Timothy J. Mitchison, Ph.D.
This page shows the publications co-authored by Timothy Mitchison and Ralph Weissleder.
A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor. Proc Natl Acad Sci U S A. 2019 06 04; 116(23):11444-11453.
Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation. ACS Nano. 2018 12 26; 12(12):12814-12826.
Site occupancy calibration of taxane pharmacology in live cells and tissues. Proc Natl Acad Sci U S A. 2018 11 27; 115(48):E11406-E11414.
IRF3 and type I interferons fuel a fatal response to myocardial infarction. Nat Med. 2017 Dec; 23(12):1481-1487.
Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response. Sci Rep. 2016 09 09; 6:32985.
In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy. Nat Methods. 2015 Jun; 12(6):577-85.
Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin. Sci Transl Med. 2014 Nov 05; 6(261):261ra152.
Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat Commun. 2013; 4:1504.
Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer Res. 2011 Jul 01; 71(13):4608-16.
In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells. Nat Commun. 2020 07 14; 11(1):3521.
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