Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Dennis Arthur Ausiello, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R13DK041148 (AUSIELLO, DENNIS A) Sep 1, 1988 - Feb 28, 1989
    Role: Principal Investigator
  2. P01DK038452 (BROWN, DENNIS) Apr 1, 1987 - Aug 31, 2013
    Role: Co-Principal Investigator
  3. T32DK007540 (BROWN, DENNIS) Jul 1, 1986 - Jun 30, 2022
    Training for Multidisciplinary Research in Nephrology
    Role: Co-Principal Investigator
  4. P30ES003828 (BOYER, JAMES LORENZEN) Sep 27, 1985 - Mar 31, 2010
    Center for Membrane Toxicity Studies
    Role: Co-Principal Investigator
  5. T32GM007753 (WALENSKY, LOREN DAVID) Jul 1, 1979 - Jun 30, 2022
    Medical Scientist Training Program
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. George CE, Scheuch G, Seifart U, Inbaraj LR, Chandrasingh S, Nair IK, Hickey AJ, Barer MR, Fletcher E, Field RD, Salzman J, Moelis N, Ausiello D, Edwards DA. COVID-19 symptoms are reduced by targeted hydration of the nose, larynx and trachea. Sci Rep. 2022 03 29; 12(1):4599. PMID: 35351914; PMCID: PMC8964810.
    Citations: 3     Fields:    Translation:HumansCells
  2. Edwards DA, Ausiello D, Salzman J, Devlin T, Langer R, Beddingfield BJ, Fears AC, Doyle-Meyers LA, Redmann RK, Killeen SZ, Maness NJ, Roy CJ. Exhaled aerosol increases with COVID-19 infection, age, and obesity. Proc Natl Acad Sci U S A. 2021 02 23; 118(8). PMID: 33563754.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  3. Bashyam A, Frangieh CJ, Raigani S, Sogo J, Bronson RT, Uygun K, Yeh H, Ausiello DA, Cima MJ. A portable single-sided magnetic-resonance sensor for the grading of liver steatosis and fibrosis. Nat Biomed Eng. 2021 03; 5(3):240-251. PMID: 33257853.
    Citations: 1     Fields:    Translation:HumansAnimals
  4. Colucci LA, Corapi KM, Li M, Parada XV, Allegretti AS, Lin HY, Ausiello DA, Rosen MS, Cima MJ. Fluid assessment in dialysis patients by point-of-care magnetic relaxometry. Sci Transl Med. 2019 07 24; 11(502). PMID: 31341060.
    Citations: 5     Fields:    Translation:HumansCells
  5. Marshansky V, Hosokawa H, Merkulova M, Bakulina A, Dip PV, Thaker YR, Bjargava A, Tonra JR, Ausiello DA, Grüber G. Structural model of a2-subunit N-terminus and its binding interface for Arf-GEF CTH2: Implication for regulation of V-ATPase, CTH2 function and rational drug design. Curr Top Membr. 2019; 83:77-106. PMID: 31196611.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Murton OM, Hillman RE, Mehta DD, Semigran M, Daher M, Cunningham T, Verkouw K, Tabtabai S, Steiner J, Dec GW, Ausiello D. Acoustic speech analysis of patients with decompensated heart failure: A pilot study. J Acoust Soc Am. 2017 10; 142(4):EL401. PMID: 29092550; PMCID: PMC5724620.
    Citations: 10     Fields:    Translation:Humans
  7. Kamaly N, He JC, Ausiello DA, Farokhzad OC. Nanomedicines for renal disease: current status and future applications. Nat Rev Nephrol. 2016 Dec; 12(12):738-753. PMID: 27795549.
    Citations: 44     Fields:    Translation:Humans
  8. Ausiello D, Lipnick S. Real-Time Assessment of Wellness and Disease in Daily Life. Big Data. 2015 Sep 01; 3(3):203-208. PMID: 26487991.
    Citations: 5     Fields:    
  9. Ausiello D, Shaw S. Quantitative human phenotyping: the next frontier in medicine. Trans Am Clin Climatol Assoc. 2014; 125:219-26; discussion 226-8. PMID: 25125736.
    Citations: 1     Fields:    Translation:Humans
  10. Hosokawa H, Dip PV, Merkulova M, Bakulina A, Zhuang Z, Khatri A, Jian X, Keating SM, Bueler SA, Rubinstein JL, Randazzo PA, Ausiello DA, Grüber G, Marshansky V. The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2. J Biol Chem. 2013 Feb 22; 288(8):5896-913. PMID: 23288846.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  11. Bouley R, Nunes P, Andriopoulos B, McLaughlin M, Webber MJ, Lin HY, Babitt JL, Gardella TJ, Ausiello DA, Brown D. Heterologous downregulation of vasopressin type 2 receptor is induced by transferrin. Am J Physiol Renal Physiol. 2013 Mar 01; 304(5):F553-64. PMID: 23235478.
    Citations: 3     Fields:    Translation:AnimalsCells
  12. Chen S, Webber MJ, Vilardaga JP, Khatri A, Brown D, Ausiello DA, Lin HY, Bouley R. Visualizing microtubule-dependent vasopressin type 2 receptor trafficking using a new high-affinity fluorescent vasopressin ligand. Endocrinology. 2011 Oct; 152(10):3893-904. PMID: 21828182; PMCID: PMC3176653.
    Citations: 4     Fields:    Translation:AnimalsCells
  13. Merkulova M, Hurtado-Lorenzo A, Hosokawa H, Zhuang Z, Brown D, Ausiello DA, Marshansky V. Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution. Am J Physiol Cell Physiol. 2011 Jun; 300(6):C1442-55. PMID: 21307348; PMCID: PMC3118619.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  14. Brown D, Breton S, Ausiello DA, Marshansky V. Sensing, signaling and sorting events in kidney epithelial cell physiology. Traffic. 2009 Mar; 10(3):275-84. PMID: 19170982.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  15. Raychowdhury MK, Ramos AJ, Zhang P, McLaughin M, Dai XQ, Chen XZ, Montalbetti N, Del Rocío Cantero M, Ausiello DA, Cantiello HF. Vasopressin receptor-mediated functional signaling pathway in primary cilia of renal epithelial cells. Am J Physiol Renal Physiol. 2009 Jan; 296(1):F87-97. PMID: 18945824.
    Citations: 37     Fields:    Translation:AnimalsCells
  16. Zalyapin EA, Bouley R, Hasler U, Vilardaga JP, Lin HY, Brown D, Ausiello DA. Effects of the renal medullary pH and ionic environment on vasopressin binding and signaling. Kidney Int. 2008 Dec; 74(12):1557-67. PMID: 18813286; PMCID: PMC3730289.
    Citations: 12     Fields:    Translation:AnimalsCells
  17. Ausiello D. Science education and communication: AAP Presidential Address. J Clin Invest. 2007 Oct; 117(10):3128-30. PMID: 17909633; PMCID: PMC1994634.
    Citations: 4     Fields:    
  18. Yi X, Bouley R, Lin HY, Bechoua S, Sun TX, Del Re E, Shioda T, Raychowdhury MK, Lu HA, Abou-Samra AB, Brown D, Ausiello DA. Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R. Am J Physiol Renal Physiol. 2007 May; 292(5):F1303-13. PMID: 17287200.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  19. Sever S, Skoch J, Newmyer S, Ramachandran R, Ko D, McKee M, Bouley R, Ausiello D, Hyman BT, Bacskai BJ. Physical and functional connection between auxilin and dynamin during endocytosis. EMBO J. 2006 Sep 20; 25(18):4163-74. PMID: 16946707; PMCID: PMC1570436.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  20. Crowley W, Courtney J, Jameson L, Pardes H, Moskowitz J, Orringer E, Rubenstein A, Wood A, Rettig R, Ausiello D, Brenner D, Collins F, Elias J, Greene W, Horowitz R, Jameson L, Kieff E, Thompson C, Swain JL. The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap. J Clin Invest. 2006 Aug; 116(8):2058-9. PMID: 16886049; PMCID: PMC1523419.
    Citations: 1     Fields:    Translation:Humans
  21. Bouley R, Hawthorn G, Russo LM, Lin HY, Ausiello DA, Brown D. Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment. Biol Cell. 2006 Apr; 98(4):215-32. PMID: 16563128.
    Citations: 26     Fields:    Translation:AnimalsCells
  22. Hurtado-Lorenzo A, Skinner M, El Annan J, Futai M, Sun-Wada GH, Bourgoin S, Casanova J, Wildeman A, Bechoua S, Ausiello DA, Brown D, Marshansky V. V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway. Nat Cell Biol. 2006 Feb; 8(2):124-36. PMID: 16415858.
    Citations: 199     Fields:    Translation:HumansAnimalsCells
  23. Raychowdhury MK, McLaughlin M, Ramos AJ, Montalbetti N, Bouley R, Ausiello DA, Cantiello HF. Characterization of single channel currents from primary cilia of renal epithelial cells. J Biol Chem. 2005 Oct 14; 280(41):34718-22. PMID: 16079132.
    Citations: 25     Fields:    Translation:AnimalsCells
  24. Bouley R, Lin HY, Raychowdhury MK, Marshansky V, Brown D, Ausiello DA. Downregulation of the vasopressin type 2 receptor after vasopressin-induced internalization: involvement of a lysosomal degradation pathway. Am J Physiol Cell Physiol. 2005 Jun; 288(6):C1390-401. PMID: 15677378.
    Citations: 19     Fields:    Translation:AnimalsCells
  25. Shaywitz DA, Ausiello DA. Preserving creativity in medicine. PLoS Med. 2004 Dec; 1(3):e34. PMID: 15630460; PMCID: PMC539041.
    Citations: 5     Fields:    Translation:Humans
  26. Raychowdhury MK, Ibarra C, Damiano A, Jackson GR, Smith PR, McLaughlin M, Prat AG, Ausiello DA, Lader AS, Cantiello HF. Characterization of Na+-permeable cation channels in LLC-PK1 renal epithelial cells. J Biol Chem. 2004 May 07; 279(19):20137-46. PMID: 14982925.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  27. Goldman L, Ausiello DA, Eds. Cecil Textbook of Medicine. 2004.
  28. El-Annan J, Brown D, Breton S, Bourgoin S, Ausiello DA, Marshansky V. Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ. Am J Physiol Cell Physiol. 2004 Apr; 286(4):C768-78. PMID: 14684384.
    Citations: 13     Fields:    Translation:AnimalsCells
  29. Bouley R, Sun TX, Chenard M, McLaughlin M, McKee M, Lin HY, Brown D, Ausiello DA. Functional role of the NPxxY motif in internalization of the type 2 vasopressin receptor in LLC-PK1 cells. Am J Physiol Cell Physiol. 2003 Oct; 285(4):C750-62. PMID: 12801889.
    Citations: 30     Fields:    Translation:AnimalsCells
  30. Marshansky V, Ausiello DA, Brown D. Physiological importance of endosomal acidification: potential role in proximal tubulopathies. Curr Opin Nephrol Hypertens. 2002 Sep; 11(5):527-37. PMID: 12187318.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  31. Shaywitz DA, Ausiello DA. Global health: a chance for Western physicians to give-and receive. Am J Med. 2002 Sep; 113(4):354-7. PMID: 12361834.
    Citations: 10     Fields:    Translation:Humans
  32. Shaywitz DA, Ausiello DA. The 15% solution for majority health concerns. Nature. 2002 Feb 07; 415(6872):575. PMID: 11832912.
    Citations: 1     Fields:    
  33. Tekirian TL, Merriam DE, Marshansky V, Miller J, Crowley AC, Chan H, Ausiello D, Brown D, Buxbaum JD, Xia W, Wasco W. Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments. Brain Res Mol Brain Res. 2001 Nov 30; 96(1-2):14-20. PMID: 11731004.
    Citations: 3     Fields:    Translation:HumansCells
  34. Shaywitz DA, Ausiello DA. The necessary risks of medical research. N Y Times Web. 2001 Jul 29; 4WK. PMID: 12154824.
    Citations:    Translation:Humans
  35. Maranda B, Brown D, Bourgoin S, Casanova JE, Vinay P, Ausiello DA, Marshansky V. Intra-endosomal pH-sensitive recruitment of the Arf-nucleotide exchange factor ARNO and Arf6 from cytoplasm to proximal tubule endosomes. J Biol Chem. 2001 May 25; 276(21):18540-50. PMID: 11278939.
    Citations: 47     Fields:    Translation:AnimalsCells
  36. Bouley R, Breton S, Sun T, McLaughlin M, Nsumu NN, Lin HY, Ausiello DA, Brown D. Nitric oxide and atrial natriuretic factor stimulate cGMP-dependent membrane insertion of aquaporin 2 in renal epithelial cells. J Clin Invest. 2000 Nov; 106(9):1115-26. PMID: 11067864; PMCID: PMC301414.
    Citations: 74     Fields:    Translation:AnimalsCells
  37. Sullivan BM, Harrison-Lavoie KJ, Marshansky V, Lin HY, Kehrl JH, Ausiello DA, Brown D, Druey KM. RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport. Mol Biol Cell. 2000 Sep; 11(9):3155-68. PMID: 10982407; PMCID: PMC14982.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  38. Shaywitz DA, Martin JB, Ausiello DA. Patient-oriented research: principles and new approaches to training. Am J Med. 2000 Aug 01; 109(2):136-40. PMID: 10967155.
    Citations: 13     Fields:    Translation:Humans
  39. Costa ST, Ausiello D, Joiner K, Neilson EG, Taylor I, Wenzel R. Supporting research in departments of internal medicine: recommendations for NIH. Am J Med. 2000 Aug 01; 109(2):178-80. PMID: 10967163.
    Citations:    Fields:    Translation:Humans
  40. Prat AG, Cunningham CC, Jackson GR, Borkan SC, Wang Y, Ausiello DA, Cantiello HF. Actin filament organization is required for proper cAMP-dependent activation of CFTR. Am J Physiol. 1999 12; 277(6):C1160-9. PMID: 10600767.
    Citations: 18     Fields:    Translation:HumansCells
  41. Nelson RD, Stricklett P, Gustafson C, Stevens A, Ausiello D, Brown D, Kohan DE. Expression of an AQP2 Cre recombinase transgene in kidney and male reproductive system of transgenic mice. Am J Physiol. 1998 07; 275(1):C216-26. PMID: 9688853.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  42. Cantiello HF, Jackson GR, Grosman CF, Prat AG, Borkan SC, Wang Y, Reisin IL, O'Riordan CR, Ausiello DA. Electrodiffusional ATP movement through the cystic fibrosis transmembrane conductance regulator. Am J Physiol. 1998 03; 274(3):C799-809. PMID: 9530112.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  43. J. Larry Jameson, Associate Editor: DA Ausiello. Principles of Molecular Medicine. 1998.
  44. Williams KP, Liu XH, Schumacher TN, Lin HY, Ausiello DA, Kim PS, Bartel DP. Bioactive and nuclease-resistant L-DNA ligand of vasopressin. Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11285-90. PMID: 9326601; PMCID: PMC23443.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  45. Katsura T, Gustafson CE, Ausiello DA, Brown D. Protein kinase A phosphorylation is involved in regulated exocytosis of aquaporin-2 in transfected LLC-PK1 cells. Am J Physiol. 1997 Jun; 272(6 Pt 2):F817-22. PMID: 9227644.
    Citations: 106     Fields:    Translation:AnimalsCells
  46. Berdiev BK, Shlyonsky VG, Senyk O, Keeton D, Guo Y, Matalon S, Cantiello HF, Prat AG, Ausiello DA, Ismailov II, Benos DJ. Protein kinase A phosphorylation and G protein regulation of type II pneumocyte Na+ channels in lipid bilayers. Am J Physiol. 1997 Apr; 272(4 Pt 1):C1262-70. PMID: 9142851.
    Citations: 2     Fields:    Translation:AnimalsCells
  47. Ismailov II, Berdiev BK, Shlyonsky VG, Fuller CM, Prat AG, Jovov B, Cantiello HF, Ausiello DA, Benos DJ. Role of actin in regulation of epithelial sodium channels by CFTR. Am J Physiol. 1997 Apr; 272(4 Pt 1):C1077-86. PMID: 9142832.
    Citations: 19     Fields:    Translation:AnimalsCells
  48. Cantiello HF, Jackson GR, Prat AG, Gazley JL, Forrest JN, Ausiello DA. cAMP activates an ATP-conductive pathway in cultured shark rectal gland cells. Am J Physiol. 1997 Feb; 272(2 Pt 1):C466-75. PMID: 9124289.
    Citations: 6     Fields:    Translation:AnimalsCells
  49. Berdiev BK, Prat AG, Cantiello HF, Ausiello DA, Fuller CM, Jovov B, Benos DJ, Ismailov II. Regulation of epithelial sodium channels by short actin filaments. J Biol Chem. 1996 Jul 26; 271(30):17704-10. PMID: 8663510.
    Citations: 33     Fields:    Translation:AnimalsCells
  50. Hozawa S, Holtzman EJ, Ausiello DA. cAMP motifs regulating transcription in the aquaporin 2 gene. Am J Physiol. 1996 Jun; 270(6 Pt 1):C1695-702. PMID: 8764152.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  51. Brand SH, Holtzman EJ, Scher DA, Ausiello DA, Stow JL. Role of myristoylation in membrane attachment and function of G alpha i-3 on Golgi membranes. Am J Physiol. 1996 May; 270(5 Pt 1):C1362-9. PMID: 8967436.
    Citations: 3     Fields:    Translation:AnimalsCells
  52. Katsura T, Ausiello DA, Brown D. Direct demonstration of aquaporin-2 water channel recycling in stably transfected LLC-PK1 epithelial cells. Am J Physiol. 1996 Mar; 270(3 Pt 2):F548-53. PMID: 8780259.
    Citations: 17     Fields:    Translation:AnimalsCells
  53. Prat AG, Reisin IL, Ausiello DA, Cantiello HF. Cellular ATP release by the cystic fibrosis transmembrane conductance regulator. Am J Physiol. 1996 Feb; 270(2 Pt 1):C538-45. PMID: 8779917.
    Citations: 22     Fields:    Translation:AnimalsCells
  54. Neilson EG, Ausiello D, Demer LL. Physician-scientists as missing persons. Association of Subspecialty Professors. J Investig Med. 1995 Dec; 43(6):534-42. PMID: 8605612.
    Citations: 2     Fields:    Translation:Humans
  55. Katsura T, Verbavatz JM, Farinas J, Ma T, Ausiello DA, Verkman AS, Brown D. Constitutive and regulated membrane expression of aquaporin 1 and aquaporin 2 water channels in stably transfected LLC-PK1 epithelial cells. Proc Natl Acad Sci U S A. 1995 Aug 01; 92(16):7212-6. PMID: 7543677; PMCID: PMC41309.
    Citations: 50     Fields:    Translation:AnimalsCells
  56. Prat AG, Xiao YF, Ausiello DA, Cantiello HF. cAMP-independent regulation of CFTR by the actin cytoskeleton. Am J Physiol. 1995 Jun; 268(6 Pt 1):C1552-61. PMID: 7541942.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  57. Kunzelmann K, Slotki IN, Klein P, Koslowsky T, Ausiello DA, Greger R, Cabantchik ZI. Effects of P-glycoprotein expression on cyclic AMP and volume-activated ion fluxes and conductances in HT-29 colon adenocarcinoma cells. J Cell Physiol. 1994 Dec; 161(3):393-406. PMID: 7962123.
    Citations: 8     Fields:    Translation:HumansCells
  58. Valenti G, Verbavatz JM, Sabolic I, Ausiello DA, Verkman AS, Brown D. A basolateral CHIP28/MIP26-related protein (BLIP) in kidney principal cells and gastric parietal cells. Am J Physiol. 1994 Sep; 267(3 Pt 1):C812-20. PMID: 7524336.
    Citations: 6     Fields:    Translation:AnimalsCells
  59. Reisin IL, Prat AG, Abraham EH, Amara JF, Gregory RJ, Ausiello DA, Cantiello HF. The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel. J Biol Chem. 1994 Aug 12; 269(32):20584-91. PMID: 7519611.
    Citations: 99     Fields:    Translation:HumansAnimalsCells
  60. Holtzman EJ, Kolakowski LF, Geifman-Holtzman O, O'Brien DG, Rasoulpour M, Guillot AP, Ausiello DA. Mutations in the vasopressin V2 receptor gene in two families with nephrogenic diabetes insipidus. J Am Soc Nephrol. 1994 Aug; 5(2):169-76. PMID: 7993996.
    Citations:    Fields:    Translation:HumansCells
  61. Cantiello HF, Prat AG, Reisin IL, Ercole LB, Abraham EH, Amara JF, Gregory RJ, Ausiello DA. External ATP and its analogs activate the cystic fibrosis transmembrane conductance regulator by a cyclic AMP-independent mechanism. J Biol Chem. 1994 Apr 15; 269(15):11224-32. PMID: 7512560.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  62. Verbavatz JM, Van Hoek AN, Ma T, Sabolic I, Valenti G, Ellisman MH, Ausiello DA, Verkman AS, Brown D. A 28 kDa sarcolemmal antigen in kidney principal cell basolateral membranes: relationship to orthogonal arrays and MIP26. J Cell Sci. 1994 Apr; 107 ( Pt 4):1083-94. PMID: 7520041.
    Citations: 8     Fields:    Translation:AnimalsCells
  63. Holtzman EJ, Ausiello DA. Nephrogenic diabetes insipidus: causes revealed. Hosp Pract (Off Ed). 1994 Mar 15; 29(3):89-93, 97-8, 103-4. PMID: 8132731.
    Citations: 3     Fields:    Translation:HumansCells
  64. de Almeida JB, Holtzman EJ, Peters P, Ercolani L, Ausiello DA, Stow JL. Targeting of chimeric G alpha i proteins to specific membrane domains. J Cell Sci. 1994 Mar; 107 ( Pt 3):507-15. PMID: 8006069.
    Citations: 11     Fields:    Translation:AnimalsCells
  65. Dosanjh A, Lencer W, Brown D, Ausiello DA, Stow JL. Heterologous expression of delta F508 CFTR results in decreased sialylation of membrane glycoconjugates. Am J Physiol. 1994 Feb; 266(2 Pt 1):C360-6. PMID: 7511336.
    Citations: 14     Fields:    Translation:AnimalsCells
  66. Breuer W, Slotki IN, Ausiello DA, Cabantchik IZ. Induction of multidrug resistance downregulates the expression of CFTR in colon epithelial cells. Am J Physiol. 1993 Dec; 265(6 Pt 1):C1711-5. PMID: 7506492.
    Citations: 13     Fields:    Translation:HumansCells
  67. Lencer WI, de Almeida JB, Moe S, Stow JL, Ausiello DA, Madara JL. Entry of cholera toxin into polarized human intestinal epithelial cells. Identification of an early brefeldin A sensitive event required for A1-peptide generation. J Clin Invest. 1993 Dec; 92(6):2941-51. PMID: 8254049; PMCID: PMC288498.
    Citations: 48     Fields:    Translation:HumansCells
  68. de Almeida JB, Doherty J, Ausiello DA, Stow JL. Binding of the cytosolic p200 protein to Golgi membranes is regulated by heterotrimeric G proteins. J Cell Sci. 1993 Dec; 106 ( Pt 4):1239-48. PMID: 8126104.
    Citations: 9     Fields:    Translation:AnimalsCells
  69. Verbavatz JM, Brown D, Sabolic I, Valenti G, Ausiello DA, Van Hoek AN, Ma T, Verkman AS. Tetrameric assembly of CHIP28 water channels in liposomes and cell membranes: a freeze-fracture study. J Cell Biol. 1993 Nov; 123(3):605-18. PMID: 7693713; PMCID: PMC2200118.
    Citations: 53     Fields:    Translation:AnimalsCells
  70. Ausiello DA. Renal tubular transport mechanisms. Semin Nephrol. 1993 Sep; 13(5):472-8. PMID: 7692578.
    Citations:    Fields:    Translation:HumansAnimalsCells
  71. Holtzman EJ, Kolakowski LF, O'Brien D, Crawford JD, Ausiello DA. A Null mutation in the vasopressin V2 receptor gene (AVPR2) associated with nephrogenic diabetes insipidus in the Hopewell kindred. Hum Mol Genet. 1993 Aug; 2(8):1201-4. PMID: 8401502.
    Citations: 4     Fields:    Translation:HumansCells
  72. Breuer W, Glickstein H, Kartner N, Riordan JR, Ausiello DA, Cabantchik IZ. Protein kinase C mediates down-regulation of cystic fibrosis transmembrane conductance regulator levels in epithelial cells. J Biol Chem. 1993 Jul 05; 268(19):13935-9. PMID: 7686146.
    Citations: 5     Fields:    Translation:HumansCells
  73. Prat AG, Ausiello DA, Cantiello HF. Vasopressin and protein kinase A activate G protein-sensitive epithelial Na+ channels. Am J Physiol. 1993 Jul; 265(1 Pt 1):C218-23. PMID: 8393279.
    Citations: 8     Fields:    Translation:AnimalsCells
  74. Prat AG, Bertorello AM, Ausiello DA, Cantiello HF. Activation of epithelial Na+ channels by protein kinase A requires actin filaments. Am J Physiol. 1993 Jul; 265(1 Pt 1):C224-33. PMID: 8393280.
    Citations: 25     Fields:    Translation:AnimalsCells
  75. Holtzman EJ, Harris HW, Kolakowski LF, Guay-Woodford LM, Botelho B, Ausiello DA. Brief report: a molecular defect in the vasopressin V2-receptor gene causing nephrogenic diabetes insipidus. N Engl J Med. 1993 May 27; 328(21):1534-7. PMID: 8479490.
    Citations: 11     Fields:    Translation:HumansCells
  76. Cantiello HF, Prat AG, Bonventre JV, Cunningham CC, Hartwig JH, Ausiello DA. Actin-binding protein contributes to cell volume regulatory ion channel activation in melanoma cells. J Biol Chem. 1993 Mar 05; 268(7):4596-9. PMID: 8383118.
    Citations: 28     Fields:    Translation:HumansCells
  77. Holtzman EJ, Kinane TB, West K, Soper BW, Karga H, Ausiello DA, Ercolani L. Transcriptional regulation of G-protein alpha i subunit genes in LLC-PK1 renal cells and characterization of the porcine G alpha 1-3 gene promoter. J Biol Chem. 1993 Feb 25; 268(6):3964-75. PMID: 8440688.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  78. Ausiello DA, Massry S. Basic science research. Am J Kidney Dis. 1993 Jan; 21(1):120. PMID: 8418618.
    Citations:    Fields:    Translation:HumansCells
  79. Sabolic I, Valenti G, Verbavatz JM, Van Hoek AN, Verkman AS, Ausiello DA, Brown D. Localization of the CHIP28 water channel in rat kidney. Am J Physiol. 1992 Dec; 263(6 Pt 1):C1225-33. PMID: 1282299.
    Citations: 60     Fields:    Translation:Animals
  80. Sabolic I, Wuarin F, Shi LB, Verkman AS, Ausiello DA, Gluck S, Brown D. Apical endosomes isolated from kidney collecting duct principal cells lack subunits of the proton pumping ATPase. J Cell Biol. 1992 Oct; 119(1):111-22. PMID: 1388176; PMCID: PMC2289636.
    Citations: 8     Fields:    Translation:AnimalsCells
  81. Ausiello DA, Stow JL, Cantiello HF, de Almeida JB, Benos DJ. Purified epithelial Na+ channel complex contains the pertussis toxin-sensitive G alpha i-3 protein. J Biol Chem. 1992 Mar 05; 267(7):4759-65. PMID: 1311319.
    Citations: 14     Fields:    Translation:AnimalsCells
  82. Sabolic I, Shi LB, Brown D, Ausiello DA, Verkman AS. Proteinases inhibit H(+)-ATPase and Na+/H+ exchange but not water transport in apical and endosomal membranes from rat proximal tubule. Biochim Biophys Acta. 1992 Jan 10; 1103(1):137-47. PMID: 1309658.
    Citations: 2     Fields:    Translation:AnimalsCells
  83. Cantiello HF, Stow JL, Prat AG, Ausiello DA. Actin filaments regulate epithelial Na+ channel activity. Am J Physiol. 1991 Nov; 261(5 Pt 1):C882-8. PMID: 1659214.
    Citations: 78     Fields:    Translation:AnimalsCells
  84. Stow JL, de Almeida JB, Narula N, Holtzman EJ, Ercolani L, Ausiello DA. A heterotrimeric G protein, G alpha i-3, on Golgi membranes regulates the secretion of a heparan sulfate proteoglycan in LLC-PK1 epithelial cells. J Cell Biol. 1991 Sep; 114(6):1113-24. PMID: 1910049; PMCID: PMC2289129.
    Citations: 88     Fields:    Translation:AnimalsCells
  85. Holtzman EJ, Soper BW, Stow JL, Ausiello DA, Ercolani L. Regulation of the G-protein alpha i-2 subunit gene in LLC-PK1 renal cells and isolation of porcine genomic clones encoding the gene promoter. J Biol Chem. 1991 Jan 25; 266(3):1763-71. PMID: 1899094.
    Citations: 5     Fields:    Translation:AnimalsCells
  86. Ausiello DA, Stow JL, Patenaude CR, Cantiello HF. Guanine nucleotide binding proteins regulate epithelial Na+ channels. Adv Exp Med Biol. 1991; 290:333-43; discussion 343-5. PMID: 1659144.
    Citations: 1     Fields:    Translation:AnimalsCells
  87. Cantiello HF, Patenaude CR, Codina J, Birnbaumer L, Ausiello DA. G alpha i-3 regulates epithelial Na+ channels by activation of phospholipase A2 and lipoxygenase pathways. J Biol Chem. 1990 Dec 15; 265(35):21624-8. PMID: 2174882.
    Citations: 14     Fields:    Translation:AnimalsCells
  88. Lencer WI, Brown D, Ausiello DA, Verkman AS. Endocytosis of water channels in rat kidney: cell specificity and correlation with in vivo antidiuresis. Am J Physiol. 1990 Dec; 259(6 Pt 1):C920-32. PMID: 1701969.
    Citations: 8     Fields:    Translation:AnimalsCells
  89. Lencer WI, Verkman AS, Arnaout MA, Ausiello DA, Brown D. Endocytic vesicles from renal papilla which retrieve the vasopressin-sensitive water channel do not contain a functional H+ ATPase. J Cell Biol. 1990 Aug; 111(2):379-89. PMID: 1696262; PMCID: PMC2116183.
    Citations: 14     Fields:    Translation:AnimalsCells
  90. Hartwig JH, Brown D, Ausiello DA, Stossel TP, Orci L. Polarization of gelsolin and actin binding protein in kidney epithelial cells. J Histochem Cytochem. 1990 Aug; 38(8):1145-53. PMID: 2164058.
    Citations: 3     Fields:    Translation:AnimalsCells
  91. Ercolani L, Stow JL, Boyle JF, Holtzman EJ, Lin H, Grove JR, Ausiello DA. Membrane localization of the pertussis toxin-sensitive G-protein subunits alpha i-2 and alpha i-3 and expression of a metallothionein-alpha i-2 fusion gene in LLC-PK1 cells. Proc Natl Acad Sci U S A. 1990 Jun; 87(12):4635-9. PMID: 1693774; PMCID: PMC54171.
    Citations: 34     Fields:    Translation:AnimalsCells
  92. Lencer WI, Weyer P, Verkman AS, Ausiello DA, Brown D. FITC-dextran as a probe for endosome function and localization in kidney. Am J Physiol. 1990 Feb; 258(2 Pt 1):C309-17. PMID: 1689545.
    Citations: 29     Fields:    Translation:AnimalsCells
  93. Brown D, Verkman A, Skorecki K, Ausiello D. The cellular action of antidiuretic hormone. Methods Enzymol. 1990; 191:551-71. PMID: 2074776.
    Citations: 1     Fields:    Translation:AnimalsCells
  94. Cantiello HF, Patenaude CR, Ausiello DA. G protein subunit, alpha i-3, activates a pertussis toxin-sensitive Na+ channel from the epithelial cell line, A6. J Biol Chem. 1989 Dec 15; 264(35):20867-70. PMID: 2556387.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  95. Verkman AS, Weyer P, Brown D, Ausiello DA. Functional water channels are present in clathrin-coated vesicles from bovine kidney but not from brain. J Biol Chem. 1989 Dec 05; 264(34):20608-13. PMID: 2573601.
    Citations: 15     Fields:    Translation:AnimalsCells
  96. Ausiello DA. Symposium on signal transduction. Kidney Int. 1989 Dec; 36(6):945-8. PMID: 2601263.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  97. Ausiello D. Cellular biology of the water channel. Kidney Int. 1989 Sep; 36(3):497-506. PMID: 2593494.
    Citations:    Fields:    Translation:HumansAnimalsCells
  98. Light DB, Ausiello DA, Stanton BA. Guanine nucleotide-binding protein, alpha i-3, directly activates a cation channel in rat renal inner medullary collecting duct cells. J Clin Invest. 1989 Jul; 84(1):352-6. PMID: 2472428; PMCID: PMC303990.
    Citations: 13     Fields:    Translation:Animals
  99. Brown D, Sorscher EJ, Ausiello DA, Benos DJ. Immunocytochemical localization of Na+ channels in rat kidney medulla. Am J Physiol. 1989 Feb; 256(2 Pt 2):F366-9. PMID: 2537028.
    Citations: 10     Fields:    Translation:Animals
  100. Crabos M, Ausiello DA, Haupert GT, Cantiello HF. Atrial natriuretic peptide regulates release of Na+-K+-ATPase inhibitor from rat brain. Am J Physiol. 1988 Jun; 254(6 Pt 2):F912-7. PMID: 2837911.
    Citations: 4     Fields:    Translation:AnimalsCells
  101. Verkman AS, Lencer WI, Brown D, Ausiello DA. Endosomes from kidney collecting tubule cells contain the vasopressin-sensitive water channel. Nature. 1988 May 19; 333(6170):268-9. PMID: 3368004.
    Citations: 38     Fields:    Translation:AnimalsCells
  102. Editors: A.W. Cowley, J.F. Liard, and D.A. Ausiello. Vasopressin: Cellular and Integrative Functions. 1988.
  103. Ausiello DA, Verkman AS, Skorecki KL. Vasopressin-sensitive adenylate cyclase: subunit interactions assessed by target analysis and computer modelling. Kidney Int Suppl. 1987 Dec; 23:S43-55. PMID: 3126336.
    Citations:    Fields:    Translation:AnimalsCells
  104. Mohrmann M, Cantiello HF, Ausiello DA. Renal epithelial cell growth can occur in absence of Na+-H+ exchanger activity. Am J Physiol. 1987 Nov; 253(5 Pt 1):C633-8. PMID: 2825529.
    Citations: 2     Fields:    Translation:Cells
  105. Hartwig JH, Ausiello DA, Brown D. Vasopressin-induced changes in the three-dimensional structure of toad bladder apical surface. Am J Physiol. 1987 Nov; 253(5 Pt 1):C707-20. PMID: 3120594.
    Citations: 5     Fields:    Translation:AnimalsCells
  106. Mohrmann M, Cantiello HF, Ausiello DA. Inhibition of epithelial Na+ transport by atriopeptin, protein kinase c, and pertussis toxin. Am J Physiol. 1987 Aug; 253(2 Pt 2):F372-6. PMID: 2956893.
    Citations: 12     Fields:    Translation:Cells
  107. Brown D, McCluskey RT, Ausiello DA. The cell biology of Heymann nephritis: a model of human membranous glomerulonephritis. Am J Kidney Dis. 1987 Jul; 10(1):74-6. PMID: 3300288.
    Citations: 1     Fields:    Translation:HumansAnimals
  108. Ausiello DA, Skorecki KL, Verkman AS, Bonventre JV. Vasopressin signaling in kidney cells. Kidney Int. 1987 Feb; 31(2):521-9. PMID: 2951552.
    Citations: 10     Fields:    Translation:HumansAnimals
  109. Skorecki KL, Verkman AS, Ausiello DA. Cross talk between stimulatory and inhibitory guanosine 5'-triphosphate binding proteins: role in activation and desensitization of the adenylate cyclase response to vasopressin. Biochemistry. 1987 Jan 27; 26(2):639-45. PMID: 3103683.
    Citations: 10     Fields:    Translation:AnimalsCells
  110. Ausiello DA, Hartwig J, Brown D. Membrane and microfilament organization and vasopressin action in transporting epithelia. Soc Gen Physiol Ser. 1987; 42:259-75. PMID: 3333192.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  111. Skorecki KL, Conte JM, Ausiello DA. Effects of hypertonicity on cAMP production in cultured renal epithelial cells (LLC-PK1). Miner Electrolyte Metab. 1987; 13(3):165-72. PMID: 3041190.
    Citations: 2     Fields:    Translation:AnimalsCells
  112. Axelrod L, Ryan CA, Shaw JL, Kieffer JD, Ausiello DA. Prostacyclin production by isolated rat adipocytes: evidence for cyclic adenosine 3',5'-monophosphate-dependent and independent mechanisms and for a selective effect of insulin. Endocrinology. 1986 Nov; 119(5):2233-9. PMID: 2429831.
    Citations: 2     Fields:    Translation:Animals
  113. Verkman AS, Skorecki KL, Jung CY, Ausiello DA. Target molecular weights for red cell band 3 stilbene and mercurial binding sites. Am J Physiol. 1986 Oct; 251(4 Pt 1):C541-8. PMID: 3020989.
    Citations: 1     Fields:    Translation:HumansCells
  114. Verkman AS, Ausiello DA, Jung CY, Skorecki KL. Mechanisms of nonhormonal activation of adenylate cyclase based on target analysis. Biochemistry. 1986 Aug 12; 25(16):4566-72. PMID: 3768298.
    Citations: 3     Fields:    Translation:Cells
  115. Cantiello HF, Ausiello DA. Atrial natriuretic factor and cGMP inhibit amiloride-sensitive Na+ transport in the cultured renal epithelial cell line, LLC-PK1. Biochem Biophys Res Commun. 1986 Jan 29; 134(2):852-60. PMID: 3004467.
    Citations: 12     Fields:    Translation:AnimalsCells
  116. Skorecki KL, Verkman AS, Ausiello DA. Vasopressin receptor-adenylate cyclase interactions. Studies in an intact cultured renal epithelial cell line (LLC-PK1). Miner Electrolyte Metab. 1986; 12(1):64-70. PMID: 3007962.
    Citations: 3     Fields:    Translation:AnimalsCells
  117. Verkman AS, Skorecki KL, Ausiello DA. Radiation inactivation of multimeric enzymes: application to subunit interactions of adenylate cyclase. Am J Physiol. 1986 Jan; 250(1 Pt 1):C103-14. PMID: 3942201.
    Citations: 1     Fields:    
  118. Skorecki KL, Verkman AS, Jung CY, Ausiello DA. Evidence for vasopressin activation of adenylate cyclase by subunit dissociation. Am J Physiol. 1986 Jan; 250(1 Pt 1):C115-23. PMID: 3942202.
    Citations: 1     Fields:    Translation:AnimalsCells
  119. Dix JA, Ausiello DA, Jung CY, Verkman AS. Target analysis studies of red cell water and urea transport. Biochim Biophys Acta. 1985 Dec 05; 821(2):243-52. PMID: 2998469.
    Citations: 7     Fields:    Translation:HumansCells
  120. Verkman AS, Dix JA, Seifter JL, Skorecki KL, Jung CY, Ausiello DA. Radiation inactivation studies of renal brush border water and urea transport. Am J Physiol. 1985 Dec; 249(6 Pt 2):F806-12. PMID: 3934983.
    Citations: 4     Fields:    Translation:AnimalsCells
  121. Ausiello DA, Zusman RM. The role of calcium in the stimulation of prostaglandin synthesis by vasopressin in rabbit renal-medullary interstitial cells in tissue culture. Biochem J. 1984 May 15; 220(1):139-45. PMID: 6430278; PMCID: PMC1153603.
    Citations: 3     Fields:    Translation:Animals
  122. Ausiello DA, Corwin HL, Hartwig JH. Identification of actin-binding protein and villin in toad bladder epithelia. Am J Physiol. 1984 Jan; 246(1 Pt 2):F101-4. PMID: 6421172.
    Citations: 1     Fields:    Translation:Animals
  123. Verkman AS, Skorecki K, Ausiello DA. Radiation inactivation of oligomeric enzyme systems: theoretical considerations. Proc Natl Acad Sci U S A. 1984 Jan; 81(1):150-4. PMID: 6582472; PMCID: PMC344628.
    Citations: 12     Fields:    
  124. Ausiello DA. A role for calmodulin in the activation of adenylate cyclase by vasopressin. Prog Clin Biol Res. 1982; 91:543-50. PMID: 6815663.
    Citations:    Fields:    Translation:AnimalsCells
  125. Ausiello DA, Hall D. Regulation of vasopressin-sensitive adenylate cyclase by calmodulin. J Biol Chem. 1981 Oct 10; 256(19):9796-8. PMID: 7275976.
    Citations: 7     Fields:    Translation:AnimalsCells
  126. Roy C, Hall D, Karish M, Ausiello DA. Relationship of (8-lysine) vasopressin receptor transition to receptor functional properties in a pig kidney cell line (LLC-PK1). J Biol Chem. 1981 Apr 10; 256(7):3423-7. PMID: 6162846.
    Citations: 9     Fields:    Translation:AnimalsCells
  127. Roy C, Ausiello DA. Characterization of (8-lysine) vasopressin binding sites on a pig kidney cell line (LLC-PK1). Evidence for hormone-induced receptor transition. J Biol Chem. 1981 Apr 10; 256(7):3415-22. PMID: 6259166.
    Citations: 10     Fields:    Translation:AnimalsCells
  128. Mills JW, Macknight AD, Jarrell JA, Dayer JM, Ausiello DA. Interaction of ouabain with the Na+ pump in intact epithelial cells. J Cell Biol. 1981 Mar; 88(3):637-43. PMID: 6260815; PMCID: PMC2112757.
    Citations: 8     Fields:    Translation:AnimalsCells
  129. Roy C, Ausiello DA. Regulation of vasopressin binding to intact cells. Ann N Y Acad Sci. 1981; 372:92-105. PMID: 6951430.
    Citations: 1     Fields:    Translation:AnimalsCells
  130. Ausiello DA and Kiprov D. Case records of the Massachusetts General Hospital: Renal failure in a 29-year-old man with manic psychosis. New Eng J Med. 1981; 304:1025-1032.
  131. Ausiello DA, Rosenblatt M, Dayer JM. Parathyroid hormone modulates protein kinase in giant cell tumors of human bone. Am J Physiol. 1980 Aug; 239(2):E144-9. PMID: 6250407.
    Citations: 1     Fields:    Translation:HumansCells
  132. Ausiello DA, Hall DH, Dayer JM. Modulation of cyclic AMP-dependent protein kinase by vasopressin and calcitonin in cultured porcine renal LLC-PK1 cells. Biochem J. 1980 Mar 15; 186(3):773-80. PMID: 6249260; PMCID: PMC1161713.
    Citations: 7     Fields:    Translation:AnimalsCells
  133. Ausiello DA, Kreisberg JI, Roy C, Karnovsky MJ. Contraction of cultured rat glomerular cells of apparent mesangial origin after stimulation with angiotensin II and arginine vasopressin. J Clin Invest. 1980 Mar; 65(3):754-60. PMID: 6153393; PMCID: PMC371419.
    Citations: 81     Fields:    Translation:AnimalsCells
  134. Rabito CA, Ausiello DA. Na+-dependent sugar transport in a cultured epithelial cell line from pig kidney. J Membr Biol. 1980; 54(1):31-8. PMID: 7205941.
    Citations: 21     Fields:    Translation:AnimalsCells
  135. Mills JW, Macknight AD, Dayer JM, Ausiello DA. Localization of [3H]ouabain-sensitive Na+ pump sites in cultured pig kidney cells. Am J Physiol. 1979 Mar; 236(3):C157-62. PMID: 426047.
    Citations: 13     Fields:    Translation:AnimalsCells
  136. Goldring SR, Dayer JM, Ausiello DA, Krane SM. A cell strain cultured from porcine kidney increases cyclic AMP content upon exposure to calcitonin or vasopressin. Biochem Biophys Res Commun. 1978 Jul 28; 83(2):434-40. PMID: 212055.
    Citations: 24     Fields:    Translation:AnimalsCells
  137. Ausiello D, Handler J, Orloff J. Effect of parathyroid hormone and cyclic AMP on protein phosphorylation in rabbit kidney cortex. Biochim Biophys Acta. 1976 Dec 21; 451(2):372-81. PMID: 187225.
    Citations: 2     Fields:    Translation:Animals
  138. Ausiello DA, Segal S, Thier SO. Cellular accumulation of L-lysine in rat kidney cortex in vivo. Am J Physiol. 1972 Jun; 222(6):1473-8. PMID: 5030205.
    Citations: 6     Fields:    Translation:Animals
  139. Kleinzeller A, Ausiello DA, Almendares J, Davis A . The effect of pH on sugar transport and ion distribution in kidney cortex cells. Biochim Biophys Acta. 1970; 211:293-307.
  140. Ausiello DA, Sharp GW. Localization of physiological receptor sites for aldosteone in the bladder of the toad, Bufo marinus. Endocrinology. 1968 Jun; 82(6):1163-9. PMID: 4869626.
    Citations: 5     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.