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Ludy Chen Shih, M.D.

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Stanford University, Stanford, CABS06/1997Biological Sciences
UCLA School of Medicine, Los Angeles, CAMD05/2002Medicine
Beth Israel Deaconess Medical Center, Boston, MA06/2003Internship, Internal Medicine
Beth Israel Deaconess Medical Center, Boston, MA06/2006Residency, Neurology
Beth Israel Deaconess Medical Center, Boston, MA06/2007Fellowship, Movement Disorders
Harvard-MIT Health Sciences and Technology, Boston, MAMMSc06/2010Clinical Investigation
Alpha Omega Alpha Student Research Fellowship
American Stroke Association Student Scholarship in Cerebrovascular Disease
Carl and Edith Lasky Research Award
Richard D. Walter Award, UCLA Dept. of Neurology
Alpha Omega Alpha Honor Medical Society
2007 - 2008
Judith Goldberg Translational Research in Parkinson's Disease Grant
2008 - 2009
Harvard-MIT Clinical Investigator Training Program Fellowship

My clinical and research interests focus primarily on the use of deep brain stimulation for disorders of the basal ganglia. The primary conditions for which this therapy is used include dystonia, tremor and Parkinson's disease (PD). I am interested in characterization of circuitry of specific motor phenomenology in movement disorders, such as essential tremor and gait disorder associated with Parkinson's disease.

My clinical practice consists of evaluation and ongoing treatment of movement disorders including tremor, Parkinson's disease, and dystonia. In addition, I am the co-director of our multidisciplinary deep brain stimulation (DBS) program for movement disorders along with Ron Alterman, MD (neurosurgery).

Currently ongoing projects include a translational approach to gait analysis in human subjects with Parkinson's disease along with Dr. Veronique Vanderhorst. We are examining the utility and validity of measuring gait in a velocity-dependent manner in subjects with PD under various conditions.

Other projects under development noninvasive stimulation of the cerebellum for essential tremor, study of new investigational drugs for treatment of essential tremor and standardization of screening and outcomes guiding selection of patients for deep brain stimulation therapy. I am also involved in the planning of a nationwide registry for deep brain stimulation for Parkinson's disease.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Schneider RB, Jimenez-Shahed J, Abraham DS, Thibault DP, Mantri S, Fullard M, Burack MA, Chou KL, Spindler M, Jermakowicz WJ, D'Haese PF, York MK, Kirk JC, Schwalb JM, Espay AJ, Shih LC, Simon DK, Hunter C, Crispo JAG, Willis AW. Acute readmission following deep brain stimulation surgery for Parkinson's disease: A nationwide analysis. Parkinsonism Relat Disord. 2020 01; 70:96-102. PMID: 31866156.
  2. Joutsa J, Shih LC, Fox MD. Mapping holmes tremor circuit using the human brain connectome. Ann Neurol. 2019 12; 86(6):812-820. PMID: 31614012.
  3. Broom L, Worley A, Gao F, Hernandez LD, Ashton CE, Shih LC, VanderHorst VG. Translational methods to detect asymmetries in temporal and spatial walking metrics in parkinsonian mouse models and human subjects with Parkinson's disease. Sci Rep. 2019 02 21; 9(1):2437. PMID: 30792396.
  4. Joutsa J, Shih LC, Horn A, Reich MM, Wu O, Rost NS, Fox MD. Identifying therapeutic targets from spontaneous beneficial brain lesions. Ann Neurol. 2018 07; 84(1):153-157. PMID: 30014594.
    Citations:    Fields:    
  5. Ondo W, Hashem V, LeWitt PA, Pahwa R, Shih L, Tarsy D, Zesiewicz T, Elble R. Comparison of the Fahn-Tolosa-Marin Clinical Rating Scale and the Essential Tremor Rating Assessment Scale. Mov Disord Clin Pract. 2018 Jan-Feb; 5(1):60-65. PMID: 30363460.
  6. Beck CA, Beran DB, Biglan KM, Boyd CM, Dorsey ER, Schmidt PN, Simone R, Willis AW, Galifianakis NB, Katz M, Tanner CM, Dodenhoff K, Aldred J, Carter J, Fraser A, Jimenez-Shahed J, Hunter C, Spindler M, Reichwein S, Mari Z, Dunlop B, Morgan JC, McLane D, Hickey P, Gauger L, Richard IH, Mejia NI, Bwala G, Nance M, Shih LC, Singer C, Vargas-Parra S, Zadikoff C, Okon N, Feigin A, Ayan J, Vaughan C, Pahwa R, Dhall R, Hassan A, DeMello S, Riggare SS, Wicks P, Achey MA, Elson MJ, Goldenthal S, Keenan HT, Korn R, Schwarz H, Sharma S, Stevenson EA, Zhu W. National randomized controlled trial of virtual house calls for Parkinson disease. Neurology. 2017 Sep 12; 89(11):1152-1161. PMID: 28814455.
    Citations: 3     Fields:    Translation:Humans
  7. Broom L, Ellison BA, Worley A, Wagenaar L, Sörberg E, Ashton C, Bennett DA, Buchman AS, Saper CB, Shih LC, Hausdorff JM, VanderHorst VG. A translational approach to capture gait signatures of neurological disorders in mice and humans. Sci Rep. 2017 06 12; 7(1):3225. PMID: 28607434.
    Citations: 2     Fields:    Translation:HumansAnimals
  8. Shih LC, Pascual-Leone A. Non-invasive Brain Stimulation for Essential Tremor. Tremor Other Hyperkinet Mov (N Y). 2017; 7:458. PMID: 28373927.
    Citations: 1     Fields:    
  9. Horn A, Kühn AA, Merkl A, Shih L, Alterman R, Fox M. Probabilistic conversion of neurosurgical DBS electrode coordinates into MNI space. Neuroimage. 2017 04 15; 150:395-404. PMID: 28163141.
    Citations: 3     Fields:    Translation:Humans
  10. Norris SA, Jinnah HA, Espay AJ, Klein C, Brüggemann N, Barbano RL, Malaty IA, Rodriguez RL, Vidailhet M, Roze E, Reich SG, Berman BD, LeDoux MS, Richardson SP, Agarwal P, Mari Z, Ondo WG, Shih LC, Fox SH, Berardelli A, Testa CM, Cheng FC, Truong D, Nahab FB, Xie T, Hallett M, Rosen AR, Wright LJ, Perlmutter JS. Clinical and demographic characteristics related to onset site and spread of cervical dystonia. Mov Disord. 2016 12; 31(12):1874-1882. PMID: 27753188.
    Citations: 1     Fields:    Translation:Humans
  11. Graebner AK, Tarsy D, Shih LC, Vanderhorst V, Kulkarni O, Kaplan S, Simon DK. Clinical Impact of 123I-Ioflupane SPECT (DaTscan) in a Movement Disorder Center. Neurodegener Dis. 2017; 17(1):38-43. PMID: 27614874.
    Citations:    Fields:    Translation:Humans
  12. Gibbons CH, Garcia J, Wang N, Shih LC, Freeman R. The diagnostic discrimination of cutaneous a-synuclein deposition in Parkinson disease. Neurology. 2016 Aug 02; 87(5):505-12. PMID: 27385742.
    Citations: 9     Fields:    Translation:Humans
  13. Rossi PJ, Gunduz A, Judy J, Wilson L, Machado A, Giordano JJ, Elias WJ, Rossi MA, Butson CL, Fox MD, McIntyre CC, Pouratian N, Swann NC, de Hemptinne C, Gross RE, Chizeck HJ, Tagliati M, Lozano AM, Goodman W, Langevin JP, Alterman RL, Akbar U, Gerhardt GA, Grill WM, Hallett M, Herrington T, Herron J, van Horne C, Kopell BH, Lang AE, Lungu C, Martinez-Ramirez D, Mogilner AY, Molina R, Opri E, Otto KJ, Oweiss KG, Pathak Y, Shukla A, Shute J, Sheth SA, Shih LC, Steinke GK, Tröster AI, Vanegas N, Zaghloul KA, Cendejas-Zaragoza L, Verhagen L, Foote KD, Okun MS. Proceedings of the Third Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies. Front Neurosci. 2016; 10:119. PMID: 27092042.
    Citations: 8     
  14. Dorsey ER, Achey MA, Beck CA, Beran DB, Biglan KM, Boyd CM, Schmidt PN, Simone R, Willis AW, Galifianakis NB, Katz M, Tanner CM, Dodenhoff K, Ziman N, Aldred J, Carter J, Jimenez-Shahed J, Hunter C, Spindler M, Mari Z, Morgan JC, McLane D, Hickey P, Gauger L, Richard IH, Bull MT, Mejia NI, Bwala G, Nance M, Shih L, Anderson L, Singer C, Zadikoff C, Okon N, Feigin A, Ayan J, Vaughan C, Pahwa R, Cooper J, Webb S, Dhall R, Hassan A, Weis D, DeMello S, Riggare SS, Wicks P, Smith J, Keenan HT, Korn R, Schwarz H, Sharma S, Stevenson EA, Zhu W. National Randomized Controlled Trial of Virtual House Calls for People with Parkinson's Disease: Interest and Barriers. Telemed J E Health. 2016 07; 22(7):590-8. PMID: 26886406.
    Citations: 6     Fields:    Translation:Humans
  15. Lee SI, Daneault JF, Golabchi FN, Patel S, Paganoni S, Shih L, Bonato P. A novel method for assessing the severity of levodopa-induced dyskinesia using wearable sensors. Annu Int Conf IEEE Eng Med Biol Soc. 2015 Aug; 2015:8087-90. PMID: 26738170.
    Citations: 1     Fields:    Translation:Humans
  16. Parihar R, Alterman R, Papavassiliou E, Tarsy D, Shih LC. Comparison of VIM and STN DBS for Parkinsonian Resting and Postural/Action Tremor. Tremor Other Hyperkinet Mov (N Y). 2015; 5:321. PMID: 26196027.
    Citations: 3     Fields:    
  17. Huang CY, Tsai CW, Hsu CM, Shih LC, Chang WS, Shui HA, Bau DT. The role of XRCC6/Ku70 in nasopharyngeal carcinoma. Int J Oral Maxillofac Surg. 2015 Dec; 44(12):1480-5. PMID: 26149939.
    Citations: 3     Fields:    Translation:Humans
  18. Gunduz A, Morita H, Rossi PJ, Allen WL, Alterman RL, Bronte-Stewart H, Butson CR, Charles D, Deckers S, de Hemptinne C, DeLong M, Dougherty D, Ellrich J, Foote KD, Giordano J, Goodman W, Greenberg BD, Greene D, Gross R, Judy JW, Karst E, Kent A, Kopell B, Lang A, Lozano A, Lungu C, Lyons KE, Machado A, Martens H, McIntyre C, Min HK, Neimat J, Ostrem J, Pannu S, Ponce F, Pouratian N, Reymers D, Schrock L, Sheth S, Shih L, Stanslaski S, Steinke GK, Stypulkowski P, Tröster AI, Verhagen L, Walker H, Okun MS. Proceedings of the Second Annual Deep Brain Stimulation Think Tank: What's in the Pipeline. Int J Neurosci. 2015; 125(7):475-85. PMID: 25526555.
    Citations: 5     Fields:    Translation:HumansAnimals
  19. Smith KM, O'Connor M, Papavassiliou E, Tarsy D, Shih LC. Phonemic verbal fluency decline after subthalamic nucleus deep brain stimulation does not depend on number of microelectrode recordings or lead tip placement. Parkinsonism Relat Disord. 2014 Apr; 20(4):400-4. PMID: 24495709.
    Citations: 3     Fields:    Translation:Humans
  20. Sarkar SN, Papavassiliou E, Hackney DB, Alsop DC, Shih LC, Madhuranthakam AJ, Busse RF, La Ruche S, Bhadelia RA. Three-dimensional brain MRI for DBS patients within ultra-low radiofrequency power limits. Mov Disord. 2014 Apr; 29(4):546-9. PMID: 24442797.
    Citations: 2     Fields:    Translation:Humans
  21. Shih LC, Tarsy D, Okun MS. The current state and needs of north american movement disorders fellowship programs. Parkinsons Dis. 2013; 2013:701426. PMID: 23984186.
  22. Shih LC, LaFaver K, Lim C, Papavassiliou E, Tarsy D. Loss of benefit in VIM thalamic deep brain stimulation (DBS) for essential tremor (ET): how prevalent is it? Parkinsonism Relat Disord. 2013 Jul; 19(7):676-9. PMID: 23582712.
    Citations: 9     Fields:    Translation:Humans
  23. Shih LC, Vanderhorst VG, Lozano AM, Hamani C, Moro E. Improvement of pisa syndrome with contralateral pedunculopontine stimulation. Mov Disord. 2013 Apr; 28(4):555-6. PMID: 23389993.
    Citations: 5     Fields:    Translation:Humans
  24. Kulkarni O, Lafaver K, Papavassiliou E, Tarsy D, Shih LC. Thalamic and subthalamic deep brain stimulation for parkinsonian tremor: are two circuits involved? Mov Disord. 2013 Apr; 28(4):554-5. PMID: 23389961.
    Citations:    Fields:    Translation:Humans
  25. Shih LC, Piel J, Warren A, Kraics L, Silver A, Vanderhorst V, Simon DK, Tarsy D. Singing in groups for Parkinson's disease (SING-PD): a pilot study of group singing therapy for PD-related voice/speech disorders. Parkinsonism Relat Disord. 2012 Jun; 18(5):548-52. PMID: 22436653.
    Citations: 2     Fields:    Translation:Humans
  26. Shih LC, Vanderhorst V, Papavassiliou E, Tarsy D. Sustained dyskinesias following elective cessation and reactivation of chronic subthalamic nucleus deep brain stimulation for a surgical procedure. Neuromodulation. 2011 Nov-Dec; 14(6):512-4; discussion 514. PMID: 21854491.
    Citations:    Fields:    Translation:Humans
  27. Shih LC, Tarsy D. Survey of U.S. neurologists' attitudes towards deep brain stimulation for Parkinson's disease. Neuromodulation. 2011 May-Jun; 14(3):208-13; discussion 213. PMID: 21992241.
    Citations: 1     Fields:    Translation:Humans
  28. Patel S, Chen BR, Mancinelli C, Paganoni S, Shih L, Welsh M, Dy J, Bonato P. Longitudinal monitoring of patients with Parkinson's disease via wearable sensor technology in the home setting. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:1552-5. PMID: 22254617.
    Citations: 2     Fields:    
  29. Chen BR, Patel S, Buckley T, Rednic R, McClure DJ, Shih L, Tarsy D, Welsh M, Bonato P. A web-based system for home monitoring of patients with Parkinson's disease using wearable sensors. IEEE Trans Biomed Eng. 2011 Mar; 58(3):831-6. PMID: 21041152.
    Citations: 18     Fields:    Translation:Humans
  30. Ekstein D, Shih LC, Sheen V. Neurological picture. Focal botulinum toxin injections lead to rapid resolution of myogenic artefact during EEG monitoring. J Neurol Neurosurg Psychiatry. 2010 Jun; 81(6):637-8. PMID: 20522871.
    Citations:    Fields:    Translation:Humans
  31. Shih LC and Tarsy D. Paradoxical akinesia. Katie Kompoliti and Leonard Verhagen, editors. Encyclopedia of Movement Disorders. 2010.
  32. Shih LC, Tarsy D. Alien limb. Katie Kompoliti and Leonard Verhagen, editors. Encyclopedia of Movement Disorders. 2010.
  33. Patel S, Chen BR, Buckley T, Rednic R, McClure D, Tarsy D, Shih L, Dy J, Welsh M, Bonato P. Home monitoring of patients with Parkinson's disease via wearable technology and a web-based application. Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:4411-4. PMID: 21096462.
    Citations: 13     Fields:    Translation:Humans
  34. Shih LC, Tarsy D. Dopamine Depletors. Katie Kompoliti and Leonard Verhagen, editors. Encyclopedia of Movement Disorders. 2010.
  35. Vanderhorst VG, Papavassiliou E, Tarsy D, Shih L. Early brain abscess: A rare complication of deep brain stimulation. Mov Disord. 2009 Jul 15; 24(9):1395-7. PMID: 19412938.
    Citations: 2     Fields:    Translation:Humans
  36. Simon DK, Tarsy D and Shih LC. BMJ Point-of-Care 2009; www.pointofcare.bmj.com. (Last accessed July, 2009) . Dystonia. 2009.
  37. Shih LC, Tarsy D and Papavassiliou E. Unsuccessful revision of Vim DBS leads in essential tremor (ET) patients with late failures: three cases. Movement Disorders. 2009; 24(Suppl 1):S492.
  38. Lungu C, Aia PG, Shih LC, Esper CD, Factor SA, Tarsy D. Tardive dyskinesia due to aripiprazole: report of 2 cases. J Clin Psychopharmacol. 2009 Apr; 29(2):185-6. PMID: 19512985.
    Citations: 2     Fields:    Translation:Humans
  39. Shih L and Tarsy D. Parkinson’s Disease. Waldman S and Terzic A, editors, Pharmacology and Therapeutics: Principles to Practice. 2009; 651-662.
  40. Shih LC and Tarsy D. Movement disorders. Savitz SI and Ronthal M, editors, Neurology Review for Psychiatrists. 2009; 81-105.
  41. Shih L and Tarsy D. Deep Brain Stimulation in Atypical Parkinsonism. Tarsy D, Okun M, Starr P and Vitek J, eds. Deep Brain Stimulation in Neurological and Psychiatric Disorders. 2008; 291-303.
  42. Shih LC, Tarsy D. Deep brain stimulation for the treatment of atypical parkinsonism. Mov Disord. 2007 Nov 15; 22(15):2149-55. PMID: 17659638.
    Citations: 15     Fields:    Translation:Humans
  43. Shih LC, Sobeih M, Tarsy D. Secondary nonkinesigenic paroxysmal dystonia after thalamic infarcts. Movement Disorders. 2007; 22(Suppl 16):S155.
  44. Shih LC, Saver JL, Alger JR, Starkman S, Leary MC, Vinuela F, Duckwiler G, Gobin YP, Jahan R, Villablanca JP, Vespa PM, Kidwell CS. Perfusion-weighted magnetic resonance imaging thresholds identifying core, irreversibly infarcted tissue. Stroke. 2003 Jun; 34(6):1425-30. PMID: 12738899.
    Citations: 46     Fields:    Translation:HumansCTClinical Trials
  45. Shih LC, Jarvinen N, Peltonen L. Positional cloning of the gene for Lethal Congenital Contracture Syndrome (LCCS). Journal of Investigative Medicine. 2000; 48(1 Suppl):77.
  46. Jarvinen NA, Makela-Bengs P, Chen L, Vuopala K, Peltonen L. Towards the gene for Lethal Congenital Contracture Syndrome. American Journal of Human Genetics. 1999; 65(4 Suppl):1698.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.