Harvard Catalyst Profiles

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Lisa V. Goodrich, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21EY032392 (GOODRICH, LISA V) Dec 1, 2020 - Nov 30, 2022
    NIH
    A novel mechanism for synapse localization in the retina
    Role: Principal Investigator
  2. R01NS118402 (GOODRICH, LISA V) Sep 30, 2020 - May 31, 2025
    NIH
    Single-cell computation in auditory brainstem and its impact on cortical coding and behavior
    Role: Principal Investigator
  3. R21NS113562 (GOODRICH, LISA V) Jul 1, 2019 - Jun 30, 2021
    NIH
    Generation of mouse models to define the structural basis of Ntn1-DCC activity
    Role: Principal Investigator
  4. R01DC015974 (GOODRICH, LISA V) Dec 1, 2016 - Nov 30, 2021
    NIH
    Afferent-efferent interactions in the developing cochlea
    Role: Principal Investigator
  5. R21DC014916 (GOODRICH, LISA V) Jul 1, 2016 - Jun 30, 2018
    NIH
    Non-sensory cells as a potential source for signaling molecules in the cochlea
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tasdemir-Yilmaz OE, Druckenbrod NR, Olukoya OO, Dong W, Yung AR, Bastille I, Pazyra-Murphy MF, Sitko AA, Hale EB, Vigneau S, Gimelbrant AA, Kharchenko PV, Goodrich LV, Segal RA. Diversity of developing peripheral glia revealed by single-cell RNA sequencing. Dev Cell. 2021 Aug 26. PMID: 34469751.
    Citations:    Fields:    
  2. Sitko AA, Goodrich LV. Making sense of neural development by comparing wiring strategies for seeing and hearing. Science. 2021 01 08; 371(6525). PMID: 33414193.
    Citations:    Fields:    Translation:AnimalsCells
  3. Lyon KA, Rood BD, Wu L, Senft RA, Goodrich LV, Dymecki SM. Sex-Specific Role for Dopamine Receptor D2 in Dorsal Raphe Serotonergic Neuron Modulation of Defensive Acoustic Startle and Dominance Behavior. eNeuro. 2020 Nov-Dec; 7(6). PMID: 33214315.
    Citations: 1     Fields:    Translation:AnimalsCells
  4. Druckenbrod NR, Hale EB, Olukoya OO, Shatzer WE, Goodrich LV. Neuronal processes and glial precursors form a scaffold for wiring the developing mouse cochlea. Nat Commun. 2020 11 17; 11(1):5866. PMID: 33203842.
    Citations: 3     Fields:    Translation:AnimalsCells
  5. Hardy H, Prendergast JG, Patel A, Dutta S, Trejo-Reveles V, Kroeger H, Yung AR, Goodrich LV, Brooks B, Sowden JC, Rainger J. Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential mediator of epithelial fusion. Elife. 2019 06 04; 8. PMID: 31162046.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  6. Pai EL, Vogt D, Clemente-Perez A, McKinsey GL, Cho FS, Hu JS, Wimer M, Paul A, Fazel Darbandi S, Pla R, Nowakowski TJ, Goodrich LV, Paz JT, Rubenstein JLR. Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function. Cell Rep. 2019 01 29; 26(5):1157-1173.e5. PMID: 30699346.
    Citations: 9     Fields:    Translation:AnimalsCells
  7. Shrestha BR, Chia C, Wu L, Kujawa SG, Liberman MC, Goodrich LV. Sensory Neuron Diversity in the Inner Ear Is Shaped by Activity. Cell. 2018 08 23; 174(5):1229-1246.e17. PMID: 30078709.
    Citations: 71     Fields:    Translation:AnimalsCells
  8. Frank MM, Goodrich LV. Talking back: Development of the olivocochlear efferent system. Wiley Interdiscip Rev Dev Biol. 2018 11; 7(6):e324. PMID: 29944783.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  9. Yung AR, Druckenbrod NR, Cloutier JF, Wu Z, Tessier-Lavigne M, Goodrich LV. Netrin-1 Confines Rhombic Lip-Derived Neurons to the CNS. Cell Rep. 2018 02 13; 22(7):1666-1680. PMID: 29444422.
    Citations: 8     Fields:    Translation:AnimalsCells
  10. Nishitani AM, Ohta S, Yung AR, Del Rio T, Gordon MI, Abraira VE, Avilés EC, Schoenwolf GC, Fekete DM, Goodrich LV. Distinct functions for netrin 1 in chicken and murine semicircular canal morphogenesis. Development. 2017 09 15; 144(18):3349-3360. PMID: 28851705.
    Citations: 5     Fields:    Translation:Animals
  11. Avilés EC, Goodrich LV. Configuring a robust nervous system with Fat cadherins. Semin Cell Dev Biol. 2017 09; 69:91-101. PMID: 28603077.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  12. Junge HJ, Yung AR, Goodrich LV, Chen Z. Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord. Neural Dev. 2016 10 26; 11(1):19. PMID: 27784329.
    Citations: 7     Fields:    Translation:AnimalsCells
  13. Banerjee RR, Cyphert HA, Walker EM, Chakravarthy H, Peiris H, Gu X, Liu Y, Conrad E, Goodrich L, Stein RW, Kim SK. Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet ß-Cells. Diabetes. 2016 08; 65(8):2331-41. PMID: 27217483.
    Citations: 25     Fields:    Translation:AnimalsCells
  14. Krol A, Henle SJ, Goodrich LV. Fat3 and Ena/VASP proteins influence the emergence of asymmetric cell morphology in the developing retina. Development. 2016 06 15; 143(12):2172-82. PMID: 27122175.
    Citations: 15     Fields:    Translation:AnimalsCells
  15. Druckenbrod NR, Goodrich LV. Sequential Retraction Segregates SGN Processes during Target Selection in the Cochlea. J Neurosci. 2015 Dec 09; 35(49):16221-35. PMID: 26658872.
    Citations: 19     Fields:    Translation:AnimalsCells
  16. Conrad E, Dai C, Spaeth J, Guo M, Cyphert HA, Scoville D, Carroll J, Yu WM, Goodrich LV, Harlan DM, Grove KL, Roberts CT, Powers AC, Gu G, Stein R. The MAFB transcription factor impacts islet a-cell function in rodents and represents a unique signature of primate islet ß-cells. Am J Physiol Endocrinol Metab. 2016 Jan 01; 310(1):E91-E102. PMID: 26554594.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  17. Yung AR, Nishitani AM, Goodrich LV. Phenotypic analysis of mice completely lacking netrin 1. Development. 2015 Nov 01; 142(21):3686-91. PMID: 26395479.
    Citations: 28     Fields:    Translation:AnimalsCells
  18. Lu CC, Cao XJ, Wright S, Ma L, Oertel D, Goodrich LV. Mutation of Npr2 leads to blurred tonotopic organization of central auditory circuits in mice. PLoS Genet. 2014 Dec; 10(12):e1004823. PMID: 25473838.
    Citations: 16     Fields:    Translation:AnimalsCells
  19. Yu WM, Goodrich LV. Morphological and physiological development of auditory synapses. Hear Res. 2014 May; 311:3-16. PMID: 24508369.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  20. Yung A, Goodrich LV. How to survive a nerve-wracking journey. Elife. 2013 Dec 17; 2:e01845. PMID: 24347551.
    Citations:    Fields:    Translation:AnimalsCells
  21. Yu WM, Appler JM, Kim YH, Nishitani AM, Holt JR, Goodrich LV. A Gata3-Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing. Elife. 2013 Dec 10; 2:e01341. PMID: 24327562.
    Citations: 34     Fields:    Translation:HumansCells
  22. Del Rio T, Nishitani AM, Yu WM, Goodrich LV. In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear. PLoS Genet. 2013; 9(9):e1003824. PMID: 24086156.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  23. Appler JM, Lu CC, Druckenbrod NR, Yu WM, Koundakjian EJ, Goodrich LV. Gata3 is a critical regulator of cochlear wiring. J Neurosci. 2013 Feb 20; 33(8):3679-91. PMID: 23426694.
    Citations: 48     Fields:    Translation:Animals
  24. Saburi S, Hester I, Goodrich L, McNeill H. Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity. Development. 2012 May; 139(10):1806-20. PMID: 22510986.
    Citations: 51     Fields:    Translation:AnimalsCells
  25. Yin H, Copley CO, Goodrich LV, Deans MR. Comparison of phenotypes between different vangl2 mutants demonstrates dominant effects of the Looptail mutation during hair cell development. PLoS One. 2012; 7(2):e31988. PMID: 22363783.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  26. Roberts KA, Abraira VE, Tucker AF, Goodrich LV, Andrews NC. Mutation of Rubie, a novel long non-coding RNA located upstream of Bmp4, causes vestibular malformation in mice. PLoS One. 2012; 7(1):e29495. PMID: 22253730.
    Citations: 13     Fields:    Translation:AnimalsCells
  27. Deans MR, Krol A, Abraira VE, Copley CO, Tucker AF, Goodrich LV. Control of neuronal morphology by the atypical cadherin Fat3. Neuron. 2011 Sep 08; 71(5):820-32. PMID: 21903076.
    Citations: 45     Fields:    Translation:AnimalsCells
  28. Lu CC, Appler JM, Houseman EA, Goodrich LV. Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J Neurosci. 2011 Jul 27; 31(30):10903-18. PMID: 21795542.
    Citations: 76     Fields:    Translation:AnimalsCells
  29. Goodrich LV, Strutt D. Principles of planar polarity in animal development. Development. 2011 May; 138(10):1877-92. PMID: 21521735.
    Citations: 244     Fields:    Translation:AnimalsCells
  30. Kim EJ, Hori K, Wyckoff A, Dickel LK, Koundakjian EJ, Goodrich LV, Johnson JE. Spatiotemporal fate map of neurogenin1 (Neurog1) lineages in the mouse central nervous system. J Comp Neurol. 2011 May 01; 519(7):1355-70. PMID: 21452201.
    Citations: 27     Fields:    Translation:AnimalsCells
  31. Appler JM, Goodrich LV. Connecting the ear to the brain: Molecular mechanisms of auditory circuit assembly. Prog Neurobiol. 2011 Apr; 93(4):488-508. PMID: 21232575.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  32. Abraira VE, Satoh T, Fekete DM, Goodrich LV. Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis. PLoS One. 2010 Feb 01; 5(2):e8981. PMID: 20126551.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  33. Abraira VE, Del Rio T, Tucker AF, Slonimsky J, Keirnes HL, Goodrich LV. Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear. Development. 2008 Dec; 135(24):4091-9. PMID: 19004851.
    Citations: 31     Fields:    Translation:AnimalsCells
  34. Goodrich LV. The plane facts of PCP in the CNS. Neuron. 2008 Oct 09; 60(1):9-16. PMID: 18940584.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  35. Koundakjian EJ, Appler JL, Goodrich LV. Auditory neurons make stereotyped wiring decisions before maturation of their targets. J Neurosci. 2007 Dec 19; 27(51):14078-88. PMID: 18094247.
    Citations: 90     Fields:    Translation:Animals
  36. Raft S, Koundakjian EJ, Quinones H, Jayasena CS, Goodrich LV, Johnson JE, Segil N, Groves AK. Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development. Development. 2007 Dec; 134(24):4405-15. PMID: 18039969.
    Citations: 104     Fields:    Translation:AnimalsCells
  37. Abraira VE, Hyun N, Tucker AF, Coling DE, Brown MC, Lu C, Hoffman GR, Goodrich LV. Changes in Sef levels influence auditory brainstem development and function. J Neurosci. 2007 Apr 18; 27(16):4273-82. PMID: 17442811.
    Citations: 16     Fields:    Translation:Animals
  38. Deans MR, Antic D, Suyama K, Scott MP, Axelrod JD, Goodrich LV. Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear. J Neurosci. 2007 Mar 21; 27(12):3139-47. PMID: 17376975.
    Citations: 70     Fields:    Translation:AnimalsCells
  39. Goodrich LV. Hear, hear for the zebrafish. Neuron. 2005 Jan 06; 45(1):3-5. PMID: 15629695.
    Citations: 3     Fields:    Translation:AnimalsCells
  40. Mazerbourg S, Bouley DM, Sudo S, Klein CA, Zhang JV, Kawamura K, Goodrich LV, Rayburn H, Tessier-Lavigne M, Hsueh AJ. Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality. Mol Endocrinol. 2004 Sep; 18(9):2241-54. PMID: 15192078.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  41. Mitchell KJ, Pinson KI, Kelly OG, Brennan J, Zupicich J, Scherz P, Leighton PA, Goodrich LV, Lu X, Avery BJ, Tate P, Dill K, Pangilinan E, Wakenight P, Tessier-Lavigne M, Skarnes WC. Functional analysis of secreted and transmembrane proteins critical to mouse development. Nat Genet. 2001 Jul; 28(3):241-9. PMID: 11431694.
    Citations: 170     Fields:    Translation:AnimalsCells
  42. Leighton PA, Mitchell KJ, Goodrich LV, Lu X, Pinson K, Scherz P, Skarnes WC, Tessier-Lavigne M. Defining brain wiring patterns and mechanisms through gene trapping in mice. Nature. 2001 Mar 08; 410(6825):174-9. PMID: 11242070.
    Citations: 128     Fields:    Translation:HumansAnimalsCells
  43. Milenkovic L, Goodrich LV, Higgins KM, Scott MP. Mouse patched1 controls body size determination and limb patterning. Development. 1999 Oct; 126(20):4431-40. PMID: 10498679.
    Citations: 44     Fields:    Translation:AnimalsCells
  44. Goodrich LV, Jung D, Higgins KM, Scott MP. Overexpression of ptc1 inhibits induction of Shh target genes and prevents normal patterning in the neural tube. Dev Biol. 1999 Jul 15; 211(2):323-34. PMID: 10395791.
    Citations: 18     Fields:    Translation:HumansAnimals
  45. Keys DN, Lewis DL, Selegue JE, Pearson BJ, Goodrich LV, Johnson RL, Gates J, Scott MP, Carroll SB. Recruitment of a hedgehog regulatory circuit in butterfly eyespot evolution. Science. 1999 Jan 22; 283(5401):532-4. PMID: 9915699.
    Citations: 92     Fields:    Translation:AnimalsCells
  46. Goodrich LV, Scott MP. Hedgehog and patched in neural development and disease. Neuron. 1998 Dec; 21(6):1243-57. PMID: 9883719.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  47. Goodrich LV, Milenkovic L, Higgins KM, Scott MP. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science. 1997 Aug 22; 277(5329):1109-13. PMID: 9262482.
    Citations: 639     Fields:    Translation:Animals
  48. Concordet JP, Lewis KE, Moore JW, Goodrich LV, Johnson RL, Scott MP, Ingham PW. Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning. Development. 1996 Sep; 122(9):2835-46. PMID: 8787757.
    Citations: 110     Fields:    Translation:AnimalsCells
  49. Johnson RL, Rothman AL, Xie J, Goodrich LV, Bare JW, Bonifas JM, Quinn AG, Myers RM, Cox DR, Epstein EH, Scott MP. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science. 1996 Jun 14; 272(5268):1668-71. PMID: 8658145.
    Citations: 463     Fields:    Translation:HumansAnimalsCells
  50. Marigo V, Scott MP, Johnson RL, Goodrich LV, Tabin CJ. Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb. Development. 1996 Apr; 122(4):1225-33. PMID: 8620849.
    Citations: 53     Fields:    Translation:AnimalsCells
  51. Goodrich LV, Johnson RL, Milenkovic L, McMahon JA, Scott MP. Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev. 1996 Feb 01; 10(3):301-12. PMID: 8595881.
    Citations: 242     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.