Harvard Catalyst Profiles

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Francis X. McGowan Jr., M.D.

Co-Author

This page shows the publications co-authored by Francis McGowan and Pedro Del Nido.
Connection Strength

3.960
  1. McGowan FX, Davis PJ, Siewers RD, del Nido PJ. Coronary vasoconstriction mediated by endothelin-1 in neonates. Reversal by nitroglycerin. J Thorac Cardiovasc Surg. 1995 Jan; 109(1):88-97; discussion 97-8.
    View in: PubMed
    Score: 0.166
  2. McGowan FX, Cao-Danh H, Takeuchi K, Davis PJ, del Nido PJ. Prolonged neonatal myocardial preservation with a highly buffered low-calcium solution. J Thorac Cardiovasc Surg. 1994 Oct; 108(4):772-9.
    View in: PubMed
    Score: 0.163
  3. Allan CK, Newburger JW, McGrath E, Elder J, Psoinos C, Laussen PC, del Nido PJ, Wypij D, McGowan FX. The relationship between inflammatory activation and clinical outcome after infant cardiopulmonary bypass. Anesth Analg. 2010 Nov; 111(5):1244-51.
    View in: PubMed
    Score: 0.123
  4. Griffiths ER, Friehs I, Scherr E, Poutias D, McGowan FX, Del Nido PJ. Electron transport chain dysfunction in neonatal pressure-overload hypertrophy precedes cardiomyocyte apoptosis independent of oxidative stress. J Thorac Cardiovasc Surg. 2010 Jun; 139(6):1609-17.
    View in: PubMed
    Score: 0.117
  5. Kitahori K, He H, Kawata M, Cowan DB, Friehs I, Del Nido PJ, McGowan FX. Development of left ventricular diastolic dysfunction with preservation of ejection fraction during progression of infant right ventricular hypertrophy. Circ Heart Fail. 2009 Nov; 2(6):599-607.
    View in: PubMed
    Score: 0.115
  6. Gonnella PA, Del Nido PJ, McGowan FX. Oral tolerization with cardiac myosin peptide (614-629) ameliorates experimental autoimmune myocarditis: role of STAT 6 genes in BALB/CJ mice. J Clin Immunol. 2009 Jul; 29(4):434-43.
    View in: PubMed
    Score: 0.112
  7. Choi YH, Cowan DB, Moran AM, Colan SD, Stamm C, Takeuchi K, Friehs I, del Nido PJ, McGowan FX. Myocyte apoptosis occurs early during the development of pressure-overload hypertrophy in infant myocardium. J Thorac Cardiovasc Surg. 2009 Jun; 137(6):1356-62, 1362.e1-3.
    View in: PubMed
    Score: 0.111
  8. Choi YH, Cowan DB, Nathan M, Poutias D, Stamm C, del Nido PJ, McGowan FX. Myocardial hypertrophy overrides the angiogenic response to hypoxia. PLoS One. 2008; 3(12):e4042.
    View in: PubMed
    Score: 0.110
  9. Gonnella PA, Waldner H, Del Nido PJ, McGowan FX. Inhibition of experimental autoimmune myocarditis: peripheral deletion of TcR Vbeta 8.1, 8.2+ CD4+ T cells in TLR-4 deficient mice. J Autoimmun. 2008 Sep; 31(2):180-7.
    View in: PubMed
    Score: 0.107
  10. Roy N, Friehs I, Cowan DB, Zurakowski D, McGowan FX, del Nido PJ. Dopamine induces postischemic cardiomyocyte apoptosis in vivo: an effect ameliorated by propofol. Ann Thorac Surg. 2006 Dec; 82(6):2192-9.
    View in: PubMed
    Score: 0.095
  11. Almond CS, Harrington J, Thiagarajan R, Duncan CN, LaPierre R, Halwick D, Blume ED, Del Nido PJ, Neufeld EJ, McGowan FX. Successful use of bivalirudin for cardiac transplantation in a child with heparin-induced thrombocytopenia. J Heart Lung Transplant. 2006 Nov; 25(11):1376-9.
    View in: PubMed
    Score: 0.094
  12. Friehs I, Barillas R, Vasilyev NV, Roy N, McGowan FX, del Nido PJ. Vascular endothelial growth factor prevents apoptosis and preserves contractile function in hypertrophied infant heart. Circulation. 2006 Jul 04; 114(1 Suppl):I290-5.
    View in: PubMed
    Score: 0.092
  13. Takeuchi K, McGowan FX, Bacha EA, Mayer JE, Zurakowski D, Otaki M, del Nido PJ. Analysis of surgical outcome in complex double-outlet right ventricle with heterotaxy syndrome or complete atrioventricular canal defect. Ann Thorac Surg. 2006 Jul; 82(1):146-52.
    View in: PubMed
    Score: 0.092
  14. Friehs I, Cao-Danh H, Nathan M, McGowan FX, del Nido PJ. Impaired insulin-signaling in hypertrophied hearts contributes to ischemic injury. Biochem Biophys Res Commun. 2005 May 27; 331(1):15-22.
    View in: PubMed
    Score: 0.085
  15. Nathan M, Friehs I, Choi YH, Cowan DB, Cao-Danh H, McGowan FX, del Nido PJ. Cyclosporin A but not FK-506 protects against dopamine-induced apoptosis in the stunned heart. Ann Thorac Surg. 2005 May; 79(5):1620-6.
    View in: PubMed
    Score: 0.085
  16. Friehs I, Moran AM, Stamm C, Choi YH, Cowan DB, McGowan FX, del Nido PJ. Promoting angiogenesis protects severely hypertrophied hearts from ischemic injury. Ann Thorac Surg. 2004 Jun; 77(6):2004-10; discussion 2011.
    View in: PubMed
    Score: 0.080
  17. Cowan DB, Jones M, Garcia LM, Noria S, del Nido PJ, McGowan FX. Hypoxia and stretch regulate intercellular communication in vascular smooth muscle cells through reactive oxygen species formation. Arterioscler Thromb Vasc Biol. 2003 Oct 01; 23(10):1754-60.
    View in: PubMed
    Score: 0.076
  18. Stamm C, Friehs I, Choi YH, Zurakowski D, McGowan FX, del Nido PJ. Cytosolic calcium in the ischemic rabbit heart: assessment by pH- and temperature-adjusted rhod-2 spectrofluorometry. Cardiovasc Res. 2003 Sep 01; 59(3):695-704.
    View in: PubMed
    Score: 0.076
  19. Friehs I, Cao-Danh H, Stamm C, Cowan DB, McGowan FX, del Nido PJ. Postnatal increase in insulin-sensitive glucose transporter expression is associated with improved recovery of postischemic myocardial function. J Thorac Cardiovasc Surg. 2003 Jul; 126(1):263-71.
    View in: PubMed
    Score: 0.075
  20. Chanani NK, Cowan DB, Takeuchi K, Poutias DN, Garcia LM, del Nido PJ, McGowan FX. Differential effects of amrinone and milrinone upon myocardial inflammatory signaling. Circulation. 2002 Sep 24; 106(12 Suppl 1):I284-9.
    View in: PubMed
    Score: 0.071
  21. Stamm C, Friehs I, Cowan DB, Cao-Danh H, Choi YH, Duebener LF, McGowan FX, del Nido PJ. Dopamine treatment of postischemic contractile dysfunction rapidly induces calcium-dependent pro-apoptotic signaling. Circulation. 2002 Sep 24; 106(12 Suppl 1):I290-8.
    View in: PubMed
    Score: 0.071
  22. Munakata M, Stamm C, Friehs I, Zurakowski D, Cowan DB, Cao-Danh H, McGowan FX, del Nido PJ. Protective effects of protein kinase C during myocardial ischemia require activation of phosphatidyl-inositol specific phospholipase C. Ann Thorac Surg. 2002 Apr; 73(4):1236-45.
    View in: PubMed
    Score: 0.069
  23. Takeuchi K, Simplaceanu E, McGowan FX, Tsushima T, del Nido PJ. L-arginine potentiates negative inotropic and metabolic effects to myocardium partly through the amiloride sensitive mechanism. Jpn J Physiol. 2002 Apr; 52(2):207-15.
    View in: PubMed
    Score: 0.069
  24. Stamm C, Cowan DB, Friehs I, Noria S, del Nido PJ, McGowan FX. Rapid endotoxin-induced alterations in myocardial calcium handling: obligatory role of cardiac TNF-alpha. Anesthesiology. 2001 Dec; 95(6):1396-405.
    View in: PubMed
    Score: 0.067
  25. Takeuchi K, Nagashima M, Itoh K, Minagawa M, Munakata M, Ichinoseki I, Fukui K, McGowan FX, del Nido PJ. Improving glucose metabolism and/or sarcoplasmic reticulum Ca2+-ATPase function is warranted for immature pressure overload hypertrophied myocardium. Jpn Circ J. 2001 Dec; 65(12):1064-70.
    View in: PubMed
    Score: 0.067
  26. Friehs I, Stamm C, Cao-Danh H, McGowan FX, del Nido PJ. Insulin-like growth factor-1 improves postischemic recovery in hypertrophied hearts. Ann Thorac Surg. 2001 Nov; 72(5):1650-6.
    View in: PubMed
    Score: 0.067
  27. Stamm C, Friehs I, Cowan DB, Moran AM, Cao-Danh H, Duebener LF, del Nido PJ, McGowan FX. Inhibition of tumor necrosis factor-alpha improves postischemic recovery of hypertrophied hearts. Circulation. 2001 Sep 18; 104(12 Suppl 1):I350-5.
    View in: PubMed
    Score: 0.066
  28. Stamm C, Friehs I, Cowan DB, Cao-Danh H, Noria S, Munakata M, McGowan FX, del Nido PJ. Post-ischemic PKC inhibition impairs myocardial calcium handling and increases contractile protein calcium sensitivity. Cardiovasc Res. 2001 Jul; 51(1):108-21.
    View in: PubMed
    Score: 0.065
  29. Cowan DB, Noria S, Stamm C, Garcia LM, Poutias DN, del Nido PJ, McGowan FX. Lipopolysaccharide internalization activates endotoxin-dependent signal transduction in cardiomyocytes. Circ Res. 2001 Mar 16; 88(5):491-8.
    View in: PubMed
    Score: 0.064
  30. MacGowan GA, Du C, Cowan DB, Stamm C, McGowan FX, Solaro RJ, Koretsky AP, Del Nido PJ. Ischemic dysfunction in transgenic mice expressing troponin I lacking protein kinase C phosphorylation sites. . 2001 Feb; 280(2):H835-43.
    View in: PubMed
    Score: 0.063
  31. Takeuchi K, McGowan FX, Moran AM, Zurakowski D, Mayer JE, Jonas RA, del Nido PJ. Surgical outcome of double-outlet right ventricle with subpulmonary VSD. Ann Thorac Surg. 2001 Jan; 71(1):49-52; discussion 52-3.
    View in: PubMed
    Score: 0.063
  32. Takeuchi K, del Nido PJ, Poutias DN, Cowan DB, Munakata M, McGowan FX. Vesnarinone restores contractility and calcium handling in early endotoxemia. Circulation. 2000 Nov 07; 102(19 Suppl 3):III365-9.
    View in: PubMed
    Score: 0.062
  33. Odegard KC, Kirse DJ, del Nido PJ, Laussen PC, Casta A, Booke J, Kenna MA, McGowan FX. Intraoperative recurrent laryngeal nerve monitoring during video-assisted throracoscopic surgery for patent ductus arteriosus. J Cardiothorac Vasc Anesth. 2000 Oct; 14(5):562-4.
    View in: PubMed
    Score: 0.062
  34. Cowan DB, Poutias DN, Del Nido PJ, McGowan FX. CD14-independent activation of cardiomyocyte signal transduction by bacterial endotoxin. . 2000 Aug; 279(2):H619-29.
    View in: PubMed
    Score: 0.061
  35. Laussen PC, Bichell DP, McGowan FX, Zurakowski D, DeMaso DR, del Nido PJ. Postoperative recovery in children after minimum versus full-length sternotomy. Ann Thorac Surg. 2000 Feb; 69(2):591-6.
    View in: PubMed
    Score: 0.059
  36. Friehs I, Moran AM, Stamm C, Colan SD, Takeuchi K, Cao-Danh H, Rader CM, McGowan FX, del Nido PJ. Impaired glucose transporter activity in pressure-overload hypertrophy is an early indicator of progression to failure. Circulation. 1999 Nov 09; 100(19 Suppl):II187-93.
    View in: PubMed
    Score: 0.058
  37. Takeuchi K, Cao-Danh H, Kawai A, Ohkado A, Konishi H, McGowan FX, del Nido PJ. Prolonged preservation of the blood-perfused canine heart with glycolysis-promoting solution. Ann Thorac Surg. 1999 Sep; 68(3):903-7.
    View in: PubMed
    Score: 0.057
  38. Takeuchi K, del Nido PJ, Ibrahim AE, Poutias DN, Glynn P, Cao-Danh H, Cowan DB, McGowan FX. Increased myocardial calcium cycling and reduced myofilament calcium sensitivity in early endotoxemia. Surgery. 1999 Aug; 126(2):231-8.
    View in: PubMed
    Score: 0.057
  39. Takeuchi K, del Nido PJ, Ibrahim AE, Cao-Danh H, Friehs I, Glynn P, Poutias D, Cowan DB, McGowan FX. Vesnarinone and amrinone reduce the systemic inflammatory response syndrome. J Thorac Cardiovasc Surg. 1999 Feb; 117(2):375-82.
    View in: PubMed
    Score: 0.055
  40. Takeuchi K, McGowan FX, Glynn P, Moran AM, Rader CM, Cao-Danh H, del Nido PJ. Glucose transporter upregulation improves ischemic tolerance in hypertrophied failing heart. Circulation. 1998 Nov 10; 98(19 Suppl):II234-9; discussion II240-1.
    View in: PubMed
    Score: 0.054
  41. Takeuchi K, Cao-Danh H, Friehs I, Glynn P, D'Agostino D, Simplaceanu E, McGowan FX, del Nido PJ. Administration of fructose 1,6-diphosphate during early reperfusion significantly improves recovery of contractile function in the postischemic heart. J Thorac Cardiovasc Surg. 1998 Aug; 116(2):335-43.
    View in: PubMed
    Score: 0.053
  42. Friehs I, Cao-Danh H, Takahashi S, Buenaventura P, Glynn P, McGowan FX, del Nido PJ. Adenosine prevents protein kinase C activation during hypothermic ischemia. Circulation. 1997 Nov 04; 96(9 Suppl):II-221-5; discussion II-225-6.
    View in: PubMed
    Score: 0.051
  43. Buenaventura P, Cao-Danh H, Glynn P, Takeuchi K, Takahashi S, Simplaceanu E, McGowan FX, del Nido PJ. Protein kinase C activation in the heart: effects on calcium and contractile proteins. Ann Thorac Surg. 1995 Dec; 60(6 Suppl):S505-8.
    View in: PubMed
    Score: 0.044
  44. Takeuchi K, Buenaventura P, Cao-Danh H, Glynn P, Simplaceanu E, McGowan FX, del Nido PJ. Improved protection of the hypertrophied left ventricle by histidine-containing cardioplegia. Circulation. 1995 Nov 01; 92(9 Suppl):II395-9.
    View in: PubMed
    Score: 0.044
  45. Luss H, Watkins SC, Freeswick PD, Imro AK, Nussler AK, Billiar TR, Simmons RL, del Nido PJ, McGowan FX. Characterization of inducible nitric oxide synthase expression in endotoxemic rat cardiac myocytes in vivo and following cytokine exposure in vitro. J Mol Cell Cardiol. 1995 Sep; 27(9):2015-29.
    View in: PubMed
    Score: 0.043
  46. Takeuchi K, McGowan FX, Danh HC, Glynn P, Simplaceanu E, del Nido PJ. Direct detrimental effects of L-arginine upon ischemia--reperfusion injury to myocardium. J Mol Cell Cardiol. 1995 Jul; 27(7):1405-14.
    View in: PubMed
    Score: 0.043
  47. McGowan FX, Davis PJ, del Nido PJ, Sobek M, Allen JW, Downing SE. Endothelium-dependent regulation of coronary tone in the neonatal pig. Anesth Analg. 1994 Dec; 79(6):1094-101.
    View in: PubMed
    Score: 0.041
  48. McGowan FX, Takeuchi K, del Nido PJ, Davis PJ, Lancaster JR, Hattler BG. Myocardial effects of interleukin-2. Transplant Proc. 1994 Feb; 26(1):209-10.
    View in: PubMed
    Score: 0.039
  49. McGowan FX, Ikegami M, del Nido PJ, Motoyama EK, Kurland G, Davis PJ, Siewers RD. Cardiopulmonary bypass significantly reduces surfactant activity in children. J Thorac Cardiovasc Surg. 1993 Dec; 106(6):968-77.
    View in: PubMed
    Score: 0.039
  50. Friehs I, Cowan DB, Choi YH, Black KM, Barnett R, Bhasin MK, Daly C, Dillon SJ, Libermann TA, McGowan FX, del Nido PJ, Levitsky S, McCully JD. Pressure-overload hypertrophy of the developing heart reveals activation of divergent gene and protein pathways in the left and right ventricular myocardium. . 2013 Mar 01; 304(5):H697-708.
    View in: PubMed
    Score: 0.036
  51. Nikolova A, Ablasser K, Wyler von Ballmoos MC, Poutias D, Kaza E, McGowan FX, Moses MA, Del Nido PJ, Friehs I. Endogenous angiogenesis inhibitors prevent adaptive capillary growth in left ventricular pressure overload hypertrophy. Ann Thorac Surg. 2012 Nov; 94(5):1509-17.
    View in: PubMed
    Score: 0.035
  52. Wolf CM, Seslar SP, den Boer K, Juraszek AL, McGowan FX, Cowan DB, Del Nido P, Triedman JK, Berul CI, Walsh EP. Atrial remodeling after the Fontan operation. Am J Cardiol. 2009 Dec 15; 104(12):1737-42.
    View in: PubMed
    Score: 0.029
  53. Perez AL, Bachrach E, Illigens BM, Jun SJ, Bagden E, Steffen L, Flint A, McGowan FX, Del Nido P, Montecino-Rodriguez E, Tidball JG, Kunkel LM. CXCR4 enhances engraftment of muscle progenitor cells. Muscle Nerve. 2009 Oct; 40(4):562-72.
    View in: PubMed
    Score: 0.029
  54. Bachrach E, Perez AL, Choi YH, Illigens BM, Jun SJ, del Nido P, McGowan FX, Li S, Flint A, Chamberlain J, Kunkel LM. Muscle engraftment of myogenic progenitor cells following intraarterial transplantation. Muscle Nerve. 2006 Jul; 34(1):44-52.
    View in: PubMed
    Score: 0.023
  55. Choi YH, Stamm C, Hammer PE, Kwaku KF, Marler JJ, Friehs I, Jones M, Rader CM, Roy N, Eddy MT, Triedman JK, Walsh EP, McGowan FX, del Nido PJ, Cowan DB. Cardiac conduction through engineered tissue. Am J Pathol. 2006 Jul; 169(1):72-85.
    View in: PubMed
    Score: 0.023
  56. Odegard KC, McGowan FX, Zurakowski D, Dinardo JA, Castro RA, del Nido PJ, Laussen PC. Procoagulant and anticoagulant factor abnormalities following the Fontan procedure: increased factor VIII may predispose to thrombosis. J Thorac Cardiovasc Surg. 2003 Jun; 125(6):1260-7.
    View in: PubMed
    Score: 0.019
  57. Moran AM, Friehs I, Takeuchi K, Stamm C, Hammer PE, McGowan FX, del Nido PJ, Colan SD. Noninvasive serial evaluation of myocardial mechanics in pressure overload hypertrophy of rabbit myocardium. Herz. 2003 Feb; 28(1):52-62.
    View in: PubMed
    Score: 0.018
  58. Odegard KC, McGowan FX, Zurakowski D, DiNardo JA, Castro RA, del Nido PJ, Laussen PC. Coagulation factor abnormalities in patients with single-ventricle physiology immediately prior to the Fontan procedure. Ann Thorac Surg. 2002 Jun; 73(6):1770-7.
    View in: PubMed
    Score: 0.017
  59. Odegard KC, McGowan FX, DiNardo JA, Castro RA, Zurakowski D, Connor CM, Hansen DD, Neufeld EJ, del Nido PJ, Laussen PC. Coagulation abnormalities in patients with single-ventricle physiology precede the Fontan procedure. J Thorac Cardiovasc Surg. 2002 Mar; 123(3):459-65.
    View in: PubMed
    Score: 0.017
  60. Luppi P, Rudert WA, Zanone MM, Stassi G, Trucco G, Finegold D, Boyle GJ, Del Nido P, McGowan FX, Trucco M. Idiopathic dilated cardiomyopathy: a superantigen-driven autoimmune disease. Circulation. 1998 Aug 25; 98(8):777-85.
    View in: PubMed
    Score: 0.013
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.