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Edwin Choy, M.D.,Ph.D.

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Biography
education and training
Yale University, New HavenBS05/1993Molecular Biophysics and Biochemistry
New York University, New YorkMD PhD05/2000PhD in Cell Biology
Massachusetts General Hospital, Boston05-2003Residency in Internal Medicine
Dana Farber Cancer Institute, Boston05/2007Fellowship in Medical Oncology
Broad Institute of MIT and Harvard, Cambridge, MA2008Postdoctoral Fellow in Population Genetics
awards and honors
2004 - 2007
T32 NCI Institutional Research Training Grant
2008 - 2010
K12 NIH Mentored Research Support Grant
2009
Partners in Excellence
2009
The One Hundred, Honoree
2012
Chawla-Rosenfeld Symposium Honoree
2013
MGPO nominee for the “2013 Brian McGovern Award for Clinical Excellence”
2018 - 2019
Top Doctor, Boston Magazine

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Suster DI, Kurzawa P, Neyaz A, Jarzembowski JA, Lozano-Calderon S, Raskin K, Schwab J, Choy E, Chebib I, Deshpande V. Chondroblastoma Expresses RANKL by RNA In Situ Hybridization and May Respond to Denosumab Therapy. Am J Surg Pathol. 2020 Aug 20. PMID: 32826531.
    Citations:    
  2. Weiss AR, Chen YL, Scharschmidt TJ, Chi YY, Tian J, Black JO, Davis JL, Fanburg-Smith JC, Zambrano E, Anderson J, Arens R, Binitie O, Choy E, Davis JW, Hayes-Jordan A, Kao SC, Kayton ML, Kessel S, Lim R, Meyer WH, Million L, Okuno SH, Ostrenga A, Parisi MT, Pryma DA, Randall RL, Rosen MA, Schlapkohl M, Shulkin BL, Smith EA, Sorger JI, Terezakis S, Hawkins DS, Spunt SL, Wang D. Pathological response in children and adults with large unresected intermediate-grade or high-grade soft tissue sarcoma receiving preoperative chemoradiotherapy with or without pazopanib (ARST1321): a multicentre, randomised, open-label, phase 2 trial. Lancet Oncol. 2020 08; 21(8):1110-1122. PMID: 32702309.
    Citations:    
  3. Baumann BC, Bernstein KA, DeLaney TF, Simone CB, Kolker JD, Choy E, Levin WP, Weber KL, Muniappan A, Berman AT, Staddon A, Hartner L, Van Tine B, Hirbe A, Glatstein E, Hahn SM, Nagda SN, Chen YL. Multi-institutional analysis of stereotactic body radiotherapy for sarcoma pulmonary metastases: High rates of local control with favorable toxicity. J Surg Oncol. 2020 Jun 25. PMID: 32588468.
    Citations:    
  4. Keskin T, Bakaric A, Waszyk P, Boulay G, Torsello M, Cornaz-Buros S, Chevalier N, Geiser T, Martin P, Volorio A, Iyer S, Kulkarni A, Letovanec I, Cherix S, Cote GM, Choy E, Digklia A, Montemurro M, Chebib I, Nielsen PG, Carcaboso AM, Mora J, Renella R, Suvà ML, Fusco C, Provero P, Rivera MN, Riggi N, Stamenkovic I. LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma. Cell Rep. 2020 Apr 14; 31(2):107539. PMID: 32294441.
    Citations:    
  5. Keskin T, Bakaric A, Waszyk P, Boulay G, Torsello M, Cornaz-Buros S, Chevalier N, Geiser T, Martin P, Volorio A, Iyer S, Kulkarni A, Letovanec I, Cherix S, Cote GM, Choy E, Digklia A, Montemurro M, Chebib I, Nielsen PG, Carcaboso AM, Mora J, Renella R, Suvà ML, Fusco C, Provero P, Rivera MN, Riggi N, Stamenkovic I. LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma LIN28B Control of EWS-FLI1 Stability. Cell Rep. 2020 Mar 31; 30(13):4567-4583.e5. PMID: 32234488.
    Citations:    
  6. Lietz CE, Garbutt C, Barry WT, Deshpande V, Chen YL, Lozano-Calderon SA, Wang Y, Lawney B, Ebb D, Cote GM, Duan Z, Hornicek FJ, Choy E, Petur Nielsen G, Haibe-Kains B, Quackenbush J, Spentzos D. MicroRNA-mRNA networks define translatable molecular outcome phenotypes in osteosarcoma. Sci Rep. 2020 03 10; 10(1):4409. PMID: 32157112.
    Citations:    
  7. Cote GM, Choy E, Chen T, Marino-Enriquez A, Morgan J, Merriam P, Thornton K, Wagner AJ, Nathenson MJ, Demetri G, George S. A phase II multi-strata study of lurbinectedin as a single agent or in combination with conventional chemotherapy in metastatic and/or unresectable sarcomas. Eur J Cancer. 2020 02; 126:21-32. PMID: 31896519.
    Citations:    
  8. Fintelmann FJ, Braun P, Mirzan SH, Huang AJ, Best TD, Keyes CM, Choy E, Leppelmann KS, Muniappan A, Soto DE, Som A, Uppot RN. Percutaneous Cryoablation: Safety and Efficacy for Pain Palliation of Metastases to Pleura and Chest Wall. J Vasc Interv Radiol. 2020 Feb; 31(2):294-300. PMID: 31899108.
    Citations:    
  9. Miao R, Choy E, Raskin KA, Schwab JH, Nielsen GP, Deshpande V, Chebib I, DeLaney TF, Hornicek FJ, Cote GM, Chen YE. Prognostic Factors in Dedifferentiated Chondrosarcoma: A Retrospective Analysis of a Large Series Treated at a Single Institution. Sarcoma. 2019; 2019:9069272. PMID: 31915413.
    Citations:    
  10. Chawla S, Blay JY, Rutkowski P, Le Cesne A, Reichardt P, Gelderblom H, Grimer RJ, Choy E, Skubitz K, Seeger L, Schuetze SM, Henshaw R, Dai T, Jandial D, Palmerini E. Denosumab in patients with giant-cell tumour of bone: a multicentre, open-label, phase 2 study. Lancet Oncol. 2019 12; 20(12):1719-1729. PMID: 31704134.
    Citations:    
  11. Choy E, Ballman K, Chen J, Dickson MA, Chugh R, George S, Okuno S, Pollock R, Patel RM, Hoering A, Patel S. Corrigendum to "SARC018_SPORE02: Phase II Study of Mocetinostat Administered with Gemcitabine for Patients with Metastatic Leiomyosarcoma with Progression or Relapse following Prior Treatment with Gemcitabine-Containing Therapy". Sarcoma. 2019; 2019:7608743. PMID: 31534435.
    Citations:    
  12. Miao R, Wang H, Jacobson A, Lietz AP, Choy E, Raskin KA, Schwab JH, Deshpande V, Nielsen GP, DeLaney TF, Cote GM, Hornicek FJ, Chen YE. Radiation-induced and neurofibromatosis-associated malignant peripheral nerve sheath tumors (MPNST) have worse outcomes than sporadic MPNST. Radiother Oncol. 2019 08; 137:61-70. PMID: 31078939.
    Citations:    
  13. Chougule A, Taylor MS, Nardi V, Chebib I, Cote GM, Choy E, Nielsen GP, Deshpande V. Spindle and Round Cell Sarcoma With EWSR1-PATZ1 Gene Fusion: A Sarcoma With Polyphenotypic Differentiation. Am J Surg Pathol. 2019 02; 43(2):220-228. PMID: 30379650.
    Citations:    Fields:    
  14. Rosen EA, Vallurupalli M, Choy E, Lennerz JK, Kuter DJ. Management of disseminated intravascular coagulation in a patient with hepatic angiosarcoma: A case report. Medicine (Baltimore). 2018 Nov; 97(47):e13321. PMID: 30461646.
    Citations:    Fields:    Translation:Humans
  15. Choy E, Ballman K, Chen J, Dickson MA, Chugh R, George S, Okuno S, Pollock R, Patel RM, Hoering A, Patel S. SARC018_SPORE02: Phase II Study of Mocetinostat Administered with Gemcitabine for Patients with Metastatic Leiomyosarcoma with Progression or Relapse following Prior Treatment with Gemcitabine-Containing Therapy. Sarcoma. 2018; 2018:2068517. PMID: 30473623.
    Citations:    
  16. Engellau J, Seeger L, Grimer R, Henshaw R, Gelderblom H, Choy E, Chawla S, Reichardt P, O'Neal M, Feng A, Jacobs I, Roberts ZJ, Braun A, Bach BA. Assessment of denosumab treatment effects and imaging response in patients with giant cell tumor of bone. World J Surg Oncol. 2018 Sep 19; 16(1):191. PMID: 30231890.
    Citations:    Fields:    Translation:Humans
  17. Sanford NN, Miao R, Wang H, Goldberg S, Jacobson A, Brunner AM, Cote GM, Yock TI, Ebb DH, Chen YB, Jee KW, Hornicek F, DeLaney TF, Choy E, Chen YL. Characteristics and Predictors for Secondary Leukemia and Myelodysplastic Syndrome in Ewing and Osteosarcoma Survivors. Int J Radiat Oncol Biol Phys. 2019 01 01; 103(1):52-61. PMID: 30165126.
    Citations:    Fields:    
  18. Liao Y, Sassi S, Halvorsen S, Feng Y, Shen J, Gao Y, Cote G, Choy E, Harmon D, Mankin H, Hornicek F, Duan Z. Author Correction: Androgen receptor is a potential novel prognostic marker and oncogenic target in osteosarcoma with dependence on CDK11. Sci Rep. 2018 Aug 09; 8(1):12107. PMID: 30093700.
    Citations:    Fields:    
  19. Cote GM, Barysauskas CM, DeLaney TF, Schwab J, Raskin K, Lozano-Calderon S, Bernstein K, Mullen JT, Haynes AB, Hornicek F, Chen YE, Choy E. A Phase 1 Study of Nilotinib Plus Radiation in High-Risk Chordoma. Int J Radiat Oncol Biol Phys. 2018 12 01; 102(5):1496-1504. PMID: 30077789.
    Citations:    Fields:    
  20. Schuetze SM, Bolejack V, Thomas DG, von Mehren M, Patel S, Samuels B, Choy E, D'Amato G, Staddon AP, Ganjoo KN, Chow WA, Rushing DA, Forscher CA, Priebat DA, Loeb DM, Chugh R, Okuno S, Reinke DK, Baker LH. Association of Dasatinib With Progression-Free Survival Among Patients With Advanced Gastrointestinal Stromal Tumors Resistant to Imatinib. JAMA Oncol. 2018 06 01; 4(6):814-820. PMID: 29710216.
    Citations:    Fields:    
  21. Liu T, Yan Z, Liu Y, Choy E, Hornicek FJ, Mankin H, Duan Z. CRISPR-Cas9-Mediated Silencing of CD44 in Human Highly Metastatic Osteosarcoma Cells. Cell Physiol Biochem. 2018; 46(3):1218-1230. PMID: 29672299.
    Citations:    Fields:    Translation:HumansCells
  22. Shih AR, Cote GM, Chebib I, Choy E, DeLaney T, Deshpande V, Hornicek FJ, Miao R, Schwab JH, Nielsen GP, Chen YL. Clinicopathologic characteristics of poorly differentiated chordoma. Mod Pathol. 2018 08; 31(8):1237-1245. PMID: 29483606.
    Citations:    Fields:    
  23. Wang H, Miao R, Jacobson A, Harmon D, Choy E, Hornicek F, Raskin K, Chebib I, DeLaney TF, Chen YE. Extraskeletal osteosarcoma: A large series treated at a single institution. Rare Tumors. 2018; 10:2036361317749651. PMID: 31508194.
    Citations:    
  24. Liu T, Shen JK, Choy E, Zhang Y, Mankin HJ, Hornicek FJ, Duan Z. CDK4 expression in chordoma: A potential therapeutic target. J Orthop Res. 2018 06; 36(6):1581-1589. PMID: 29194728.
    Citations:    Fields:    
  25. Lopez G, Braggio D, Zewdu A, Casadei L, Batte K, Bid HK, Koller D, Yu P, Iwenofu OH, Strohecker A, Choy E, Lev D, Pollock R. Mocetinostat combined with gemcitabine for the treatment of leiomyosarcoma: Preclinical correlates. PLoS One. 2017; 12(11):e0188859. PMID: 29186204.
    Citations:    Fields:    Translation:HumansCells
  26. Chen H, Shen J, Choy E, Hornicek FJ, Shan A, Duan Z. Targeting DYRK1B suppresses the proliferation and migration of liposarcoma cells. Oncotarget. 2018 Mar 02; 9(17):13154-13166. PMID: 29568347.
    Citations:    Fields:    
  27. Sanford NN, Martin AM, Brunner AM, Cote GM, Choy E, DeLaney TF, Aizer AA, Chen YL. Secondary Acute Leukemia in Sarcoma Patients: A Population-Based Study. Int J Radiat Oncol Biol Phys. 2018 03 01; 100(3):687-694. PMID: 29413281.
    Citations:    Fields:    Translation:Humans
  28. Cote GM, He J, Choy E. Next-Generation Sequencing for Patients with Sarcoma: A Single Center Experience. Oncologist. 2018 02; 23(2):234-242. PMID: 28860410.
    Citations:    Fields:    
  29. Tang F, Choy E, Tu C, Hornicek F, Duan Z. Therapeutic applications of histone deacetylase inhibitors in sarcoma. Cancer Treat Rev. 2017 Sep; 59:33-45. PMID: 28732326.
    Citations: 2     Fields:    Translation:Humans
  30. Chen H, Garbutt CC, Spentzos D, Choy E, Hornicek FJ, Duan Z. Expression and Therapeutic Potential of SOX9 in Chordoma. Clin Cancer Res. 2017 Sep 01; 23(17):5176-5186. PMID: 28606919.
    Citations: 1     Fields:    Translation:HumansCells
  31. Pretz JL, Barysauskas CM, George S, Hornick JL, Raut CP, Chen YE, Marcus KJ, Choy E, Hornicek F, Ready JE, DeLaney TF, Baldini EH. Localized Adult Ewing Sarcoma: Favorable Outcomes with Alternating Vincristine, Doxorubicin, Cyclophosphamide, and Ifosfamide, Etoposide (VDC/IE)-Based Multimodality Therapy. Oncologist. 2017 10; 22(10):1265-1270. PMID: 28550026.
    Citations: 2     Fields:    Translation:Humans
  32. Hill KE, Kelly AD, Kuijjer ML, Barry W, Rattani A, Garbutt CC, Kissick H, Janeway K, Perez-Atayde A, Goldsmith J, Gebhardt MC, Arredouani MS, Cote G, Hornicek F, Choy E, Duan Z, Quackenbush J, Haibe-Kains B, Spentzos D. An imprinted non-coding genomic cluster at 14q32 defines clinically relevant molecular subtypes in osteosarcoma across multiple independent datasets. J Hematol Oncol. 2017 05 15; 10(1):107. PMID: 28506242.
    Citations: 1     Fields:    Translation:HumansCells
  33. Min L, Choy E, Tu C, Hornicek F, Duan Z. Application of metabolomics in sarcoma: From biomarkers to therapeutic targets. Crit Rev Oncol Hematol. 2017 08; 116:1-10. PMID: 28693790.
    Citations:    Fields:    
  34. Liao Y, Chen L, Feng Y, Shen J, Gao Y, Cote G, Choy E, Harmon D, Mankin H, Hornicek F, Duan Z. Targeting programmed cell death ligand 1 by CRISPR/Cas9 in osteosarcoma cells. Oncotarget. 2017 May 02; 8(18):30276-30287. PMID: 28415820.
    Citations: 6     Fields:    Translation:HumansCells
  35. Bhatt AD, Jacobson A, Lee RY, Giraud C, Schwab JH, Hornicek FJ, Nielsen P, Choy E, Harmon D, DeLaney TF, Chen YE. High-Dose Proton Beam-Based Radiation Therapy in the Management of Extracranial Chondrosarcomas. Int J Part Ther. 2017; 3(3):373-381. PMID: 31772986.
    Citations:    
  36. Liao Y, Sassi S, Halvorsen S, Feng Y, Shen J, Gao Y, Cote G, Choy E, Harmon D, Mankin H, Hornicek F, Duan Z. Androgen receptor is a potential novel prognostic marker and oncogenic target in osteosarcoma with dependence on CDK11. Sci Rep. 2017 03 06; 7:43941. PMID: 28262798.
    Citations:    Fields:    Translation:HumansCells
  37. Gao Y, Shen J, Choy E, Mankin H, Hornicek F, Duan Z. Inhibition of CDK4 sensitizes multidrug resistant ovarian cancer cells to paclitaxel by increasing apoptosiss. Cell Oncol (Dordr). 2017 Jun; 40(3):209-218. PMID: 28243976.
    Citations: 1     Fields:    Translation:HumansCells
  38. Min L, Choy E, Pollock RE, Tu C, Hornicek F, Duan Z. Autophagy as a potential target for sarcoma treatment. Biochim Biophys Acta Rev Cancer. 2017 Aug; 1868(1):40-50. PMID: 28242349.
    Citations: 3     Translation:HumansAnimals
  39. DeLaney TF, Chen YL, Baldini EH, Wang D, Adams J, Hickey SB, Yeap BY, Hahn SM, De Amorim Bernstein K, Nielsen GP, Choy E, Mullen JT, Yoon SS. Phase 1 trial of preoperative image guided intensity modulated proton radiation therapy with simultaneously integrated boost to the high risk margin for retroperitoneal sarcomas. Adv Radiat Oncol. 2017 Jan-Mar; 2(1):85-93. PMID: 28740917.
    Citations: 2     
  40. Sebro R, DeLaney TF, Hornicek F, Schwab J, Choy E, Nielsen GP, Rosenthal DI. Frequency and Risk Factors for Additional Lesions in the Axial Spine in Subjects With Chordoma: Indications for Screening. Spine (Phila Pa 1976). 2017 Jan 01; 42(1):E37-E40. PMID: 27254658.
    Citations: 1     Fields:    Translation:Humans
  41. Liu T, Li Z, Zhang Q, De Amorim Bernstein K, Lozano-Calderon S, Choy E, Hornicek FJ, Duan Z. Targeting ABCB1 (MDR1) in multi-drug resistant osteosarcoma cells using the CRISPR-Cas9 system to reverse drug resistance. Oncotarget. 2016 Dec 13; 7(50):83502-83513. PMID: 27835872.
    Citations: 8     Fields:    Translation:HumansCells
  42. De Amorim Bernstein K, Liebsch N, Chen YL, Niemierko A, Schwab JH, Raskin K, Lozano-Calderon SA, Cote G, Harmon DC, Choy E, Haynes A, Mullen J, Hornicek FJ, DeLaney TF. Clinical outcomes for patients after surgery and radiation therapy for mesenchymal chondrosarcomas. J Surg Oncol. 2016 Dec; 114(8):982-986. PMID: 27790706.
    Citations: 1     Fields:    Translation:Humans
  43. Duan Z, Gao Y, Shen J, Choy E, Cote G, Harmon D, Bernstein K, Lozano-Calderon S, Mankin H, Hornicek FJ. miR-15b modulates multidrug resistance in human osteosarcoma in vitro and in vivo. Mol Oncol. 2017 02; 11(2):151-166. PMID: 28145098.
    Citations: 3     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  44. Kabolizadeh P, Chen YL, Liebsch N, Hornicek FJ, Schwab JH, Choy E, Rosenthal DI, Niemierko A, DeLaney TF. Updated Outcome and Analysis of Tumor Response in Mobile Spine and Sacral Chordoma Treated With Definitive High-Dose Photon/Proton Radiation Therapy. Int J Radiat Oncol Biol Phys. 2017 02 01; 97(2):254-262. PMID: 27986348.
    Citations: 1     Fields:    Translation:Humans
  45. Schuetze SM, Bolejack V, Choy E, Ganjoo KN, Staddon AP, Chow WA, Tawbi HA, Samuels BL, Patel SR, von Mehren M, D'Amato G, Leu KM, Loeb DM, Forscher CA, Milhem MM, Rushing DA, Lucas DR, Chugh R, Reinke DK, Baker LH. Phase 2 study of dasatinib in patients with alveolar soft part sarcoma, chondrosarcoma, chordoma, epithelioid sarcoma, or solitary fibrous tumor. Cancer. 2017 Jan 01; 123(1):90-97. PMID: 27696380.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  46. Ryan CW, Merimsky O, Agulnik M, Blay JY, Schuetze SM, Van Tine BA, Jones RL, Elias AD, Choy E, Alcindor T, Keedy VL, Reed DR, Taub RN, Italiano A, Garcia Del Muro X, Judson IR, Buck JY, Lebel F, Lewis JJ, Maki RG, Schöffski P. PICASSO III: A Phase III, Placebo-Controlled Study of Doxorubicin With or Without Palifosfamide in Patients With Metastatic Soft Tissue Sarcoma. J Clin Oncol. 2016 11 10; 34(32):3898-3905. PMID: 27621408.
    Citations: 14     Fields:    Translation:HumansCTClinical Trials
  47. Molina G, Hull MA, Chen YL, DeLaney TF, De Amorim Bernstein K, Choy E, Cote G, Harmon DC, Mullen JT, Haynes AB. Preoperative radiation therapy combined with radical surgical resection is associated with a lower rate of local recurrence when treating unifocal, primary retroperitoneal liposarcoma. J Surg Oncol. 2016 Dec; 114(7):814-820. PMID: 27634478.
    Citations: 3     Fields:    Translation:Humans
  48. Sebro R, DeLaney T, Hornicek F, Schwab J, Choy E, Nielsen GP, Rosenthal DI. Differences in sex distribution, anatomic location and MR imaging appearance of pediatric compared to adult chordomas. BMC Med Imaging. 2016 09 08; 16(1):53. PMID: 27609115.
    Citations:    Fields:    Translation:Humans
  49. Jung J, Lee JS, Dickson MA, Schwartz GK, Le Cesne A, Varga A, Bahleda R, Wagner AJ, Choy E, de Jonge MJ, Light M, Rowley S, Macé S, Watters J. TP53 mutations emerge with HDM2 inhibitor SAR405838 treatment in de-differentiated liposarcoma. Nat Commun. 2016 08 31; 7:12609. PMID: 27576846.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  50. Choy E, Hornicek FJ, Chen YL, Rosenthal DI, Kerr DA. CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 26-2016. A 28-Year-Old Woman with Back Pain and a Lesion in the Lumbar Spine. N Engl J Med. 2016 Aug 25; 375(8):779-88. PMID: 27557305.
    Citations:    Fields:    Translation:Humans
  51. Ahmad R, Jacobson A, Hornicek F, Haynes AB, Choy E, Cote G, Nielsen GP, Chen YL, DeLaney TF, Mullen JT. The Width of the Surgical Margin Does Not Influence Outcomes in Extremity and Truncal Soft Tissue Sarcoma Treated With Radiotherapy. Oncologist. 2016 10; 21(10):1269-1276. PMID: 27440063.
    Citations: 1     Fields:    Translation:Humans
  52. Liu X, Gao Y, Shen J, Yang W, Choy E, Mankin H, Hornicek FJ, Duan Z. Cyclin-Dependent Kinase 11 (CDK11) Is Required for Ovarian Cancer Cell Growth In Vitro and In Vivo, and Its Inhibition Causes Apoptosis and Sensitizes Cells to Paclitaxel. . 2016 07; 15(7):1691-701. PMID: 27207777.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  53. Gao Y, Shen JK, Choy E, Zhang Z, Mankin HJ, Hornicek FJ, Duan Z. Pharmacokinetics and tolerability of NSC23925b, a novel P-glycoprotein inhibitor: preclinical study in mice and rats. Sci Rep. 2016 05 09; 6:25659. PMID: 27157103.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  54. Shen JK, Cote GM, Gao Y, Choy E, Mankin HJ, Hornicek FJ, Duan Z. Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro. Sci Rep. 2016 04 29; 6:25239. PMID: 27125524.
    Citations: 6     Fields:    Translation:HumansCells
  55. Schöffski P, Chawla S, Maki RG, Italiano A, Gelderblom H, Choy E, Grignani G, Camargo V, Bauer S, Rha SY, Blay JY, Hohenberger P, D'Adamo D, Guo M, Chmielowski B, Le Cesne A, Demetri GD, Patel SR. Eribulin versus dacarbazine in previously treated patients with advanced liposarcoma or leiomyosarcoma: a randomised, open-label, multicentre, phase 3 trial. Lancet. 2016 Apr 16; 387(10028):1629-37. PMID: 26874885.
    Citations: 71     Fields:    Translation:HumansCTClinical Trials
  56. Gao Y, Liao Y, Shen JK, Feng Y, Choy E, Cote G, Harmon D, Mankin HJ, Hornicek FJ, Duan Z. Evaluation of P-glycoprotein (Pgp) expression in human osteosarcoma by high-throughput tissue microarray. J Orthop Res. 2016 09; 34(9):1606-12. PMID: 26790551.
    Citations: 2     Fields:    Translation:Humans
  57. Wang H, Jacobson A, Harmon DC, Choy E, Hornicek FJ, Raskin KA, Chebib IA, DeLaney TF, Chen YL. Prognostic factors in alveolar soft part sarcoma: A SEER analysis. J Surg Oncol. 2016 Apr; 113(5):581-6. PMID: 26804150.
    Citations: 2     Fields:    Translation:Humans
  58. Liu T, Shen JK, Li Z, Choy E, Hornicek FJ, Duan Z. Development and potential applications of CRISPR-Cas9 genome editing technology in sarcoma. Cancer Lett. 2016 Apr 01; 373(1):109-118. PMID: 26806808.
    Citations: 5     Fields:    Translation:HumansAnimals
  59. Ye S, Zhang J, Shen J, Gao Y, Li Y, Choy E, Cote G, Harmon D, Mankin H, Gray NS, Hornicek FJ, Duan Z. NVP-TAE684 reverses multidrug resistance (MDR) in human osteosarcoma by inhibiting P-glycoprotein (PGP1) function. Br J Pharmacol. 2016 Feb; 173(3):613-26. PMID: 26603906.
    Citations: 3     Fields:    Translation:HumansCells
  60. Wojcik J, Rosenberg AE, Bredella MA, Choy E, Hornicek FJ, Nielsen GP, Deshpande V. Denosumab-treated Giant Cell Tumor of Bone Exhibits Morphologic Overlap With Malignant Giant Cell Tumor of Bone. Am J Surg Pathol. 2016 Jan; 40(1):72-80. PMID: 26414220.
    Citations: 10     Fields:    Translation:HumansCells
  61. Liao Y, Feng Y, Shen J, Gao Y, Cote G, Choy E, Harmon D, Mankin H, Hornicek F, Duan Z. Clinical and biological significance of PIM1 kinase in osteosarcoma. J Orthop Res. 2016 07; 34(7):1185-94. PMID: 26687194.
    Citations: 3     Fields:    Translation:HumansCells
  62. Schuetze SM, Wathen JK, Lucas DR, Choy E, Samuels BL, Staddon AP, Ganjoo KN, von Mehren M, Chow WA, Loeb DM, Tawbi HA, Rushing DA, Patel SR, Thomas DG, Chugh R, Reinke DK, Baker LH. SARC009: Phase 2 study of dasatinib in patients with previously treated, high-grade, advanced sarcoma. Cancer. 2016 Mar 15; 122(6):868-74. PMID: 26710211.
    Citations: 15     Fields:    Translation:HumansCTClinical Trials
  63. Ye S, Shen J, Choy E, Yang C, Mankin H, Hornicek F, Duan Z. p53 overexpression increases chemosensitivity in multidrug-resistant osteosarcoma cell lines. Cancer Chemother Pharmacol. 2016 Feb; 77(2):349-56. PMID: 26698867.
    Citations: 5     Fields:    Translation:HumansCells
  64. Chen H, Shen J, Choy E, Hornicek FJ, Duan Z. Targeting protein kinases to reverse multidrug resistance in sarcoma. Cancer Treat Rev. 2016 Feb; 43:8-18. PMID: 26827688.
    Citations: 1     Fields:    Translation:Humans
  65. Sun R, Shen JK, Choy E, Yu Z, Hornicek FJ, Duan Z. The emerging roles and therapeutic potential of microRNAs (miRs) in liposarcoma. Discov Med. 2015 Nov; 20(111):311-24. PMID: 26645903.
    Citations: 2     Fields:    Translation:Humans
  66. Lim SY, Rastalsky N, Choy E, Bolster MB. Tibial stress reaction presenting as bilateral shin pain in a man taking denosumab for giant cell tumor of the bone. Bone. 2015 Dec; 81:31-35. PMID: 26117225.
    Citations:    Fields:    Translation:Humans
  67. Gao Y, Feng Y, Shen JK, Lin M, Choy E, Cote GM, Harmon DC, Mankin HJ, Hornicek FJ, Duan Z. CD44 is a direct target of miR-199a-3p and contributes to aggressive progression in osteosarcoma. Sci Rep. 2015 Jun 16; 5:11365. PMID: 26079799.
    Citations: 17     Fields:    Translation:HumansCells
  68. Feng Y, Shen J, Gao Y, Liao Y, Cote G, Choy E, Chebib I, Mankin H, Hornicek F, Duan Z. Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma. Oncotarget. 2015 May 10; 6(13):11139-49. PMID: 25871477.
    Citations: 13     Fields:    Translation:HumansCells
  69. Osaka E, Kelly AD, Spentzos D, Choy E, Yang X, Shen JK, Yang P, Mankin HJ, Hornicek FJ, Duan Z. MicroRNA-155 expression is independently predictive of outcome in chordoma. Oncotarget. 2015 Apr 20; 6(11):9125-39. PMID: 25823817.
    Citations: 8     Fields:    Translation:HumansCells
  70. Yang X, Iyer AK, Singh A, Choy E, Hornicek FJ, Amiji MM, Duan Z. MDR1 siRNA loaded hyaluronic acid-based CD44 targeted nanoparticle systems circumvent paclitaxel resistance in ovarian cancer. Sci Rep. 2015 Feb 17; 5:8509. PMID: 25687880.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  71. Yang X, Feng Y, Gao Y, Shen J, Choy E, Cote G, Harmon D, Zhang Z, Mankin H, Hornicek FJ, Duan Z. NSC23925 prevents the emergence of multidrug resistance in ovarian cancer in vitro and in vivo. Gynecol Oncol. 2015 Apr; 137(1):134-42. PMID: 25677062.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  72. Lee HJ, Yoon C, Park DJ, Kim YJ, Schmidt B, Lee YJ, Tap WD, Eisinger-Mathason TS, Choy E, Kirsch DG, Simon MC, Yoon SS. Inhibition of vascular endothelial growth factor A and hypoxia-inducible factor 1a maximizes the effects of radiation in sarcoma mouse models through destruction of tumor vasculature. Int J Radiat Oncol Biol Phys. 2015 Mar 01; 91(3):621-30. PMID: 25544668.
    Citations: 4     Fields:    Translation:AnimalsCells
  73. Choy E, Flamand Y, Balasubramanian S, Butrynski JE, Harmon DC, George S, Cote GM, Wagner AJ, Morgan JA, Sirisawad M, Mani C, Hornicek FJ, Duan Z, Demetri GD. Phase 1 study of oral abexinostat, a histone deacetylase inhibitor, in combination with doxorubicin in patients with metastatic sarcoma. Cancer. 2015 Apr 15; 121(8):1223-30. PMID: 25536954.
    Citations: 13     Fields:    Translation:HumansCTClinical Trials
  74. Yang X, Iyer AK, Singh A, Milane L, Choy E, Hornicek FJ, Amiji MM, Duan Z. Cluster of Differentiation 44 Targeted Hyaluronic Acid Based Nanoparticles for MDR1 siRNA Delivery to Overcome Drug Resistance in Ovarian Cancer. Pharm Res. 2015 Jun; 32(6):2097-109. PMID: 25515492.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  75. Choy E, Butrynski JE, Harmon DC, Morgan JA, George S, Wagner AJ, D'Adamo D, Cote GM, Flamand Y, Benes CH, Haber DA, Baselga JM, Demetri GD. Phase II study of olaparib in patients with refractory Ewing sarcoma following failure of standard chemotherapy. BMC Cancer. 2014 Nov 05; 14:813. PMID: 25374341.
    Citations: 21     Fields:    Translation:HumansCTClinical Trials
  76. Choy E, Attar EC, Oh KS, Huang AJ, Kerr DA. Case records of the Massachusetts General Hospital. Case 33-2014. A 60-year-old man with bone pain. N Engl J Med. 2014 Oct 23; 371(17):1630-40. PMID: 25337753.
    Citations:    Fields:    Translation:Humans
  77. Duan Z, Zhang J, Ye S, Shen J, Choy E, Cote G, Harmon D, Mankin H, Hua Y, Zhang Y, Gray NS, Hornicek FJ. A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells. BMC Cancer. 2014 Sep 19; 14:681. PMID: 25236161.
    Citations: 4     Fields:    Translation:HumansCells
  78. Shen JK, Cote GM, Choy E, Hornicek FJ, Duan Z. Targeting programmed cell death ligand 1 in osteosarcoma: an auto-commentary on therapeutic potential. Oncoimmunology. 2014; 3(8):e954467. PMID: 25610746.
    Citations: 3     
  79. Mullen JT, Hornicek FJ, Harmon DC, Raskin KA, Chen YL, Szymonifka J, Yeap BY, Choy E, DeLaney TF, Nielsen GP. Prognostic significance of treatment-induced pathologic necrosis in extremity and truncal soft tissue sarcoma after neoadjuvant chemoradiotherapy. Cancer. 2014 Dec 01; 120(23):3676-82. PMID: 25081640.
    Citations: 9     Fields:    Translation:Humans
  80. Choy E, MacConaill LE, Cote GM, Le LP, Shen JK, Nielsen GP, Iafrate AJ, Garraway LA, Hornicek FJ, Duan Z. Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes and areas of chromosomal loss involving CDKN2A, PTEN, and SMARCB1. PLoS One. 2014; 9(7):e101283. PMID: 24983247.
    Citations: 11     Fields:    Translation:Humans
  81. Choy E. Sarcoma after 5 years of progression-free survival: lessons from the French sarcoma group. Cancer. 2014 Oct 01; 120(19):2942-3. PMID: 24942785.
    Citations:    Fields:    Translation:HumansPHPublic Health
  82. Shen JK, Cote GM, Choy E, Yang P, Harmon D, Schwab J, Nielsen GP, Chebib I, Ferrone S, Wang X, Wang Y, Mankin H, Hornicek FJ, Duan Z. Programmed cell death ligand 1 expression in osteosarcoma. Cancer Immunol Res. 2014 Jul; 2(7):690-698. PMID: 24866169.
    Citations: 38     Fields:    Translation:HumansCells
  83. Guo S, Lopez-Marquez H, Fan KC, Choy E, Cote G, Harmon D, Nielsen GP, Yang C, Zhang C, Mankin H, Hornicek FJ, Borger DR, Duan Z. Synergistic effects of targeted PI3K signaling inhibition and chemotherapy in liposarcoma. PLoS One. 2014; 9(4):e93996. PMID: 24695632.
    Citations: 6     Fields:    Translation:HumansCells
  84. Duan Z, Shen J, Yang X, Yang P, Osaka E, Choy E, Cote G, Harmon D, Zhang Y, Nielsen GP, Spentzos D, Mankin H, Hornicek F. Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma. J Orthop Res. 2014 May; 32(5):695-701. PMID: 24501096.
    Citations: 12     Fields:    Translation:HumansCells
  85. Shinagare AB, Jagannathan JP, Kurra V, Urban T, Manola J, Choy E, Demetri GD, George S, Ramaiya NH. Comparison of performance of various tumour response criteria in assessment of regorafenib activity in advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib. Eur J Cancer. 2014 Mar; 50(5):981-6. PMID: 24388774.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  86. Cheney MD, Giraud C, Goldberg SI, Rosenthal DI, Hornicek FJ, Choy E, Mullen JT, Chen YL, Delaney TF. MRI surveillance following treatment of extremity soft tissue sarcoma. J Surg Oncol. 2014 May; 109(6):593-6. PMID: 24374823.
    Citations: 6     Fields:    Translation:Humans
  87. Choy E, Jacobs IA. Biosimilar safety considerations in clinical practice. Semin Oncol. 2014 Feb; 41 Suppl 1:S3-14. PMID: 24560025.
    Citations: 3     Fields:    Translation:Humans
  88. Gullick NJ, Abozaid HS, Jayaraj DM, Evans HG, Scott DL, Choy EH, Taams LS. Enhanced and persistent levels of interleukin (IL)-17? CD4? T cells and serum IL-17 in patients with early inflammatory arthritis. Clin Exp Immunol. 2013 Nov; 174(2):292-301. PMID: 23815507.
    Citations: 12     Fields:    Translation:HumansCells
  89. Ceeraz S, Hall C, Choy EH, Spencer J, Corrigall VM. Defective CD8+CD28+ regulatory T cell suppressor function in rheumatoid arthritis is restored by tumour necrosis factor inhibitor therapy. Clin Exp Immunol. 2013 Oct; 174(1):18-26. PMID: 23786396.
    Citations: 10     Fields:    Translation:HumansCells
  90. Zhang L, Guo S, Schwab JH, Nielsen GP, Choy E, Ye S, Zhang Z, Mankin H, Hornicek FJ, Duan Z. Tissue microarray immunohistochemical detection of brachyury is not a prognostic indicator in chordoma. PLoS One. 2013; 8(9):e75851. PMID: 24086644.
    Citations: 15     Fields:    Translation:Humans
  91. Jia B, Choy E, Cote G, Harmon D, Ye S, Kan Q, Mankin H, Hornicek F, Duan Z. Cyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cells. Cancer Lett. 2014 Jan 01; 342(1):104-12. PMID: 24007862.
    Citations: 16     Fields:    Translation:HumansCells
  92. Cote GM, Choy E. Role of epigenetic modulation for the treatment of sarcoma. Curr Treat Options Oncol. 2013 Sep; 14(3):454-64. PMID: 23749746.
    Citations: 9     Fields:    Translation:Humans
  93. Mullen JT, DeLaney TF, Rosenberg AE, Le L, Iafrate AJ, Kobayashi W, Szymonifka J, Yeap BY, Chen YL, Harmon DC, Choy E, Yoon SS, Raskin KA, Hornicek FJ, Nielsen GP. ß-Catenin mutation status and outcomes in sporadic desmoid tumors. Oncologist. 2013; 18(9):1043-9. PMID: 23960186.
    Citations: 16     Fields:    Translation:Humans
  94. Cote GM, Choy E. Update in treatment and targets in Ewing sarcoma. Hematol Oncol Clin North Am. 2013 Oct; 27(5):1007-19. PMID: 24093173.
    Citations: 4     Fields:    Translation:Humans
  95. Chawla S, Henshaw R, Seeger L, Choy E, Blay JY, Ferrari S, Kroep J, Grimer R, Reichardt P, Rutkowski P, Schuetze S, Skubitz K, Staddon A, Thomas D, Qian Y, Jacobs I. Safety and efficacy of denosumab for adults and skeletally mature adolescents with giant cell tumour of bone: interim analysis of an open-label, parallel-group, phase 2 study. Lancet Oncol. 2013 Aug; 14(9):901-8. PMID: 23867211.
    Citations: 93     Fields:    Translation:HumansCTClinical Trials
  96. Look Hong NJ, Hornicek FJ, Harmon DC, Choy E, Chen YL, Yoon SS, Nielsen GP, Szymonifka J, Yeap BY, DeLaney TF, Mullen JT. Neoadjuvant chemoradiotherapy for patients with high-risk extremity and truncal sarcomas: a 10-year single institution retrospective study. Eur J Cancer. 2013 Mar; 49(4):875-83. PMID: 23092789.
    Citations: 11     Fields:    Translation:HumansCTClinical Trials
  97. Yang W, Liu X, Choy E, Mankin H, Hornicek FJ, Duan Z. Targeting hedgehog-GLI-2 pathway in osteosarcoma. J Orthop Res. 2013 Mar; 31(3):502-9. PMID: 22968906.
    Citations: 14     Fields:    Translation:HumansCells
  98. Mullen JT, Delaney TF, Kobayashi WK, Szymonifka J, Yeap BY, Chen YL, Rosenberg AE, Harmon DC, Choy E, Yoon SS, Raskin KA, Petur Nielsen G, Hornicek FJ. Desmoid tumor: analysis of prognostic factors and outcomes in a surgical series. Ann Surg Oncol. 2012 Dec; 19(13):4028-35. PMID: 22965569.
    Citations: 19     Fields:    Translation:Humans
  99. Duan Z, Zhang J, Choy E, Harmon D, Liu X, Nielsen P, Mankin H, Gray NS, Hornicek FJ. Systematic kinome shRNA screening identifies CDK11 (PITSLRE) kinase expression is critical for osteosarcoma cell growth and proliferation. Clin Cancer Res. 2012 Sep 01; 18(17):4580-8. PMID: 22791884.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  100. George S, Wang Q, Heinrich MC, Corless CL, Zhu M, Butrynski JE, Morgan JA, Wagner AJ, Choy E, Tap WD, Yap JT, Van den Abbeele AD, Manola JB, Solomon SM, Fletcher JA, von Mehren M, Demetri GD. Efficacy and safety of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of imatinib and sunitinib: a multicenter phase II trial. J Clin Oncol. 2012 Jul 01; 30(19):2401-7. PMID: 22614970.
    Citations: 57     Fields:    Translation:HumansCTClinical Trials
  101. Wagner AJ, Goldberg JM, Dubois SG, Choy E, Rosen L, Pappo A, Geller J, Judson I, Hogg D, Senzer N, Davis IJ, Chai F, Waghorne C, Schwartz B, Demetri GD. Tivantinib (ARQ 197), a selective inhibitor of MET, in patients with microphthalmia transcription factor-associated tumors: results of a multicenter phase 2 trial. Cancer. 2012 Dec 01; 118(23):5894-902. PMID: 22605650.
    Citations: 41     Fields:    Translation:HumansCTClinical Trials
  102. Liu X, Nielsen GP, Rosenberg AE, Waterman PR, Yang W, Choy E, Sassi S, Yang S, Harmon DC, Yang C, Schwab JH, Kobayashi E, Mankin HJ, Xavier R, Weissleder R, Duan Z, Hornicek FJ. Establishment and characterization of a novel chordoma cell line: CH22. J Orthop Res. 2012 Oct; 30(10):1666-73. PMID: 22504929.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  103. Duan Z, Li X, Huang H, Yuan W, Zheng SL, Liu X, Zhang Z, Choy E, Harmon D, Mankin H, Hornicek F. Synthesis and evaluation of (2-(4-methoxyphenyl)-4-quinolinyl)(2-piperidinyl)methanol (NSC23925) isomers to reverse multidrug resistance in cancer. J Med Chem. 2012 Apr 12; 55(7):3113-21. PMID: 22400811.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  104. Mullen JT, Kobayashi W, Wang JJ, Harmon DC, Choy E, Hornicek FJ, Rosenberg AE, Chen YL, Spiro IJ, DeLaney TF. Long-term follow-up of patients treated with neoadjuvant chemotherapy and radiotherapy for large, extremity soft tissue sarcomas. Cancer. 2012 Aug 01; 118(15):3758-65. PMID: 22180344.
    Citations: 16     Fields:    Translation:Humans
  105. Choy E, Hornicek F, MacConaill L, Harmon D, Tariq Z, Garraway L, Duan Z. High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes. Cancer. 2012 Jun 01; 118(11):2905-14. PMID: 22006429.
    Citations: 25     Fields:    Translation:HumansCells
  106. Duan Z, Choy E, Harmon D, Liu X, Susa M, Mankin H, Hornicek F. MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration. . 2011 Aug; 10(8):1337-45. PMID: 21666078.
    Citations: 84     Fields:    Translation:HumansCells
  107. Liu X, Choy E, Harmon D, Yang S, Yang C, Mankin H, Hornicek FJ, Duan Z. Inhibition of polo-like kinase 1 leads to the suppression of osteosarcoma cell growth in vitro and in vivo. Anticancer Drugs. 2011 Jun; 22(5):444-53. PMID: 21399492.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  108. Yang C, Choy E, Hornicek FJ, Wood KB, Schwab JH, Liu X, Mankin H, Duan Z. Histone deacetylase inhibitor PCI-24781 enhances chemotherapy-induced apoptosis in multidrug-resistant sarcoma cell lines. Anticancer Res. 2011 Apr; 31(4):1115-23. PMID: 21508354.
    Citations: 13     Fields:    Translation:HumansCells
  109. Ciernik IF, Niemierko A, Harmon DC, Kobayashi W, Chen YL, Yock TI, Ebb DH, Choy E, Raskin KA, Liebsch N, Hornicek FJ, Delaney TF. Proton-based radiotherapy for unresectable or incompletely resected osteosarcoma. Cancer. 2011 Oct 01; 117(19):4522-30. PMID: 21448934.
    Citations: 21     Fields:    Translation:Humans
  110. Liu X, Choy E, Hornicek FJ, Yang S, Yang C, Harmon D, Mankin H, Duan Z. ROCK1 as a potential therapeutic target in osteosarcoma. J Orthop Res. 2011 Aug; 29(8):1259-66. PMID: 21387396.
    Citations: 27     Fields:    Translation:HumansCells
  111. Yoon SS, Duda DG, Karl DL, Kim TM, Kambadakone AR, Chen YL, Rothrock C, Rosenberg AE, Nielsen GP, Kirsch DG, Choy E, Harmon DC, Hornicek FJ, Dreyfuss J, Ancukiewicz M, Sahani DV, Park PJ, Jain RK, Delaney TF. Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas. Int J Radiat Oncol Biol Phys. 2011 Nov 15; 81(4):1081-90. PMID: 20932656.
    Citations: 21     Fields:    Translation:HumansCTClinical Trials
  112. Susa M, Choy E, Liu X, Schwab J, Hornicek FJ, Mankin H, Duan Z. Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking. . 2010 Dec; 9(12):3342-50. PMID: 20881269.
    Citations: 8     Fields:    Translation:HumansCells
  113. Yang C, Hornicek FJ, Wood KB, Schwab JH, Choy E, Mankin H, Duan Z. Blockage of Stat3 with CDDO-Me inhibits tumor cell growth in chordoma. Spine (Phila Pa 1976). 2010 Aug 15; 35(18):1668-75. PMID: 20386502.
    Citations: 8     Fields:    Translation:Humans
  114. Guo Y, Nemeth J, O'Brien C, Susa M, Liu X, Zhang Z, Choy E, Mankin H, Hornicek F, Duan Z. Effects of siltuximab on the IL-6-induced signaling pathway in ovarian cancer. Clin Cancer Res. 2010 Dec 01; 16(23):5759-69. PMID: 20699329.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  115. Ryu K, Choy E, Yang C, Susa M, Hornicek FJ, Mankin H, Duan Z. Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis. J Orthop Res. 2010 Jul; 28(7):971-8. PMID: 20063378.
    Citations: 23     Fields:    Translation:HumansCells
  116. Duan Z, Choy E, Nielsen GP, Rosenberg A, Iafrate J, Yang C, Schwab J, Mankin H, Xavier R, Hornicek FJ. Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression. J Orthop Res. 2010 Jun; 28(6):746-52. PMID: 20041488.
    Citations: 29     Fields:    Translation:HumansCells
  117. Yang C, Hornicek FJ, Wood KB, Schwab JH, Choy E, Iafrate J, Rosenberg A, Nielsen GP, Xavier RJ, Mankin H, Duan Z. Characterization and analysis of human chordoma cell lines. Spine (Phila Pa 1976). 2010 Jun 01; 35(13):1257-64. PMID: 20461036.
    Citations: 12     Fields:    Translation:HumansCells
  118. Susa M, Iyer AK, Ryu K, Choy E, Hornicek FJ, Mankin H, Milane L, Amiji MM, Duan Z. Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma. PLoS One. 2010 May 24; 5(5):e10764. PMID: 20520719.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  119. Yang C, Choy E, Hornicek FJ, Wood KB, Schwab JH, Liu X, Mankin H, Duan Z. Histone deacetylase inhibitor (HDACI) PCI-24781 potentiates cytotoxic effects of doxorubicin in bone sarcoma cells. Cancer Chemother Pharmacol. 2011 Feb; 67(2):439-46. PMID: 20461381.
    Citations: 22     Fields:    Translation:HumansCells
  120. Ryu K, Susa M, Choy E, Yang C, Hornicek FJ, Mankin HJ, Duan Z. Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. BMC Cancer. 2010 May 10; 10:187. PMID: 20459702.
    Citations: 21     Fields:    Translation:HumansCells
  121. Yoon SS, Chen YL, Kirsch DG, Maduekwe UN, Rosenberg AE, Nielsen GP, Sahani DV, Choy E, Harmon DC, DeLaney TF. Proton-beam, intensity-modulated, and/or intraoperative electron radiation therapy combined with aggressive anterior surgical resection for retroperitoneal sarcomas. Ann Surg Oncol. 2010 Jun; 17(6):1515-29. PMID: 20151216.
    Citations: 22     Fields:    Translation:Humans
  122. Susa M, Choy E, Yang C, Schwab J, Mankin H, Hornicek F, Duan Z. Multidrug resistance reversal agent, NSC77037, identified with a cell-based screening assay. J Biomol Screen. 2010 Mar; 15(3):287-96. PMID: 20150589.
    Citations: 5     Fields:    Translation:HumansCells
  123. Duan Z, Ji D, Weinstein EJ, Liu X, Susa M, Choy E, Yang C, Mankin H, Hornicek FJ. Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma. Cancer Lett. 2010 Jul 28; 293(2):220-9. PMID: 20144850.
    Citations: 14     Fields:    Translation:HumansCells
  124. Yang C, Ji D, Weinstein EJ, Choy E, Hornicek FJ, Wood KB, Liu X, Mankin H, Duan Z. The kinase Mirk is a potential therapeutic target in osteosarcoma. Carcinogenesis. 2010 Apr; 31(4):552-8. PMID: 20042639.
    Citations: 19     Fields:    Translation:HumansCells
  125. Choy, E., Digumarthy, S., and Koplin, S. "A 23 year old man with cough, hoarseness, and fever" Case Records of the Massachusetts General Hospital. New Engl J Med. 2009; (Manuscript in press).
  126. Choy E, Digumarthy SR, Koplin SA. Case records of the Massachusetts General Hospital. Case 36-2009. A 23-year-old man with cough, hoarseness, and abnormalities on chest imaging. N Engl J Med. 2009 Nov 19; 361(21):2080-7. PMID: 19923580.
    Citations: 1     Fields:    Translation:Humans
  127. Duan Z, Choy E, Hornicek FJ. NSC23925, identified in a high-throughput cell-based screen, reverses multidrug resistance. PLoS One. 2009 Oct 12; 4(10):e7415. PMID: 19823672.
    Citations: 15     Fields:    Translation:Humans
  128. Yang C, Schwab JH, Schoenfeld AJ, Hornicek FJ, Wood KB, Choy E, Nielsen P, Mankin H, and Duan Z. A novel target for treatment of chordoma: Stat3. Mol Cancer Ther. 2009; 8(9).
  129. Duan Z, Choy E, Harmon D, Yang C, Ryu K, Schwab J, Mankin H, Hornicek FJ. ZNF93 increases resistance to ET-743 (Trabectedin; Yondelis) and PM00104 (Zalypsis) in human cancer cell lines. PLoS One. 2009 Sep 09; 4(9):e6967. PMID: 19742314.
    Citations: 4     Fields:    Translation:HumansCells
  130. Yang C, Schwab JH, Schoenfeld AJ, Hornicek FJ, Wood KB, Nielsen GP, Choy E, Mankin H, Duan Z. A novel target for treatment of chordoma: signal transducers and activators of transcription 3. . 2009 Sep; 8(9):2597-605. PMID: 19723879.
    Citations: 18     Fields:    Translation:HumansCells
  131. Duan Z, Choy E, Harmon D, Yang C, Ryu K, Schwab J, Mankin H, Hornicek FJ. Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines. . 2009 Aug; 8(8):2122-30. PMID: 19638450.
    Citations: 31     Fields:    Translation:HumansCells
  132. Schwab J, Antonescu C, Boland P, Healey J, Rosenberg A, Nielsen P, Iafrate J, Delaney T, Yoon S, Choy E, Harmon D, Raskin K, Yang C, Mankin H, Springfield D, Hornicek F, Duan Z. Combination of PI3K/mTOR inhibition demonstrates efficacy in human chordoma. Anticancer Res. 2009 Jun; 29(6):1867-71. PMID: 19528441.
    Citations: 21     Fields:    Translation:HumansCells
  133. Duan Z, Choy E, Jimeno J, Cuevas C, Mankin H, Hornicek F. Diverse cross-resistance phenotype to ET-743 (Yondelis®;Trabectedin) and PM00104 (Zalypsis®) in multi-drug resistant cell lines selected in vitro using paclitaxel, doxorubicin or cisplatin. Cancer Chemother Pharmacol. 2009; 63(6):1121-9.
  134. Maduekwe UN, Hornicek FJ, Springfield DS, Raskin KA, Harmon DC, Choy E, Rosenberg AE, Nielsen GP, DeLaney TF, Chen YL, Ott MJ, Yoon SS. Role of sentinel lymph node biopsy in the staging of synovial, epithelioid, and clear cell sarcomas. Ann Surg Oncol. 2009 May; 16(5):1356-63. PMID: 19259743.
    Citations: 5     Fields:    Translation:Humans
  135. De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, McCauley JL, Sawcer S, Goris A, Saarela J, Yelensky R, Price A, Leppa V, Patterson N, de Bakker PI, Tran D, Aubin C, Pobywajlo S, Rossin E, Hu X, Ashley CW, Choy E, Rioux JD, Pericak-Vance MA, Ivinson A, Booth DR, Stewart GJ, Palotie A, Peltonen L, Dubois B, Haines JL, Weiner HL, Compston A, Hauser SL, Daly MJ, Reich D, Oksenberg JR, Hafler DA. The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5264-9. PMID: 19237575.
    Citations: 61     Fields:    Translation:HumansCells
  136. Duan, Z., Choy, E., Yang, C., Mankin, H., and Hornicek, F.J. . IGF-1 receptor tyrosine kinase inhibitor cyclolignan PPP inhibits proliferation and induces apoptosis in osteosarcoma drug sensitive and resistant cells. 55th Annual Meeting of the Orthopaedic Research Society . 2009.
  137. Choy E, Yelensky R, Bonakdar S, Plenge RM, Saxena R, De Jager PL, Shaw SY, Wolfish CS, Slavik JM, Cotsapas C, Rivas M, Dermitzakis ET, Cahir-McFarland E, Kieff E, Hafler D, Daly MJ, Altshuler D. Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines. PLoS Genet. 2008 Nov; 4(11):e1000287. PMID: 19043577.
    Citations: 123     Fields:    Translation:HumansCells
  138. Duan, Z., Choy, E., Schwab, J., Jimeno, J.M., del Maria Cuevas, C., Mankin, H.J., and Hornicek, F.J. . Diverse cross-resistance phenotype to ET-743 (Yondelis; Trabectedin) and PM00104 (Zalypsis) in multi-drug resistant cell lines selected in vitro using paclitaxel, doxorubicin or cisplatin. Cancer Chemotherapy and Pharmacology. 2008.
  139. Duan Z, Choy E, Jimeno JM, Cuevas Cdel M, Mankin HJ, Hornicek FJ. Diverse cross-resistance phenotype to ET-743 and PM00104 in multi-drug resistant cell lines. Cancer Chemother Pharmacol. 2009 May; 63(6):1121-9. PMID: 18828019.
    Citations: 7     Fields:    Translation:HumansCells
  140. Duan Z, Weinstein EJ, Ji D, Ames RY, Choy E, Mankin H, Hornicek FJ. Lentiviral short hairpin RNA screen of genes associated with multidrug resistance identifies PRP-4 as a new regulator of chemoresistance in human ovarian cancer. . 2008 Aug; 7(8):2377-85. PMID: 18687998.
    Citations: 8     Fields:    Translation:HumansCells
  141. Duan, Z., Weinstein, E., Ji, D., Ames, R., Choy, E., Mankin, H., and Hornicek, F. Lentiviral shRNA screen of human kinases identifies new regulators of osteosarcoma cell survival and apoptosis. 14th Annual Connective Tissue Oncology Society Meeting. 2008.
  142. Maduekwe, U., Hornicek, F., Ott, M., Springfield, D., Raskin, K., Choy, E., Harmon, D., Rosenberg, A., Nielsen, G., DeLaney, T., and Yoon, S. Role of Sentinel Lymph Node Biopsy in the Staging of Synovial, Epithelioid, and Clear Cell Sarcomas. 14th Annual Connective Tissue Oncology Society Meeting. 2008.
  143. Kambadakone, AR, Yoon, S, Harmon, D, Choy, E, Delaney, T, Rosenberg, A, Nielsen, P, Hornicek, F, Springfield, D, Raskin, K, Sahani,D. . Assessing Tumor Biology and Anti-angiogenic Response in Soft Tissue Sarcomas: Initial Observations on Perfusion CT (CTp). 94th Scientific Assembly and Annual meeting of the Radiological Society of North America (RSNA). 2008.
  144. Wagner, A.J., Yazji, S., Morgan, J.A., Choy, E, George, S., Tap, W., and Demetri, G. A Phase 2 Study of the KIT Inhibitor XL820 in Patients with Advanced Gastrointestinal Stromal Tumors (GIST) Resistant to or Intolerant of the Tyrosine Kinase Inhibitors (TKI) Imatinib and/or Sunitinib. 14th Annual Connective Tissue Oncology Society Meeting. 2008.
  145. Reich D, Patterson N, Ramesh V, De Jager PL, McDonald GJ, Tandon A, Choy E, Hu D, Tamraz B, Pawlikowska L, Wassel-Fyr C, Huntsman S, Waliszewska A, Rossin E, Li R, Garcia M, Reiner A, Ferrell R, Cummings S, Kwok PY, Harris T, Zmuda JM, Ziv E. Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels. Am J Hum Genet. 2007 Apr; 80(4):716-26. PMID: 17357077.
    Citations: 80     Fields:    Translation:HumansCells
  146. Reich, D., Patterson, N., Ramesh, V., De Jager, P.L., McDonald G.V., Tandon, A., Choy, E., Hu, D., Tamraz, B., Pawlikowska, L., Wassel-Fyr, C., Huntsman, S., Waliszewska, A., Rossin, E., Li, R., Garcia, M., Reiner, A., Ferrell, R., Cummings, S., Kwok, P., Harris, T., Zmuda, J., and Ziv, E. Admixture mapping of an allele affecting serum IL6 and IL6 receptor levels. The American Journal of Human Genetics. 2007.
  147. Haglund, K.E., Goldberg, S., Rosenberg, A., Harmon, D., Kirsch, D., Hornicek, F., Springfield, D., Raskin, K., Choy, E., and Delaney, T. . Percent Necrosis in Extremity Soft Tissue Sarcoma After Preoperative Radiation Alone Versus Preoperative Radiation and Chemotherapy. 49th Annual ASTRO Meeting, Boston, MA. Proceedings of the 49th Annual ASTRO Meeting. Abst.#169. 2007.
  148. Yelensky, R., Choy, E., Bonakdar, S., Daly, M., and Altshuler, D. Genetic and non-genetic sources of phenotypic variation in human lymphoblastoid cell lines. 57th Annual Meeting of the American Society of Human Genetics. 2007.
  149. Yelensky, R., Choy, E., Bonakdar, S., Daly, M., and Altshuler, D. Quantitative Trait Locus Mapping and the Sources of Phenotypic Variation in Human Cell-Lines. 18th Annual Meeting at Cold Spring Harbor on Genome Science, “Biology of Genomes”. 2007.
  150. Pollard LC, Choy EH, Gonzalez J, Khoshaba B, Scott DL. Fatigue in rheumatoid arthritis reflects pain, not disease activity. Rheumatology (Oxford). 2006 Jul; 45(7):885-9. PMID: 16449363.
    Citations:    
  151. Choy, E., Yelensky, R., Bonakdar, S., Shaw, S., Daly, M., and Altshuler, D. Whole Genome Association Study of Chemotherapeutic Drug Response in HapMap Cell Lines. 3rd Annual International HapMap Project Community Analysis Meeting. 2006.
  152. Choy E, Philips M. Green fluorescent protein-tagged Ras proteins for intracellular localization. Methods Enzymol. 2001; 332:50-64. PMID: 11305117.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  153. Choy, E., Kehoe, L., Fleming, N., Wiest, F., Forcione, D.G., Friedman, L.S. Dyspepsia: GERD, PUD, and Nonulcer Dyspepsia. The MGH Ambulatory Care Syllabus, Edited by Basch, E., Messersmith, W., Birnbaum, S., and Garza, C. 2001.
  154. Choy, E. and Philips, M.R. Expression and activity of a prenylcysteine-directed carboxyl methyltransferase. Methods of Enzymology. 2000; 325:101-14.
  155. Choy E, Philips M. Expression and activity of human prenylcysteine-directed carboxyl methyltransferase. Methods Enzymol. 2000; 325:101-14. PMID: 11036596.
    Citations: 2     Fields:    Translation:HumansCells
  156. Choy, E., Chiu, V.K., Silletti, J., Feoktistov, M., Morimoto, T., Michaelson, D., Ivanov, I.E., and Philips, M.R. Endomembrane Trafficking of Ras: the CAAX Motif Targets Proteins to the ER and Golgi. Cell. 1999; 98(1):69-80.
  157. Choy E, Chiu VK, Silletti J, Feoktistov M, Morimoto T, Michaelson D, Ivanov IE, Philips MR. Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi. Cell. 1999 Jul 09; 98(1):69-80. PMID: 10412982.
    Citations: 222     Fields:    Translation:AnimalsCells
  158. Choy, Edwin. CAAX Proteins Target Ras to Intracellular Compartments. 1999.
  159. Dai, Q., Choy, E., Chiu, V., Romano, J., Slivka, S.R., Steitz, S.A., Michaelis, S., and Philips, M.R. . Mammalian Prenylcysteine Prenyltransferase is in the Endoplasmic Reticulum. Journal of Biological Chemistry. 1998; 273(24):15030-4.
  160. Dai Q, Choy E, Chiu V, Romano J, Slivka SR, Steitz SA, Michaelis S, Philips MR. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. J Biol Chem. 1998 Jun 12; 273(24):15030-4. PMID: 9614111.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  161. Choy, E., Chiu, V., and Philips, M.R. . The CAAX Motif Targets Proteins to the Endoplasmic Reticulum. 38th American Society for Cell Biology Annual Meeting, San Francisco, California. Molecular Biology of the Cell. 1998; 9:458a.
  162. Choy, E., Dai, Q., Slivka, S., Steitz, S., and Philips, M.R. Prenylcysteine Carboxyl Methyltransferase in the ER Directs Ras to the Vesicular Transport Pathway. 37th American Society for Cell Biology Annual Meeting, San Francisco, California. Molecular Biology of the Cell. 1997; 8:305a.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.