Harvard Catalyst Profiles

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Audrey E.K. Hutcheon, B.S.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yeung V, Boychev N, Farhat W, Ntentakis DP, Hutcheon AEK, Ross AE, Ciolino JB. Extracellular Vesicles in Corneal Fibrosis/Scarring. Int J Mol Sci. 2022 May 25; 23(11). PMID: 35682600; PMCID: PMC9180085.
    Citations:    Fields:    Translation:HumansCells
  2. Yeung V, Zhang TC, Yuan L, Parekh M, Cortinas JA, Delavogia E, Hutcheon AEK, Guo X, Ciolino JB. Extracellular Vesicles Secreted by Corneal Myofibroblasts Promote Corneal Epithelial Cell Migration. Int J Mol Sci. 2022 Mar 15; 23(6). PMID: 35328555; PMCID: PMC8951135.
    Citations: 2     Fields:    Translation:HumansCells
  3. Yeung V, Sriram S, Tran JA, Guo X, Hutcheon AEK, Zieske JD, Karamichos D, Ciolino JB. FAK Inhibition Attenuates Corneal Fibroblast Differentiation In Vitro. Biomolecules. 2021 11 12; 11(11). PMID: 34827680; PMCID: PMC8616004.
    Citations: 5     Fields:    Translation:HumansCells
  4. McKay TB, Yeung V, Hutcheon AEK, Guo X, Zieske JD, Ciolino JB. Extracellular Vesicles in the Cornea: Insights from Other Tissues. Anal Cell Pathol (Amst). 2021; 2021:9983900. PMID: 34336556; PMCID: PMC8324376.
    Citations: 7     Fields:    Translation:HumansCells
  5. Rhodes G, Segars KL, Lee YK, Hutcheon AEK, Rich CB, Trinkaus-Randall V. Pannexin1: Role as a Sensor to Injury Is Attenuated in Pretype 2 Corneal Diabetic Epithelium. Anal Cell Pathol (Amst). 2021; 2021:4793338. PMID: 34336553; PMCID: PMC8295002.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. McKay TB, Guo X, Hutcheon AEK, Karamichos D, Ciolino JB. Methods for Investigating Corneal Cell Interactions and Extracellular Vesicles In Vitro. Curr Protoc Cell Biol. 2020 12; 89(1):e114. PMID: 32986311.
    Citations: 2     Fields:    Translation:HumansCells
  7. McKay TB, Hutcheon AEK, Guo X, Zieske JD, Karamichos D. Modeling the cornea in 3-dimensions: Current and future perspectives. Exp Eye Res. 2020 08; 197:108127. PMID: 32619578; PMCID: PMC8116933.
    Citations: 5     Fields:    Translation:HumansCells
  8. McKay TB, Hutcheon AEK, Zieske JD, Ciolino JB. Extracellular Vesicles Secreted by Corneal Epithelial Cells Promote Myofibroblast Differentiation. Cells. 2020 04 26; 9(5). PMID: 32357574.
    Citations: 12     Fields:    Translation:HumansCells
  9. McKay TB, Hutcheon AEK, Zieske JD. Biology of corneal fibrosis: soluble mediators, integrins, and extracellular vesicles. Eye (Lond). 2020 02; 34(2):271-278. PMID: 31831879; PMCID: PMC7002485.
    Citations: 5     Fields:    Translation:HumansCells
  10. McKay TB, Karamichos D, Hutcheon AEK, Guo X, Zieske JD. Corneal Epithelial-Stromal Fibroblast Constructs to Study Cell-Cell Communication in Vitro. Bioengineering (Basel). 2019 Dec 04; 6(4). PMID: 31817298; PMCID: PMC6956392.
    Citations: 11     
  11. Pal-Ghosh S, Tadvalkar G, Lieberman VR, Guo X, Zieske JD, Hutcheon A, Stepp MA. Transient Mitomycin C-treatment of human corneal epithelial cells and fibroblasts alters cell migration, cytokine secretion, and matrix accumulation. Sci Rep. 2019 09 25; 9(1):13905. PMID: 31554858.
    Citations: 6     Fields:    Translation:HumansCells
  12. Zieske JD, Hutcheon AEK, Guo X. Extracellular Vesicles and Cell-Cell Communication in the Cornea. Anat Rec (Hoboken). 2020 06; 303(6):1727-1734. PMID: 31136100.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  13. Shu DY, Hutcheon AEK, Zieske JD, Guo X. Epidermal Growth Factor Stimulates Transforming Growth Factor-Beta Receptor Type II Expression In Corneal Epithelial Cells. Sci Rep. 2019 05 30; 9(1):8079. PMID: 31147562.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  14. Hutcheon AEK, Zieske JD, Guo X. 3D in vitro model for human corneal endothelial cell maturation. Exp Eye Res. 2019 07; 184:183-191. PMID: 30980816; PMCID: PMC6684281.
    Citations: 8     Fields:    Translation:HumansCells
  15. Wu W, Hutcheon AEK, Sriram S, Tran JA, Zieske JD. Initiation of fibrosis in the integrin ?vß6 knockout mice. Exp Eye Res. 2019 03; 180:23-28. PMID: 30500364; PMCID: PMC6540115.
    Citations: 9     Fields:    Translation:Animals
  16. Guo X, Sriram S, Tran JA, Hutcheon AEK, Zieske JD. Inhibition of Human Corneal Myofibroblast Formation. Invest Ophthalmol Vis Sci. 2018 07 02; 59(8):3511-3520. PMID: 30025094; PMCID: PMC6044211.
    Citations: 3     Fields:    Translation:HumansCells
  17. Lee A, Karamichos D, Onochie OE, Hutcheon AEK, Rich CB, Zieske JD, Trinkaus-Randall V. Hypoxia modulates the development of a corneal stromal matrix model. Exp Eye Res. 2018 05; 170:127-137. PMID: 29496505; PMCID: PMC5924608.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  18. Sriram S, Tran JA, Guo X, Hutcheon AEK, Kazlauskas A, Zieske JD. Development of wound healing models to study TGFß3's effect on SMA. Exp Eye Res. 2017 08; 161:52-60. PMID: 28599847; PMCID: PMC5577797.
    Citations: 11     Fields:    Translation:AnimalsCells
  19. Sriram S, Tran JA, Guo X, Hutcheon AE, Lei H, Kazlauskas A, Zieske JD. PDGFRa Is a Key Regulator of T1 and T3's Differential Effect on SMA Expression in Human Corneal Fibroblasts. Invest Ophthalmol Vis Sci. 2017 02 01; 58(2):1179-1186. PMID: 28245298; PMCID: PMC5338631.
    Citations: 7     Fields:    Translation:HumansCells
  20. Guo X, Hutcheon AEK, Tran JA, Zieske JD. TGF-ß-target genes are differentially regulated in corneal epithelial cells and fibroblasts. New Front Ophthalmol. 2017; 3(1). PMID: 28649665; PMCID: PMC5482276.
    Citations: 9     
  21. Rittié L, Hutcheon AEK, Zieske JD. Mouse Models of Corneal Scarring. Methods Mol Biol. 2017; 1627:117-122. PMID: 28836198.
    Citations: 4     Fields:    Translation:Animals
  22. Guo X, Hutcheon AEK, Zieske JD. Molecular insights on the effect of TGF-ß1/-ß3 in human corneal fibroblasts. Exp Eye Res. 2016 05; 146:233-241. PMID: 26992778.
    Citations: 22     Fields:    Translation:HumansCells
  23. Sarker-Nag A, Hutcheon AE, Karamichos D. Mitochondrial Profile and Responses to TGF-ß Ligands in Keratoconus. Curr Eye Res. 2016 07; 41(7):900-7. PMID: 26430764; PMCID: PMC5317202.
    Citations: 6     Fields:    Translation:HumansCells
  24. Karamichos D, Funderburgh ML, Hutcheon AE, Zieske JD, Du Y, Wu J, Funderburgh JL. A role for topographic cues in the organization of collagenous matrix by corneal fibroblasts and stem cells. PLoS One. 2014; 9(1):e86260. PMID: 24465995.
    Citations: 34     Fields:    Translation:HumansCells
  25. Karamichos D, Rich CB, Zareian R, Hutcheon AE, Ruberti JW, Trinkaus-Randall V, Zieske JD. TGF-ß3 stimulates stromal matrix assembly by human corneal keratocyte-like cells. Invest Ophthalmol Vis Sci. 2013 Oct 09; 54(10):6612-9. PMID: 24022012.
    Citations: 20     Fields:    Translation:HumansCells
  26. Blanco-Mezquita JT, Hutcheon AE, Zieske JD. Role of thrombospondin-1 in repair of penetrating corneal wounds. Invest Ophthalmol Vis Sci. 2013 Sep 17; 54(9):6262-8. PMID: 23963165.
    Citations: 26     Fields:    Translation:AnimalsCells
  27. Karamichos D, Zareian R, Guo X, Hutcheon AE, Ruberti JW, Zieske JD. Novel in Vitro Model for Keratoconus Disease. J Funct Biomater. 2012 Nov 13; 3(4):760-775. PMID: 23888249.
    Citations: 40     
  28. Saeidi N, Guo X, Hutcheon AE, Sander EA, Bale SS, Melotti SA, Zieske JD, Trinkaus-Randall V, Ruberti JW. Disorganized collagen scaffold interferes with fibroblast mediated deposition of organized extracellular matrix in vitro. Biotechnol Bioeng. 2012 Oct; 109(10):2683-98. PMID: 22528405.
    Citations: 21     Fields:    Translation:HumansCells
  29. Blanco-Mezquita JT, Hutcheon AE, Stepp MA, Zieske JD. aVß6 integrin promotes corneal wound healing. Invest Ophthalmol Vis Sci. 2011 Oct 31; 52(11):8505-13. PMID: 21960555.
    Citations: 22     Fields:    Translation:AnimalsCells
  30. Karamichos D, Rich CB, Hutcheon AE, Ren R, Saitta B, Trinkaus-Randall V, Zieske JD. Self-assembled matrix by umbilical cord stem cells. J Funct Biomater. 2011 Sep 01; 2(3):213-29. PMID: 24956304.
    Citations: 6     
  31. Matsuba M, Hutcheon AE, Zieske JD. Localization of thrombospondin-1 and myofibroblasts during corneal wound repair. Exp Eye Res. 2011 Oct; 93(4):534-40. PMID: 21749870.
    Citations: 33     Fields:    Translation:AnimalsCells
  32. Karamichos D, Guo XQ, Hutcheon AE, Zieske JD. Human corneal fibrosis: an in vitro model. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1382-8. PMID: 19875671.
    Citations: 84     Fields:    Translation:HumansCells
  33. Guo X, Hutcheon AE, Melotti SA, Zieske JD, Trinkaus-Randall V, Ruberti JW. Morphologic characterization of organized extracellular matrix deposition by ascorbic acid-stimulated human corneal fibroblasts. Invest Ophthalmol Vis Sci. 2007 Sep; 48(9):4050-60. PMID: 17724187; PMCID: PMC4961093.
    Citations: 88     Fields:    Translation:HumansCells
  34. Hutcheon AE, Sippel KC, Zieske JD. Examination of the restoration of epithelial barrier function following superficial keratectomy. Exp Eye Res. 2007 Jan; 84(1):32-8. PMID: 17067576; PMCID: PMC1766331.
    Citations: 20     Fields:    Translation:AnimalsCells
  35. Hutcheon AE, Guo XQ, Stepp MA, Simon KJ, Weinreb PH, Violette SM, Zieske JD. Effect of wound type on Smad 2 and 4 translocation. Invest Ophthalmol Vis Sci. 2005 Jul; 46(7):2362-8. PMID: 15980223.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  36. Netto MV, Mohan RR, Ambrósio R, Hutcheon AE, Zieske JD, Wilson SE. Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy. Cornea. 2005 Jul; 24(5):509-22. PMID: 15968154.
    Citations: 135     Fields:    Translation:HumansAnimals
  37. Guo X, Hutcheon AE, Zieske JD. TAT-mediated protein transduction into human corneal epithelial cells: p15(INK4b) inhibits cell proliferation and stimulates cell migration. Invest Ophthalmol Vis Sci. 2004 Jun; 45(6):1804-11. PMID: 15161843.
    Citations: 3     Fields:    Translation:HumansCells
  38. Guo X, Hutcheon AE, Zieske JD. Transduction of functionally active TAT fusion proteins into cornea. Exp Eye Res. 2004 May; 78(5):997-1005. PMID: 15051480.
    Citations: 4     Fields:    Translation:AnimalsCells
  39. Wilson SE, Mohan RR, Hutcheon AE, Mohan RR, Ambrósio R, Zieske JD, Hong J, Lee J. Effect of ectopic epithelial tissue within the stroma on keratocyte apoptosis, mitosis, and myofibroblast transformation. Exp Eye Res. 2003 Feb; 76(2):193-201. PMID: 12565807.
    Citations: 15     Fields:    Translation:AnimalsCells
  40. Mohan RR, Hutcheon AE, Choi R, Hong J, Lee J, Mohan RR, Ambrósio R, Zieske JD, Wilson SE. Apoptosis, necrosis, proliferation, and myofibroblast generation in the stroma following LASIK and PRK. Exp Eye Res. 2003 Jan; 76(1):71-87. PMID: 12589777.
    Citations: 137     Fields:    Translation:AnimalsCells
  41. Zieske JD, Hutcheon AE, Guo X, Chung EH, Joyce NC. TGF-beta receptor types I and II are differentially expressed during corneal epithelial wound repair. Invest Ophthalmol Vis Sci. 2001 Jun; 42(7):1465-71. PMID: 11381048.
    Citations: 36     Fields:    Translation:AnimalsCells
  42. Zieske JD, Guimarães SR, Hutcheon AE. Kinetics of keratocyte proliferation in response to epithelial debridement. Exp Eye Res. 2001 Jan; 72(1):33-9. PMID: 11133180.
    Citations: 61     Fields:    Translation:Animals
  43. Zieske JD, Takahashi H, Hutcheon AE, Dalbone AC. Activation of epidermal growth factor receptor during corneal epithelial migration. Invest Ophthalmol Vis Sci. 2000 May; 41(6):1346-55. PMID: 10798649.
    Citations: 75     Fields:    Translation:AnimalsCells
  44. Francesconi CM, Hutcheon AE, Chung EH, Dalbone AC, Joyce NC, Zieske JD. Expression patterns of retinoblastoma and E2F family proteins during corneal development. Invest Ophthalmol Vis Sci. 2000 Apr; 41(5):1054-62. PMID: 10752941.
    Citations: 11     Fields:    Translation:Animals
  45. Chung EH, Hutcheon AE, Joyce NC, Zieske JD. Synchronization of the G1/S transition in response to corneal debridement. Invest Ophthalmol Vis Sci. 1999 Aug; 40(9):1952-8. PMID: 10440248.
    Citations: 20     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.