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T. Keith Blackwell, Ph.D., M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Blackwell TK, Sewell AK, Wu Z, Han M. TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging. Genetics. 2019 10; 213(2):329-360. PMID: 31594908.
    Citations:    
  2. Wu Z, Isik M, Moroz N, Steinbaugh MJ, Zhang P, Blackwell TK. Dietary Restriction Extends Lifespan through Metabolic Regulation of Innate Immunity. Cell Metab. 2019 05 07; 29(5):1192-1205.e8. PMID: 30905669.
    Citations:    
  3. Wu Z, Senchuk MM, Dues DJ, Johnson BK, Cooper JF, Lew L, Machiela E, Schaar CE, DeJonge H, Blackwell TK, Van Raamsdonk JM. Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways. BMC Biol. 2018 12 18; 16(1):147. PMID: 30563508.
    Citations:    Fields:    
  4. Burman A, Kropski JA, Calvi CL, Serezani AP, Pascoalino BD, Han W, Sherrill T, Gleaves L, Lawson WE, Young LR, Blackwell TS, Tanjore H. Localized hypoxia links ER stress to lung fibrosis through induction of C/EBP homologous protein. JCI Insight. 2018 08 23; 3(16). PMID: 30135303.
    Citations:    
  5. Burman A, Tanjore H, Blackwell TS. Endoplasmic reticulum stress in pulmonary fibrosis. Matrix Biol. 2018 08; 68-69:355-365. PMID: 29567124.
    Citations:    
  6. Lee G, Zheng Y, Cho S, Jang C, England C, Dempsey JM, Yu Y, Liu X, He L, Cavaliere PM, Chavez A, Zhang E, Isik M, Couvillon A, Dephoure NE, Blackwell TK, Yu JJ, Rabinowitz JD, Cantley LC, Blenis J. Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling. Cell. 2017 Dec 14; 171(7):1545-1558.e18. PMID: 29153836.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  7. Yoon DS, Choi Y, Cha DS, Zhang P, Choi SM, Alfhili MA, Polli JR, Pendergrass D, Taki FA, Kapalavavi B, Pan X, Zhang B, Blackwell TK, Lee JW, Lee MH. Triclosan Disrupts SKN-1/Nrf2-Mediated Oxidative Stress Response in C. elegans and Human Mesenchymal Stem Cells. Sci Rep. 2017 10 03; 7(1):12592. PMID: 28974696.
    Citations: 1     Fields:    
  8. Ewald CY, Castillo-Quan JI, Blackwell TK. Untangling Longevity, Dauer, and Healthspan in Caenorhabditis elegans Insulin/IGF-1-Signalling. Gerontology. 2018; 64(1):96-104. PMID: 28934747.
    Citations:    Fields:    Translation:AnimalsCells
  9. Ha Kim K, Sadikot RT, Yeon Lee J, Jeong HS, Oh YK, Blackwell TS, Joo M. Suppressed ubiquitination of Nrf2 by p47phox contributes to Nrf2 activation. Free Radic Biol Med. 2017 12; 113:48-58. PMID: 28939422.
    Citations:    
  10. Ewald CY, Hourihan JM, Blackwell TK. Oxidative Stress Assays (arsenite and tBHP) in Caenorhabditis elegans. Bio Protoc. 2017 Jul 05; 7(13). PMID: 29445761.
    Citations: 3     
  11. Ewald CY, Hourihan JM, Bland MS, Obieglo C, Katic I, Moronetti Mazzeo LE, Alcedo J, Blackwell TK, Hynes NE. NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans. Elife. 2017 01 13; 6. PMID: 28085666.
    Citations: 7     Fields:    Translation:AnimalsCells
  12. Castillo-Quan JI, Blackwell TK. Metformin: Restraining Nucleocytoplasmic Shuttling to Fight Cancer and Aging. Cell. 2016 12 15; 167(7):1670-1671. PMID: 27984715.
    Citations:    Fields:    Translation:HumansAnimals
  13. Isik M, Blackwell TK, Berezikov E. MicroRNA mir-34 provides robustness to environmental stress response via the DAF-16 network in C. elegans. Sci Rep. 2016 12 01; 6:36766. PMID: 27905558.
    Citations: 3     Fields:    Translation:Animals
  14. Hourihan JM, Moronetti Mazzeo LE, Fernández-Cárdenas LP, Blackwell TK. Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response. Mol Cell. 2016 08 18; 63(4):553-566. PMID: 27540856.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  15. Zhao YY, Blackwell T, Ensrud KE, Stone KL, Omachi TA, Redline S. Sleep Apnea and Obstructive Airway Disease in Older Men: Outcomes of Sleep Disorders in Older Men Study. Sleep. 2016 Jul 01; 39(7):1343-51. PMID: 27091524.
    Citations:    Fields:    Translation:Humans
  16. Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M. Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep. 2016 Feb 22; 6:21611. PMID: 26899496.
    Citations: 11     Fields:    Translation:AnimalsCells
  17. Steinbaugh MJ, Narasimhan SD, Robida-Stubbs S, Moronetti Mazzeo LE, Dreyfuss JM, Hourihan JM, Raghavan P, Operaña TN, Esmaillie R, Blackwell TK. Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence. Elife. 2015 Aug 24; 4. PMID: 26196144.
    Citations: 36     Fields:    Translation:AnimalsCells
  18. Winkelman JW, Blackwell T, Stone K, Ancoli-Israel S, Tranah GJ, Redline S. Genetic associations of periodic limb movements of sleep in the elderly for the MrOS sleep study. Sleep Med. 2015 Nov; 16(11):1360-1365. PMID: 26498236.
    Citations: 1     Fields:    Translation:Humans
  19. Blackwell TK, Steinbaugh MJ, Hourihan JM, Ewald CY, Isik M. SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans. Free Radic Biol Med. 2015 Nov; 88(Pt B):290-301. PMID: 26232625.
    Citations: 43     Fields:    Translation:Animals
  20. Aritake S, Blackwell T, Peters KW, Rueschman M, Mobley D, Morrical MG, Platt SF, Dam TT, Redline S, Winkelman JW. Prevalence and associations of respiratory-related leg movements: the MrOS sleep study. Sleep Med. 2015 Oct; 16(10):1236-44. PMID: 26429752.
    Citations: 3     Fields:    Translation:Humans
  21. Ewald CY, Landis JN, Porter Abate J, Murphy CT, Blackwell TK. Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity. Nature. 2015 Mar 05; 519(7541):97-101. PMID: 25517099.
    Citations: 41     Fields:    Translation:AnimalsCells
  22. Moroz N, Carmona JJ, Anderson E, Hart AC, Sinclair DA, Blackwell TK. Dietary restriction involves NAD? -dependent mechanisms and a shift toward oxidative metabolism. Aging Cell. 2014 Dec; 13(6):1075-85. PMID: 25257342.
    Citations: 25     Fields:    Translation:AnimalsCells
  23. Mizunuma M, Neumann-Haefelin E, Moroz N, Li Y, Blackwell TK. mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity. Aging Cell. 2014 Oct; 13(5):869-78. PMID: 25040785.
    Citations: 17     Fields:    Translation:AnimalsCells
  24. Stouch AN, Zaynagetdinov R, Barham WJ, Stinnett AM, Slaughter JC, Yull FE, Hoffman HM, Blackwell TS, Prince LS. I?B kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm. J Immunol. 2014 Aug 01; 193(3):1184-93. PMID: 24981452.
    Citations:    
  25. Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ. GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci U S A. 2014 Mar 11; 111(10):3781-6. PMID: 24556985.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  26. Patel SR, Hayes AL, Blackwell T, Evans DS, Ancoli-Israel S, Wing YK, Stone KL. The association between sleep patterns and obesity in older adults. Int J Obes (Lond). 2014 Sep; 38(9):1159-64. PMID: 24458262.
    Citations:    
  27. Sun X, He S, Wara AKM, Icli B, Shvartz E, Tesmenitsky Y, Belkin N, Li D, Blackwell TS, Sukhova GK, Croce K, Feinberg MW. Systemic delivery of microRNA-181b inhibits nuclear factor-?B activation, vascular inflammation, and atherosclerosis in apolipoprotein E-deficient mice. Circ Res. 2014 Jan 03; 114(1):32-40. PMID: 24084690.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  28. Glover-Cutter KM, Lin S, Blackwell TK. Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf. PLoS Genet. 2013; 9(9):e1003701. PMID: 24068940.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  29. Kim KH, Sadikot RT, Xiao L, Christman JW, Freeman ML, Chan JY, Oh YK, Blackwell TS, Joo M. Nrf2 is essential for the expression of lipocalin-prostaglandin D synthase induced by prostaglandin D2. Free Radic Biol Med. 2013 Dec; 65:1134-1142. PMID: 24029383.
    Citations:    
  30. Ruf V, Holzem C, Peyman T, Walz G, Blackwell TK, Neumann-Haefelin E. TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development. Dev Biol. 2013 Dec 15; 384(2):214-27. PMID: 23973804.
    Citations: 4     Fields:    Translation:AnimalsCells
  31. Barham W, Frump AL, Sherrill TP, Garcia CB, Saito-Diaz K, VanSaun MN, Fingleton B, Gleaves L, Orton D, Capecchi MR, Blackwell TS, Lee E, Yull F, Eid JE. Targeting the Wnt pathway in synovial sarcoma models. Cancer Discov. 2013 Nov; 3(11):1286-301. PMID: 23921231.
    Citations:    
  32. Carver BJ, Plosa EJ, Stinnett AM, Blackwell TS, Prince LS. Interactions between NF-?B and SP3 connect inflammatory signaling with reduced FGF-10 expression. J Biol Chem. 2013 May 24; 288(21):15318-25. PMID: 23558680.
    Citations:    
  33. Ishikado A, Sono Y, Matsumoto M, Robida-Stubbs S, Okuno A, Goto M, King GL, Keith Blackwell T, Makino T. Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans. Free Radic Biol Med. 2013 Dec; 65:1506-1515. PMID: 23277146.
    Citations: 11     Fields:    Translation:AnimalsCells
  34. Paek J, Lo JY, Narasimhan SD, Nguyen TN, Glover-Cutter K, Robida-Stubbs S, Suzuki T, Yamamoto M, Blackwell TK, Curran SP. Mitochondrial SKN-1/Nrf mediates a conserved starvation response. Cell Metab. 2012 Oct 03; 16(4):526-37. PMID: 23040073.
    Citations: 52     Fields:    Translation:AnimalsCells
  35. Mori MA, Raghavan P, Thomou T, Boucher J, Robida-Stubbs S, Macotela Y, Russell SJ, Kirkland JL, Blackwell TK, Kahn CR. Role of microRNA processing in adipose tissue in stress defense and longevity. Cell Metab. 2012 Sep 05; 16(3):336-47. PMID: 22958919.
    Citations: 63     Fields:    Translation:HumansAnimals
  36. Sun X, Icli B, Wara AK, Belkin N, He S, Kobzik L, Hunninghake GM, Vera MP, Blackwell TS, Baron RM, Feinberg MW. MicroRNA-181b regulates NF-?B-mediated vascular inflammation. J Clin Invest. 2012 Jun; 122(6):1973-90. PMID: 22622040.
    Citations: 144     Fields:    Translation:HumansAnimalsCells
  37. Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, Neumann-Haefelin E, Sabatini DM, Blackwell TK. TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 2012 May 02; 15(5):713-24. PMID: 22560223.
    Citations: 161     Fields:    Translation:AnimalsCells
  38. Segal BH, Grimm MJ, Khan AN, Han W, Blackwell TS. Regulation of innate immunity by NADPH oxidase. Free Radic Biol Med. 2012 Jul 01; 53(1):72-80. PMID: 22583699.
    Citations:    
  39. Arima Y, Harada M, Kamimura D, Park JH, Kawano F, Yull FE, Kawamoto T, Iwakura Y, Betz UA, Márquez G, Blackwell TS, Ohira Y, Hirano T, Murakami M. Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier. Cell. 2012 Feb 03; 148(3):447-57. PMID: 22304915.
    Citations:    
  40. Li X, Matilainen O, Jin C, Glover-Cutter KM, Holmberg CI, Blackwell TK. Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity. PLoS Genet. 2011 Jun; 7(6):e1002119. PMID: 21695230.
    Citations: 54     Fields:    Translation:AnimalsCells
  41. Dworski R, Han W, Blackwell TS, Hoskins A, Freeman ML. Vitamin E prevents NRF2 suppression by allergens in asthmatic alveolar macrophages in vivo. Free Radic Biol Med. 2011 Jul 15; 51(2):516-21. PMID: 21605660.
    Citations:    
  42. Wang J, Robida-Stubbs S, Tullet JM, Rual JF, Vidal M, Blackwell TK. RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition. PLoS Genet. 2010 Aug 05; 6(8). PMID: 20700440.
    Citations: 69     Fields:    Translation:AnimalsCells
  43. Tranah GJ, Blackwell T, Ancoli-Israel S, Paudel ML, Ensrud KE, Cauley JA, Redline S, Hillier TA, Cummings SR, Stone KL. Circadian activity rhythms and mortality: the study of osteoporotic fractures. J Am Geriatr Soc. 2010 Feb; 58(2):282-91. PMID: 20374404.
    Citations: 22     Fields:    Translation:Humans
  44. Blackwell T, Cawthon PM, Marshall LM, Brand R. Consistency of leg extension power assessments in older men: the Osteoporotic Fractures in Men (MrOS) Study. Am J Phys Med Rehabil. 2009 Nov; 88(11):934-40. PMID: 19893385.
    Citations: 4     Fields:    Translation:Humans
  45. Porter Abate J, Blackwell TK. Life is short, if sweet. Cell Metab. 2009 Nov; 10(5):338-9. PMID: 19883611.
    Citations: 4     Fields:    
  46. Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel AR. The protein kinase IKKepsilon regulates energy balance in obese mice. Cell. 2009 Sep 04; 138(5):961-75. PMID: 19737522.
    Citations:    
  47. Oliveira RP, Porter Abate J, Dilks K, Landis J, Ashraf J, Murphy CT, Blackwell TK. Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf. Aging Cell. 2009 09; 8(5):524-41. PMID: 19575768.
    Citations: 116     Fields:    Translation:AnimalsCells
  48. Rao MN, Blackwell T, Redline S, Stefanick ML, Ancoli-Israel S, Stone KL. Association between sleep architecture and measures of body composition. Sleep. 2009 Apr; 32(4):483-90. PMID: 19413142.
    Citations: 37     Fields:    Translation:Humans
  49. Hammell CM, Lubin I, Boag PR, Blackwell TK, Ambros V. nhl-2 Modulates microRNA activity in Caenorhabditis elegans. Cell. 2009 Mar 06; 136(5):926-38. PMID: 19269369.
    Citations: 70     Fields:    Translation:AnimalsCells
  50. Yaffe K, Weston AL, Blackwell T, Krueger KA. The metabolic syndrome and development of cognitive impairment among older women. Arch Neurol. 2009 Mar; 66(3):324-8. PMID: 19273750.
    Citations: 45     Fields:    Translation:Humans
  51. Oláhová M, Taylor SR, Khazaipoul S, Wang J, Morgan BA, Matsumoto K, Blackwell TK, Veal EA. A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):19839-44. PMID: 19064914.
    Citations: 47     Fields:    Translation:AnimalsCells
  52. Blackwell TK, Walker AK. OMA-gosh, where's that TAF? Cell. 2008 Oct 03; 135(1):18-20. PMID: 18854150.
    Citations:    Fields:    Translation:AnimalsCells
  53. Stone KL, Ancoli-Israel S, Blackwell T, Ensrud KE, Cauley JA, Redline S, Hillier TA, Schneider J, Claman D, Cummings SR. Actigraphy-measured sleep characteristics and risk of falls in older women. Arch Intern Med. 2008 Sep 08; 168(16):1768-75. PMID: 18779464.
    Citations: 43     Fields:    Translation:Humans
  54. Gartner A, Boag PR, Blackwell TK. Germline survival and apoptosis. WormBook. 2008 Sep 04; 1-20. PMID: 18781708.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  55. Boag PR, Atalay A, Robida S, Reinke V, Blackwell TK. Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis. J Cell Biol. 2008 Aug 11; 182(3):543-57. PMID: 18695045.
    Citations: 58     Fields:    Translation:AnimalsCells
  56. Barnes DE, Blackwell T, Stone KL, Goldman SE, Hillier T, Yaffe K. Cognition in older women: the importance of daytime movement. J Am Geriatr Soc. 2008 Sep; 56(9):1658-64. PMID: 18662201.
    Citations: 27     Fields:    Translation:Humans
  57. Lawson WE, Crossno PF, Polosukhin VV, Roldan J, Cheng DS, Lane KB, Blackwell TR, Xu C, Markin C, Ware LB, Miller GG, Loyd JE, Blackwell TS. Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6):L1119-26. PMID: 18390830.
    Citations:    
  58. Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Liu S, Oliveira RP, Baumeister R, Blackwell TK. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell. 2008 Mar 21; 132(6):1025-38. PMID: 18358814.
    Citations: 293     Fields:    Translation:AnimalsCells
  59. Blackwell T, Redline S, Ancoli-Israel S, Schneider JL, Surovec S, Johnson NL, Cauley JA, Stone KL. Comparison of sleep parameters from actigraphy and polysomnography in older women: the SOF study. Sleep. 2008 Feb; 31(2):283-91. PMID: 18274276.
    Citations: 58     Fields:    Translation:Humans
  60. Tager AM, LaCamera P, Shea BS, Campanella GS, Selman M, Zhao Z, Polosukhin V, Wain J, Karimi-Shah BA, Kim ND, Hart WK, Pardo A, Blackwell TS, Xu Y, Chun J, Luster AD. The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat Med. 2008 Jan; 14(1):45-54. PMID: 18066075.
    Citations: 200     Fields:    Translation:AnimalsCells
  61. Salinas LS, Maldonado E, Macías-Silva M, Blackwell TK, Navarro RE. The DEAD box RNA helicase VBH-1 is required for germ cell function in C. elegans. Genesis. 2007 Sep; 45(9):533-46. PMID: 17868112.
    Citations: 11     Fields:    Translation:AnimalsCells
  62. Mehra R, Stone KL, Blackwell T, Ancoli Israel S, Dam TT, Stefanick ML, Redline S. Prevalence and correlates of sleep-disordered breathing in older men: osteoporotic fractures in men sleep study. J Am Geriatr Soc. 2007 Sep; 55(9):1356-64. PMID: 17767677.
    Citations: 51     Fields:    Translation:Humans
  63. Zhang H, Lawson WE, Polosukhin VV, Pozzi A, Blackwell TS, Litingtung Y, Chiang C. Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice. Am J Pathol. 2007 Oct; 171(4):1113-26. PMID: 17717145.
    Citations:    
  64. Yaffe K, Haan M, Blackwell T, Cherkasova E, Whitmer RA, West N. Metabolic syndrome and cognitive decline in elderly Latinos: findings from the Sacramento Area Latino Study of Aging study. J Am Geriatr Soc. 2007 May; 55(5):758-62. PMID: 17493197.
    Citations: 54     Fields:    Translation:Humans
  65. Huang A, Grady D, Blackwell T, Bauer D. Hot flushes, bone mineral density, and fractures in older postmenopausal women. Obstet Gynecol. 2007 Apr; 109(4):841-7. PMID: 17400844.
    Citations: 3     Fields:    Translation:Humans
  66. Walker AK, Boag PR, Blackwell TK. Transcription reactivation steps stimulated by oocyte maturation in C. elegans. Dev Biol. 2007 Apr 01; 304(1):382-93. PMID: 17291483.
    Citations: 17     Fields:    Translation:AnimalsCells
  67. Claman DM, Redline S, Blackwell T, Ancoli-Israel S, Surovec S, Scott N, Cauley JA, Ensrud KE, Stone KL. Prevalence and correlates of periodic limb movements in older women. J Clin Sleep Med. 2006 Oct 15; 2(4):438-45. PMID: 17557474.
    Citations: 20     Fields:    Translation:Humans
  68. Blackwell TK, Walker AK. Transcription mechanisms. WormBook. 2006 Sep 05; 1-16. PMID: 18050436.
    Citations: 7     Fields:    Translation:AnimalsCells
  69. Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villén J, Becker EB, DiBacco S, de la Iglesia N, Gygi S, Blackwell TK, Bonni A. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell. 2006 Jun 02; 125(5):987-1001. PMID: 16751106.
    Citations: 281     Fields:    Translation:AnimalsCells
  70. Everhart MB, Han W, Sherrill TP, Arutiunov M, Polosukhin VV, Burke JR, Sadikot RT, Christman JW, Yull FE, Blackwell TS. Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury. J Immunol. 2006 Apr 15; 176(8):4995-5005. PMID: 16585596.
    Citations:    
  71. Blackwell T, Yaffe K, Ancoli-Israel S, Schneider JL, Cauley JA, Hillier TA, Fink HA, Stone KL. Poor sleep is associated with impaired cognitive function in older women: the study of osteoporotic fractures. J Gerontol A Biol Sci Med Sci. 2006 Apr; 61(4):405-10. PMID: 16611709.
    Citations: 95     Fields:    Translation:Humans
  72. Blackwell T, Ancoli-Israel S, Gehrman PR, Schneider JL, Pedula KL, Stone KL. Actigraphy scoring reliability in the study of osteoporotic fractures. Sleep. 2005 Dec; 28(12):1599-605. PMID: 16408420.
    Citations: 43     Fields:    Translation:Humans
  73. An JH, Vranas K, Lucke M, Inoue H, Hisamoto N, Matsumoto K, Blackwell TK. Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3. Proc Natl Acad Sci U S A. 2005 Nov 08; 102(45):16275-80. PMID: 16251270.
    Citations: 78     Fields:    Translation:AnimalsCells
  74. Boag PR, Nakamura A, Blackwell TK. A conserved RNA-protein complex component involved in physiological germline apoptosis regulation in C. elegans. Development. 2005 Nov; 132(22):4975-86. PMID: 16221731.
    Citations: 57     Fields:    Translation:AnimalsCells
  75. Inoue H, Hisamoto N, An JH, Oliveira RP, Nishida E, Blackwell TK, Matsumoto K. The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev. 2005 Oct 01; 19(19):2278-83. PMID: 16166371.
    Citations: 123     Fields:    Translation:AnimalsCells
  76. Navarro RE, Blackwell TK. Requirement for P granules and meiosis for accumulation of the germline RNA helicase CGH-1. Genesis. 2005 Jul; 42(3):172-80. PMID: 15986473.
    Citations: 10     Fields:    Translation:AnimalsCells
  77. Antoniucci DM, Vittinghoff E, Blackwell T, Black DM, Sellmeyer DE. Vitamin D insufficiency does not affect bone mineral density response to raloxifene. J Clin Endocrinol Metab. 2005 Aug; 90(8):4566-72. PMID: 15899959.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  78. Yaffe K, Krueger K, Cummings SR, Blackwell T, Henderson VW, Sarkar S, Ensrud K, Grady D. Effect of raloxifene on prevention of dementia and cognitive impairment in older women: the Multiple Outcomes of Raloxifene Evaluation (MORE) randomized trial. Am J Psychiatry. 2005 Apr; 162(4):683-90. PMID: 15800139.
    Citations: 38     Fields:    Translation:HumansCTClinical Trials
  79. Everhart MB, Han W, Parman KS, Polosukhin VV, Zeng H, Sadikot RT, Li B, Yull FE, Christman JW, Blackwell TS. Intratracheal administration of liposomal clodronate accelerates alveolar macrophage reconstitution following fetal liver transplantation. J Leukoc Biol. 2005 Feb; 77(2):173-80. PMID: 15563581.
    Citations:    
  80. Blackwell, T. Keith. Laura Bush and Stem Cells, letter to the editor. The New York Times. 2004; 154(52970).
  81. Blackwell, T. K. and An, J. H. SKN-1 and GSK-3 Genes and Proteins. 2004.
  82. Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ, Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M, Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP, Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch AG, Holmberg S, Holstege FC, Jaehning JA, Kim YJ, Kuras L, Leutz A, Lis JT, Meisterernest M, Naar AM, Nasmyth K, Parvin JD, Ptashne M, Reinberg D, Ronne H, Sadowski I, Sakurai H, Sipiczki M, Sternberg PW, Stillman DJ, Strich R, Struhl K, Svejstrup JQ, Tuck S, Winston F, Roeder RG, Kornberg RD. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell. 2004 Jun 04; 14(5):553-7. PMID: 15175151.
    Citations: 99     Fields:    
  83. Wang JC, Walker A, Blackwell TK, Yamamoto KR. The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis. J Biol Chem. 2004 Jul 09; 279(28):29270-7. PMID: 15073178.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  84. Blackwell TK. Germ cells: finding programs of mass repression. Curr Biol. 2004 Mar 23; 14(6):R229-30. PMID: 15043831.
    Citations: 9     Fields:    Translation:AnimalsCells
  85. Stoecklin G, Stubbs T, Kedersha N, Wax S, Rigby WF, Blackwell TK, Anderson P. MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. EMBO J. 2004 Mar 24; 23(6):1313-24. PMID: 15014438.
    Citations: 206     Fields:    Translation:HumansAnimalsCells
  86. Walker AK, Shi Y, Blackwell TK. An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription. J Biol Chem. 2004 Apr 09; 279(15):15339-47. PMID: 14726532.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  87. Blackwell TK, Walker AK. Transcription elongation: TLKing to chromatin? Curr Biol. 2003 Dec 02; 13(23):R915-6. PMID: 14654017.
    Citations: 3     Fields:    Translation:AnimalsCells
  88. Shi Y, Blackwell TK. A two-tiered transcription regulation mechanism that protects germ cell identity. Mol Cell. 2003 Nov; 12(5):1062-4. PMID: 14636565.
    Citations:    Fields:    Translation:AnimalsCells
  89. An JH, Blackwell TK. SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev. 2003 Aug 01; 17(15):1882-93. PMID: 12869585.
    Citations: 214     Fields:    Translation:AnimalsCells
  90. Tice JA, Ettinger B, Ensrud K, Wallace R, Blackwell T, Cummings SR. Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) Study: a randomized controlled trial. JAMA. 2003 Jul 09; 290(2):207-14. PMID: 12851275.
    Citations: 31     Fields:    Translation:HumansAnimalsCTClinical Trials
  91. Zhang F, Barboric M, Blackwell TK, Peterlin BM. A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb. Genes Dev. 2003 Mar 15; 17(6):748-58. PMID: 12651893.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  92. Takagi T, Walker AK, Sawa C, Diehn F, Takase Y, Blackwell TK, Buratowski S. The Caenorhabditis elegans mRNA 5'-capping enzyme. In vitro and in vivo characterization. J Biol Chem. 2003 Apr 18; 278(16):14174-84. PMID: 12576476.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  93. Walker AK, Blackwell TK. A broad but restricted requirement for TAF-5 (human TAFII100) for embryonic transcription in Caenorhabditis elegans. J Biol Chem. 2003 Feb 21; 278(8):6181-6. PMID: 12458202.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  94. Shim EY, Walker AK, Shi Y, Blackwell TK. CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo. Genes Dev. 2002 Aug 15; 16(16):2135-46. PMID: 12183367.
    Citations: 81     Fields:    Translation:AnimalsCells
  95. Shim EY, Walker AK, Blackwell TK. Broad requirement for the mediator subunit RGR-1 for transcription in the Caenorhabditis elegans embryo. J Biol Chem. 2002 Aug 23; 277(34):30413-6. PMID: 12089139.
    Citations: 7     Fields:    Translation:AnimalsCells
  96. Johnson BA, Blackwell TK. Multiple tristetraprolin sequence domains required to induce apoptosis and modulate responses to TNFalpha through distinct pathways. Oncogene. 2002 Jun 20; 21(27):4237-46. PMID: 12082611.
    Citations: 22     Fields:    Translation:AnimalsCells
  97. Blackwell TK, Walker AK. Getting the right dose of repression. Genes Dev. 2002 Apr 01; 16(7):769-72. PMID: 11937484.
    Citations:    Fields:    Translation:AnimalsCells
  98. Johnson BA, Stehn JR, Yaffe MB, Blackwell TK. Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms. J Biol Chem. 2002 May 17; 277(20):18029-36. PMID: 11886850.
    Citations: 53     Fields:    Translation:AnimalsCells
  99. Walker AK, Rothman JH, Shi Y, Blackwell TK. Distinct requirements for C.elegans TAF(II)s in early embryonic transcription. EMBO J. 2001 Sep 17; 20(18):5269-79. PMID: 11566890.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  100. Navarro RE, Shim EY, Kohara Y, Singson A, Blackwell TK. cgh-1, a conserved predicted RNA helicase required for gametogenesis and protection from physiological germline apoptosis in C. elegans. Development. 2001 Sep; 128(17):3221-32. PMID: 11546739.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  101. Johnson BA, Yaffe M, Blackwell TK. Molecular Analysis of TTP, a Key Regulator of TNF Activity. ScientificWorldJournal. 2001; 1:38. PMID: 30147482.
    Citations:    Fields:    
  102. Johnson B, Yaffe M, Blackwell TK. . Molecular analysis of TTP, a key regulator of TNF activity. Scientific World Journal. 2001; 1(Suppl 3):38.
  103. Walker AK, See R, Batchelder C, Kophengnavong T, Gronniger JT, Shi Y, Blackwell TK. A conserved transcription motif suggesting functional parallels between Caenorhabditis elegans SKN-1 and Cap'n'Collar-related basic leucine zipper proteins. J Biol Chem. 2000 Jul 21; 275(29):22166-71. PMID: 10764775.
    Citations: 25     Fields:    Translation:AnimalsCells
  104. Johnson BA, Geha M, Blackwell TK. Similar but distinct effects of the tristetraprolin/TIS11 immediate-early proteins on cell survival. Oncogene. 2000 Mar 23; 19(13):1657-64. PMID: 10763822.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  105. Kophengnavong T, Michnowicz JE, Blackwell TK. Establishment of distinct MyoD, E2A, and twist DNA binding specificities by different basic region-DNA conformations. Mol Cell Biol. 2000 Jan; 20(1):261-72. PMID: 10594029.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  106. Kophengnavong T, Carroll AS, Blackwell TK. The SKN-1 amino-terminal arm is a DNA specificity segment. Mol Cell Biol. 1999 Apr; 19(4):3039-50. PMID: 10082571.
    Citations: 11     Fields:    Translation:AnimalsCells
  107. De J, Lai WS, Thorn JM, Goldsworthy SM, Liu X, Blackwell TK, Blackshear PJ. Identification of four CCCH zinc finger proteins in Xenopus, including a novel vertebrate protein with four zinc fingers and severely restricted expression. Gene. 1999 Mar 04; 228(1-2):133-45. PMID: 10072766.
    Citations: 16     Fields:    Translation:AnimalsCells
  108. Batchelder C, Dunn MA, Choy B, Suh Y, Cassie C, Shim EY, Shin TH, Mello C, Seydoux G, Blackwell TK. Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1. Genes Dev. 1999 Jan 15; 13(2):202-12. PMID: 9925644.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  109. Carroll AS, Gilbert DE, Liu X, Cheung JW, Michnowicz JE, Wagner G, Ellenberger TE, Blackwell TK. SKN-1 domain folding and basic region monomer stabilization upon DNA binding. Genes Dev. 1997 Sep 01; 11(17):2227-38. PMID: 9303538.
    Citations: 14     Fields:    Translation:AnimalsCells
  110. Huang J, Blackwell TK, Kedes L, Weintraub H. Differences between MyoD DNA binding and activation site requirements revealed by functional random sequence selection. Mol Cell Biol. 1996 Jul; 16(7):3893-900. PMID: 8668207.
    Citations: 14     Fields:    Translation:AnimalsCells
  111. Lansford R, Okada A, Chen J, Oltz EM, Blackwell TK, Alt FW, Rathbun G. . Mechanism and control of immunoglobulin gene rearrangement. Frontiers in Molecular Immunology. Hames BD, Glover DM, editors. 1996; 1-100.
  112. Blackwell TK. Selection of protein binding sites from random nucleic acid sequences. Methods Enzymol. 1995; 254:604-18. PMID: 8531718.
    Citations: 11     Fields:    Translation:Cells
  113. Blackwell TK, Bowerman B, Priess JR, Weintraub H. Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements. Science. 1994 Oct 28; 266(5185):621-8. PMID: 7939715.
    Citations: 59     Fields:    Translation:AnimalsCells
  114. Young F, Ardman B, Shinkai Y, Lansford R, Blackwell TK, Mendelsohn M, Rolink A, Melchers F, Alt FW. Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation. Genes Dev. 1994 May 01; 8(9):1043-57. PMID: 7926786.
    Citations: 53     Fields:    Translation:AnimalsCells
  115. Blackwell TK, Huang J, Ma A, Kretzner L, Alt FW, Eisenman RN, Weintraub H. Binding of myc proteins to canonical and noncanonical DNA sequences. Mol Cell Biol. 1993 Sep; 13(9):5216-24. PMID: 8395000.
    Citations: 127     Fields:    Translation:AnimalsCells
  116. Ma A, Moroy T, Collum R, Weintraub H, Alt FW, Blackwell TK. DNA binding by N- and L-Myc proteins. Oncogene. 1993 Apr; 8(4):1093-8. PMID: 8455937.
    Citations: 11     Fields:    Translation:AnimalsCells
  117. Starovasnik MA, Blackwell TK, Laue TM, Weintraub H, Klevit RE. Folding topology of the disulfide-bonded dimeric DNA-binding domain of the myogenic determination factor MyoD. Biochemistry. 1992 Oct 20; 31(41):9891-903. PMID: 1327135.
    Citations: 9     Fields:    Translation:AnimalsCells
  118. Bailey NC, Kasturi KN, Blackwell TK, Alt FW, Bona CA. Complexity of the immunoglobulin light chain V kappa 1 gene family in the New Zealand black mouse. Int Immunol. 1991 Aug; 3(8):751-60. PMID: 1911544.
    Citations: 4     Fields:    Translation:AnimalsCells
  119. Weintraub H, Davis R, Tapscott S, Thayer M, Krause M, Benezra R, Blackwell TK, Turner D, Rupp R, Hollenberg S, et al. The myoD gene family: nodal point during specification of the muscle cell lineage. Science. 1991 Feb 15; 251(4995):761-6. PMID: 1846704.
    Citations: 388     Fields:    Translation:HumansAnimals
  120. Blackwell TK, Weintraub H. Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection. Science. 1990 Nov 23; 250(4984):1104-10. PMID: 2174572.
    Citations: 334     Fields:    Translation:Cells
  121. Blackwell TK, Kretzner L, Blackwood EM, Eisenman RN, Weintraub H. Sequence-specific DNA binding by the c-Myc protein. Science. 1990 Nov 23; 250(4984):1149-51. PMID: 2251503.
    Citations: 282     Fields:    Translation:Cells
  122. Ferrier P, Covey LR, Li SC, Suh H, Malynn BA, Blackwell TK, Morrow MA, Alt FW. Normal recombination substrate VH to DJH rearrangements in pre-B cell lines from scid mice. J Exp Med. 1990 Jun 01; 171(6):1909-18. PMID: 2112584.
    Citations: 14     Fields:    Translation:AnimalsCells
  123. Ferrier P, Krippl B, Blackwell TK, Furley AJ, Suh H, Winoto A, Cook WD, Hood L, Costantini F, Alt FW. Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate. EMBO J. 1990 Jan; 9(1):117-25. PMID: 2153073.
    Citations: 74     Fields:    Translation:AnimalsCells
  124. Blackwell TK, Alt FW. Molecular characterization of the lymphoid V(D)J recombination activity. J Biol Chem. 1989 Jun 25; 264(18):10327-30. PMID: 2499576.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  125. Blackwell TK, Malynn BA, Pollock RR, Ferrier P, Covey LR, Fulop GM, Phillips RA, Yancopoulos GD, Alt FW. Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins. EMBO J. 1989 Mar; 8(3):735-42. PMID: 2785917.
    Citations: 45     Fields:    Translation:AnimalsCells
  126. Ferrier P, Krippl B, Furley AJ, Blackwell TK, Suh H, Mendelsohn M, Winoto A, Cook WD, Hood L, Costantini F, et al. Control of VDJ recombinase activity. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 1:191-202. PMID: 2517919.
    Citations: 5     Fields:    Translation:Animals
  127. Blackwell TK, Alt FW. Mechanism and developmental program of immunoglobulin gene rearrangement in mammals. Annu Rev Genet. 1989; 23:605-36. PMID: 2694945.
    Citations: 47     Fields:    Translation:AnimalsCells
  128. Blackwell TK, Ferrier P, Malynn BA, Pollock RR, Covey LR, Suh HY, Heinke LB, Fulop GM, Phillips RA, Yancopoulos GD, et al. The effect of the scid mutation on mechanism and control of immunoglobulin heavy and light chain gene rearrangement. Curr Top Microbiol Immunol. 1989; 152:85-94. PMID: 2805801.
    Citations: 4     Fields:    Translation:AnimalsCells
  129. Malynn BA, Blackwell TK, Fulop GM, Rathbun GA, Furley AJ, Ferrier P, Heinke LB, Phillips RA, Yancopoulos GD, Alt FW. The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism. Cell. 1988 Aug 12; 54(4):453-60. PMID: 3135938.
    Citations: 80     Fields:    Translation:AnimalsCells
  130. Blackwell TK, Alt FW. Immunoglobulin genes. Frontiers in Molecular Immunology. Hames BD, Glover D, editors. 1988; 1-60.
  131. Blackwell TK. Development and application of a novel system for investigating the mechanism and regulation of immunoglobulin gene assembly [dissertation]. 1988.
  132. Alt FW, Blackwell TK, Yancopoulos GD. Development of the primary antibody repertoire. Science. 1987 Nov 20; 238(4830):1079-87. PMID: 3317825.
    Citations: 158     Fields:    Translation:HumansAnimalsCells
  133. Blackwell TK, Moore MW, Yancopoulos GD, Suh H, Lutzker S, Selsing E, Alt FW. Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature. 1986 Dec 11-17; 324(6097):585-9. PMID: 3491327.
    Citations: 127     Fields:    Translation:AnimalsCells
  134. Berman JE, Malynn BA, Blackwell TK, Alt FW. Regulation fo immunoglobulin variable region gene assembly: development of the primary antibody repertoire. Bioessays. 1986 Nov; 5(5):197-203. PMID: 3545193.
    Citations: 1     Fields:    Translation:AnimalsCells
  135. Alt FW, Reth MG, Blackwell TK, Yancopoulos GD. Regulation of immunoglobulin variable-region gene assembly. Mt Sinai J Med. 1986 Mar; 53(3):166-9. PMID: 3084957.
    Citations: 1     Fields:    Translation:AnimalsCells
  136. Alt FW, Blackwell TK, DePinho RA, Reth MG, Yancopoulos GD. Regulation of genome rearrangement events during lymphocyte differentiation. Immunol Rev. 1986 Feb; 89:5-30. PMID: 3081433.
    Citations: 122     Fields:    Translation:AnimalsCells
  137. Yancopoulos GD, Blackwell TK, Suh H, Hood L, Alt FW. Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase. Cell. 1986 Jan 31; 44(2):251-9. PMID: 3484682.
    Citations: 127     Fields:    Translation:AnimalsCells
  138. Alt FW, Blackwell TK, Yancopoulos GD. Immunoglobulin genes in transgenic mice. Trends in Genetics. 1985; 1:231-6.
  139. Alt FW, Yancopoulos GD, Blackwell TK, Wood C, Thomas E, Boss M, Coffman R, Rosenberg N, Tonegawa S, Baltimore D. Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J. 1984 Jun; 3(6):1209-19. PMID: 6086308.
    Citations: 234     Fields:    Translation:HumansAnimalsCells
  140. Blackwell TK, Alt FW. Site-specific recombination between immunoglobulin D and JH segments that were introduced into the genome of a murine pre-B cell line. Cell. 1984 May; 37(1):105-12. PMID: 6327046.
    Citations: 23     Fields:    Translation:AnimalsCells
  141. Blackwell TK, Yancopoulos GD, Alt FW. Joining of immunoglobulin heavy chain variable region gene segments in vivo and within a recombination substrate. Molecular Biology of Development, UCLA Symp Mol Cell Biol, New Series. 1984; 19:537-47.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.