RA. Management of multiple intracranial aneurysms: neuroanesthetic considerations of sickle cell disease. J Neurosurg Anesthesiol. 2000 Oct; 12(4):366-71. PMID: 11147387.
    View in: PubMed
  38. Fulling PD, Peterfreund RA. Alkalinization and precipitation characteristics of 0.2% ropivacaine. Reg Anesth Pain Med. 2000 Sep-Oct; 25(5):518-21. PMID: 11009239.
    View in: PubMed
  39. Salim H, Ferré S, Dalal A, Peterfreund RA, Fuxe K, Vincent JD, Lledo PM. Activation of adenosine A1 and A2A receptors modulates dopamine D2 receptor-induced responses in stably transfected human neuroblastoma cells. J Neurochem. 2000 Jan; 74(1):432-9. PMID: 10617149.
    View in: PubMed
  40. Dull RO, Peterfreund RA. Variations in the composition of spinal anesthetic solutions: the effects of drug addition order and preparation methods. Anesth Analg. 1998 Dec; 87(6):1326-30. PMID: 9842821.
    View in: PubMed
  41. Peters DM, Gies EK, Gelb CR, Peterfreund RA. Agonist-induced desensitization of A2B adenosine receptors. Biochem Pharmacol. 1998 Mar 15; 55(6):873-82. PMID: 9586960.
    View in: PubMed
  42. Gies EK, Peters DM, Gelb CR, Knag KM, Peterfreund RA. Regulation of mu opioid receptor mRNA levels by activation of protein kinase C in human SH-SY5Y neuroblastoma cells. Anesthesiology. 1997 Nov; 87(5):1127-38. PMID: 9366465.
    View in: PubMed
  43. Peterfreund RA, Gies EK, Fink JS. Protein kinase C regulates adenosine A2a receptor mRNA expression in SH-SY5Y cells. Eur J Pharmacol. 1997 Oct 01; 336(1):71-80. PMID: 9384256.
    View in: PubMed
  44. Willsey DB, Peterfreund RA. Compartment syndrome of the upper arm after pressurized infiltration of intravenous fluid. J Clin Anesth. 1997 Aug; 9(5):428-30. PMID: 9257213.
    View in: PubMed
  45. Qvist J, Peterfreund RA, Perlmutter GS. Transient compartment syndrome of the forearm after attempted radial artery cannulation. Anesth Analg. 1996 Jul; 83(1):183-5. PMID: 8659734.
    View in: PubMed
  46. Peterfreund RA, MacCollin M, Gusella J, Fink JS. Characterization and expression of the human A2a adenosine receptor gene. J Neurochem. 1996 Jan; 66(1):362-8. PMID: 8522976.
    View in: PubMed
  47. Peterfreund RA, Kosofsky BE, Fink JS. Cellular localization of dopamine D2 receptor messenger RNA in the rat trigeminal ganglion. Anesth Analg. 1995 Dec; 81(6):1181-5. PMID: 7486101.
    View in: PubMed
  48. Hess D, Fisher D, Peterfreund RA, Kacmarek RM. The delivery of aerosolized steroids from MDIs with nozzle extensions: quantitative laboratory evaluation of a method to improve aerosol delivery to intubated patients. Intensive Care Med. 1995 Nov; 21(11):945-51. PMID: 8636529.
    View in: PubMed
  49. MacCollin M, Peterfreund R, MacDonald M, Fink JS, Gusella J. Mapping of a human A2a adenosine receptor (ADORA2) to chromosome 22. Genomics. 1994 Mar 15; 20(2):332-3. PMID: 8020991.
    View in: PubMed
  50. Peterfreund RA, Niven RW, Kacmarek RM. Syringe-actuated metered dose inhalers: a quantitative laboratory evaluation of albuterol delivery through nozzle extensions. Anesth Analg. 1994 Mar; 78(3):554-8. PMID: 8109777.
    View in: PubMed
  51. Niven RW, Kacmarek RM, Brain JD, Peterfreund RA. Small bore nozzle extensions to improve the delivery efficiency of drugs from metered dose inhalers: laboratory evaluation. Am Rev Respir Dis. 1993 Jun; 147(6 Pt 1):1590-4. PMID: 8503573.
    View in: PubMed
  52. Fink JS, Weaver DR, Rivkees SA, Peterfreund RA, Pollack AE, Adler EM, Reppert SM. Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatum. Brain Res Mol Brain Res. 1992 Jul; 14(3):186-95. PMID: 1279342.
    View in: PubMed
  53. Peterfreund RA, Datta S, Ostheimer GW. pH adjustment of local anesthetic solutions with sodium bicarbonate: laboratory evaluation of alkalinization and precipitation. Reg Anesth. 1989 Nov-Dec; 14(6):265-70. PMID: 2562097.
    View in: PubMed
  54. Peterfreund RA, Vale WW. Local anesthetics inhibit veratridine-induced secretion of calcitonin gene-related peptide (CGRP) from cultured rat trigeminal ganglion cells. Brain Res. 1986 Aug 13; 380(1):159-61. PMID: 3489500.
    View in: PubMed
  55. Peterfreund RA, Sawchenko PE, Vale W. Thyroid hormones reversibly suppress somatostatin secretion and immunoreactivity in cultured neocortical cells. Brain Res. 1985 Mar 04; 328(2):259-70. PMID: 2859080.
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  56. Peterfreund RA, Vale WW. Somatostatin secretion from the hypothalamus. Adv Exp Med Biol. 1985; 188:183-200. PMID: 2863930.
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  57. Peterfreund RA, Vale WW. Somatostatin analogs inhibit somatostatin secretion from cultured hypothalamus cells. Neuroendocrinology. 1984 Nov; 39(5):397-402. PMID: 6151126.
    View in: PubMed
  58. Peterfreund RA, Vale WW. Picrotoxinin and phorbol-12-myristate-13-acetate stimulate the secretion of multiple forms of somatostatin from cultured rat brain cells. J Neurochem. 1984 Jul; 43(1):126-30. PMID: 6726241.
    View in: PubMed
  59. Mason RT, Peterfreund RA, Sawchenko PE, Corrigan AZ, Rivier JE, Vale WW. Release of the predicted calcitonin gene-related peptide from cultured rat trigeminal ganglion cells. Nature. 1984 Apr 12-18; 308(5960):653-5. PMID: 6369148.
    View in: PubMed
  60. Peterfreund RA, Vale WW. Phorbol diesters stimulate somatostatin secretion from cultured brain cells. Endocrinology. 1983 Jul; 113(1):200-8. PMID: 6407821.
    View in: PubMed
  61. Peterfreund RA, Vale WW. Ovine corticotropin-releasing factor stimulates somatostatin secretion from cultured brain cells. Endocrinology. 1983 Apr; 112(4):1275-8. PMID: 6131810.
    View in: PubMed
  62. Peterfreund RA, Vale WW. Muscarinic cholinergic stimulation of somatostatin secretion from long term dispersed cell cultures of fetal rat hypothalamus: inhibition by gamma-aminobutyric acid and serotonin. Endocrinology. 1983 Feb; 112(2):526-34. PMID: 6129132.
    View in: PubMed
  63. Shoemaker WJ, Peterfreund RA, Vale W. Methodological considerations in culturing peptidergic neurons. Methods Enzymol. 1983; 103:347-62. PMID: 6321891.
    View in: PubMed
  64. Peterfreund RA, Vale W. High molecular weight somatostatin secretion by cultured rat brain cells. Brain Res. 1982 May 13; 239(2):463-77. PMID: 6124303.
    View in: PubMed
  65. Trotta PP, Peterfreund RA, Schonberg R, Balis ME. Rabbit adenosine deaminase conversion proteins. Purification and characterization. Biochemistry. 1979 Jul 10; 18(14):2953-9. PMID: 465449.
    View in: PubMed
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