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Elaine A. Elion, Ph.D.


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  1. R01GM046962 (ELION, ELAINE A.) Aug 1, 1992 - Jul 31, 2010
    Cell Cycle Arrest and Signal Transduction in Yeast
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hu Z, Wang Y, Yu L, Mahanty SK, Mendoza N, Elion EA. Mapping regions in Ste5 that support Msn5-dependent and -independent nuclear export. Biochem Cell Biol. 2016 Apr; 94(2):109-28. PMID: 26824509.
    Citations: 1     Fields:    Translation:AnimalsCells
  2. Elion EA. MAP Kinase Modules in Signaling, Biomedical Sciences - Cancer and Endocrine Diseases, in the section Pathobiology of Cancer and Neoplasia, pp1-30 Michael Caplan, editor. Elsevier, Inc., Waltham, MA in press. 2015.
  3. Wang X, Sheff MA, Simpson DM, Elion EA. Ste11p MEKK signals through HOG, mating, calcineurin and PKC pathways to regulate the FKS2 gene. BMC Mol Biol. 2011 Nov 24; 12:51. PMID: 22114773.
    Citations: 4     Fields:    Translation:AnimalsCells
  4. Elion EA, Sahoo R. Analysis of mitogen-activated protein kinase activity in yeast. Methods Mol Biol. 2010; 661:387-99. PMID: 20811996.
    Citations: 2     Fields:    Translation:Animals
  5. Yu L, Qi M, Sheff MA, Elion EA. Counteractive control of polarized morphogenesis during mating by mitogen-activated protein kinase Fus3 and G1 cyclin-dependent kinase. Mol Biol Cell. 2008 Apr; 19(4):1739-52. PMID: 18256288; PMCID: PMC2291402.
    Citations: 18     Fields:    Translation:AnimalsCells
  6. Sahoo R, Husain A and Elion EA. MAP kinase in yeast. Handbook of Cellular Signaling, Bradshaw R. and Dennis E, editors, T. Hunter T and Scott JD, associate editors. Academic Press. 2008.
  7. Elion EA. Detection of protein-protein interactions by coprecipitation. Curr Protoc Protein Sci. 2007 Aug; Chapter 19:19.4.1-19.4.10. PMID: 18429314.
    Citations: 1     Fields:    Translation:Cells
  8. Elion EA, Marina P, Yu L. Constructing recombinant DNA molecules by PCR. Curr Protoc Mol Biol. 2007 Apr; Chapter 3:Unit 3.17. PMID: 18265404.
    Citations: 4     Fields:    Translation:Animals
  9. Elion EA. Detection of protein-protein interactions by coprecipitation. Curr Protoc Immunol. 2007 Feb; Chapter 8:8.7.1-8.7.10. PMID: 18432998.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  10. Elion EA. Detection of protein-protein interactions by coprecipitation. Curr Protoc Mol Biol. 2006 Nov; Chapter 20:Unit20.5. PMID: 18265378.
    Citations: 1     Fields:    Translation:HumansAnimals
  11. Elion EA. Methods for analyzing MAPK cascades. Methods. 2006 Nov; 40(3):207-8. PMID: 17071405.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  12. Elion EA. Detection of protein-protein interactions by coprecipitation. Curr Protoc Neurosci. 2006 May; Chapter 5:Unit 5.25. PMID: 18428641.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Qi M, Elion EA. MAP kinase pathways. J Cell Sci. 2005 Aug 15; 118(Pt 16):3569-72. PMID: 16105880.
    Citations: 198     Fields:    Translation:HumansAnimalsCells
  14. Qi M, Elion EA. Formin-induced actin cables are required for polarized recruitment of the Ste5 scaffold and high level activation of MAPK Fus3. J Cell Sci. 2005 Jul 01; 118(Pt 13):2837-48. PMID: 15961405.
    Citations: 17     Fields:    Translation:AnimalsCells
  15. Elion EA, Qi M, Chen W. Signal transduction. Signaling specificity in yeast. Science. 2005 Feb 04; 307(5710):687-8. PMID: 15692041.
    Citations: 21     Fields:    Translation:AnimalsCells
  16. Wang Y, Chen W, Simpson DM, Elion EA. Cdc24 regulates nuclear shuttling and recruitment of the Ste5 scaffold to a heterotrimeric G protein in Saccharomyces cerevisiae. J Biol Chem. 2005 Apr 01; 280(13):13084-96. PMID: 15657049.
    Citations: 8     Fields:    Translation:AnimalsCells
  17. Flotho A, Simpson DM, Qi M, Elion EA. Localized feedback phosphorylation of Ste5p scaffold by associated MAPK cascade. J Biol Chem. 2004 Nov 05; 279(45):47391-401. PMID: 15322134.
    Citations: 11     Fields:    Translation:AnimalsCells
  18. Andersson J, Simpson DM, Qi M, Wang Y, Elion EA. Differential input by Ste5 scaffold and Msg5 phosphatase route a MAPK cascade to multiple outcomes. EMBO J. 2004 Jul 07; 23(13):2564-76. PMID: 15192700; PMCID: PMC449765.
    Citations: 36     Fields:    Translation:AnimalsCells
  19. Elion EA. Co-precipitating proteins. For: Signal Transduction Protocols in Methods in Molecular Biology, R.C. Dickson RC and Mendenhall MD, editors. Human Press. 2004.
  20. Elion EA, Wang Y. Making protein immunoprecipitates. Methods Mol Biol. 2004; 284:1-14. PMID: 15173605.
    Citations: 2     Fields:    Translation:AnimalsCells
  21. Cherkasova VA, McCully R, Wang Y, Hinnebusch A, Elion EA. A novel functional link between MAP kinase cascades and the Ras/cAMP pathway that regulates survival. Curr Biol. 2003 Jul 15; 13(14):1220-6. PMID: 12867033.
    Citations: 14     Fields:    Translation:AnimalsCells
  22. Wang Y, Elion EA. Nuclear export and plasma membrane recruitment of the Ste5 scaffold are coordinated with oligomerization and association with signal transduction components. Mol Biol Cell. 2003 Jun; 14(6):2543-58. PMID: 12808050; PMCID: PMC194901.
    Citations: 15     Fields:    Translation:AnimalsCells
  23. Elion EA. MAP kinase in yeast. Handbook of Cellular Signaling, Bradshaw R. and Dennis E, editors, T. Hunter T and Scott JD, associate editors. Academic Press. 2003.
  24. Cherkasova V McCully R Wang Y Hinnebusch A and Elion EA. . A novel functional link between MAPKs and the Ras/cAMP pathway required for survival. Current Biology. 2003; (13):1214-1219.
  25. Elion EA. MAP Kinase Modules in Signaling; Encyclopedia of Cancer, Second Edition I. Biology of Cancer, Wang J, editor. San Diego, California: Academic Press. 2002.
  26. Elion EA. How to monitor nuclear shuttling. Methods Enzymol. 2002; 351:607-22. PMID: 12073371.
    Citations: 4     Fields:    Translation:Animals
  27. Elion EA. The Ste5p scaffold. J Cell Sci. 2001 Nov; 114(Pt 22):3967-78. PMID: 11739629.
    Citations: 91     Fields:    Translation:AnimalsCells
  28. Cherkasova V, Elion EA. far4, far5, and far6 define three genes required for efficient activation of MAPKs Fus3 and Kss1 and accumulation of glycogen. Curr Genet. 2001 Aug; 40(1):13-26. PMID: 11570512.
    Citations: 5     Fields:    Translation:AnimalsCells
  29. Elion EA. Pheromone response, mating and cell biology. Curr Opin Microbiol. 2000 Dec; 3(6):573-81. PMID: 11121776.
    Citations: 100     Fields:    Translation:AnimalsCells
  30. Elion EA. Co-precipitating proteins. Current Protocols in Molecular Biology, Ausubel,F, Brent R Kingston R, Moore D, Smith JA, Seidman J, Struhl K, editors.. Guilford, CT: Greene Publishing Associates and Wiley. 2000.
  31. Lee BN, Elion EA. The MAPKKK Ste11 regulates vegetative growth through a kinase cascade of shared signaling components. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12679-84. PMID: 10535982; PMCID: PMC23046.
    Citations: 53     Fields:    Translation:AnimalsCells
  32. Mahanty SK, Wang Y, Farley FW, Elion EA. Nuclear shuttling of yeast scaffold Ste5 is required for its recruitment to the plasma membrane and activation of the mating MAPK cascade. Cell. 1999 Aug 20; 98(4):501-12. PMID: 10481914.
    Citations: 56     Fields:    Translation:AnimalsCells
  33. Choi KY, Kranz JE, Mahanty SK, Park KS, Elion EA. Characterization of Fus3 localization: active Fus3 localizes in complexes of varying size and specific activity. Mol Biol Cell. 1999 May; 10(5):1553-68. PMID: 10233162; PMCID: PMC25340.
    Citations: 16     Fields:    Translation:AnimalsCells
  34. Farley FW, Satterberg B, Goldsmith EJ, Elion EA. Relative dependence of different outputs of the Saccharomyces cerevisiae pheromone response pathway on the MAP kinase Fus3p. Genetics. 1999 Apr; 151(4):1425-44. PMID: 10101167.
    Citations: 24     Fields:    Translation:AnimalsCells
  35. Cherkasova V, Lyons DM, Elion EA. Fus3p and Kss1p control G1 arrest in Saccharomyces cerevisiae through a balance of distinct arrest and proliferative functions that operate in parallel with Far1p. Genetics. 1999 Mar; 151(3):989-1004. PMID: 10049917.
    Citations: 23     Fields:    Translation:AnimalsCells
  36. Leza MA, Elion EA. POG1, a novel yeast gene, promotes recovery from pheromone arrest via the G1 cyclin CLN2. Genetics. 1999 Feb; 151(2):531-43. PMID: 9927449.
    Citations: 10     Fields:    Translation:Animals
  37. Elion EA. Routing MAP kinase cascades. Science. 1998 Sep 11; 281(5383):1625-6. PMID: 9767029.
    Citations: 36     Fields:    Translation:AnimalsCells
  38. Feng Y, Song LY, Kincaid E, Mahanty SK, Elion EA. Functional binding between Gbeta and the LIM domain of Ste5 is required to activate the MEKK Ste11. Curr Biol. 1998 Feb 26; 8(5):267-78. PMID: 9501067.
    Citations: 45     Fields:    Translation:AnimalsCells
  39. Hall JP, Cherkasova V, Elion E, Gustin MC, Winter E. The osmoregulatory pathway represses mating pathway activity in Saccharomyces cerevisiae: isolation of a FUS3 mutant that is insensitive to the repression mechanism. Mol Cell Biol. 1996 Dec; 16(12):6715-23. PMID: 8943326.
    Citations: 41     Fields:    Translation:AnimalsCells
  40. Lyons DM, Mahanty SK, Choi KY, Manandhar M, Elion EA. The SH3-domain protein Bem1 coordinates mitogen-activated protein kinase cascade activation with cell cycle control in Saccharomyces cerevisiae. Mol Cell Biol. 1996 Aug; 16(8):4095-106. PMID: 8754808; PMCID: PMC231406.
    Citations: 44     Fields:    Translation:AnimalsCells
  41. Elion EA, Trueheart J, Fink GR. Fus2 localizes near the site of cell fusion and is required for both cell fusion and nuclear alignment during zygote formation. J Cell Biol. 1995 Sep; 130(6):1283-96. PMID: 7559752; PMCID: PMC2120577.
    Citations: 39     Fields:    Translation:AnimalsCells
  42. Elion EA. Ste5: a meeting place for MAP kinases and their associates. Trends Cell Biol. 1995 Aug; 5(8):322-7. PMID: 14732097.
    Citations: 22     Fields:    
  43. Elion EA. . Using the polymerase chain reaction to construct recombinant DNA molecules (Unit 3.17) In: Current Protocols in Molecular Biology, Ausubel,F, Brent R Kingston R, Moore D, Smith JA, Seidman J, Struhl K, editors.. Guilford, CT: Greene Publishing Associates and Wiley. 1995.
  44. Choi KY, Satterberg B, Lyons DM, Elion EA. Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Cell. 1994 Aug 12; 78(3):499-512. PMID: 8062390.
    Citations: 176     Fields:    Translation:AnimalsCells
  45. Brill JA, Elion EA, Fink GR. A role for autophosphorylation revealed by activated alleles of FUS3, the yeast MAP kinase homolog. Mol Biol Cell. 1994 Mar; 5(3):297-312. PMID: 8049522; PMCID: PMC301038.
    Citations: 27     Fields:    Translation:AnimalsCells
  46. Kranz JE, Satterberg B, Elion EA. The MAP kinase Fus3 associates with and phosphorylates the upstream signaling component Ste5. Genes Dev. 1994 Feb 01; 8(3):313-27. PMID: 8314085.
    Citations: 45     Fields:    Translation:AnimalsCells
  47. Elion EA, Satterberg B, Kranz JE. FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1. Mol Biol Cell. 1993 May; 4(5):495-510. PMID: 8334305; PMCID: PMC300953.
    Citations: 111     Fields:    Translation:AnimalsCells
  48. Elion EA, Brill JA, Fink GR. FUS3 represses CLN1 and CLN2 and in concert with KSS1 promotes signal transduction. Proc Natl Acad Sci U S A. 1991 Nov 01; 88(21):9392-6. PMID: 1946350; PMCID: PMC52723.
    Citations: 99     Fields:    Translation:AnimalsCells
  49. Elion EA, Brill JA, Fink GR. Functional redundancy in the yeast cell cycle: FUS3 and KSS1 have both overlapping and unique functions. Cold Spring Harb Symp Quant Biol. 1991; 56:41-9. PMID: 1819502.
    Citations: 25     Fields:    Translation:AnimalsCells
  50. Elion EA, Grisafi PL, Fink GR. FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation. Cell. 1990 Feb 23; 60(4):649-64. PMID: 2406028.
    Citations: 167     Fields:    Translation:AnimalsCells
  51. Warner J R, Elion E A, Dabeva M D, and Schwindinger WF. The ribosomal genes of yeast and their regulation. Ribosomes: Genetics, Structure and Function. 1988.
  52. Elion EA and Fink GR. FUS3. In: Protein Kinase Factsbook, Hanks S and Hardie DG, editors, Academic Press. 1988.
  53. Elion EA, Warner JR. An RNA polymerase I enhancer in Saccharomyces cerevisiae. Mol Cell Biol. 1986 Jun; 6(6):2089-97. PMID: 3537713.
    Citations: 88     Fields:    Translation:AnimalsCells
  54. Elion EA and Warner JR. Sequence Specificty in Transcription and Translation, UCLA Symposia on Molecular and Cellular Biology, New Series, Calendar R and Gold L, editors. Functional elements of the yeast rRNA transcription uni. 1985; 30.
  55. Elion EA and Warner JR. Characterization of a yeast RNA polymerase I enhancer. Transcriptional Control Mechanisms, UCLA Symposia on Molecular and Cellular Biology, New Series, Volume 52, Granner DK, Rosenfeld G and Chang S, editors. 1985.
  56. Elion EA, Warner JR. The major promoter element of rRNA transcription in yeast lies 2 kb upstream. Cell. 1984 Dec; 39(3 Pt 2):663-73. PMID: 6096018.
    Citations: 118     Fields:    Translation:AnimalsCells
  57. Fillit H, Elion E, Sullivan J, Sherman R, Zabriskie JB. Thiobarbituric acid reactive material in uremic blood. Nephron. 1981; 29(1-2):40-3. PMID: 7329472.
    Citations: 3     Fields:    Translation:Humans
  58. Elion EA and Wang YM. Making protein immunoprecipitates. Methods in Molecular Biology 2004; 284: 1-14.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.