Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Esperance Anne Kreek Schaefer, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. F32DK097855 (SCHAEFER, ESPERANCE ANNE KREEK) Dec 1, 2012 - Nov 30, 2013
    Characterization of microRNA-lipid-HCV interactions
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lagon EP, Soffer MD, James KE, Mecklai K, Li DK, Schaefer EA, Duzyj CM. Trends in gestational age at delivery for intrahepatic cholestasis of pregnancy and adoption of society guidelines. Am J Obstet Gynecol MFM. 2022 Aug 11; 4(6):100709. PMID: 35964933.
    Citations: 1     Fields:    
  2. Luther J, Vannier AG, Schaefer EA, Goodman RP. The circulating proteomic signature of alcohol-associated liver disease. JCI Insight. 2022 07 22; 7(14). PMID: 35866482; PMCID: PMC9431701.
    Citations:    Fields:    Translation:Humans
  3. Li W, Duan X, Zhu C, Liu X, Jeyarajan AJ, Xu M, Tu Z, Sheng Q, Chen D, Zhu C, Shao T, Cheng Z, Salloum S, Schaefer EA, Kruger AJ, Holmes JA, Chung RT, Lin W. Hepatitis B and Hepatitis C Virus Infection Promote Liver Fibrogenesis through a TGF-ß1-Induced OCT4/Nanog Pathway. J Immunol. 2022 02 01; 208(3):672-684. PMID: 35022275; PMCID: PMC8770612.
    Citations:    Fields:    Translation:HumansCells
  4. Schaefer EAK. A Deep Ravine Rather Than a Shallow Gap: Many More Bridges Needed to Improve Care of Chronic Hepatitis B in the United States. Am J Gastroenterol. 2021 09 01; 116(9):1842-1843. PMID: 34187982.
    Citations:    Fields:    Translation:HumansPHPublic Health
  5. Salloum S, Jeyarajan AJ, Kruger AJ, Holmes JA, Shao T, Sojoodi M, Kim MH, Zhuo Z, Shroff SG, Kassa A, Corey KE, Khan SK, Lin W, Alatrakchi N, Schaefer EAK, Chung RT. Fatty Acids Activate the Transcriptional Coactivator YAP1 to Promote Liver Fibrosis via p38 Mitogen-Activated Protein Kinase. Cell Mol Gastroenterol Hepatol. 2021; 12(4):1297-1310. PMID: 34118488; PMCID: PMC8463869.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  6. Schaefer EAK, Arvind A, Bloom PP, Chung RT. Interrelationship Between Coronavirus Infection and Liver Disease. Clin Liver Dis (Hoboken). 2020 May; 15(5):175-180. PMID: 32489653; PMCID: PMC7242011.
    Citations: 23     
  7. Schaefer EA, Anderson MA, Kim AY, Sfeir MM. Case 15-2019: A 55-Year-Old Man with Jaundice. N Engl J Med. 2019 May 16; 380(20):1955-1963. PMID: 31091378.
    Citations:    Fields:    Translation:Humans
  8. Duan X, Liu X, Li W, Holmes JA, Kruger AJ, Yang C, Li Y, Xu M, Ye H, Li S, Liao X, Sheng Q, Chen D, Shao T, Cheng Z, Kaj B, Schaefer EA, Li S, Chen L, Lin W, Chung RT. Microrna-130a Downregulates HCV Replication through an atg5-Dependent Autophagy Pathway. Cells. 2019 04 10; 8(4). PMID: 30974864.
    Citations: 8     Fields:    Translation:HumansCells
  9. Liu X, Duan X, Holmes JA, Li W, Lee SH, Tu Z, Zhu C, Salloum S, Lidofsky A, Schaefer EA, Cai D, Li S, Wang H, Huang Y, Zhao Y, Yu ML, Xu Z, Chen L, Hong J, Lin W, Chung RT. A Long Noncoding RNA Regulates Hepatitis C Virus Infection Through Interferon Alpha-Inducible Protein 6. Hepatology. 2019 03; 69(3):1004-1019. PMID: 30199576.
    Citations: 24     Fields:    Translation:HumansCells
  10. Lidofsky A, Holmes JA, Feeney ER, Kruger AJ, Salloum S, Zheng H, Seguin IS, Altinbas A, Masia R, Corey KE, Gustafson JL, Schaefer EA, Hunt PW, Deeks S, Somsouk M, Chew KW, Chung RT, Alatrakchi N. Macrophage Activation Marker Soluble CD163 Is a Dynamic Marker of Liver Fibrogenesis in Human Immunodeficiency Virus/Hepatitis C Virus Coinfection. J Infect Dis. 2018 09 22; 218(9):1394-1403. PMID: 29868909; PMCID: PMC6151081.
    Citations: 21     Fields:    Translation:HumansCells
  11. Duan X, Li S, Holmes JA, Tu Z, Li Y, Cai D, Liu X, Li W, Yang C, Jiao B, Schaefer EA, Fusco DN, Salloum S, Chen L, Lin W, Chung RT. MicroRNA 130a Regulates both Hepatitis C Virus and Hepatitis B Virus Replication through a Central Metabolic Pathway. J Virol. 2018 04 01; 92(7). PMID: 29321333; PMCID: PMC5972888.
    Citations: 11     Fields:    Translation:HumansCells
  12. Shih AR, Lauwers GY, Mattia A, Schaefer EA, Misdraji J. Vascular Injury Characterizes Doxycycline-induced Upper Gastrointestinal Tract Mucosal Injury. Am J Surg Pathol. 2017 Mar; 41(3):374-381. PMID: 28009607.
    Citations: 2     Fields:    Translation:Humans
  13. Olson KR, Davarpanah AH, Schaefer EA, Elias N, Misdraji J. Case 2-2017. An 18-Year-Old Woman with Acute Liver Failure. N Engl J Med. 2017 01 19; 376(3):268-278. PMID: 28099829.
    Citations: 1     Fields:    Translation:Humans
  14. Schaefer EA, Meixiong J, Mark C, Deik A, Motola DL, Fusco D, Yang A, Brisac C, Salloum S, Lin W, Clish CB, Peng LF, Chung RT. Apolipoprotein B100 is required for hepatitis C infectivity and Mipomersen inhibits hepatitis C. World J Gastroenterol. 2016 Dec 07; 22(45):9954-9965. PMID: 28018102; PMCID: PMC5143762.
    Citations: 4     Fields:    Translation:HumansCells
  15. Salloum S, Holmes JA, Jindal R, Bale SS, Brisac C, Alatrakchi N, Lidofsky A, Kruger AJ, Fusco DN, Luther J, Schaefer EA, Lin W, Yarmush ML, Chung RT. Exposure to human immunodeficiency virus/hepatitis C virus in hepatic and stellate cell lines reveals cooperative profibrotic transcriptional activation between viruses and cell types. Hepatology. 2016 12; 64(6):1951-1968. PMID: 27531241.
    Citations: 21     Fields:    Translation:HumansCells
  16. Brisac C, Salloum S, Yang V, Schaefer EA, Holmes JA, Chevaliez S, Hong J, Carlton-Smith C, Alatrakchi N, Kruger A, Lin W, Chung RT. IQGAP2 is a novel interferon-alpha antiviral effector gene acting non-conventionally through the NF-?B pathway. J Hepatol. 2016 11; 65(5):972-979. PMID: 27401546; PMCID: PMC5656012.
    Citations: 8     Fields:    Translation:HumansCells
  17. Chusri P, Kumthip K, Hong J, Zhu C, Duan X, Jilg N, Fusco DN, Brisac C, Schaefer EA, Cai D, Peng LF, Maneekarn N, Lin W, Chung RT. HCV induces transforming growth factor ß1 through activation of endoplasmic reticulum stress and the unfolded protein response. Sci Rep. 2016 Mar 01; 6:22487. PMID: 26927933; PMCID: PMC4772380.
    Citations: 40     Fields:    Translation:HumansCells
  18. Zhu C, Xiao F, Hong J, Wang K, Liu X, Cai D, Fusco DN, Zhao L, Jeong SW, Brisac C, Chusri P, Schaefer EA, Zhao H, Peng LF, Lin W, Chung RT. EFTUD2 Is a Novel Innate Immune Regulator Restricting Hepatitis C Virus Infection through the RIG-I/MDA5 Pathway. J Virol. 2015 Jul; 89(13):6608-18. PMID: 25878102; PMCID: PMC4468487.
    Citations: 19     Fields:    Translation:HumansCells
  19. Lin W, Zhu C, Hong J, Zhao L, Jilg N, Fusco DN, Schaefer EA, Brisac C, Liu X, Peng LF, Xu Q, Chung RT. The spliceosome factor SART1 exerts its anti-HCV action through mRNA splicing. J Hepatol. 2015 May; 62(5):1024-32. PMID: 25481564; PMCID: PMC4404186.
    Citations: 19     Fields:    Translation:HumansCells
  20. Jilg N, Lin W, Hong J, Schaefer EA, Wolski D, Meixong J, Goto K, Brisac C, Chusri P, Fusco DN, Chevaliez S, Luther J, Kumthip K, Urban TJ, Peng LF, Lauer GM, Chung RT. Kinetic differences in the induction of interferon stimulated genes by interferon-a and interleukin 28B are altered by infection with hepatitis C virus. Hepatology. 2014 Apr; 59(4):1250-61. PMID: 23913866.
    Citations: 58     Fields:    Translation:HumansCells
  21. Schaefer EA, Chung RT. HCV and host lipids: an intimate connection. Semin Liver Dis. 2013 Nov; 33(4):358-68. PMID: 24222093.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  22. Goto K, Lin W, Zhang L, Jilg N, Shao RX, Schaefer EA, Zhao H, Fusco DN, Peng LF, Kato N, Chung RT. The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-ß signaling. J Hepatol. 2013 Nov; 59(5):942-8. PMID: 23831117; PMCID: PMC3866804.
    Citations: 15     Fields:    Translation:HumansCells
  23. Ding Q, Lee YK, Schaefer EA, Peters DT, Veres A, Kim K, Kuperwasser N, Motola DL, Meissner TB, Hendriks WT, Trevisan M, Gupta RM, Moisan A, Banks E, Friesen M, Schinzel RT, Xia F, Tang A, Xia Y, Figueroa E, Wann A, Ahfeldt T, Daheron L, Zhang F, Rubin LL, Peng LF, Chung RT, Musunuru K, Cowan CA. A TALEN genome-editing system for generating human stem cell-based disease models. Cell Stem Cell. 2013 Feb 07; 12(2):238-51. PMID: 23246482.
    Citations: 235     Fields:    Translation:HumansCells
  24. Kumthip K, Chusri P, Jilg N, Zhao L, Fusco DN, Zhao H, Goto K, Cheng D, Schaefer EA, Zhang L, Pantip C, Thongsawat S, O'Brien A, Peng LF, Maneekarn N, Chung RT, Lin W. Hepatitis C virus NS5A disrupts STAT1 phosphorylation and suppresses type I interferon signaling. J Virol. 2012 Aug; 86(16):8581-91. PMID: 22674974.
    Citations: 41     Fields:    Translation:HumansCells
  25. Schaefer EA, Chung RT. Anti-hepatitis C virus drugs in development. Gastroenterology. 2012 May; 142(6):1340-1350.e1. PMID: 22537441.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  26. Rodgers MA, Villareal VA, Schaefer EA, Peng LF, Corey KE, Chung RT, Yang PL. Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus. J Am Chem Soc. 2012 Apr 25; 134(16):6896-9. PMID: 22480142.
    Citations: 16     Fields:    Translation:HumansCells
  27. Schaefer EA, Pratt DS. Autoimmune hepatitis: current challenges in diagnosis and management in a chronic progressive liver disease. Curr Opin Rheumatol. 2012 Jan; 24(1):84-9. PMID: 22089102.
    Citations: 1     Fields:    Translation:Humans
  28. Schaefer EA, Chung RT. The impact of human gene polymorphisms on HCV infection and disease outcome. Semin Liver Dis. 2011 Nov; 31(4):375-86. PMID: 22189977.
    Citations: 8     Fields:    Translation:HumansCells
  29. Peng LF, Schaefer EA, Maloof N, Skaff A, Berical A, Belon CA, Heck JA, Lin W, Frick DN, Allen TM, Miziorko HM, Schreiber SL, Chung RT. Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase. J Infect Dis. 2011 Aug 15; 204(4):609-16. PMID: 21791663; PMCID: PMC3144167.
    Citations: 7     Fields:    Translation:HumansCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Schaefer's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (171)
Co-Authors (27)
Similar People (60)
Same Department 
Physical Neighbors
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.