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Florence Lai, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Janelidze S, Christian BT, Price J, Laymon C, Schupf N, Klunk WE, Lott I, Silverman W, Rosas HD, Zaman S, Mapstone M, Lai F, Ances BM, Handen BL, Hansson O. Detection of Brain Tau Pathology in Down Syndrome Using Plasma Biomarkers. JAMA Neurol. 2022 08 01; 79(8):797-807. PMID: 35789365; PMCID: PMC9257682.
    Citations:    Fields:    
  2. Hom CL, Kirby KA, Ricks-Oddie J, Keator DB, Krinsky-McHale SJ, Pulsifer MB, Rosas HD, Lai F, Schupf N, Lott IT, Silverman W. Correction: Hom et al. Cognitive Function during the Prodromal Stage of Alzheimer's Disease in Down Syndrome: Comparing Models. BrainSci. 2021, 11, 1220. Brain Sci. 2022 Jul 15; 12(7). PMID: 35884766; PMCID: PMC9313374.
  3. Queder N, Phelan MJ, Taylor L, Tustison N, Doran E, Hom C, Nguyen D, Lai F, Pulsifer M, Price J, Kreisl WC, Rosas HD, Krinsky-McHale S, Brickman AM, Yassa MA, Schupf N, Silverman W, Lott IT, Head E, Mapstone M, Keator DB. Joint-label fusion brain atlases for dementia research in Down syndrome. Alzheimers Dement (Amst). 2022; 14(1):e12324. PMID: 35634535; PMCID: PMC9131930.
    Citations: 1     
  4. Lao P, Zimmerman ME, Hartley SL, Gutierrez J, Keator D, Igwe KC, Laing KK, Cotton-Samuel D, Sathishkumar M, Moni F, Andrews H, Krinsky-McHale S, Head E, Lee JH, Lai F, Yassa MA, Diana Rosas H, Silverman W, Lott IT, Schupf N, Brickman AM. Obstructive sleep apnea, cerebrovascular disease, and amyloid in older adults with Down syndrome across the Alzheimer's continuum. Sleep Adv. 2022; 3(1):zpac013. PMID: 35669316; PMCID: PMC9154738.
  5. Moni F, Petersen ME, Zhang F, Lao PJ, Zimmerman ME, Gu Y, Gutierrez J, Rizvi B, Laing KK, Igwe KC, Sathishkumar M, Keator D, Andrews H, Krinsky-McHale S, Head E, Lee JH, Lai F, Yassa MA, Rosas HD, Silverman W, Lott IT, Schupf N, O'Bryant S, Brickman AM. Probing the proteome to explore potential correlates of increased Alzheimer's-related cerebrovascular disease in adults with Down syndrome. Alzheimers Dement. 2022 Oct; 18(10):1744-1753. PMID: 35212182; PMCID: PMC9399305.
    Citations:    Fields:    
  6. Wegiel J, Flory M, Kuchna I, Nowicki K, Wegiel J, Ma SY, Zhong N, Bobrowicz TW, de Leon M, Lai F, Silverman WP, Wisniewski T. Developmental deficits and staging of dynamics of age associated Alzheimer's disease neurodegeneration and neuronal loss in subjects with Down syndrome. Acta Neuropathol Commun. 2022 01 04; 10(1):2. PMID: 34983655; PMCID: PMC8728914.
    Citations: 2     Fields:    Translation:HumansCells
  7. Hom CL, Kirby KA, Ricks-Oddie J, Keator DB, Krinsky-McHale SJ, Pulsifer MB, Rosas HD, Lai F, Schupf N, Lott IT, Silverman W. Cognitive Function during the Prodromal Stage of Alzheimer's Disease in Down Syndrome: Comparing Models. Brain Sci. 2021 Sep 16; 11(9). PMID: 34573242; PMCID: PMC8471085.
    Citations: 1     
  8. Lai F, Mercaldo ND, Wang CM, Hersch MS, Hersch GG, Rosas HD. Association between Hypothyroidism Onset and Alzheimer Disease Onset in Adults with Down Syndrome. Brain Sci. 2021 Sep 16; 11(9). PMID: 34573243.
    Citations: 1     
  9. Fagan AM, Henson RL, Li Y, Boerwinkle AH, Xiong C, Bateman RJ, Goate A, Ances BM, Doran E, Christian BT, Lai F, Rosas HD, Schupf N, Krinsky-McHale S, Silverman W, Lee JH, Klunk WE, Handen BL, Allegri RF, Chhatwal JP, Day GS, Graff-Radford NR, Jucker M, Levin J, Martins RN, Masters CL, Mori H, Mummery CJ, Niimi Y, Ringman JM, Salloway S, Schofield PR, Shoji M, Lott IT. Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study. Lancet Neurol. 2021 08; 20(8):615-626. PMID: 34302786; PMCID: PMC8496347.
    Citations: 8     Fields:    Translation:Humans
  10. Lai F, Mercaldo N, Wang CM, Hersch GG, Rosas HD. Association between Inflammatory Conditions and Alzheimer's Disease Age of Onset in Down Syndrome. J Clin Med. 2021 Jul 15; 10(14). PMID: 34300282; PMCID: PMC8307987.
    Citations: 2     
  11. Rosas HD, Lewis LR, Mercaldo ND, Nasr S, Brickman AM, Siless V, Yassa M, Sathishkumar M, Lott I, Schupf N, Silverman W, Lai F. Altered connectivity of the default mode network in cognitively stable adults with Down syndrome: "Accelerated aging" or a prelude to Alzheimer's disease? Alzheimers Dement (Amst). 2021; 13(1):e12105. PMID: 34027014; PMCID: PMC8136300.
    Citations: 2     
  12. Hendrix JA, Airey DC, Britton A, Burke AD, Capone GT, Chavez R, Chen J, Chicoine B, Costa ACS, Dage JL, Doran E, Esbensen A, Evans CL, Faber KM, Foroud TM, Hart S, Haugen K, Head E, Hendrix S, Hillerstrom H, Kishnani PS, Krell K, Ledesma DL, Lai F, Lott I, Ochoa-Lubinoff C, Mason J, Nicodemus-Johnson J, Proctor NK, Pulsifer MB, Revta C, Rosas HD, Rosser TC, Santoro S, Schafer K, Scheidemantel T, Schmitt F, Skotko BG, Stasko MR, Talboy A, Torres A, Wilmes K, Woodward J, Zimmer JA, Feldman HH, Mobley W. Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer's Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study. J Clin Med. 2021 Apr 28; 10(9). PMID: 33924960; PMCID: PMC8124643.
    Citations: 4     
  13. Knox K, Stanley J, Hendrix JA, Hillerstrom H, Dunn T, Achenbach J, Chicoine BA, Lai F, Lott I, Stanojevic S, Howlett SE, Rockwood K. Development of a symptom menu to facilitate Goal Attainment Scaling in adults with Down syndrome-associated Alzheimer's disease: a qualitative study to identify meaningful symptoms. J Patient Rep Outcomes. 2021 Jan 11; 5(1):5. PMID: 33427993.
    Citations: 1     
  14. Petersen ME, Rafii MS, Zhang F, Hall J, Julovich D, Ances BM, Schupf N, Krinsky-McHale SJ, Mapstone M, Silverman W, Lott I, Klunk W, Head E, Christian B, Foroud T, Lai F, Diana Rosas H, Zaman S, Wang MC, Tycko B, Lee JH, Handen B, Hartley S, Fortea J, O'Bryant S. Plasma Total-Tau and Neurofilament Light Chain as Diagnostic Biomarkers of Alzheimer's Disease Dementia and Mild Cognitive Impairment in Adults with Down Syndrome. J Alzheimers Dis. 2021; 79(2):671-681. PMID: 33337378.
    Citations: 9     Fields:    Translation:Humans
  15. Silverman W, Krinsky-McHale SJ, Lai F, Diana Rosas H, Hom C, Doran E, Pulsifer M, Lott I, Schupf N. Evaluation of the National Task Group-Early Detection Screen for Dementia: Sensitivity to 'mild cognitive impairment' in adults with Down syndrome. J Appl Res Intellect Disabil. 2021 May; 34(3):905-915. PMID: 33314467; PMCID: PMC8356176.
    Citations: 2     Fields:    Translation:Humans
  16. Rosas HD, Hsu E, Mercaldo ND, Lai F, Pulsifer M, Keator D, Brickman AM, Price J, Yassa M, Hom C, Krinsky-McHale SJ, Silverman W, Lott I, Schupf N. Alzheimer-related altered white matter microstructural integrity in Down syndrome: A model for sporadic AD? Alzheimers Dement (Amst). 2020; 12(1):e12040. PMID: 33204811; PMCID: PMC7648416.
  17. Rafii MS, Ances BM, Schupf N, Krinsky-McHale SJ, Mapstone M, Silverman W, Lott I, Klunk W, Head E, Christian B, Lai F, Rosas HD, Zaman S, Petersen ME, Strydom A, Fortea J, Handen B, O'Bryant S. The AT(N) framework for Alzheimer's disease in adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12062. PMID: 33134477.
    Citations: 6     
  18. Lao PJ, Gutierrez J, Keator D, Rizvi B, Banerjee A, Igwe KC, Laing KK, Sathishkumar M, Moni F, Andrews H, Krinsky-McHale S, Head E, Lee JH, Lai F, Yassa MA, Rosas HD, Silverman W, Lott IT, Schupf N, Brickman AM. Alzheimer-Related Cerebrovascular Disease in Down Syndrome. Ann Neurol. 2020 12; 88(6):1165-1177. PMID: 32944999.
    Citations: 14     Fields:    Translation:Humans
  19. Roman MA, Abbasciano RG, Lai FY, Murphy GJ. Interpretation of network meta-analysis of isolated patient blood management interventions. Response to Br J Anaesth 2020 BJA-2020-01426-HH887.R1. Br J Anaesth. 2021 01; 126(1):e2-e4. PMID: 32977958.
    Citations:    Fields:    Translation:Humans
  20. Lai F, Mhatre PG, Yang Y, Wang MC, Schupf N, Rosas HD. Sex differences in risk of Alzheimer's disease in adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12084. PMID: 32995462; PMCID: PMC7507514.
    Citations: 6     
  21. Pulsifer MB, Evans CL, Hom C, Krinsky-McHale SJ, Silverman W, Lai F, Lott I, Schupf N, Wen J, Rosas HD. Language skills as a predictor of cognitive decline in adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12080. PMID: 32875055; PMCID: PMC7447889.
    Citations: 6     
  22. Handen BL, Lott IT, Christian BT, Schupf N, OBryant S, Mapstone M, Fagan AM, Lee JH, Tudorascu D, Wang MC, Head E, Klunk W, Ances B, Lai F, Zaman S, Krinsky-McHale S, Brickman AM, Rosas HD, Cohen A, Andrews H, Hartley S, Silverman W. The Alzheimer's Biomarker Consortium-Down Syndrome: Rationale and methodology. Alzheimers Dement (Amst). 2020; 12(1):e12065. PMID: 32775597; PMCID: PMC7396809.
    Citations: 20     
  23. Henson RL, Doran E, Christian BT, Handen BL, Klunk WE, Lai F, Lee JH, Rosas HD, Schupf N, Zaman SH, Lott IT, Fagan AM. Cerebrospinal fluid biomarkers of Alzheimer's disease in a cohort of adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12057. PMID: 32671183; PMCID: PMC7346867.
    Citations: 8     
  24. Petersen ME, Zhang F, Schupf N, Krinsky-McHale SJ, Hall J, Mapstone M, Cheema A, Silverman W, Lott I, Rafii MS, Handen B, Klunk W, Head E, Christian B, Foroud T, Lai F, Rosas HD, Zaman S, Ances BM, Wang MC, Tycko B, Lee JH, O'Bryant S. Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study. Alzheimers Dement (Amst). 2020; 12(1):e12039. PMID: 32626817; PMCID: PMC7327223.
    Citations: 9     
  25. Roman MA, Abbasciano RG, Pathak S, Oo S, Yusoff S, Wozniak M, Qureshi S, Lai FY, Kumar T, Richards T, Yao G, Estcourt L, Murphy GJ. Patient blood management interventions do not lead to important clinical benefits or cost-effectiveness for major surgery: a network meta-analysis. Br J Anaesth. 2021 01; 126(1):149-156. PMID: 32620259.
    Citations: 7     Fields:    Translation:Humans
  26. Snyder HM, Bain LJ, Brickman AM, Carrillo MC, Esbensen AJ, Espinosa JM, Fernandez F, Fortea J, Hartley SL, Head E, Hendrix J, Kishnani PS, Lai F, Lao P, Lemere C, Mobley W, Mufson EJ, Potter H, Zaman SH, Granholm AC, Rosas HD, Strydom A, Whitten MS, Rafii MS. Further understanding the connection between Alzheimer's disease and Down syndrome. Alzheimers Dement. 2020 07; 16(7):1065-1077. PMID: 32544310; PMCID: PMC8865308.
    Citations: 19     Fields:    Translation:Humans
  27. Keator DB, Phelan MJ, Taylor L, Doran E, Krinsky-McHale S, Price J, Ballard EE, Kreisl WC, Hom C, Nguyen D, Pulsifer M, Lai F, Rosas DH, Brickman AM, Schupf N, Yassa MA, Silverman W, Lott IT. Down syndrome: Distribution of brain amyloid in mild cognitive impairment. Alzheimers Dement (Amst). 2020; 12(1):e12013. PMID: 32435685; PMCID: PMC7233421.
    Citations: 5     
  28. Pais P, Robinson S, Majithia-Beet G, Lotto A, Kumar T, Westrope C, Sullo N, Eagle Hemming B, Joel-David L, JnTala M, Corazzari C, Grazioli L, Smallwood D, Murphy GJ, Lai FY, Wozniak MJ. Biomarkers of Inflammation and Lung Recovery in Extracorporeal Membrane Oxygenation Patients With Persistent Pulmonary Hypertension of the Newborn: A Feasibility Study. Pediatr Crit Care Med. 2020 04; 21(4):363-372. PMID: 31725531.
    Citations:    Fields:    Translation:Humans
  29. Mengel D, Liu W, Glynn RJ, Selkoe DJ, Strydom A, Lai F, Rosas HD, Torres A, Patsiogiannis V, Skotko B, Walsh DM. Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aß42 decrease with age, whereas NT1 tau and NfL increase. Alzheimers Res Ther. 2020 03 19; 12(1):27. PMID: 32192521.
    Citations: 8     Fields:    Translation:Humans
  30. Teo KW, Lai FY, Bandi S, Allen DJ, Tang JW. Emergence of Coxsackie A6 hand-foot-and-mouth disease and comparative severity of Coxsackie B vs. echovirus infections, 2014-2016, UK. J Infect. 2019 01; 78(1):75-86. PMID: 30134142.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  31. Gupta P, Patel P, Štrauch B, Lai FY, Akbarov A, Gulsin GS, Beech A, Marešová V, Topham PS, Stanley A, Thurston H, Smith PR, Horne R, Widimský J, Keavney B, Heagerty A, Samani NJ, Williams B, Tomaszewski M. Biochemical Screening for Nonadherence Is Associated With Blood Pressure Reduction and Improvement in Adherence. Hypertension. 2017 11; 70(5):1042-1048. PMID: 28847892.
    Citations: 31     Fields:    Translation:Humans
  32. Gupta P, Patel P, Štrauch B, Lai FY, Akbarov A, Marešová V, White CMJ, Petrák O, Gulsin GS, Patel V, Rosa J, Cole R, Zelinka T, Holaj R, Kinnell A, Smith PR, Thompson JR, Squire I, Widimský J, Samani NJ, Williams B, Tomaszewski M. Risk Factors for Nonadherence to Antihypertensive Treatment. Hypertension. 2017 06; 69(6):1113-1120. PMID: 28461599.
    Citations: 46     Fields:    Translation:Humans
  33. Khan JN, Nazir SA, Singh A, Shetye A, Lai FY, Peebles C, Wong J, Greenwood JP, McCann GP. Relationship of Myocardial Strain and Markers of Myocardial Injury to Predict Segmental Recovery After Acute ST-Segment-Elevation Myocardial Infarction. Circ Cardiovasc Imaging. 2016 Jun; 9(6). PMID: 27283007.
    Citations: 10     Fields:    Translation:Humans
  34. Sano M, Aisen PS, Andrews HF, Tsai WY, Lai F, Dalton AJ. Vitamin E in aging persons with Down syndrome: A randomized, placebo-controlled clinical trial. Neurology. 2016 May 31; 86(22):2071-6. PMID: 27164691; PMCID: PMC4891209.
    Citations: 19     Fields:    Translation:Humans
  35. Jennings D, Seibyl J, Sabbagh M, Lai F, Hopkins W, Bullich S, Gimenez M, Reininger C, Putz B, Stephens A, Catafau AM, Marek K. Age dependence of brain ß-amyloid deposition in Down syndrome: An [18F]florbetaben PET study. Neurology. 2015 Feb 03; 84(5):500-7. PMID: 25568295.
    Citations: 31     Fields:    Translation:HumansCTClinical Trials
  36. Lim C, Ang LW, Ma S, Lai FY, James L, Cutter J. Comparison of severely ill patients with influenza A(H1N1)pdm09 infection during the pandemic and post-pandemic periods in Singapore. Vaccine. 2015 Jan 29; 33(5):615-20. PMID: 25545594.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  37. Lee CK, Lee HK, Loh TP, Lai FY, Tambyah PA, Chiu L, Koay ES, Tang JW. Comparison of pandemic (H1N1) 2009 and seasonal influenza viral loads, Singapore. Emerg Infect Dis. 2011 Feb; 17(2):287-91. PMID: 21291608.
    Citations: 23     Fields:    Translation:HumansCellsPHPublic Health
  38. Wegiel J, Kaczmarski W, Barua M, Kuchna I, Nowicki K, Wang KC, Wegiel J, Yang SM, Frackowiak J, Mazur-Kolecka B, Silverman WP, Reisberg B, Monteiro I, de Leon M, Wisniewski T, Dalton A, Lai F, Hwang YW, Adayev T, Liu F, Iqbal K, Iqbal IG, Gong CX. Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome. J Neuropathol Exp Neurol. 2011 Jan; 70(1):36-50. PMID: 21157379; PMCID: PMC3083064.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  39. Tang JW, Tambyah PA, Lai FY, Lee HK, Lee CK, Loh TP, Chiu L, Koay ES. Differing symptom patterns in early pandemic vs seasonal influenza infections. Arch Intern Med. 2010 May 24; 170(10):861-7. PMID: 20498413.
    Citations: 24     Fields:    Translation:HumansCellsPHPublic Health
  40. Subramony H, Lai FY, Ang LW, Cutter JL, Lim PL, James L. An epidemiological study of 1348 cases of pandemic H1N1 influenza admitted to Singapore Hospitals from July to September 2009. Ann Acad Med Singap. 2010 Apr; 39(4):283-8. PMID: 20473452.
    Citations: 16     Fields:    Translation:HumansCellsPHPublic Health
  41. Cutter JL, Ang LW, Lai FY, Subramony H, Ma S, James L. Outbreak of pandemic influenza A (H1N1-2009) in Singapore, May to September 2009. Ann Acad Med Singap. 2010 Apr; 39(4):273-10. PMID: 20473451.
    Citations: 20     Fields:    Translation:HumansCellsPHPublic Health
  42. Schupf N, Pang D, Patel BN, Silverman W, Schubert R, Lai F, Kline JK, Stern Y, Ferin M, Tycko B, Mayeux R. Onset of dementia is associated with age at menopause in women with Down's syndrome. Ann Neurol. 2003 Oct; 54(4):433-8. PMID: 14520653.
    Citations: 26     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.