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Edwin Kepner Silverman, Ph.D., M.D.

Co-Author

This page shows the publications co-authored by Edwin Silverman and Dawn Demeo.
Connection Strength

11.758
  1. Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. Am J Hum Genet. 2009 Oct; 85(4):493-502.
    View in: PubMed
    Score: 0.406
  2. Heritability of lung function in severe alpha-1 antitrypsin deficiency. Hum Hered. 2009; 67(1):38-45.
    View in: PubMed
    Score: 0.380
  3. IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency. Am J Respir Cell Mol Biol. 2008 Jan; 38(1):114-20.
    View in: PubMed
    Score: 0.350
  4. Determinants of airflow obstruction in severe alpha-1-antitrypsin deficiency. Thorax. 2007 Sep; 62(9):806-13.
    View in: PubMed
    Score: 0.341
  5. Genetic determinants of emphysema distribution in the national emphysema treatment trial. Am J Respir Crit Care Med. 2007 Jul 01; 176(1):42-8.
    View in: PubMed
    Score: 0.340
  6. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Aug; 3(6):502.
    View in: PubMed
    Score: 0.326
  7. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet. 2006 Feb; 78(2):253-64.
    View in: PubMed
    Score: 0.312
  8. Concordance of genotypes in pre- and post-lung transplantation DNA samples. Am J Respir Cell Mol Biol. 2005 Oct; 33(4):402-5.
    View in: PubMed
    Score: 0.302
  9. Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004 Dec 15; 170(12):1294-301.
    View in: PubMed
    Score: 0.286
  10. Familial aggregation of FEF(25-75) and FEF(25-75)/FVC in families with severe, early onset COPD. Thorax. 2004 May; 59(5):396-400.
    View in: PubMed
    Score: 0.279
  11. Alpha1-antitrypsin deficiency. 2: genetic aspects of alpha(1)-antitrypsin deficiency: phenotypes and genetic modifiers of emphysema risk. Thorax. 2004 Mar; 59(3):259-64.
    View in: PubMed
    Score: 0.276
  12. Genetics of chronic obstructive pulmonary disease. Semin Respir Crit Care Med. 2003 Apr; 24(2):151-60.
    View in: PubMed
    Score: 0.259
  13. Protein interaction networks provide insight into fetal origins of chronic obstructive pulmonary disease. Respir Res. 2022 Mar 24; 23(1):69.
    View in: PubMed
    Score: 0.241
  14. Optimism is associated with respiratory symptoms and functional status in chronic obstructive pulmonary disease. Respir Res. 2022 Jan 29; 23(1):19.
    View in: PubMed
    Score: 0.239
  15. Significant Spirometric Transitions and Preserved Ratio Impaired Spirometry Among Ever Smokers. Chest. 2022 03; 161(3):651-661.
    View in: PubMed
    Score: 0.233
  16. DNA methylation perturbations may link altered development and aging in the lung. Aging (Albany NY). 2021 01 19; 13(2):1742-1764.
    View in: PubMed
    Score: 0.222
  17. Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD. Eur Respir J. 2020 10; 56(4).
    View in: PubMed
    Score: 0.219
  18. Sex-specific associations with DNA methylation in lung tissue demonstrate smoking interactions. Epigenetics. 2021 06; 16(6):692-703.
    View in: PubMed
    Score: 0.217
  19. DNA Methylation Is Predictive of Mortality in Current and Former Smokers. Am J Respir Crit Care Med. 2020 05 01; 201(9):1099-1109.
    View in: PubMed
    Score: 0.211
  20. The Association of Multiparity with Lung Function and Chronic Obstructive Pulmonary Disease-Related Phenotypes. Chronic Obstr Pulm Dis. 2020 Apr; 7(2):86-98.
    View in: PubMed
    Score: 0.210
  21. Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. Am J Respir Crit Care Med. 2019 09 15; 200(6):677-690.
    View in: PubMed
    Score: 0.202
  22. Human Lung DNA Methylation Quantitative Trait Loci Colocalize with Chronic Obstructive Pulmonary Disease Genome-Wide Association Loci. Am J Respir Crit Care Med. 2018 05 15; 197(10):1275-1284.
    View in: PubMed
    Score: 0.185
  23. DNA methylation profiling in human lung tissue identifies genes associated with COPD. Epigenetics. 2016 Oct 02; 11(10):730-739.
    View in: PubMed
    Score: 0.165
  24. Genome-wide site-specific differential methylation in the blood of individuals with Klinefelter syndrome. Mol Reprod Dev. 2015 May; 82(5):377-86.
    View in: PubMed
    Score: 0.149
  25. The impact of genetic variation and cigarette smoke on DNA methylation in current and former smokers from the COPDGene study. Epigenetics. 2015; 10(11):1064-73.
    View in: PubMed
    Score: 0.146
  26. Sexually-dimorphic targeting of functionally-related genes in COPD. BMC Syst Biol. 2014 Nov 28; 8:118.
    View in: PubMed
    Score: 0.145
  27. Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency. Respir Res. 2012 Feb 22; 13:16.
    View in: PubMed
    Score: 0.120
  28. Opportunities and challenges in the genetics of COPD 2010: an International COPD Genetics Conference report. COPD. 2011 Apr; 8(2):121-35.
    View in: PubMed
    Score: 0.113
  29. Association of SERPINE2 with asthma. Chest. 2011 Sep; 140(3):667-674.
    View in: PubMed
    Score: 0.112
  30. Impact of non-linear smoking effects on the identification of gene-by-smoking interactions in COPD genetics studies. Thorax. 2011 Oct; 66(10):903-9.
    View in: PubMed
    Score: 0.110
  31. Clinical predictors of frequent exacerbations in subjects with severe chronic obstructive pulmonary disease (COPD). Respir Med. 2011 Apr; 105(4):588-94.
    View in: PubMed
    Score: 0.110
  32. Association of COPD candidate genes with computed tomography emphysema and airway phenotypes in severe COPD. Eur Respir J. 2011 Jan; 37(1):39-43.
    View in: PubMed
    Score: 0.106
  33. Gender differences in COPD: are women more susceptible to smoking effects than men? Thorax. 2010 Jun; 65(6):480-5.
    View in: PubMed
    Score: 0.106
  34. Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene. Am J Respir Crit Care Med. 2010 Sep 01; 182(5):605-13.
    View in: PubMed
    Score: 0.106
  35. Polymorphisms in surfactant protein-D are associated with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2011 Mar; 44(3):316-22.
    View in: PubMed
    Score: 0.106
  36. Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet. 2010 Mar; 42(3):200-2.
    View in: PubMed
    Score: 0.104
  37. Development of predictive models for airflow obstruction in alpha-1-antitrypsin deficiency. Am J Epidemiol. 2009 Oct 15; 170(8):1005-13.
    View in: PubMed
    Score: 0.101
  38. Genetic association analysis of COPD candidate genes with bronchodilator responsiveness. Respir Med. 2009 Apr; 103(4):552-7.
    View in: PubMed
    Score: 0.096
  39. Polymorphic variation in surfactant protein B is associated with COPD exacerbations. Eur Respir J. 2008 Oct; 32(4):938-44.
    View in: PubMed
    Score: 0.093
  40. National Emphysema Treatment Trial state of the art: genetics of emphysema. Proc Am Thorac Soc. 2008 May 01; 5(4):486-93.
    View in: PubMed
    Score: 0.092
  41. Clinical determinants of exacerbations in severe, early-onset COPD. Eur Respir J. 2007 Dec; 30(6):1124-30.
    View in: PubMed
    Score: 0.088
  42. Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery. Respir Res. 2007 Aug 08; 8:59.
    View in: PubMed
    Score: 0.087
  43. Genetic linkage and association analysis of COPD-related traits on chromosome 8p. COPD. 2006 Dec; 3(4):189-94.
    View in: PubMed
    Score: 0.083
  44. Genetic determinants of functional impairment in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Aug; 3(6):476.
    View in: PubMed
    Score: 0.082
  45. Genetic association analysis of functional impairment in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006 May 01; 173(9):977-84.
    View in: PubMed
    Score: 0.079
  46. Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Am J Respir Cell Mol Biol. 2005 Jul; 33(1):71-8.
    View in: PubMed
    Score: 0.074
  47. Smoke and mirrors: Mouse models as a reflection of human chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004 Nov 01; 170(9):929-31.
    View in: PubMed
    Score: 0.072
  48. Predictors of survival in severe, early onset COPD. Chest. 2004 Nov; 126(5):1443-51.
    View in: PubMed
    Score: 0.072
  49. The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet. 2004 Aug 01; 13(15):1649-56.
    View in: PubMed
    Score: 0.070
  50. Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program. Genet Epidemiol. 2002 Nov; 23(4):335-48.
    View in: PubMed
    Score: 0.063
  51. A polygenic risk score and age of diagnosis of COPD. Eur Respir J. 2022 09; 60(3).
    View in: PubMed
    Score: 0.062
  52. Interstitial lung abnormalities are associated with decreased mean telomere length. Eur Respir J. 2022 08; 60(2).
    View in: PubMed
    Score: 0.062
  53. Covariate adjustment of spirometric and smoking phenotypes: The potential of neural network models. PLoS One. 2022; 17(5):e0266752.
    View in: PubMed
    Score: 0.061
  54. Lung tissue shows divergent gene expression between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Respir Res. 2022 Apr 21; 23(1):97.
    View in: PubMed
    Score: 0.061
  55. Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential. Sci Adv. 2022 Apr 08; 8(14):eabl6579.
    View in: PubMed
    Score: 0.060
  56. Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2022 02 01; 205(3):313-323.
    View in: PubMed
    Score: 0.060
  57. Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed. Cell Genom. 2022 Jan 12; 2(1).
    View in: PubMed
    Score: 0.059
  58. Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program. Am J Hum Genet. 2021 10 07; 108(10):1836-1851.
    View in: PubMed
    Score: 0.058
  59. Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease. J Cachexia Sarcopenia Muscle. 2021 12; 12(6):1803-1817.
    View in: PubMed
    Score: 0.058
  60. Secondary polycythemia in chronic obstructive pulmonary disease: prevalence and risk factors. BMC Pulm Med. 2021 Jul 14; 21(1):235.
    View in: PubMed
    Score: 0.057
  61. Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain. Genet Epidemiol. 2021 10; 45(7):685-693.
    View in: PubMed
    Score: 0.057
  62. Epigenetics and pulmonary diseases in the horizon of precision medicine: a review. Eur Respir J. 2021 06; 57(6).
    View in: PubMed
    Score: 0.057
  63. Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD. Respir Res. 2021 Apr 27; 22(1):127.
    View in: PubMed
    Score: 0.057
  64. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Nature. 2021 02; 590(7845):290-299.
    View in: PubMed
    Score: 0.056
  65. A Risk Prediction Model for Mortality Among Smokers in the COPDGene® Study. Chronic Obstr Pulm Dis. 2020 Oct; 7(4):346-361.
    View in: PubMed
    Score: 0.054
  66. Somatotypes trajectories during adulthood and their association with COPD phenotypes. ERJ Open Res. 2020 Jul; 6(3).
    View in: PubMed
    Score: 0.054
  67. Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts. Lancet Respir Med. 2020 07; 8(7):696-708.
    View in: PubMed
    Score: 0.053
  68. COPDGene® 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease. Chronic Obstr Pulm Dis. 2019 Nov; 6(5):384-399.
    View in: PubMed
    Score: 0.051
  69. Omics and the Search for Blood Biomarkers in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. Am J Respir Cell Mol Biol. 2019 08; 61(2):143-149.
    View in: PubMed
    Score: 0.050
  70. Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nat Genet. 2019 Jun; 51(6):1067.
    View in: PubMed
    Score: 0.050
  71. Clinical Epidemiology of COPD: Insights From 10 Years of the COPDGene Study. Chest. 2019 08; 156(2):228-238.
    View in: PubMed
    Score: 0.050
  72. Common and Rare Variants Genetic Association Analysis of Cigarettes per Day Among Ever-Smokers in Chronic Obstructive Pulmonary Disease Cases and Controls. Nicotine Tob Res. 2019 05 21; 21(6):714-722.
    View in: PubMed
    Score: 0.049
  73. RNA-sequencing across three matched tissues reveals shared and tissue-specific gene expression and pathway signatures of COPD. Respir Res. 2019 Apr 02; 20(1):65.
    View in: PubMed
    Score: 0.049
  74. Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution. Am J Respir Cell Mol Biol. 2019 04; 60(4):388-398.
    View in: PubMed
    Score: 0.049
  75. New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nat Genet. 2019 03; 51(3):481-493.
    View in: PubMed
    Score: 0.049
  76. Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations. Nat Genet. 2019 03; 51(3):494-505.
    View in: PubMed
    Score: 0.049
  77. Longitudinal Phenotypes and Mortality in Preserved Ratio Impaired Spirometry in the COPDGene Study. Am J Respir Crit Care Med. 2018 12 01; 198(11):1397-1405.
    View in: PubMed
    Score: 0.048
  78. Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease. Hum Genomics. 2018 01 15; 12(1):1.
    View in: PubMed
    Score: 0.045
  79. The value of blood cytokines and chemokines in assessing COPD. Respir Res. 2017 10 24; 18(1):180.
    View in: PubMed
    Score: 0.044
  80. Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression. Chest. 2018 01; 153(1):65-76.
    View in: PubMed
    Score: 0.044
  81. Electronic Cigarette Use in US Adults at Risk for or with COPD: Analysis from Two Observational Cohorts. J Gen Intern Med. 2017 Dec; 32(12):1315-1322.
    View in: PubMed
    Score: 0.044
  82. Alpha-1 Antitrypsin PiMZ Genotype Is Associated with Chronic Obstructive Pulmonary Disease in Two Racial Groups. Ann Am Thorac Soc. 2017 Aug; 14(8):1280-1287.
    View in: PubMed
    Score: 0.044
  83. Metabolomic profiling in a Hedgehog Interacting Protein (Hhip) murine model of chronic obstructive pulmonary disease. Sci Rep. 2017 05 31; 7(1):2504.
    View in: PubMed
    Score: 0.043
  84. Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution. Am J Respir Crit Care Med. 2017 03 15; 195(6):757-771.
    View in: PubMed
    Score: 0.043
  85. Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue. Sci Rep. 2017 03 13; 7:44232.
    View in: PubMed
    Score: 0.043
  86. Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. Am J Respir Cell Mol Biol. 2017 03; 56(3):332-341.
    View in: PubMed
    Score: 0.042
  87. Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD. PLoS Genet. 2016 Aug; 12(8):e1006011.
    View in: PubMed
    Score: 0.041
  88. Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice. Nat Med. 2016 Feb; 22(2):163-74.
    View in: PubMed
    Score: 0.039
  89. A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. BMC Genet. 2015 Dec 03; 16:138.
    View in: PubMed
    Score: 0.039
  90. Sex-specific features of emphysema among current and former smokers with COPD. Eur Respir J. 2016 Jan; 47(1):104-12.
    View in: PubMed
    Score: 0.039
  91. Clinical and Radiologic Disease in Smokers With Normal Spirometry. JAMA Intern Med. 2015 Sep; 175(9):1539-49.
    View in: PubMed
    Score: 0.038
  92. Reduced Bone Density and Vertebral Fractures in Smokers. Men and COPD Patients at Increased Risk. Ann Am Thorac Soc. 2015 May; 12(5):648-56.
    View in: PubMed
    Score: 0.037
  93. A simplified score to quantify comorbidity in COPD. PLoS One. 2014; 9(12):e114438.
    View in: PubMed
    Score: 0.036
  94. Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus. BMC Pulm Med. 2014 Oct 24; 14:164.
    View in: PubMed
    Score: 0.036
  95. Prediction of acute respiratory disease in current and former smokers with and without COPD. Chest. 2014 Oct; 146(4):941-950.
    View in: PubMed
    Score: 0.036
  96. Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene. Respir Med. 2014 Oct; 108(10):1469-80.
    View in: PubMed
    Score: 0.036
  97. Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene. Respir Res. 2014 Aug 06; 15:89.
    View in: PubMed
    Score: 0.036
  98. Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema. Thorax. 2014 May; 69(5):415-22.
    View in: PubMed
    Score: 0.034
  99. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med. 2014 Mar; 2(3):214-25.
    View in: PubMed
    Score: 0.034
  100. Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS One. 2013; 8(2):e56179.
    View in: PubMed
    Score: 0.032
  101. Racial differences in CT phenotypes in COPD. COPD. 2013 Feb; 10(1):20-7.
    View in: PubMed
    Score: 0.032
  102. Gene-environment interaction testing in family-based association studies with phenotypically ascertained samples: a causal inference approach. Biostatistics. 2012 Jul; 13(3):468-81.
    View in: PubMed
    Score: 0.029
  103. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet. 2012 Feb 15; 21(4):947-57.
    View in: PubMed
    Score: 0.029
  104. Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study. Am J Respir Crit Care Med. 2011 Aug 15; 184(4):414-20.
    View in: PubMed
    Score: 0.029
  105. Peripheral blood gene expression profiles in COPD subjects. J Clin Bioinforma. 2011 Apr 24; 1(1):12.
    View in: PubMed
    Score: 0.028
  106. Combining disease models to test for gene-environment interaction in nuclear families. Biometrics. 2011 Dec; 67(4):1260-70.
    View in: PubMed
    Score: 0.028
  107. Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):304-10.
    View in: PubMed
    Score: 0.027
  108. Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPD. COPD. 2010 Aug; 7(4):262-8.
    View in: PubMed
    Score: 0.027
  109. MMP12, lung function, and COPD in high-risk populations. N Engl J Med. 2009 Dec 31; 361(27):2599-608.
    View in: PubMed
    Score: 0.026
  110. Parsing the effects of individual SNPs in candidate genes with family data. Hum Hered. 2010; 69(2):91-103.
    View in: PubMed
    Score: 0.026
  111. Associations of IL6 polymorphisms with lung function decline and COPD. Thorax. 2009 Aug; 64(8):698-704.
    View in: PubMed
    Score: 0.025
  112. Molecular biomarkers for quantitative and discrete COPD phenotypes. Am J Respir Cell Mol Biol. 2009 Mar; 40(3):359-67.
    View in: PubMed
    Score: 0.024
  113. Testing and estimating gene-environment interactions in family-based association studies. Biometrics. 2008 Jun; 64(2):458-67.
    View in: PubMed
    Score: 0.022
  114. Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood. J Allergy Clin Immunol. 2007 Jul; 120(1):84-90.
    View in: PubMed
    Score: 0.022
  115. Microarray data-based prioritization of chronic obstructive pulmonary disease susceptibility genes. Proc Am Thorac Soc. 2006 Aug; 3(6):472.
    View in: PubMed
    Score: 0.020
  116. Genomic screening and replication using the same data set in family-based association testing. Nat Genet. 2005 Jul; 37(7):683-91.
    View in: PubMed
    Score: 0.019
  117. A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects. Stat Appl Genet Mol Biol. 2004; 3:Article17.
    View in: PubMed
    Score: 0.018
  118. PBAT: tools for family-based association studies. Am J Hum Genet. 2004 Feb; 74(2):367-9.
    View in: PubMed
    Score: 0.017
  119. Using the noninformative families in family-based association tests: a powerful new testing strategy. Am J Hum Genet. 2003 Oct; 73(4):801-11.
    View in: PubMed
    Score: 0.017
  120. A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies. Hum Hered. 2003; 56(1-3):10-7.
    View in: PubMed
    Score: 0.016
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.