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profileBeate Klara Maria Lanske, Ph.D.

TitleProfessor of Oral Medicine, Infection, and Immunity
InstitutionHarvard School of Dental Medicine
DepartmentOral Med - Infection + Immunity
AddressHarvard School of Dental Medicine
Oral Medicine, Infection & Immunity, REB, Rm 303
188 Longwood Ave
Boston MA 02115
Phone617/432-5748
Fax617/432-5767
vCardDownload vCard (login for email)
Other Positions
TitleAssociate Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
DivisionEndocrinology


Collapse Mentoring 
Collapse completed student projects
Ablation of Napi2a Changes Expression Profile of Bone Markers in FGF-23 KO Mice
Summer, 06/16/06 - 08/25/06
Effects of Age on Regulation of Human Osteoclast Differentiation in Marrow Cells from Pediatric and Adult Subjects
Summer, 06/14/10 - 05/31/13
Signaling Pathways in Mechanotransduction of Bone Cell Networks
Summer, 06/01/11 - 08/05/11
Role of Indian hedgehog during endochondral bone formation
Summer, 07/03/06 - 08/25/06
Assessment of laser-mediated dentin repair in rodent model by raman spectroscopy
Part Time, 11/01/10 - 04/30/11

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R56DK112374     (LANSKE, BEATE)Sep 1, 2016 - Aug 31, 2017
NIH/NIDDK
PTH resistance and bone marrow adipogenesis
Role: Principle Investigator

R01DK097105     (LANSKE, BEATE)Sep 26, 2012 - Jun 30, 2016
NIH/NIDDK
The Regulation of the Parathyroid Gland
Role: Principal Investigator

RC1DK087289     (LANSKE, BEATE)Sep 19, 2009 - Aug 31, 2012
NIH/NIDDK
Innovative mouse model to study parathyroids and an application to human disease
Role: Principal Investigator

R01DK073944     (LANSKE, BEATE)Apr 20, 2007 - Mar 31, 2012
NIH/NIDDK
Pathophysiologic Regulation of Fgf-23 in Phosphate Homeostasis: Role of Vitamin D
Role: Principal Investigator

R56DK073944     (LANSKE, BEATE)Dec 1, 2005 - Feb 28, 2013
NIH/NIDDK
Pathophysiologic Regulation of Fgf-23 in Phosphate Homeostasis: Role of Vitamin D
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Komaba H, Kaludjerovic J, Hu DZ, Nagano K, Amano K, Ide N, Sato T, Densmore MJ, Hanai JI, Olauson H, Bellido T, Larsson TE, Baron R, Lanske B. Klotho expression in osteocytes regulates bone metabolism and controls bone formation. Kidney Int. 2017 Apr 08. PMID: 28396120.
    View in: PubMed
  2. Sato T, Courbebaisse M, Ide N, Fan Y, Hanai JI, Kaludjerovic J, Densmore MJ, Yuan Q, Toka HR, Pollak MR, Hou J, Lanske B. Parathyroid hormone controls paracellular Ca2+ transport in the thick ascending limb by regulating the tight-junction protein Claudin14. Proc Natl Acad Sci U S A. 2017 Apr 18; 114(16):E3344-E3353. PMID: 28373577.
    View in: PubMed
  3. Bone Marrow Adipose Tissue: The First 40 Years. J Bone Miner Res. 2017 Mar 31. PMID: 28370194.
    View in: PubMed
  4. Kaludjerovic J, Komaba H, Lanske B. Effects of klotho deletion from bone during chronic kidney disease. Bone. 2017 Feb 20. PMID: 28232146.
    View in: PubMed
  5. Kaludjerovic J, Komaba H, Sato T, Erben RG, Baron R, Olauson H, Larsson TE, Lanske B. Klotho expression in long bones regulates FGF23 production during renal failure. FASEB J. 2017 May; 31(5):2050-2064. PMID: 28183805.
    View in: PubMed
  6. Fan Y, Hanai JI, Le PT, Bi R, Maridas D, DeMambro V, Figueroa CA, Kir S, Zhou X, Mannstadt M, Baron R, Bronson RT, Horowitz MC, Wu JY, Bilezikian JP, Dempster DW, Rosen CJ, Lanske B. Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate. Cell Metab. 2017 Mar 07; 25(3):661-672. PMID: 28162969.
    View in: PubMed
  7. Boisen IM, Bøllehuus Hansen L, Mortensen LJ, Lanske B, Juul A, Blomberg Jensen M. Possible influence of vitamin D on male reproduction. J Steroid Biochem Mol Biol. 2016 Sep 28. PMID: 27693423.
    View in: PubMed
  8. Blomberg Jensen M, Gerner Lawaetz J, Andersson AM, Petersen JH, Nordkap L, Bang AK, Ekbom P, Joensen UN, Prætorius L, Lundstrøm P, Boujida VH, Lanske B, Juul A, Jørgensen N. Vitamin D deficiency and low ionized calcium are linked with semen quality and sex steroid levels in infertile men. Hum Reprod. 2016 Aug; 31(8):1875-85. PMID: 27496946.
    View in: PubMed
  9. Ide N, Olauson H, Sato T, Densmore MJ, Wang H, Hanai J, Larsson TE, Lanske B. In vivo evidence for a limited role of proximal tubular Klotho in renal phosphate handling. Kidney Int. 2016 Aug; 90(2):348-62. PMID: 27292223.
    View in: PubMed
  10. Kir S, Komaba H, Garcia AP, Economopoulos KP, Liu W, Lanske B, Hodin RA, Spiegelman BM. PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer. Cell Metab. 2016 Feb 09; 23(2):315-23. PMID: 26669699; PMCID: PMC4749423 [Available on 02/09/17].
  11. Amano K, Densmore M, Fan Y, Lanske B. Ihh and PTH1R signaling in limb mesenchyme is required for proper segmentation and subsequent formation and growth of digit bones. Bone. 2016 Feb; 83:256-66. PMID: 26620087.
    View in: PubMed
  12. Fan Y, Bi R, Densmore MJ, Sato T, Kobayashi T, Yuan Q, Zhou X, Erben RG, Lanske B. Parathyroid hormone 1 receptor is essential to induce FGF23 production and maintain systemic mineral ion homeostasis. FASEB J. 2016 Jan; 30(1):428-40. PMID: 26428657; PMCID: PMC4684518 [Available on 01/01/17].
  13. Amano K, Densmore MJ, Lanske B. Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation. J Bone Miner Res. 2015 Dec; 30(12):2262-72. PMID: 26094741.
    View in: PubMed
  14. Lanske B, Razzaque MS. Molecular interactions of FGF23 and PTH in phosphate regulation. Kidney Int. 2014 Dec; 86(6):1072-4. PMID: 25427080; PMCID: PMC4246422.
  15. Lysaght AC, Yuan Q, Fan Y, Kalwani N, Caruso P, Cunnane M, Lanske B, Stankovic KM. FGF23 deficiency leads to mixed hearing loss and middle ear malformation in mice. PLoS One. 2014; 9(9):e107681. PMID: 25243481; PMCID: PMC4171482.
  16. Amano K, Densmore M, Nishimura R, Lanske B. Indian hedgehog signaling regulates transcription and expression of collagen type X via Runx2/Smads interactions. J Biol Chem. 2014 Sep 05; 289(36):24898-910. PMID: 25028519; PMCID: PMC4155658.
  17. Ma Y, Samaraweera M, Cooke-Hubley S, Kirby BJ, Karaplis AC, Lanske B, Kovacs CS. Neither absence nor excess of FGF23 disturbs murine fetal-placental phosphorus homeostasis or prenatal skeletal development and mineralization. Endocrinology. 2014 May; 155(5):1596-605. PMID: 24601885; PMCID: PMC3990847.
  18. Yuan Q, Jiang Y, Zhao X, Sato T, Densmore M, Schüler C, Erben RG, McKee MD, Lanske B. Increased osteopontin contributes to inhibition of bone mineralization in FGF23-deficient mice. J Bone Miner Res. 2014 Mar; 29(3):693-704. PMID: 24038141; PMCID: PMC3937302.
  19. Agarwal I, Ide N, Ix JH, Kestenbaum B, Lanske B, Schiller NB, Whooley MA, Mukamal KJ. Fibroblast growth factor-23 and cardiac structure and function. J Am Heart Assoc. 2014 Feb 13; 3(1):e000584. PMID: 24525546; PMCID: PMC3959672.
  20. Coe LM, Madathil SV, Casu C, Lanske B, Rivella S, Sitara D. FGF-23 is a negative regulator of prenatal and postnatal erythropoiesis. J Biol Chem. 2014 Apr 04; 289(14):9795-810. PMID: 24509850; PMCID: PMC3975025.
  21. Lanske B, Densmore MJ, Erben RG. Vitamin D endocrine system and osteocytes. Bonekey Rep. 2014; 3:494. PMID: 24605211; PMCID: PMC3944125.
  22. Andrukhova O, Smorodchenko A, Egerbacher M, Streicher C, Zeitz U, Goetz R, Shalhoub V, Mohammadi M, Pohl EE, Lanske B, Erben RG. FGF23 promotes renal calcium reabsorption through the TRPV5 channel. EMBO J. 2014 Feb 03; 33(3):229-46. PMID: 24434184; PMCID: PMC3983685.
  23. Zhou J, Chen Q, Lanske B, Fleming BC, Terek R, Wei X, Zhang G, Wang S, Li K, Wei L. Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice. Arthritis Res Ther. 2014 Jan 15; 16(1):R11. PMID: 24428864; PMCID: PMC3978435.
  24. Olauson H, Lindberg K, Amin R, Sato T, Jia T, Goetz R, Mohammadi M, Andersson G, Lanske B, Larsson TE. Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion. PLoS Genet. 2013; 9(12):e1003975. PMID: 24348262; PMCID: PMC3861040.
  25. Zou H, Zhao X, Sun N, Zhang S, Sato T, Yu H, Chen Q, Weber HP, Dard M, Yuan Q, Lanske B. Effect of chronic kidney disease on the healing of titanium implants. Bone. 2013 Oct; 56(2):410-5. PMID: 23876979; PMCID: PMC3812922.
  26. Kakanj P, Reuter K, Séquaris G, Wodtke C, Schettina P, Frances D, Zouboulis CC, Lanske B, Niemann C. Indian hedgehog controls proliferation and differentiation in skin tumorigenesis and protects against malignant progression. Cell Rep. 2013 Jul 25; 4(2):340-51. PMID: 23871669.
    View in: PubMed
  27. Andrukhova O, Zeitz U, Goetz R, Mohammadi M, Lanske B, Erben RG. FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2-SGK1 signaling pathway. Bone. 2012 Sep; 51(3):621-8. PMID: 22647968; PMCID: PMC3419258.
  28. Yuan Q, Sato T, Densmore M, Saito H, Schüler C, Erben RG, Lanske B. Deletion of PTH rescues skeletal abnormalities and high osteopontin levels in Klotho-/- mice. PLoS Genet. 2012; 8(5):e1002726. PMID: 22615584; PMCID: PMC3355080.
  29. Streicher C, Zeitz U, Andrukhova O, Rupprecht A, Pohl E, Larsson TE, Windisch W, Lanske B, Erben RG. Long-term Fgf23 deficiency does not influence aging, glucose homeostasis, or fat metabolism in mice with a nonfunctioning vitamin D receptor. Endocrinology. 2012 Apr; 153(4):1795-805. PMID: 22294750; PMCID: PMC3320267.
  30. Takei Y, Yamamoto H, Sato T, Otani A, Kozai M, Masuda M, Taketani Y, Muto-Sato K, Lanske B, Takeda E. Stanniocalcin 2 is associated with ectopic calcification in a-klotho mutant mice and inhibits hyperphosphatemia-induced calcification in aortic vascular smooth muscle cells. Bone. 2012 Apr; 50(4):998-1005. PMID: 22285620.
    View in: PubMed
  31. Yuan Q, Sitara D, Sato T, Densmore M, Saito H, Schüler C, Erben RG, Lanske B. PTH ablation ameliorates the anomalies of Fgf23-deficient mice by suppressing the elevated vitamin D and calcium levels. Endocrinology. 2011 Nov; 152(11):4053-61. PMID: 21896668; PMCID: PMC3199001.
  32. Yuan Q, Sato T, Densmore M, Saito H, Schüler C, Erben RG, Lanske B. FGF-23/Klotho signaling is not essential for the phosphaturic and anabolic functions of PTH. J Bone Miner Res. 2011 Sep; 26(9):2026-35. PMID: 21590742; PMCID: PMC4343543.
  33. Seriwatanachai D, Densmore MJ, Sato T, Correa D, Neff L, Baron R, Lanske B. Deletion of Zfp521 rescues the growth plate phenotype in a mouse model of Jansen metaphyseal chondrodysplasia. FASEB J. 2011 Sep; 25(9):3057-67. PMID: 21642473; PMCID: PMC3157684.
  34. Christov M, Koren S, Yuan Q, Baron R, Lanske B. Genetic ablation of sfrp4 in mice does not affect serum phosphate homeostasis. Endocrinology. 2011 May; 152(5):2031-6. PMID: 21427221; PMCID: PMC3075942.
  35. Hristova M, van Beek C, Schurgers LJ, Lanske B, Danziger J. Rapidly progressive severe vascular calcification sparing the kidney allograft following warfarin initiation. Am J Kidney Dis. 2010 Dec; 56(6):1158-62. PMID: 20817370; PMCID: PMC2991526.
  36. Correa D, Hesse E, Seriwatanachai D, Kiviranta R, Saito H, Yamana K, Neff L, Atfi A, Coillard L, Sitara D, Maeda Y, Warming S, Jenkins NA, Copeland NG, Horne WC, Lanske B, Baron R. Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. Dev Cell. 2010 Oct 19; 19(4):533-46. PMID: 20951345; PMCID: PMC2958174.
  37. van Dop WA, Heijmans J, Büller NV, Snoek SA, Rosekrans SL, Wassenberg EA, van den Bergh Weerman MA, Lanske B, Clarke AR, Winton DJ, Wijgerde M, Offerhaus GJ, Hommes DW, Hardwick JC, de Jonge WJ, Biemond I, van den Brink GR. Loss of Indian Hedgehog activates multiple aspects of a wound healing response in the mouse intestine. Gastroenterology. 2010 Nov; 139(5):1665-76, 1676.e1-10. PMID: 20682322.
    View in: PubMed
  38. Chu EY, Fong H, Blethen FA, Tompkins KA, Foster BL, Yeh KD, Nagatomo KJ, Matsa-Dunn D, Sitara D, Lanske B, Rutherford RB, Somerman MJ. Ablation of systemic phosphate-regulating gene fibroblast growth factor 23 (Fgf23) compromises the dentoalveolar complex. Anat Rec (Hoboken). 2010 Jul; 293(7):1214-26. PMID: 20583265; PMCID: PMC3075109.
  39. Hu MC, Shi M, Zhang J, Pastor J, Nakatani T, Lanske B, Razzaque MS, Rosenblatt KP, Baum MG, Kuro-o M, Moe OW. Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J. 2010 Sep; 24(9):3438-50. PMID: 20466874; PMCID: PMC2923354.
  40. Ochiai T, Shibukawa Y, Nagayama M, Mundy C, Yasuda T, Okabe T, Shimono K, Kanyama M, Hasegawa H, Maeda Y, Lanske B, Pacifici M, Koyama E. Indian hedgehog roles in post-natal TMJ development and organization. J Dent Res. 2010 Apr; 89(4):349-54. PMID: 20200412; PMCID: PMC2899888.
  41. Franco HL, Lee KY, Broaddus RR, White LD, Lanske B, Lydon JP, Jeong JW, DeMayo FJ. Ablation of Indian hedgehog in the murine uterus results in decreased cell cycle progression, aberrant epidermal growth factor signaling, and increased estrogen signaling. Biol Reprod. 2010 Apr; 82(4):783-90. PMID: 20056671; PMCID: PMC2842491.
  42. Ohnishi M, Nakatani T, Lanske B, Razzaque MS. In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levels. Circ Cardiovasc Genet. 2009 Dec; 2(6):583-90. PMID: 20031638; PMCID: PMC2801877.
  43. Maeda Y, Schipani E, Densmore MJ, Lanske B. Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptor. Bone. 2010 Feb; 46(2):472-8. PMID: 19761883; PMCID: PMC2818229.
  44. Fong H, Chu EY, Tompkins KA, Foster BL, Sitara D, Lanske B, Somerman MJ. Aberrant cementum phenotype associated with the hypophosphatemic hyp mouse. J Periodontol. 2009 Aug; 80(8):1348-54. PMID: 19656036; PMCID: PMC2776621.
  45. Ohnishi M, Nakatani T, Lanske B, Razzaque MS. Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase. Kidney Int. 2009 Jun; 75(11):1166-72. PMID: 19225558; PMCID: PMC3143194.
  46. Outram SV, Hager-Theodorides AL, Shah DK, Rowbotham NJ, Drakopoulou E, Ross SE, Lanske B, Dessens JT, Crompton T. Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation. Blood. 2009 Mar 05; 113(10):2217-28. PMID: 19109233.
    View in: PubMed
  47. DeLuca S, Sitara D, Kang K, Marsell R, Jonsson K, Taguchi T, Erben RG, Razzaque MS, Lanske B. Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23. J Pathol. 2008 Nov; 216(3):345-55. PMID: 18729070; PMCID: PMC2776048.
  48. Nakatani T, Sarraj B, Ohnishi M, Densmore MJ, Taguchi T, Goetz R, Mohammadi M, Lanske B, Razzaque MS. In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis. FASEB J. 2009 Feb; 23(2):433-41. PMID: 18835926; PMCID: PMC2630784.
  49. Sitara D, Kim S, Razzaque MS, Bergwitz C, Taguchi T, Schüler C, Erben RG, Lanske B. Genetic evidence of serum phosphate-independent functions of FGF-23 on bone. PLoS Genet. 2008 Aug 08; 4(8):e1000154. PMID: 18688277; PMCID: PMC2483943.
  50. Medici D, Razzaque MS, Deluca S, Rector TL, Hou B, Kang K, Goetz R, Mohammadi M, Kuro-O M, Olsen BR, Lanske B. FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis. J Cell Biol. 2008 Aug 11; 182(3):459-65. PMID: 18678710; PMCID: PMC2500132.
  51. Memon F, El-Abbadi M, Nakatani T, Taguchi T, Lanske B, Razzaque MS. Does Fgf23-klotho activity influence vascular and soft tissue calcification through regulating mineral ion metabolism? Kidney Int. 2008 Sep; 74(5):566-70. PMID: 18528324; PMCID: PMC2771539.
  52. Razzaque MS, Lanske B. The emerging role of the fibroblast growth factor-23-klotho axis in renal regulation of phosphate homeostasis. J Endocrinol. 2007 Jul; 194(1):1-10. PMID: 17592015; PMCID: PMC2900827.
  53. Lanske B, Razzaque MS. Mineral metabolism and aging: the fibroblast growth factor 23 enigma. Curr Opin Nephrol Hypertens. 2007 Jul; 16(4):311-8. PMID: 17565272; PMCID: PMC2901548.
  54. Koyama E, Young B, Nagayama M, Shibukawa Y, Enomoto-Iwamoto M, Iwamoto M, Maeda Y, Lanske B, Song B, Serra R, Pacifici M. Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis. Development. 2007 Jun; 134(11):2159-69. PMID: 17507416; PMCID: PMC2776720.
  55. Lanske B, Razzaque MS. Vitamin D and aging: old concepts and new insights. J Nutr Biochem. 2007 Dec; 18(12):771-7. PMID: 17531460; PMCID: PMC2776629.
  56. Maeda Y, Nakamura E, Nguyen MT, Suva LJ, Swain FL, Razzaque MS, Mackem S, Lanske B. Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6382-7. PMID: 17409191; PMCID: PMC1851055.
  57. Goetz R, Beenken A, Ibrahimi OA, Kalinina J, Olsen SK, Eliseenkova AV, Xu C, Neubert TA, Zhang F, Linhardt RJ, Yu X, White KE, Inagaki T, Kliewer SA, Yamamoto M, Kurosu H, Ogawa Y, Kuro-o M, Lanske B, Razzaque MS, Mohammadi M. Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Mol Cell Biol. 2007 May; 27(9):3417-28. PMID: 17339340; PMCID: PMC1899957.
  58. Berndt TJ, Craig TA, McCormick DJ, Lanske B, Sitara D, Razzaque MS, Pragnell M, Bowe AE, O'Brien SP, Schiavi SC, Kumar R. Biological activity of FGF-23 fragments. Pflugers Arch. 2007 Jul; 454(4):615-23. PMID: 17333246; PMCID: PMC3818792.
  59. Lanske B, Razzaque MS. Premature aging in klotho mutant mice: cause or consequence? Ageing Res Rev. 2007 May; 6(1):73-9. PMID: 17353153; PMCID: PMC2896497.
  60. Sitara D, Razzaque MS, St-Arnaud R, Huang W, Taguchi T, Erben RG, Lanske B. Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals. Am J Pathol. 2006 Dec; 169(6):2161-70. PMID: 17148678; PMCID: PMC1762489.
  61. Hesse M, Fröhlich LF, Zeitz U, Lanske B, Erben RG. Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice. Matrix Biol. 2007 Mar; 26(2):75-84. PMID: 17123805.
    View in: PubMed
  62. Lee K, Jeong J, Kwak I, Yu CT, Lanske B, Soegiarto DW, Toftgard R, Tsai MJ, Tsai S, Lydon JP, DeMayo FJ. Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus. Nat Genet. 2006 Oct; 38(10):1204-9. PMID: 16951680.
    View in: PubMed
  63. Razzaque MS, Lanske B. Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice. Trends Mol Med. 2006 Jul; 12(7):298-305. PMID: 16731043.
    View in: PubMed
  64. Razzaque MS, Sitara D, Taguchi T, St-Arnaud R, Lanske B. Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process. FASEB J. 2006 Apr; 20(6):720-2. PMID: 16436465; PMCID: PMC2899884.
  65. Razzaque MS, Soegiarto DW, Chang D, Long F, Lanske B. Conditional deletion of Indian hedgehog from collagen type 2alpha1-expressing cells results in abnormal endochondral bone formation. J Pathol. 2005 Dec; 207(4):453-61. PMID: 16278811.
    View in: PubMed
  66. Razzaque MS, St-Arnaud R, Taguchi T, Lanske B. FGF-23, vitamin D and calcification: the unholy triad. Nephrol Dial Transplant. 2005 Oct; 20(10):2032-5. PMID: 16030043.
    View in: PubMed
  67. Kobayashi T, Soegiarto DW, Yang Y, Lanske B, Schipani E, McMahon AP, Kronenberg HM. Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP. J Clin Invest. 2005 Jul; 115(7):1734-42. PMID: 15951842; PMCID: PMC1143590.
  68. Erben RG, Mayer D, Weber K, Jonsson K, Jüppner H, Lanske B. Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotype. J Bone Miner Res. 2005 Jul; 20(7):1149-60. PMID: 15940367.
    View in: PubMed
  69. Sitara D, Razzaque MS, Hesse M, Yoganathan S, Taguchi T, Erben RG, Jüppner H, Lanske B. Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol. 2004 Nov; 23(7):421-32. PMID: 15579309; PMCID: PMC2894977.
  70. Miao D, He B, Lanske B, Bai XY, Tong XK, Hendy GN, Goltzman D, Karaplis AC. Skeletal and Reproductive Abnormalities in PTH-Null Mice. T. Naveh-ManyMolecular Biology of the Parathyroid 2004. 2004.
  71. Miao D, He B, Lanske B, Bai XY, Tong XK, Hendy GN, Goltzman D, Karaplis AC. Skeletal abnormalities in Pth-null mice are influenced by dietary calcium. Endocrinology. 2004 Apr; 145(4):2046-53. PMID: 14701672.
    View in: PubMed
  72. Gensure RC, Ponugoti B, Gunes Y, Papasani MR, Lanske B, Bastepe M, Rubin DA, Jüppner H. Identification and characterization of two parathyroid hormone-like molecules in zebrafish. Endocrinology. 2004 Apr; 145(4):1634-9. PMID: 14684608.
    View in: PubMed
  73. Qian J, Colbert MC, Witte D, Kuan CY, Gruenstein E, Osinska H, Lanske B, Kronenberg HM, Clemens TL. Midgestational lethality in mice lacking the parathyroid hormone (PTH)/PTH-related peptide receptor is associated with abrupt cardiomyocyte death. Endocrinology. 2003 Mar; 144(3):1053-61. PMID: 12586782.
    View in: PubMed
  74. Kobayashi T, Chung UI, Schipani E, Starbuck M, Karsenty G, Katagiri T, Goad DL, Lanske B, Kronenberg HM. PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps. Development. 2002 Jun; 129(12):2977-86. PMID: 12050144.
    View in: PubMed
  75. Fröhlich L, Liu Z, Beier DR, Lanske B. Genomic structure and refined chromosomal localization of the mouse Ptch2 gene. Cytogenet Genome Res. 2002; 97(1-2):106-10. PMID: 12438747.
    View in: PubMed
  76. Soegiarto DW, Kiachopoulos S, Schipani E, Jüppner H, Erben RG, Lanske B. Partial rescue of PTH/PTHrP receptor knockout mice by targeted expression of the Jansen transgene. Endocrinology. 2001 Dec; 142(12):5303-10. PMID: 11713230.
    View in: PubMed
  77. Guo J, Lanske B, Liu BY, Divieti P, Kronenberg HM, Bringhurst FR. Signal-selectivity of parathyroid hormone (PTH)/PTH-related peptide receptor-mediated regulation of differentiation in conditionally immortalized growth-plate chondrocytes. Endocrinology. 2001 Mar; 142(3):1260-8. PMID: 11181543.
    View in: PubMed
  78. Haaijman A, Karperien M, Lanske B, Hendriks J, Löwik CW, Bronckers AL, Burger EH. Inhibition of terminal chondrocyte differentiation by bone morphogenetic protein 7 (OP-1) in vitro depends on the periarticular region but is independent of parathyroid hormone-related peptide. Bone. 1999 Oct; 25(4):397-404. PMID: 10511105.
    View in: PubMed
  79. Lanske B, Amling M, Neff L, Guiducci J, Baron R, Kronenberg HM. Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development. J Clin Invest. 1999 Aug; 104(4):399-407. PMID: 10449432; PMCID: PMC408525.
  80. Karperien M, Farih-Sips H, Hendriks JA, Lanske B, Papapoulos SE, Abou-Samra AB, Löwik CW, Defize LH. Identification of a retinoic acid-inducible element in the murine PTH/PTHrP (parathyroid hormone/parathyroid hormone-related peptide) receptor gene. Mol Endocrinol. 1999 Jul; 13(7):1183-96. PMID: 10406468.
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  81. Verheijen MH, Karperien M, Chung U, van Wijuen M, Heystek H, Hendriks JA, Veltmaat JM, Lanske B, Li E, Löwik CW, de Laat SW, Kronenberg HM, Defize LH. Parathyroid hormone-related peptide (PTHrP) induces parietal endoderm formation exclusively via the type I PTH/PTHrP receptor. Mech Dev. 1999 Mar; 81(1-2):151-61. PMID: 10330492.
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  82. Kovacs CS, Lanske B, Manley NR, Kronenberg HM. Regulation of murine fetal-placental calcium metabolism. In Danks J, Dacke C, Flik G, Gay C: Calcium Metabolism: Comparitve Endocrinology. 1999; 153-158.
  83. Lanske B, Divieti P, Kovacs CS, Pirro A, Landis WJ, Krane SM, Bringhurst FR, Kronenberg HM. The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone. Endocrinology. 1998 Dec; 139(12):5194-204. PMID: 9832460.
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  84. Divieti P, Lanske B, Kronenberg HM, Bringhurst FR. Conditionally immortalized murine osteoblasts lacking the type 1 PTH/PTHrP receptor. J Bone Miner Res. 1998 Dec; 13(12):1835-45. PMID: 9844101.
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  85. Lanske B, Divieti P, Kovacs CS, Pirro A, Landis WJ, Krane SM, Bringhurst FR, Kronenberg HM. The Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Mediates Actions of Both Ligands in Murine Bone* * This work was supported by National Institute of Health Grants DK-47038 and AM-03564. Endocrinology. 1998 Dec 01; 139(12):5194-5204. PMID: 28200291.
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  86. Dunbar ME, Young P, Zhang JP, McCaughern-Carucci J, Lanske B, Orloff JJ, Karaplis A, Cunha G, Wysolmerski JJ. Stromal cells are critical targets in the regulation of mammary ductal morphogenesis by parathyroid hormone-related protein. Dev Biol. 1998 Nov 01; 203(1):75-89. PMID: 9806774.
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  87. Chung UI, Lanske B, Lee K, Li E, Kronenberg H. The parathyroid hormone/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):13030-5. PMID: 9789035; PMCID: PMC23697.
  88. Kovacs CS, Ho-Pao CL, Hunzelman JL, Lanske B, Fox J, Seidman JG, Seidman CE, Kronenberg HM. Regulation of murine fetal-placental calcium metabolism by the calcium-sensing receptor. J Clin Invest. 1998 Jun 15; 101(12):2812-20. PMID: 9637715; PMCID: PMC508872.
  89. Wysolmerski JJ, Philbrick WM, Dunbar ME, Lanske B, Kronenberg H, Broadus AE. Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development. Development. 1998 Apr; 125(7):1285-94. PMID: 9477327.
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  90. Liu BY, Guo J, Lanske B, Divieti P, Kronenberg HM, Bringhurst FR. Conditionally immortalized murine bone marrow stromal cells mediate parathyroid hormone-dependent osteoclastogenesis in vitro. Endocrinology. 1998 Apr; 139(4):1952-64. PMID: 9528982.
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  91. Lanske B, Kovacs CS, Lee K, Segre GV, Kronenberg HM. Molecular Biology of calcium metabolism. Eds. J. Kohrle, Stuttgart:WVG Mineralstoffe und Spurenelemente. 1998; 81-91.
  92. Lanske B, Kronenberg HM. Parathyroid hormone-related peptide (PTHrP) and parathyroid hormone (PTH)/PTHrP receptor. Crit Rev Eukaryot Gene Expr. 1998; 8(3-4):297-320. PMID: 9807698.
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  93. Kronenberg HM, Lanske B, Kovacs CS, Chung UI, Lee K, Segre GV, Schipani E, Jüppner H. Functional analysis of the PTH/PTHrP network of ligands and receptors. Recent Prog Horm Res. 1998; 53:283-301; discussion 301-3. PMID: 9769712.
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  94. Schipani E, Lanske B, Hunzelman J, Luz A, Kovacs CS, Lee K, Pirro A, Kronenberg HM, Jüppner H. Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):13689-94. PMID: 9391087; PMCID: PMC28367.
  95. Kronenberg HM, Lee K, Lanske B, Segre GV. Parathyroid hormone-related protein and Indian hedgehog control the pace of cartilage differentiation. J Endocrinol. 1997 Sep; 154 Suppl:S39-45. PMID: 9379136.
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  96. Joun H, Lanske B, Karperien M, Qian F, Defize L, Abou-Samra A. Tissue-specific transcription start sites and alternative splicing of the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor gene: a new PTH/PTHrP receptor splice variant that lacks the signal peptide. Endocrinology. 1997 Apr; 138(4):1742-9. PMID: 9075739.
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  97. Kronenberg HM, Lee K, Lanske B, Segre GV. Parathyroid hormone-related protein in skeletal development. J Endocrinol. 1997; 154:S39-45.
  98. Segre GV, Lee K, Lanske B, Kronenberg HM. Parathyroid hormone-related protein and Indian hedgehog regulate the pace of cartilage differentiation,. J Bone Miner Metab. 1997; 15:109-114.
  99. Kovacs CS, Lanske B, Hunzelman JL, Guo J, Karaplis AC, Kronenberg HM. Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH/PTHrP receptor. Proc Natl Acad Sci U S A. 1996 Dec 24; 93(26):15233-8. PMID: 8986793; PMCID: PMC26386.
  100. Lee K, Lanske B, Karaplis AC, Deeds JD, Kohno H, Nissenson RA, Kronenberg HM, Segre GV. Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development. Endocrinology. 1996 Nov; 137(11):5109-18. PMID: 8895385.
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  101. Vortkamp A, Lee K, Lanske B, Segre GV, Kronenberg HM, Tabin CJ. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science. 1996 Aug 02; 273(5275):613-22. PMID: 8662546.
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  102. Lanske B, Karaplis AC, Lee K, Luz A, Vortkamp A, Pirro A, Karperien M, Defize LH, Ho C, Mulligan RC, Abou-Samra AB, Jüppner H, Segre GV, Kronenberg HM. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science. 1996 Aug 02; 273(5275):663-6. PMID: 8662561.
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  103. Fukayama S, Lanske B, Guo J, Kronenberg HM, Bringhurst FR. Regulation of HSP70 by PTH: a model of gene regulation not mediated by changes in cAMP levels. Am J Physiol. 1996 Jul; 271(1 Pt 1):C121-9. PMID: 8760037.
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  104. Kronenberg HM, Karaplis AC, Lanske B. Role of parathyroid hormone-related protein in skeletal development. Ann N Y Acad Sci. 1996 Jun 08; 785:119-23. PMID: 8702116.
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  105. Wetterwald A, Hoffstetter W, Cecchini MG, Lanske B, Wagner C, Fleisch H, Atkinson M. Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes. Bone. 1996 Feb; 18(2):125-32. PMID: 8833206.
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  106. Kronenberg HM, Karaplis AC, Lanske B. Role of Parathyroid hormone-related protein in skeletal development. Ann New York Acaf Sci. 1996; 785:119-123.
  107. Spanner M, Weber K, Lanske B, Ihbe A, Siggelkow H, Schütze H, Atkinson MJ. The iron-binding protein ferritin is expressed in cells of the osteoblastic lineage in vitro and in vivo. Bone. 1995 Aug; 17(2):161-5. PMID: 8554925.
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  108. Henderson JE, Amizuka N, Warshawsky H, Biasotto D, Lanske BM, Goltzman D, Karaplis AC. Nucleolar localization of parathyroid hormone-related peptide enhances survival of chondrocytes under conditions that promote apoptotic cell death. Mol Cell Biol. 1995 Aug; 15(8):4064-75. PMID: 7623802; PMCID: PMC230645.
  109. Sterner-Kock A, Lanske B, Uberschär S, Atkinson MJ. Effects of the Pasteurella multocida toxin on osteoblastic cells in vitro. Vet Pathol. 1995 May; 32(3):274-9. PMID: 7604494.
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  110. Kong XF, Schipani E, Lanske B, Joun H, Karperien M, Defize LH, Jüppner H, Potts JT, Segre GV, Kronenberg HM, et al. The rat, mouse, and human genes encoding the receptor for parathyroid hormone and parathyroid hormone-related peptide are highly homologous. Biochem Biophys Res Commun. 1994 Jun 15; 201(2):1058. PMID: 8002976.
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  111. Kong XF, Schipani E, Lanske B, Joun H, Karperien M, Defize LH, Jüppner H, Potts JT, Segre GV, Kronenberg HM, et al. The rat, mouse and human genes encoding the receptor for parathyroid hormone and parathyroid hormone-related peptide are highly homologous. Biochem Biophys Res Commun. 1994 May 16; 200(3):1290-9. PMID: 8185578.
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  112. Fukayama S, Schipani E, Jüppner H, Lanske B, Kronenberg HM, Abou-Samra AB, Bringhurst FR. Role of protein kinase-A in homologous down-regulation of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid in human osteoblast-like SaOS-2 cells. Endocrinology. 1994 Apr; 134(4):1851-8. PMID: 8137752.
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  113. Lanske B, Hesch RD, Kronenberg HM, Atkinson MJ. Characterisation of the osteoblastic phenotype by the use of differential hybridization. Verh Dtsch Ges Pathol. 1990; 74:363-4. PMID: 1708615.
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  114. Aulitzky WE, Aulitzky W, Gastl G, Lanske B, Reitter J, Frick J, Tilg H, Berger M, Herold M, Huber C. Acute effects of single doses of recombinant interferon-gamma on blood cell counts and lymphocyte subsets in patients with advanced renal cell cancer. J Interferon Res. 1989 Aug; 9(4):425-33. PMID: 2502583.
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  115. Aulitzky W, Gastl G, Aulitzky WE, Nachbaur K, Lanske B, Kemmler G, Flener R, Frick J, Huber C. Interferon-gamma for the treatment of metastatic renal cancer: dose-dependent stimulation and downregulation of beta-2 microglobulin and neopterin responses. Immunobiology. 1987 Dec; 176(1-2):85-95. PMID: 3129362.
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