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profileT. Keith Blackwell, Ph.D., M.D.

TitleProfessor of Genetics
InstitutionJoslin Diabetes Center
DepartmentGenetics
AddressJoslin Diabetes Center
Pathology
One Joslin Place
Boston MA 02215
Phone617/919-2769
Fax617/730-0023
vCardDownload vCard (login for email)

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ewald CY, Hourihan JM, Bland MS, Obieglo C, Katic I, Moronetti Mazzeo LE, Alcedo J, Blackwell TK, Hynes NE. NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans. Elife. 2017 Jan 13; 6. PMID: 28085666.
    View in: PubMed
  2. Castillo-Quan JI, Blackwell TK. Metformin: Restraining Nucleocytoplasmic Shuttling to Fight Cancer and Aging. Cell. 2016 12 15; 167(7):1670-1671. PMID: 27984715.
    View in: PubMed
  3. Isik M, Blackwell TK, Berezikov E. MicroRNA mir-34 provides robustness to environmental stress response via the DAF-16 network in C. elegans. Sci Rep. 2016 Dec 01; 6:36766. PMID: 27905558.
    View in: PubMed
  4. Hourihan JM, Moronetti Mazzeo LE, Fernández-Cárdenas LP, Blackwell TK. Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response. Mol Cell. 2016 Aug 18; 63(4):553-66. PMID: 27540856; PMCID: PMC4996358 [Available on 08/18/17].
  5. Zhao YY, Blackwell T, Ensrud KE, Stone KL, Omachi TA, Redline S. Sleep Apnea and Obstructive Airway Disease in Older Men: Outcomes of Sleep Disorders in Older Men Study. Sleep. 2016 Jul 01; 39(7):1343-51. PMID: 27091524; PMCID: PMC4909616 [Available on 01/01/17].
  6. Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M. Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep. 2016 Feb 22; 6:21611. PMID: 26899496; PMCID: PMC4761942.
  7. Steinbaugh MJ, Narasimhan SD, Robida-Stubbs S, Moronetti Mazzeo LE, Dreyfuss JM, Hourihan JM, Raghavan P, Operaña TN, Esmaillie R, Blackwell TK. Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence. Elife. 2015 Aug 24; 4. PMID: 26196144; PMCID: PMC4541496.
  8. Winkelman JW, Blackwell T, Stone K, Ancoli-Israel S, Tranah GJ, Redline S. Genetic associations of periodic limb movements of sleep in the elderly for the MrOS sleep study. Sleep Med. 2015 Nov; 16(11):1360-1365. PMID: 26498236; PMCID: PMC4621485 [Available on 11/01/16].
  9. Blackwell TK, Steinbaugh MJ, Hourihan JM, Ewald CY, Isik M. SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans. Free Radic Biol Med. 2015 Nov; 88(Pt B):290-301. PMID: 26232625; PMCID: PMC4809198 [Available on 11/01/16].
  10. Aritake S, Blackwell T, Peters KW, Rueschman M, Mobley D, Morrical MG, Platt SF, Dam TT, Redline S, Winkelman JW. Prevalence and associations of respiratory-related leg movements: the MrOS sleep study. Sleep Med. 2015 Oct; 16(10):1236-44. PMID: 26429752; PMCID: PMC4665997 [Available on 10/01/16].
  11. Ewald CY, Landis JN, Porter Abate J, Murphy CT, Blackwell TK. Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity. Nature. 2015 Mar 05; 519(7541):97-101. PMID: 25517099; PMCID: PMC4352135.
  12. Moroz N, Carmona JJ, Anderson E, Hart AC, Sinclair DA, Blackwell TK. Dietary restriction involves NAD? -dependent mechanisms and a shift toward oxidative metabolism. Aging Cell. 2014 Dec; 13(6):1075-85. PMID: 25257342; PMCID: PMC4244309.
  13. Mizunuma M, Neumann-Haefelin E, Moroz N, Li Y, Blackwell TK. mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity. Aging Cell. 2014 Oct; 13(5):869-78. PMID: 25040785; PMCID: PMC4172656.
  14. Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ. GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci U S A. 2014 Mar 11; 111(10):3781-6. PMID: 24556985; PMCID: PMC3956149.
  15. Glover-Cutter KM, Lin S, Blackwell TK. Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf. PLoS Genet. 2013; 9(9):e1003701. PMID: 24068940; PMCID: PMC3772064.
  16. Ruf V, Holzem C, Peyman T, Walz G, Blackwell TK, Neumann-Haefelin E. TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development. Dev Biol. 2013 Dec 15; 384(2):214-27. PMID: 23973804; PMCID: PMC3877771.
  17. Ishikado A, Sono Y, Matsumoto M, Robida-Stubbs S, Okuno A, Goto M, King GL, Blackwell TK, Makino T. Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans. Free Radic Biol Med. 2013 Dec; 65:1506-15. PMID: 23277146; PMCID: PMC3800243.
  18. Paek J, Lo JY, Narasimhan SD, Nguyen TN, Glover-Cutter K, Robida-Stubbs S, Suzuki T, Yamamoto M, Blackwell TK, Curran SP. Mitochondrial SKN-1/Nrf mediates a conserved starvation response. Cell Metab. 2012 Oct 03; 16(4):526-37. PMID: 23040073; PMCID: PMC3774140.
  19. Mori MA, Raghavan P, Thomou T, Boucher J, Robida-Stubbs S, Macotela Y, Russell SJ, Kirkland JL, Blackwell TK, Kahn CR. Role of microRNA processing in adipose tissue in stress defense and longevity. Cell Metab. 2012 Sep 05; 16(3):336-47. PMID: 22958919; PMCID: PMC3461823.
  20. Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, Neumann-Haefelin E, Sabatini DM, Blackwell TK. TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 2012 May 02; 15(5):713-24. PMID: 22560223; PMCID: PMC3348514.
  21. Li X, Matilainen O, Jin C, Glover-Cutter KM, Holmberg CI, Blackwell TK. Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity. PLoS Genet. 2011 Jun; 7(6):e1002119. PMID: 21695230; PMCID: PMC3111486.
  22. Wang J, Robida-Stubbs S, Tullet JM, Rual JF, Vidal M, Blackwell TK. RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition. PLoS Genet. 2010 Aug 05; 6(8). PMID: 20700440; PMCID: PMC2916858.
  23. Tranah GJ, Blackwell T, Ancoli-Israel S, Paudel ML, Ensrud KE, Cauley JA, Redline S, Hillier TA, Cummings SR, Stone KL. Circadian activity rhythms and mortality: the study of osteoporotic fractures. J Am Geriatr Soc. 2010 Feb; 58(2):282-91. PMID: 20374404; PMCID: PMC2938873.
  24. Blackwell T, Cawthon PM, Marshall LM, Brand R. Consistency of leg extension power assessments in older men: the Osteoporotic Fractures in Men (MrOS) Study. Am J Phys Med Rehabil. 2009 Nov; 88(11):934-40. PMID: 19893385; PMCID: PMC3141730.
  25. Porter Abate J, Blackwell TK. Life is short, if sweet. Cell Metab. 2009 Nov; 10(5):338-9. PMID: 19883611; PMCID: PMC4837950.
  26. Oliveira RP, Porter Abate J, Dilks K, Landis J, Ashraf J, Murphy CT, Blackwell TK. Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf. Aging Cell. 2009 Sep; 8(5):524-41. PMID: 19575768; PMCID: PMC2776707.
  27. Rao MN, Blackwell T, Redline S, Stefanick ML, Ancoli-Israel S, Stone KL. Association between sleep architecture and measures of body composition. Sleep. 2009 Apr; 32(4):483-90. PMID: 19413142; PMCID: PMC2663862.
  28. Hammell CM, Lubin I, Boag PR, Blackwell TK, Ambros V. nhl-2 Modulates microRNA activity in Caenorhabditis elegans. Cell. 2009 Mar 06; 136(5):926-38. PMID: 19269369; PMCID: PMC2670343.
  29. Yaffe K, Weston AL, Blackwell T, Krueger KA. The metabolic syndrome and development of cognitive impairment among older women. Arch Neurol. 2009 Mar; 66(3):324-8. PMID: 19273750; PMCID: PMC2685462.
  30. Oláhová M, Taylor SR, Khazaipoul S, Wang J, Morgan BA, Matsumoto K, Blackwell TK, Veal EA. A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):19839-44. PMID: 19064914; PMCID: PMC2604961.
  31. Blackwell TK, Walker AK. OMA-gosh, where's that TAF? Cell. 2008 Oct 03; 135(1):18-20. PMID: 18854150.
    View in: PubMed
  32. Stone KL, Ancoli-Israel S, Blackwell T, Ensrud KE, Cauley JA, Redline S, Hillier TA, Schneider J, Claman D, Cummings SR. Actigraphy-measured sleep characteristics and risk of falls in older women. Arch Intern Med. 2008 Sep 08; 168(16):1768-75. PMID: 18779464.
    View in: PubMed
  33. Gartner A, Boag PR, Blackwell TK. Germline survival and apoptosis. WormBook. 2008 Sep 04; 1-20. PMID: 18781708; PMCID: PMC4781258.
  34. Boag PR, Atalay A, Robida S, Reinke V, Blackwell TK. Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis. J Cell Biol. 2008 Aug 11; 182(3):543-57. PMID: 18695045; PMCID: PMC2500139.
  35. Barnes DE, Blackwell T, Stone KL, Goldman SE, Hillier T, Yaffe K. Cognition in older women: the importance of daytime movement. J Am Geriatr Soc. 2008 Sep; 56(9):1658-64. PMID: 18662201; PMCID: PMC2680379.
  36. Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Liu S, Oliveira RP, Baumeister R, Blackwell TK. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell. 2008 Mar 21; 132(6):1025-38. PMID: 18358814; PMCID: PMC2367249.
  37. Blackwell T, Redline S, Ancoli-Israel S, Schneider JL, Surovec S, Johnson NL, Cauley JA, Stone KL. Comparison of sleep parameters from actigraphy and polysomnography in older women: the SOF study. Sleep. 2008 Feb; 31(2):283-91. PMID: 18274276; PMCID: PMC2225568.
  38. Mehra R, Stone KL, Blackwell T, Ancoli Israel S, Dam TT, Stefanick ML, Redline S. Prevalence and correlates of sleep-disordered breathing in older men: osteoporotic fractures in men sleep study. J Am Geriatr Soc. 2007 Sep; 55(9):1356-64. PMID: 17767677; PMCID: PMC2780325.
  39. Salinas LS, Maldonado E, Macías-Silva M, Blackwell TK, Navarro RE. The DEAD box RNA helicase VBH-1 is required for germ cell function in C. elegans. Genesis. 2007 Sep; 45(9):533-46. PMID: 17868112.
    View in: PubMed
  40. Yaffe K, Haan M, Blackwell T, Cherkasova E, Whitmer RA, West N. Metabolic syndrome and cognitive decline in elderly Latinos: findings from the Sacramento Area Latino Study of Aging study. J Am Geriatr Soc. 2007 May; 55(5):758-62. PMID: 17493197.
    View in: PubMed
  41. Huang A, Grady D, Blackwell T, Bauer D. Hot flushes, bone mineral density, and fractures in older postmenopausal women. Obstet Gynecol. 2007 Apr; 109(4):841-7. PMID: 17400844.
    View in: PubMed
  42. Walker AK, Boag PR, Blackwell TK. Transcription reactivation steps stimulated by oocyte maturation in C. elegans. Dev Biol. 2007 Apr 01; 304(1):382-93. PMID: 17291483; PMCID: PMC1913287.
  43. Claman DM, Redline S, Blackwell T, Ancoli-Israel S, Surovec S, Scott N, Cauley JA, Ensrud KE, Stone KL. Prevalence and correlates of periodic limb movements in older women. J Clin Sleep Med. 2006 Oct 15; 2(4):438-45. PMID: 17557474.
    View in: PubMed
  44. Blackwell TK, Walker AK. Transcription mechanisms. WormBook. 2006 Sep 05; 1-16. PMID: 18050436; PMCID: PMC4781191.
  45. Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villén J, Becker EB, DiBacco S, de la Iglesia N, Gygi S, Blackwell TK, Bonni A. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell. 2006 Jun 02; 125(5):987-1001. PMID: 16751106.
    View in: PubMed
  46. Blackwell T, Yaffe K, Ancoli-Israel S, Schneider JL, Cauley JA, Hillier TA, Fink HA, Stone KL. Poor sleep is associated with impaired cognitive function in older women: the study of osteoporotic fractures. J Gerontol A Biol Sci Med Sci. 2006 Apr; 61(4):405-10. PMID: 16611709.
    View in: PubMed
  47. Blackwell T, Ancoli-Israel S, Gehrman PR, Schneider JL, Pedula KL, Stone KL. Actigraphy scoring reliability in the study of osteoporotic fractures. Sleep. 2005 Dec; 28(12):1599-605. PMID: 16408420.
    View in: PubMed
  48. An JH, Vranas K, Lucke M, Inoue H, Hisamoto N, Matsumoto K, Blackwell TK. Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3. Proc Natl Acad Sci U S A. 2005 Nov 08; 102(45):16275-80. PMID: 16251270; PMCID: PMC1283458.
  49. Boag PR, Nakamura A, Blackwell TK. A conserved RNA-protein complex component involved in physiological germline apoptosis regulation in C. elegans. Development. 2005 Nov; 132(22):4975-86. PMID: 16221731.
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  50. Inoue H, Hisamoto N, An JH, Oliveira RP, Nishida E, Blackwell TK, Matsumoto K. The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev. 2005 Oct 01; 19(19):2278-83. PMID: 16166371; PMCID: PMC1240035.
  51. Navarro RE, Blackwell TK. Requirement for P granules and meiosis for accumulation of the germline RNA helicase CGH-1. Genesis. 2005 Jul; 42(3):172-80. PMID: 15986473.
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  52. Antoniucci DM, Vittinghoff E, Blackwell T, Black DM, Sellmeyer DE. Vitamin D insufficiency does not affect bone mineral density response to raloxifene. J Clin Endocrinol Metab. 2005 Aug; 90(8):4566-72. PMID: 15899959.
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  53. Yaffe K, Krueger K, Cummings SR, Blackwell T, Henderson VW, Sarkar S, Ensrud K, Grady D. Effect of raloxifene on prevention of dementia and cognitive impairment in older women: the Multiple Outcomes of Raloxifene Evaluation (MORE) randomized trial. Am J Psychiatry. 2005 Apr; 162(4):683-90. PMID: 15800139.
    View in: PubMed
  54. Blackwell, T. Keith. Laura Bush and Stem Cells, letter to the editor. The New York Times. 2004; 154(52970).
  55. Blackwell, T. K. and An, J. H. SKN-1 and GSK-3 Genes and Proteins. 2004.
  56. Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ, Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M, Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP, Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch AG, Holmberg S, Holstege FC, Jaehning JA, Kim YJ, Kuras L, Leutz A, Lis JT, Meisterernest M, Naar AM, Nasmyth K, Parvin JD, Ptashne M, Reinberg D, Ronne H, Sadowski I, Sakurai H, Sipiczki M, Sternberg PW, Stillman DJ, Strich R, Struhl K, Svejstrup JQ, Tuck S, Winston F, Roeder RG, Kornberg RD. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell. 2004 Jun 04; 14(5):553-7. PMID: 15175151.
    View in: PubMed
  57. Wang JC, Walker A, Blackwell TK, Yamamoto KR. The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis. J Biol Chem. 2004 Jul 09; 279(28):29270-7. PMID: 15073178.
    View in: PubMed
  58. Blackwell TK. Germ cells: finding programs of mass repression. Curr Biol. 2004 Mar 23; 14(6):R229-30. PMID: 15043831.
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  59. Stoecklin G, Stubbs T, Kedersha N, Wax S, Rigby WF, Blackwell TK, Anderson P. MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. EMBO J. 2004 Mar 24; 23(6):1313-24. PMID: 15014438; PMCID: PMC381421.
  60. Walker AK, Shi Y, Blackwell TK. An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription. J Biol Chem. 2004 Apr 09; 279(15):15339-47. PMID: 14726532.
    View in: PubMed
  61. Blackwell TK, Walker AK. Transcription elongation: TLKing to chromatin? Curr Biol. 2003 Dec 02; 13(23):R915-6. PMID: 14654017.
    View in: PubMed
  62. Shi Y, Blackwell TK. A two-tiered transcription regulation mechanism that protects germ cell identity. Mol Cell. 2003 Nov; 12(5):1062-4. PMID: 14636565.
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  63. An JH, Blackwell TK. SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev. 2003 Aug 01; 17(15):1882-93. PMID: 12869585; PMCID: PMC196237.
  64. Tice JA, Ettinger B, Ensrud K, Wallace R, Blackwell T, Cummings SR. Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) Study: a randomized controlled trial. JAMA. 2003 Jul 09; 290(2):207-14. PMID: 12851275.
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  65. Zhang F, Barboric M, Blackwell TK, Peterlin BM. A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb. Genes Dev. 2003 Mar 15; 17(6):748-58. PMID: 12651893; PMCID: PMC196018.
  66. Takagi T, Walker AK, Sawa C, Diehn F, Takase Y, Blackwell TK, Buratowski S. The Caenorhabditis elegans mRNA 5'-capping enzyme. In vitro and in vivo characterization. J Biol Chem. 2003 Apr 18; 278(16):14174-84. PMID: 12576476.
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  67. Walker AK, Blackwell TK. A broad but restricted requirement for TAF-5 (human TAFII100) for embryonic transcription in Caenorhabditis elegans. J Biol Chem. 2003 Feb 21; 278(8):6181-6. PMID: 12458202.
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  68. Shim EY, Walker AK, Shi Y, Blackwell TK. CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo. Genes Dev. 2002 Aug 15; 16(16):2135-46. PMID: 12183367; PMCID: PMC186450.
  69. Shim EY, Walker AK, Blackwell TK. Broad requirement for the mediator subunit RGR-1 for transcription in the Caenorhabditis elegans embryo. J Biol Chem. 2002 Aug 23; 277(34):30413-6. PMID: 12089139.
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  70. Johnson BA, Blackwell TK. Multiple tristetraprolin sequence domains required to induce apoptosis and modulate responses to TNFalpha through distinct pathways. Oncogene. 2002 Jun 20; 21(27):4237-46. PMID: 12082611.
    View in: PubMed
  71. Blackwell TK, Walker AK. Getting the right dose of repression. Genes Dev. 2002 Apr 01; 16(7):769-72. PMID: 11937484.
    View in: PubMed
  72. Johnson BA, Stehn JR, Yaffe MB, Blackwell TK. Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms. J Biol Chem. 2002 May 17; 277(20):18029-36. PMID: 11886850.
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  73. Walker AK, Rothman JH, Shi Y, Blackwell TK. Distinct requirements for C.elegans TAF(II)s in early embryonic transcription. EMBO J. 2001 Sep 17; 20(18):5269-79. PMID: 11566890; PMCID: PMC125634.
  74. Navarro RE, Shim EY, Kohara Y, Singson A, Blackwell TK. cgh-1, a conserved predicted RNA helicase required for gametogenesis and protection from physiological germline apoptosis in C. elegans. Development. 2001 Sep; 128(17):3221-32. PMID: 11546739.
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  75. Johnson B, Yaffe M, Blackwell TK. . Molecular analysis of TTP, a key regulator of TNF activity. Scientific World Journal. 2001; 1(Suppl 3):38.
  76. Walker AK, See R, Batchelder C, Kophengnavong T, Gronniger JT, Shi Y, Blackwell TK. A conserved transcription motif suggesting functional parallels between Caenorhabditis elegans SKN-1 and Cap'n'Collar-related basic leucine zipper proteins. J Biol Chem. 2000 Jul 21; 275(29):22166-71. PMID: 10764775.
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  77. Johnson BA, Geha M, Blackwell TK. Similar but distinct effects of the tristetraprolin/TIS11 immediate-early proteins on cell survival. Oncogene. 2000 Mar 23; 19(13):1657-64. PMID: 10763822.
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  78. Kophengnavong T, Michnowicz JE, Blackwell TK. Establishment of distinct MyoD, E2A, and twist DNA binding specificities by different basic region-DNA conformations. Mol Cell Biol. 2000 Jan; 20(1):261-72. PMID: 10594029; PMCID: PMC85082.
  79. Kophengnavong T, Carroll AS, Blackwell TK. The SKN-1 amino-terminal arm is a DNA specificity segment. Mol Cell Biol. 1999 Apr; 19(4):3039-50. PMID: 10082571; PMCID: PMC84098.
  80. De J, Lai WS, Thorn JM, Goldsworthy SM, Liu X, Blackwell TK, Blackshear PJ. Identification of four CCCH zinc finger proteins in Xenopus, including a novel vertebrate protein with four zinc fingers and severely restricted expression. Gene. 1999 Mar 04; 228(1-2):133-45. PMID: 10072766.
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  81. Batchelder C, Dunn MA, Choy B, Suh Y, Cassie C, Shim EY, Shin TH, Mello C, Seydoux G, Blackwell TK. Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1. Genes Dev. 1999 Jan 15; 13(2):202-12. PMID: 9925644; PMCID: PMC316391.
  82. Carroll AS, Gilbert DE, Liu X, Cheung JW, Michnowicz JE, Wagner G, Ellenberger TE, Blackwell TK. SKN-1 domain folding and basic region monomer stabilization upon DNA binding. Genes Dev. 1997 Sep 01; 11(17):2227-38. PMID: 9303538; PMCID: PMC275399.
  83. Huang J, Blackwell TK, Kedes L, Weintraub H. Differences between MyoD DNA binding and activation site requirements revealed by functional random sequence selection. Mol Cell Biol. 1996 Jul; 16(7):3893-900. PMID: 8668207; PMCID: PMC231386.
  84. Lansford R, Okada A, Chen J, Oltz EM, Blackwell TK, Alt FW, Rathbun G. . Mechanism and control of immunoglobulin gene rearrangement. Frontiers in Molecular Immunology. Hames BD, Glover DM, editors. 1996; 1-100.
  85. Blackwell TK. Selection of protein binding sites from random nucleic acid sequences. Methods Enzymol. 1995; 254:604-18. PMID: 8531718.
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  86. Blackwell TK, Bowerman B, Priess JR, Weintraub H. Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements. Science. 1994 Oct 28; 266(5185):621-8. PMID: 7939715.
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  87. Young F, Ardman B, Shinkai Y, Lansford R, Blackwell TK, Mendelsohn M, Rolink A, Melchers F, Alt FW. Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation. Genes Dev. 1994 May 01; 8(9):1043-57. PMID: 7926786.
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  88. Blackwell TK, Huang J, Ma A, Kretzner L, Alt FW, Eisenman RN, Weintraub H. Binding of myc proteins to canonical and noncanonical DNA sequences. Mol Cell Biol. 1993 Sep; 13(9):5216-24. PMID: 8395000; PMCID: PMC360210.
  89. Ma A, Moroy T, Collum R, Weintraub H, Alt FW, Blackwell TK. DNA binding by N- and L-Myc proteins. Oncogene. 1993 Apr; 8(4):1093-8. PMID: 8455937.
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  90. Starovasnik MA, Blackwell TK, Laue TM, Weintraub H, Klevit RE. Folding topology of the disulfide-bonded dimeric DNA-binding domain of the myogenic determination factor MyoD. Biochemistry. 1992 Oct 20; 31(41):9891-903. PMID: 1327135.
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  91. Bailey NC, Kasturi KN, Blackwell TK, Alt FW, Bona CA. Complexity of the immunoglobulin light chain V kappa 1 gene family in the New Zealand black mouse. Int Immunol. 1991 Aug; 3(8):751-60. PMID: 1911544.
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  92. Weintraub H, Davis R, Tapscott S, Thayer M, Krause M, Benezra R, Blackwell TK, Turner D, Rupp R, Hollenberg S, et al. The myoD gene family: nodal point during specification of the muscle cell lineage. Science. 1991 Feb 15; 251(4995):761-6. PMID: 1846704.
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  93. Blackwell TK, Weintraub H. Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection. Science. 1990 Nov 23; 250(4984):1104-10. PMID: 2174572.
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  94. Blackwell TK, Kretzner L, Blackwood EM, Eisenman RN, Weintraub H. Sequence-specific DNA binding by the c-Myc protein. Science. 1990 Nov 23; 250(4984):1149-51. PMID: 2251503.
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  95. Ferrier P, Covey LR, Li SC, Suh H, Malynn BA, Blackwell TK, Morrow MA, Alt FW. Normal recombination substrate VH to DJH rearrangements in pre-B cell lines from scid mice. J Exp Med. 1990 Jun 01; 171(6):1909-18. PMID: 2112584; PMCID: PMC2187946.
  96. Ferrier P, Krippl B, Blackwell TK, Furley AJ, Suh H, Winoto A, Cook WD, Hood L, Costantini F, Alt FW. Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate. EMBO J. 1990 Jan; 9(1):117-25. PMID: 2153073; PMCID: PMC551637.
  97. Blackwell TK, Alt FW. Molecular characterization of the lymphoid V(D)J recombination activity. J Biol Chem. 1989 Jun 25; 264(18):10327-30. PMID: 2499576.
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  98. Blackwell TK, Malynn BA, Pollock RR, Ferrier P, Covey LR, Fulop GM, Phillips RA, Yancopoulos GD, Alt FW. Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins. EMBO J. 1989 Mar; 8(3):735-42. PMID: 2785917; PMCID: PMC400869.
  99. Ferrier P, Krippl B, Furley AJ, Blackwell TK, Suh H, Mendelsohn M, Winoto A, Cook WD, Hood L, Costantini F, et al. Control of VDJ recombinase activity. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 1:191-202. PMID: 2517919.
    View in: PubMed
  100. Blackwell TK, Alt FW. Mechanism and developmental program of immunoglobulin gene rearrangement in mammals. Annu Rev Genet. 1989; 23:605-36. PMID: 2694945.
    View in: PubMed
  101. Blackwell TK, Ferrier P, Malynn BA, Pollock RR, Covey LR, Suh HY, Heinke LB, Fulop GM, Phillips RA, Yancopoulos GD, et al. The effect of the scid mutation on mechanism and control of immunoglobulin heavy and light chain gene rearrangement. Curr Top Microbiol Immunol. 1989; 152:85-94. PMID: 2805801.
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  102. Malynn BA, Blackwell TK, Fulop GM, Rathbun GA, Furley AJ, Ferrier P, Heinke LB, Phillips RA, Yancopoulos GD, Alt FW. The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism. Cell. 1988 Aug 12; 54(4):453-60. PMID: 3135938.
    View in: PubMed
  103. Blackwell TK, Alt FW. Immunoglobulin genes. Frontiers in Molecular Immunology. Hames BD, Glover D, editors. 1988; 1-60.
  104. Blackwell TK. Development and application of a novel system for investigating the mechanism and regulation of immunoglobulin gene assembly [dissertation]. 1988.
  105. Alt FW, Blackwell TK, Yancopoulos GD. Development of the primary antibody repertoire. Science. 1987 Nov 20; 238(4830):1079-87. PMID: 3317825.
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  106. Blackwell TK, Moore MW, Yancopoulos GD, Suh H, Lutzker S, Selsing E, Alt FW. Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature. 1986 Dec 11-17; 324(6097):585-9. PMID: 3491327.
    View in: PubMed
  107. Berman JE, Malynn BA, Blackwell TK, Alt FW. Regulation fo immunoglobulin variable region gene assembly: development of the primary antibody repertoire. Bioessays. 1986 Nov; 5(5):197-203. PMID: 3545193.
    View in: PubMed
  108. Alt FW, Reth MG, Blackwell TK, Yancopoulos GD. Regulation of immunoglobulin variable-region gene assembly. Mt Sinai J Med. 1986 Mar; 53(3):166-9. PMID: 3084957.
    View in: PubMed
  109. Alt FW, Blackwell TK, DePinho RA, Reth MG, Yancopoulos GD. Regulation of genome rearrangement events during lymphocyte differentiation. Immunol Rev. 1986 Feb; 89:5-30. PMID: 3081433.
    View in: PubMed
  110. Yancopoulos GD, Blackwell TK, Suh H, Hood L, Alt FW. Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase. Cell. 1986 Jan 31; 44(2):251-9. PMID: 3484682.
    View in: PubMed
  111. Alt FW, Blackwell TK, Yancopoulos GD. Immunoglobulin genes in transgenic mice. Trends in Genetics. 1985; 1:231-6.
  112. Alt FW, Yancopoulos GD, Blackwell TK, Wood C, Thomas E, Boss M, Coffman R, Rosenberg N, Tonegawa S, Baltimore D. Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J. 1984 Jun; 3(6):1209-19. PMID: 6086308; PMCID: PMC557501.
  113. Blackwell TK, Alt FW. Site-specific recombination between immunoglobulin D and JH segments that were introduced into the genome of a murine pre-B cell line. Cell. 1984 May; 37(1):105-12. PMID: 6327046.
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  114. Blackwell TK, Yancopoulos GD, Alt FW. Joining of immunoglobulin heavy chain variable region gene segments in vivo and within a recombination substrate. Molecular Biology of Development, UCLA Symp Mol Cell Biol, New Series. 1984; 19:537-47.
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