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profileAudrey E.K. Hutcheon, B.S.

TitleResearch Associate in Ophthalmology
InstitutionSchepens Eye Research Institute
DepartmentOphthalmology
AddressSchepens Eye Research Institute
20 Staniford Street
Boston MA 02114
Phone617/912-7422
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sriram S, Tran JA, Guo X, Hutcheon AEK, Kazlauskas A, Zieske JD. Development of wound healing models to study TGFß3's effect on SMA. Exp Eye Res. 2017 Aug; 161:52-60. PMID: 28599847.
    View in: PubMed
  2. Sriram S, Tran JA, Guo X, Hutcheon AE, Lei H, Kazlauskas A, Zieske JD. PDGFRa Is a Key Regulator of T1 and T3's Differential Effect on SMA Expression in Human Corneal Fibroblasts. Invest Ophthalmol Vis Sci. 2017 Feb 01; 58(2):1179-1186. PMID: 28245298.
    View in: PubMed
  3. Guo X, Hutcheon AEK, Tran JA, Zieske JD. TGF-ß-target genes are differentially regulated in corneal epithelial cells and fibroblasts. New Front Ophthalmol. 2017; 3(1). PMID: 28649665.
    View in: PubMed
  4. Rittié L, Hutcheon AEK, Zieske JD. Mouse Models of Corneal Scarring. Methods Mol Biol. 2017; 1627:117-122. PMID: 28836198.
    View in: PubMed
  5. Guo X, Hutcheon AE, Zieske JD. Molecular insights on the effect of TGF-ß1/-ß3 in human corneal fibroblasts. Exp Eye Res. 2016 May; 146:233-41. PMID: 26992778; PMCID: PMC4893894 [Available on 05/01/17].
  6. Sarker-Nag A, Hutcheon AE, Karamichos D. Mitochondrial Profile and Responses to TGF-ß Ligands in Keratoconus. Curr Eye Res. 2016 Jul; 41(7):900-7. PMID: 26430764.
    View in: PubMed
  7. Karamichos D, Funderburgh ML, Hutcheon AE, Zieske JD, Du Y, Wu J, Funderburgh JL. A role for topographic cues in the organization of collagenous matrix by corneal fibroblasts and stem cells. PLoS One. 2014; 9(1):e86260. PMID: 24465995; PMCID: PMC3897697.
  8. Karamichos D, Rich CB, Zareian R, Hutcheon AE, Ruberti JW, Trinkaus-Randall V, Zieske JD. TGF-ß3 stimulates stromal matrix assembly by human corneal keratocyte-like cells. Invest Ophthalmol Vis Sci. 2013 Oct 09; 54(10):6612-9. PMID: 24022012; PMCID: PMC3803138.
  9. Blanco-Mezquita JT, Hutcheon AE, Zieske JD. Role of thrombospondin-1 in repair of penetrating corneal wounds. Invest Ophthalmol Vis Sci. 2013 Sep 17; 54(9):6262-8. PMID: 23963165; PMCID: PMC3776713.
  10. Karamichos D, Zareian R, Guo X, Hutcheon AE, Ruberti JW, Zieske JD. Novel in Vitro Model for Keratoconus Disease. J Funct Biomater. 2012 Nov 13; 3(4):760-775. PMID: 23888249.
    View in: PubMed
  11. Saeidi N, Guo X, Hutcheon AE, Sander EA, Bale SS, Melotti SA, Zieske JD, Trinkaus-Randall V, Ruberti JW. Disorganized collagen scaffold interferes with fibroblast mediated deposition of organized extracellular matrix in vitro. Biotechnol Bioeng. 2012 Oct; 109(10):2683-98. PMID: 22528405; PMCID: PMC3757098.
  12. Blanco-Mezquita JT, Hutcheon AE, Stepp MA, Zieske JD. aVß6 integrin promotes corneal wound healing. Invest Ophthalmol Vis Sci. 2011 Oct 31; 52(11):8505-13. PMID: 21960555; PMCID: PMC3208190.
  13. Karamichos D, Rich CB, Hutcheon AE, Ren R, Saitta B, Trinkaus-Randall V, Zieske JD. Self-assembled matrix by umbilical cord stem cells. J Funct Biomater. 2011 Sep 01; 2(3):213-29. PMID: 24956304; PMCID: PMC4030936.
  14. Matsuba M, Hutcheon AE, Zieske JD. Localization of thrombospondin-1 and myofibroblasts during corneal wound repair. Exp Eye Res. 2011 Oct; 93(4):534-40. PMID: 21749870; PMCID: PMC3206171.
  15. Karamichos D, Guo XQ, Hutcheon AE, Zieske JD. Human corneal fibrosis: an in vitro model. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1382-8. PMID: 19875671; PMCID: PMC2868432.
  16. Guo X, Hutcheon AE, Melotti SA, Zieske JD, Trinkaus-Randall V, Ruberti JW. Morphologic characterization of organized extracellular matrix deposition by ascorbic acid-stimulated human corneal fibroblasts. Invest Ophthalmol Vis Sci. 2007 Sep; 48(9):4050-60. PMID: 17724187; PMCID: PMC4961093.
  17. Hutcheon AE, Sippel KC, Zieske JD. Examination of the restoration of epithelial barrier function following superficial keratectomy. Exp Eye Res. 2007 Jan; 84(1):32-8. PMID: 17067576; PMCID: PMC1766331.
  18. Hutcheon AE, Guo XQ, Stepp MA, Simon KJ, Weinreb PH, Violette SM, Zieske JD. Effect of wound type on Smad 2 and 4 translocation. Invest Ophthalmol Vis Sci. 2005 Jul; 46(7):2362-8. PMID: 15980223.
    View in: PubMed
  19. Netto MV, Mohan RR, Ambrósio R, Hutcheon AE, Zieske JD, Wilson SE. Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy. Cornea. 2005 Jul; 24(5):509-22. PMID: 15968154.
    View in: PubMed
  20. Guo X, Hutcheon AE, Zieske JD. TAT-mediated protein transduction into human corneal epithelial cells: p15(INK4b) inhibits cell proliferation and stimulates cell migration. Invest Ophthalmol Vis Sci. 2004 Jun; 45(6):1804-11. PMID: 15161843.
    View in: PubMed
  21. Guo X, Hutcheon AE, Zieske JD. Transduction of functionally active TAT fusion proteins into cornea. Exp Eye Res. 2004 May; 78(5):997-1005. PMID: 15051480.
    View in: PubMed
  22. Wilson SE, Mohan RR, Hutcheon AE, Mohan RR, Ambrósio R, Zieske JD, Hong J, Lee J. Effect of ectopic epithelial tissue within the stroma on keratocyte apoptosis, mitosis, and myofibroblast transformation. Exp Eye Res. 2003 Feb; 76(2):193-201. PMID: 12565807.
    View in: PubMed
  23. Mohan RR, Hutcheon AE, Choi R, Hong J, Lee J, Mohan RR, Ambrósio R, Zieske JD, Wilson SE. Apoptosis, necrosis, proliferation, and myofibroblast generation in the stroma following LASIK and PRK. Exp Eye Res. 2003 Jan; 76(1):71-87. PMID: 12589777.
    View in: PubMed
  24. Zieske JD, Hutcheon AE, Guo X, Chung EH, Joyce NC. TGF-beta receptor types I and II are differentially expressed during corneal epithelial wound repair. Invest Ophthalmol Vis Sci. 2001 Jun; 42(7):1465-71. PMID: 11381048.
    View in: PubMed
  25. Zieske JD, Guimarães SR, Hutcheon AE. Kinetics of keratocyte proliferation in response to epithelial debridement. Exp Eye Res. 2001 Jan; 72(1):33-9. PMID: 11133180.
    View in: PubMed
  26. Zieske JD, Takahashi H, Hutcheon AE, Dalbone AC. Activation of epidermal growth factor receptor during corneal epithelial migration. Invest Ophthalmol Vis Sci. 2000 May; 41(6):1346-55. PMID: 10798649.
    View in: PubMed
  27. Francesconi CM, Hutcheon AE, Chung EH, Dalbone AC, Joyce NC, Zieske JD. Expression patterns of retinoblastoma and E2F family proteins during corneal development. Invest Ophthalmol Vis Sci. 2000 Apr; 41(5):1054-62. PMID: 10752941.
    View in: PubMed
  28. Chung EH, Hutcheon AE, Joyce NC, Zieske JD. Synchronization of the G1/S transition in response to corneal debridement. Invest Ophthalmol Vis Sci. 1999 Aug; 40(9):1952-8. PMID: 10440248.
    View in: PubMed
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