Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Alessandro Alessandrini, Ph.D.


Plasmacytoid Dendritic Cell Induction of Allogenic Regulatory T cells
Summer, 06/11/12 - 08/16/12

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhang H, Cavazzoni CB, Hanson BL, Bechu ED, Podestà MA, Azzi J, Blazar BR, Chong AS, Kreisel D, Alessandrini A, Sage PT. Transcriptionally Distinct B Cells Infiltrate Allografts After Kidney Transplantation. Transplantation. 2022 Nov 11. PMID: 36398326.
    Citations:    Fields:    
  2. Rosales IA, Yang C, Farkash EA, Ashry T, Ge J, Aljabban I, Ayyar A, Ndishabandi D, White R, Gildner E, Gong J, Liang Y, Lakkis FG, Nickeleit V, Russell PS, Madsen JC, Alessandrini A, Colvin RB. Novel intragraft regulatory lymphoid structures in kidney allograft tolerance. Am J Transplant. 2022 03; 22(3):705-716. PMID: 34726836.
    Citations: 1     Fields:    Translation:Animals
  3. Mohammed MT, Cai S, Hanson BL, Zhang H, Clement RL, Daccache J, Cavazzoni CB, Blazar BR, Alessandrini A, Rennke HG, Chandraker A, Sage PT. Follicular T cells mediate donor-specific antibody and rejection after solid organ transplantation. Am J Transplant. 2021 05; 21(5):1893-1901. PMID: 33421294; PMCID: PMC8096660.
    Citations: 9     Fields:    Translation:HumansAnimals
  4. Zhao Y, Li X, Yu D, Hu Y, Jin W, Qin Y, Kong D, Wang H, Li G, Alessandrini A, Wang H. Galectin-9 is required for endometrial regenerative cells to induce long-term cardiac allograft survival in mice. Stem Cell Res Ther. 2020 11 05; 11(1):471. PMID: 33153471; PMCID: PMC7643467.
    Citations: 3     Fields:    Translation:AnimalsCells
  5. Yang C, Ge J, Rosales I, Yuan Q, Szuter E, Acheampong E, Russell PS, Madsen JC, Colvin RB, Alessandrini A. Kidney-induced systemic tolerance of heart allografts in mice. JCI Insight. 2020 09 17; 5(18). PMID: 32938831; PMCID: PMC7526548.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Oh NA, O'Shea T, Ndishabandi DK, Yuan Q, Hong S, Gans J, Ge J, Gibney S, Chase C, Yang C, Rosales I, Shinoda K, Drew B, Kojima L, Russell PS, Madsen JC, Colvin RB, Alessandrini A. Plasmacytoid Dendritic Cell-driven Induction of Treg Is Strain Specific and Correlates With Spontaneous Acceptance of Kidney Allografts. Transplantation. 2020 01; 104(1):39-53. PMID: 31335760; PMCID: PMC6933071.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  7. Gunda V, Gigliotti B, Ashry T, Ndishabandi D, McCarthy M, Zhou Z, Amin S, Lee KE, Stork T, Wirth L, Freeman GJ, Alessandrini A, Parangi S. Anti-PD-1/PD-L1 therapy augments lenvatinib's efficacy by favorably altering the immune microenvironment of murine anaplastic thyroid cancer. Int J Cancer. 2019 05 01; 144(9):2266-2278. PMID: 30515783.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  8. Gunda V, Gigliotti B, Ndishabandi D, Ashry T, McCarthy M, Zhou Z, Amin S, Freeman GJ, Alessandrini A, Parangi S. Combinations of BRAF inhibitor and anti-PD-1/PD-L1 antibody improve survival and tumour immunity in an immunocompetent model of orthotopic murine anaplastic thyroid cancer. Br J Cancer. 2018 11; 119(10):1223-1232. PMID: 30327563; PMCID: PMC6251038.
    Citations: 31     Fields:    Translation:AnimalsCells
  9. Purroy C, Fairchild RL, Tanaka T, Baldwin WM, Manrique J, Madsen JC, Colvin RB, Alessandrini A, Blazar BR, Fribourg M, Donadei C, Maggiore U, Heeger PS, Cravedi P. Erythropoietin Receptor-Mediated Molecular Crosstalk Promotes T Cell Immunoregulation and Transplant Survival. J Am Soc Nephrol. 2017 Aug; 28(8):2377-2392. PMID: 28302753; PMCID: PMC5533236.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  10. Alessandrini A, Turka LA. FOXP3-Positive Regulatory T Cells and Kidney Allograft Tolerance. Am J Kidney Dis. 2017 May; 69(5):667-674. PMID: 28049555; PMCID: PMC5403573.
    Citations: 5     Fields:    Translation:HumansCells
  11. Hirohashi T, Chase CM, DellaPelle P, Sebastian D, Farkesh E, Colvin RB, Russell PS, Alessandrini A, Madsen JC. Depletion of T regulatory cells promotes natural killer cell-mediated cardiac allograft vasculopathy. Transplantation. 2014 Oct 27; 98(8):828-34. PMID: 25321164.
    Citations: 3     Fields:    Translation:AnimalsCells
  12. Badizadegan K, Thomas AR, Nagy N, Ndishabandi D, Miller SA, Alessandrini A, Belkind-Gerson J, Goldstein AM. Presence of intramucosal neuroglial cells in normal and aganglionic human colon. Am J Physiol Gastrointest Liver Physiol. 2014 Nov 15; 307(10):G1002-12. PMID: 25214400.
    Citations: 6     Fields:    Translation:HumansCells
  13. Shinoda K, Akiyoshi T, Chase CM, Farkash EA, Ndishabandi DK, Raczek CM, Sebastian DP, Pelle PD, Russell PS, Madsen JC, Colvin RB, Alessandrini A. Depletion of foxp3(+) T cells abrogates tolerance of skin and heart allografts in murine mixed chimeras without the loss of mixed chimerism. Am J Transplant. 2014 Oct; 14(10):2263-2274. PMID: 25155089; PMCID: PMC4523231.
    Citations: 8     Fields:    Translation:AnimalsCells
  14. Alessandrini A, Bromberg J. Literature Watch Implications for transplantation. Am J Transplant. 2014 Jul; 14(7):1471. PMID: 24954465.
  15. Tonsho M, Michel S, Ahmed Z, Alessandrini A, Madsen JC. Heart transplantation: challenges facing the field. Cold Spring Harb Perspect Med. 2014 May 01; 4(5). PMID: 24789875.
    Citations: 33     Fields:    Translation:HumansAnimals
  16. Alessandrini A, Bromberg JS. Literature watch: implications for transplantation. Am J Transplant. 2012 Nov; 12(11):2867. PMID: 23107267.
    Citations:    Fields:    
  17. Akiyoshi T, Hirohashi T, Alessandrini A, Chase CM, Farkash EA, Neal Smith R, Madsen JC, Russell PS, Colvin RB. Role of complement and NK cells in antibody mediated rejection. Hum Immunol. 2012 Dec; 73(12):1226-32. PMID: 22850181.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  18. Yamada Y, Aoyama A, Tocco G, Boskovic S, Nadazdin O, Alessandrini A, Madsen JC, Cosimi AB, Benichou G, Kawai T. Differential effects of denileukin diftitox IL-2 immunotoxin on NK and regulatory T cells in nonhuman primates. J Immunol. 2012 Jun 15; 188(12):6063-70. PMID: 22586034; PMCID: PMC3370077.
    Citations: 13     Fields:    Translation:AnimalsCells
  19. Alessandrini A, Bromberg JS. Literature watch: implications for transplantation. AHR and tryptophan catabolism: putting the effector T-cell response to sleep. Am J Transplant. 2012 Apr; 12(4):801. PMID: 22458381.
    Citations:    Fields:    
  20. Hirohashi T, Chase CM, Della Pelle P, Sebastian D, Alessandrini A, Madsen JC, Russell PS, Colvin RB. A novel pathway of chronic allograft rejection mediated by NK cells and alloantibody. Am J Transplant. 2012 Feb; 12(2):313-21. PMID: 22070565; PMCID: PMC3667648.
    Citations: 89     Fields:    Translation:AnimalsCells
  21. Alessandrini A, De Haseth S, Fray M, Miyajima M, Colvin RB, Williams WW, Benedict Cosimi A, Benichou G. Dendritic cell maturation occurs through the inhibition of GSK-3ß. Cell Immunol. 2011; 270(2):114-25. PMID: 21601837.
    Citations: 7     Fields:    Translation:AnimalsCells
  22. Miyajima M, Chase CM, Alessandrini A, Farkash EA, Della Pelle P, Benichou G, Graham JA, Madsen JC, Russell PS, Colvin RB. Early acceptance of renal allografts in mice is dependent on foxp3(+) cells. Am J Pathol. 2011 Apr; 178(4):1635-45. PMID: 21435448; PMCID: PMC3078464.
    Citations: 51     Fields:    Translation:AnimalsCells
  23. Graham JA, Fray M, de Haseth S, Lee KM, Lian MM, Chase CM, Madsen JC, Markmann J, Benichou G, Colvin RB, Cosimi AB, Deng S, Kim J, Alessandrini A. Suppressive regulatory T cell activity is potentiated by glycogen synthase kinase 3{beta} inhibition. J Biol Chem. 2010 Oct 22; 285(43):32852-32859. PMID: 20729209.
    Citations: 29     Fields:    Translation:AnimalsCells
  24. Benichou G, Alessandrini A, Charrad RS, Wilkes DS. Induction of autoimmunity after allotransplantation. Front Biosci. 2007 May 01; 12:4362-9. PMID: 17485380.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  25. Andreucci M, Michael A, Kramers C, Park KM, Chen A, Matthaeus T, Alessandrini A, Haq S, Force T, Bonventre JV. Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1. Kidney Int. 2003 Oct; 64(4):1189-98. PMID: 12969136.
    Citations: 23     Fields:    Translation:AnimalsCells
  26. Roelen BA, Cohen OS, Raychowdhury MK, Chadee DN, Zhang Y, Kyriakis JM, Alessandrini AA, Lin HY. Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-beta-induced nuclear accumulation. Am J Physiol Cell Physiol. 2003 Oct; 285(4):C823-30. PMID: 12801888.
    Citations: 26     Fields:    Translation:AnimalsCells
  27. Han WK, Sapirstein A, Hung CC, Alessandrini A, Bonventre JV. Cross-talk between cytosolic phospholipase A2 alpha (cPLA2 alpha) and secretory phospholipase A2 (sPLA2) in hydrogen peroxide-induced arachidonic acid release in murine mesangial cells: sPLA2 regulates cPLA2 alpha activity that is responsible for arachidonic acid release. J Biol Chem. 2003 Jun 27; 278(26):24153-63. PMID: 12676927.
    Citations: 40     Fields:    Translation:Animals
  28. Mori T, Wang X, Jung JC, Sumii T, Singhal AB, Fini ME, Dixon CE, Alessandrini A, Lo EH. Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects. J Cereb Blood Flow Metab. 2002 Apr; 22(4):444-52. PMID: 11919515.
    Citations: 56     Fields:    Translation:AnimalsCells
  29. Shevde LA, Samant RS, Goldberg SF, Sikaneta T, Alessandrini A, Donahue HJ, Mauger DT, Welch DR. Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1. Exp Cell Res. 2002 Feb 15; 273(2):229-39. PMID: 11822878.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  30. Kling DE, Narra V, Islam S, Kinane TB, Alessandrini A, Ercolani L, Donahoe PK, Schnitzer JJ. Decreased mitogen activated protein kinase activities in congenital diaphragmatic hernia-associated pulmonary hypoplasia. J Pediatr Surg. 2001 Oct; 36(10):1490-6. PMID: 11584394.
    Citations: 2     Fields:    Translation:AnimalsCells
  31. Namura S, Iihara K, Takami S, Nagata I, Kikuchi H, Matsushita K, Moskowitz MA, Bonventre JV, Alessandrini A. Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11569-74. PMID: 11504919; PMCID: PMC58770.
    Citations: 118     Fields:    Translation:AnimalsCells
  32. Yehia G, Schlotter F, Razavi R, Alessandrini A, Molina CA. Mitogen-activated protein kinase phosphorylates and targets inducible cAMP early repressor to ubiquitin-mediated destruction. J Biol Chem. 2001 Sep 21; 276(38):35272-9. PMID: 11466319.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  33. Haq S, Choukroun G, Kang ZB, Ranu H, Matsui T, Rosenzweig A, Molkentin JD, Alessandrini A, Woodgett J, Hajjar R, Michael A, Force T. Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy. J Cell Biol. 2000 Oct 02; 151(1):117-30. PMID: 11018058; PMCID: PMC2189812.
    Citations: 120     Fields:    Translation:AnimalsCells
  34. Namura S, Nagata I, Kikuchi H, Andreucci M, Alessandrini A. Serine-threonine protein kinase Akt does not mediate ischemic tolerance after global ischemia in the gerbil. J Cereb Blood Flow Metab. 2000 Sep; 20(9):1301-5. PMID: 10994851.
    Citations: 15     Fields:    Translation:AnimalsCells
  35. Welch DR, Sakamaki T, Pioquinto R, Leonard TO, Goldberg SF, Hon Q, Erikson RL, Rieber M, Rieber MS, Hicks DJ, Bonventre JV, Alessandrini A. Transfection of constitutively active mitogen-activated protein/extracellular signal-regulated kinase kinase confers tumorigenic and metastatic potentials to NIH3T3 cells. Cancer Res. 2000 Mar 15; 60(6):1552-6. PMID: 10749122.
    Citations: 20     Fields:    Translation:AnimalsCells
  36. Alessandrini A, Namura S, Moskowitz MA, Bonventre JV. MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12866-9. PMID: 10536014; PMCID: PMC23136.
    Citations: 140     Fields:    Translation:AnimalsCells
  37. Wilson DJ, Alessandrini A, Budd RC. MEK1 activation rescues Jurkat T cells from Fas-induced apoptosis. Cell Immunol. 1999 May 25; 194(1):67-77. PMID: 10357882.
    Citations: 6     Fields:    Translation:HumansCells
  38. Murray B, Alessandrini A, Cole AJ, Yee AG, Furshpan EJ. Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11975-80. PMID: 9751775; PMCID: PMC21750.
    Citations: 51     Fields:    Translation:AnimalsCells
  39. Alessandrini A, Brott BK, Erikson RL. Differential expression of MEK1 and MEK2 during mouse development. Cell Growth Differ. 1997 May; 8(5):505-11. PMID: 9149902.
    Citations: 7     Fields:    Translation:Animals
  40. Alessandrini A, Chiaur DS, Pagano M. Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation. Leukemia. 1997 Mar; 11(3):342-5. PMID: 9067571.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  41. Alessandrini A, Greulich H, Huang W, Erikson RL. Mek1 phosphorylation site mutants activate Raf-1 in NIH 3T3 cells. J Biol Chem. 1996 Dec 06; 271(49):31612-8. PMID: 8940180.
    Citations: 22     Fields:    Translation:AnimalsCells
  42. Huang W, Alessandrini A, Crews CM, Erikson RL. Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation. Proc Natl Acad Sci U S A. 1993 Dec 01; 90(23):10947-51. PMID: 8248196; PMCID: PMC47898.
    Citations: 30     Fields:    Translation:AnimalsCells
  43. Brott BK, Alessandrini A, Largaespada DA, Copeland NG, Jenkins NA, Crews CM, Erikson RL. MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues. Cell Growth Differ. 1993 Nov; 4(11):921-9. PMID: 8297798.
    Citations: 19     Fields:    Translation:AnimalsCells
  44. Crews CM, Alessandrini A, Erikson RL. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science. 1992 Oct 16; 258(5081):478-80. PMID: 1411546.
    Citations: 226     Fields:    Translation:AnimalsCells
  45. Alessandrini A, Crews CM, Erikson RL. Phorbol ester stimulates a protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product. Proc Natl Acad Sci U S A. 1992 Sep 01; 89(17):8200-4. PMID: 1518847; PMCID: PMC49885.
    Citations: 31     Fields:    Translation:AnimalsCells
  46. Crews CM, Alessandrini A, Erikson RL. Erks: their fifteen minutes has arrived. Cell Growth Differ. 1992 Feb; 3(2):135-42. PMID: 1504018.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  47. Crews CM, Alessandrini AA, Erikson RL. Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential to phosphorylate tyrosine. Proc Natl Acad Sci U S A. 1991 Oct 01; 88(19):8845-9. PMID: 1717989; PMCID: PMC52607.
    Citations: 38     Fields:    Translation:AnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Alessandrini's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (279)
Co-Authors (29)
Similar People (60)
Same Department 
Physical Neighbors
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.