Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Bradley Theodore Hyman, M.D., Ph.D.

Co-Author

This page shows the publications co-authored by Bradley Hyman and Oksana Berezovska.
Connection Strength

5.198
  1. Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein. J Neurosci. 2005 Mar 16; 25(11):3009-17.
    View in: PubMed
    Score: 0.319
  2. Monitoring proteins in intact cells. Sci Aging Knowledge Environ. 2003 Jun 11; 2003(23):PE14.
    View in: PubMed
    Score: 0.282
  3. Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging. J Neurosci. 2003 Jun 01; 23(11):4560-6.
    View in: PubMed
    Score: 0.282
  4. Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage. J Biol Chem. 2001 Aug 10; 276(32):30018-23.
    View in: PubMed
    Score: 0.246
  5. Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling. J Neurochem. 2000 Aug; 75(2):583-93.
    View in: PubMed
    Score: 0.231
  6. Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity. Ann N Y Acad Sci. 2000; 920:223-6.
    View in: PubMed
    Score: 0.222
  7. The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons. Brain Res Mol Brain Res. 1999 Jun 08; 69(2):273-80.
    View in: PubMed
    Score: 0.214
  8. Notch1 inhibits neurite outgrowth in postmitotic primary neurons. Neuroscience. 1999; 93(2):433-9.
    View in: PubMed
    Score: 0.207
  9. Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease. J Neuropathol Exp Neurol. 1998 Aug; 57(8):738-45.
    View in: PubMed
    Score: 0.201
  10. Isoform- and cell type-specific structure of apolipoprotein E lipoparticles as revealed by a novel Forster resonance energy transfer assay. J Biol Chem. 2017 09 08; 292(36):14720-14729.
    View in: PubMed
    Score: 0.187
  11. Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid ß production. Mol Neurodegener. 2017 02 13; 12(1):15.
    View in: PubMed
    Score: 0.182
  12. Pathogenic PS1 phosphorylation at Ser367. Elife. 2017 01 30; 6.
    View in: PubMed
    Score: 0.182
  13. Developmental regulation of presenilin mRNA expression parallels notch expression. J Neuropathol Exp Neurol. 1997 Jan; 56(1):40-4.
    View in: PubMed
    Score: 0.181
  14. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. BMC Biol. 2016 Mar 31; 14:25.
    View in: PubMed
    Score: 0.171
  15. Oxidative stress and lipid peroxidation are upstream of amyloid pathology. Neurobiol Dis. 2015 Dec; 84:109-19.
    View in: PubMed
    Score: 0.162
  16. Neuronal activity and secreted amyloid ß lead to altered amyloid ß precursor protein and presenilin 1 interactions. Neurobiol Dis. 2013 Feb; 50:127-34.
    View in: PubMed
    Score: 0.135
  17. Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-ß revealed by a novel fluorescence resonance energy transfer assay. J Neurosci. 2012 Apr 11; 32(15):5298-309.
    View in: PubMed
    Score: 0.130
  18. Substrate docking to ?-secretase allows access of ?-secretase modulators to an allosteric site. Nat Commun. 2010 Nov 30; 1:130.
    View in: PubMed
    Score: 0.118
  19. Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio. PLoS One. 2009 Nov 18; 4(11):e7893.
    View in: PubMed
    Score: 0.110
  20. Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase. Mol Cell Neurosci. 2009 Jun; 41(2):166-74.
    View in: PubMed
    Score: 0.105
  21. Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy. J Biomed Opt. 2008 Jan-Feb; 13(1):014008.
    View in: PubMed
    Score: 0.097
  22. Time-domain fluorescent plate reader for cell based protein-protein interaction and protein conformation assays. J Biomed Opt. 2006 Sep-Oct; 11(5):054024.
    View in: PubMed
    Score: 0.088
  23. Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader. J Biol Chem. 2006 Sep 08; 281(36):26400-7.
    View in: PubMed
    Score: 0.087
  24. Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy. Biochem Biophys Res Commun. 2006 Feb 10; 340(2):668-74.
    View in: PubMed
    Score: 0.084
  25. Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase. J Biol Chem. 2005 Jul 22; 280(29):27303-9.
    View in: PubMed
    Score: 0.081
  26. Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation. Nat Med. 2004 Oct; 10(10):1065-6.
    View in: PubMed
    Score: 0.077
  27. Clinical, pathological, and biochemical spectrum of Alzheimer disease associated with PS-1 mutations. Am J Geriatr Psychiatry. 2004 Mar-Apr; 12(2):146-56.
    View in: PubMed
    Score: 0.074
  28. Activated Notch1 associates with a presenilin-1/gamma-secretase docking site. J Neurochem. 2003 Nov; 87(4):843-50.
    View in: PubMed
    Score: 0.072
  29. Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression. J Biol Chem. 2003 Nov 28; 278(48):47370-5.
    View in: PubMed
    Score: 0.072
  30. Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus. J Neurochem. 2002 Aug; 82(4):839-47.
    View in: PubMed
    Score: 0.066
  31. The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells. J Biol Chem. 2002 Aug 09; 277(32):28530-6.
    View in: PubMed
    Score: 0.066
  32. Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons. Brain Res Mol Brain Res. 2001 Mar 05; 87(2):166-74.
    View in: PubMed
    Score: 0.060
  33. Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease. J Neurol Sci. 1998 Jun 11; 158(1):15-23.
    View in: PubMed
    Score: 0.050
  34. Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes. Structure. 2014 Jan 07; 22(1):125-35.
    View in: PubMed
    Score: 0.036
  35. Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic. 2011 Mar; 12(3):330-48.
    View in: PubMed
    Score: 0.030
  36. Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface. J Neurochem. 2009 Jul; 110(1):220-30.
    View in: PubMed
    Score: 0.026
  37. gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science. 2009 May 01; 324(5927):639-42.
    View in: PubMed
    Score: 0.026
  38. N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio. J Neurochem. 2009 Jan; 108(2):350-60.
    View in: PubMed
    Score: 0.026
  39. CHIP targets toxic alpha-Synuclein oligomers for degradation. J Biol Chem. 2008 Jun 27; 283(26):17962-8.
    View in: PubMed
    Score: 0.025
  40. Visualizing interaction of proteins relevant to Alzheimer's disease in intact cells. Methods. 2008 Apr; 44(4):299-303.
    View in: PubMed
    Score: 0.025
  41. Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells. Mol Neurodegener. 2006 Nov 14; 1:16.
    View in: PubMed
    Score: 0.022
  42. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem. 2006 Oct 27; 281(43):32240-53.
    View in: PubMed
    Score: 0.022
  43. APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation. J Neurochem. 2005 Oct; 95(2):446-56.
    View in: PubMed
    Score: 0.020
  44. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein. J Neurochem. 2004 Sep; 90(5):1132-43.
    View in: PubMed
    Score: 0.019
  45. Designed helical peptides inhibit an intramembrane protease. J Am Chem Soc. 2003 Oct 01; 125(39):11794-5.
    View in: PubMed
    Score: 0.018
  46. Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. FASEB J. 2003 Jan; 17(1):79-81.
    View in: PubMed
    Score: 0.017
  47. Biochemical and immunocytochemical characterization of calsenilin in mouse brain. Neuroscience. 2002; 114(1):247-63.
    View in: PubMed
    Score: 0.016
  48. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat Cell Biol. 2001 Oct; 3(10):905-12.
    View in: PubMed
    Score: 0.016
  49. Structure and functions of human cerebrospinal fluid lipoproteins from individuals of different APOE genotypes. Exp Neurol. 1998 Jan; 149(1):175-82.
    View in: PubMed
    Score: 0.012
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.