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Alessandro Alessandrini, Ph.D.

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Mentoring
Available: 11/15/19, Expires: 07/30/21

The main interest of the laboratory is to study the roles of regulatory T cells (Tregs), immature conventional and plasmacytoid dendritic cells in allograft tolerance. We take cellular and molecular approaches in analyzing the function of these cells in an in vitro and in vivo setting. We have found that without immunosuppression, life-sustaining, full MHC-mismatched mouse kidney allografts were spontaneously accepted in certain strain combinations (e.g., DBA/2 to B6) and in turn, induced tolerance of islet or heart allografts from the same strain combination.

We expect a student interested in working on the project to contribute by helping to define the cellular and molecular mechanisms that contribute to spontaneous and systemic tolerance. The student will get training in immunological techniques as well as getting an education on principles in immunology.

Plasmacytoid Dendritic Cell Induction of Allogenic Regulatory T cells
Summer, 06/11/12 - 08/16/12

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Yang C, Ge J, Rosales I, Yuan Q, Szuter E, Acheampong E, Russell PS, Madsen JC, Colvin RB, Alessandrini A. Kidney-induced systemic tolerance of heart allografts in mice. JCI Insight. 2020 Sep 17; 5(18). PMID: 32938831.
    Citations:    Fields:    
  2. Oh NA, O'Shea T, Ndishabandi DK, Yuan Q, Hong S, Gans J, Ge J, Gibney S, Chase C, Yang C, Rosales I, Shinoda K, Drew B, Kojima L, Russell PS, Madsen JC, Colvin RB, Alessandrini A. Plasmacytoid Dendritic Cell-driven Induction of Treg Is Strain Specific and Correlates With Spontaneous Acceptance of Kidney Allografts. Transplantation. 2020 01; 104(1):39-53. PMID: 31335760.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  3. Gunda V, Gigliotti B, Ashry T, Ndishabandi D, McCarthy M, Zhou Z, Amin S, Lee KE, Stork T, Wirth L, Freeman GJ, Alessandrini A, Parangi S. Anti-PD-1/PD-L1 therapy augments lenvatinib's efficacy by favorably altering the immune microenvironment of murine anaplastic thyroid cancer. Int J Cancer. 2019 05 01; 144(9):2266-2278. PMID: 30515783.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  4. Gunda V, Gigliotti B, Ndishabandi D, Ashry T, McCarthy M, Zhou Z, Amin S, Freeman GJ, Alessandrini A, Parangi S. Combinations of BRAF inhibitor and anti-PD-1/PD-L1 antibody improve survival and tumour immunity in an immunocompetent model of orthotopic murine anaplastic thyroid cancer. Br J Cancer. 2018 11; 119(10):1223-1232. PMID: 30327563.
    Citations: 7     Fields:    Translation:AnimalsCells
  5. Purroy C, Fairchild RL, Tanaka T, Baldwin WM, Manrique J, Madsen JC, Colvin RB, Alessandrini A, Blazar BR, Fribourg M, Donadei C, Maggiore U, Heeger PS, Cravedi P. Erythropoietin Receptor-Mediated Molecular Crosstalk Promotes T Cell Immunoregulation and Transplant Survival. J Am Soc Nephrol. 2017 Aug; 28(8):2377-2392. PMID: 28302753.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  6. Alessandrini A, Turka LA. FOXP3-Positive Regulatory T Cells and Kidney Allograft Tolerance. Am J Kidney Dis. 2017 May; 69(5):667-674. PMID: 28049555.
    Citations: 4     Fields:    Translation:HumansCells
  7. Hirohashi T, Chase CM, DellaPelle P, Sebastian D, Farkesh E, Colvin RB, Russell PS, Alessandrini A, Madsen JC. Depletion of T regulatory cells promotes natural killer cell-mediated cardiac allograft vasculopathy. Transplantation. 2014 Oct 27; 98(8):828-34. PMID: 25321164.
    Citations: 2     Fields:    Translation:AnimalsCells
  8. Badizadegan K, Thomas AR, Nagy N, Ndishabandi D, Miller SA, Alessandrini A, Belkind-Gerson J, Goldstein AM. Presence of intramucosal neuroglial cells in normal and aganglionic human colon. Am J Physiol Gastrointest Liver Physiol. 2014 Nov 15; 307(10):G1002-12. PMID: 25214400.
    Citations: 4     Fields:    Translation:HumansCells
  9. Shinoda K, Akiyoshi T, Chase CM, Farkash EA, Ndishabandi DK, Raczek CM, Sebastian DP, Pelle PD, Russell PS, Madsen JC, Colvin RB, Alessandrini A. Depletion of foxp3(+) T cells abrogates tolerance of skin and heart allografts in murine mixed chimeras without the loss of mixed chimerism. Am J Transplant. 2014 Oct; 14(10):2263-2274. PMID: 25155089.
    Citations: 5     Fields:    Translation:AnimalsCells
  10. Alessandrini A, Bromberg J. Literature Watch Implications for transplantation. Am J Transplant. 2014 Jul; 14(7):1471. PMID: 24954465.
    Citations:    
  11. Tonsho M, Michel S, Ahmed Z, Alessandrini A, Madsen JC. Heart transplantation: challenges facing the field. Cold Spring Harb Perspect Med. 2014 May 01; 4(5). PMID: 24789875.
    Citations: 17     Fields:    Translation:HumansAnimals
  12. Alessandrini A, Bromberg JS. Literature watch: implications for transplantation. Am J Transplant. 2012 Nov; 12(11):2867. PMID: 23107267.
    Citations:    Fields:    
  13. Akiyoshi T, Hirohashi T, Alessandrini A, Chase CM, Farkash EA, Neal Smith R, Madsen JC, Russell PS, Colvin RB. Role of complement and NK cells in antibody mediated rejection. Hum Immunol. 2012 Dec; 73(12):1226-32. PMID: 22850181.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  14. Yamada Y, Aoyama A, Tocco G, Boskovic S, Nadazdin O, Alessandrini A, Madsen JC, Cosimi AB, Benichou G, Kawai T. Differential effects of denileukin diftitox IL-2 immunotoxin on NK and regulatory T cells in nonhuman primates. J Immunol. 2012 Jun 15; 188(12):6063-70. PMID: 22586034.
    Citations: 10     Fields:    Translation:AnimalsCells
  15. Alessandrini A, Bromberg JS. Literature watch: implications for transplantation. AHR and tryptophan catabolism: putting the effector T-cell response to sleep. Am J Transplant. 2012 Apr; 12(4):801. PMID: 22458381.
    Citations:    Fields:    
  16. Hirohashi T, Chase CM, Della Pelle P, Sebastian D, Alessandrini A, Madsen JC, Russell PS, Colvin RB. A novel pathway of chronic allograft rejection mediated by NK cells and alloantibody. Am J Transplant. 2012 Feb; 12(2):313-21. PMID: 22070565.
    Citations: 69     Fields:    Translation:AnimalsCells
  17. Alessandrini A, De Haseth S, Fray M, Miyajima M, Colvin RB, Williams WW, Benedict Cosimi A, Benichou G. Dendritic cell maturation occurs through the inhibition of GSK-3ß. Cell Immunol. 2011; 270(2):114-25. PMID: 21601837.
    Citations: 5     Fields:    Translation:AnimalsCells
  18. Miyajima M, Chase CM, Alessandrini A, Farkash EA, Della Pelle P, Benichou G, Graham JA, Madsen JC, Russell PS, Colvin RB. Early acceptance of renal allografts in mice is dependent on foxp3(+) cells. Am J Pathol. 2011 Apr; 178(4):1635-45. PMID: 21435448.
    Citations: 40     Fields:    Translation:AnimalsCells
  19. Graham JA, Fray M, de Haseth S, Lee KM, Lian MM, Chase CM, Madsen JC, Markmann J, Benichou G, Colvin RB, Cosimi AB, Deng S, Kim J, Alessandrini A. Suppressive regulatory T cell activity is potentiated by glycogen synthase kinase 3{beta} inhibition. J Biol Chem. 2010 Oct 22; 285(43):32852-9. PMID: 20729209.
    Citations: 24     Fields:    Translation:AnimalsCells
  20. Benichou G, Alessandrini A, Charrad RS, Wilkes DS. Induction of autoimmunity after allotransplantation. Front Biosci. 2007 May 01; 12:4362-9. PMID: 17485380.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  21. Andreucci M, Michael A, Kramers C, Park KM, Chen A, Matthaeus T, Alessandrini A, Haq S, Force T, Bonventre JV. Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1. Kidney Int. 2003 Oct; 64(4):1189-98. PMID: 12969136.
    Citations: 20     Fields:    Translation:AnimalsCells
  22. Roelen BA, Cohen OS, Raychowdhury MK, Chadee DN, Zhang Y, Kyriakis JM, Alessandrini AA, Lin HY. Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-beta-induced nuclear accumulation. . 2003 Oct; 285(4):C823-30. PMID: 12801888.
    Citations: 24     Translation:AnimalsCells
  23. Han WK, Sapirstein A, Hung CC, Alessandrini A, Bonventre JV. Cross-talk between cytosolic phospholipase A2 alpha (cPLA2 alpha) and secretory phospholipase A2 (sPLA2) in hydrogen peroxide-induced arachidonic acid release in murine mesangial cells: sPLA2 regulates cPLA2 alpha activity that is responsible for arachidonic acid release. J Biol Chem. 2003 Jun 27; 278(26):24153-63. PMID: 12676927.
    Citations: 35     Fields:    Translation:Animals
  24. Mori T, Wang X, Jung JC, Sumii T, Singhal AB, Fini ME, Dixon CE, Alessandrini A, Lo EH. Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects. J Cereb Blood Flow Metab. 2002 Apr; 22(4):444-52. PMID: 11919515.
    Citations: 47     Fields:    Translation:AnimalsCells
  25. Shevde LA, Samant RS, Goldberg SF, Sikaneta T, Alessandrini A, Donahue HJ, Mauger DT, Welch DR. Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1. Exp Cell Res. 2002 Feb 15; 273(2):229-39. PMID: 11822878.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  26. Kling DE, Narra V, Islam S, Kinane TB, Alessandrini A, Ercolani L, Donahoe PK, Schnitzer JJ. Decreased mitogen activated protein kinase activities in congenital diaphragmatic hernia-associated pulmonary hypoplasia. J Pediatr Surg. 2001 Oct; 36(10):1490-6. PMID: 11584394.
    Citations: 1     Fields:    Translation:AnimalsCells
  27. Namura S, Iihara K, Takami S, Nagata I, Kikuchi H, Matsushita K, Moskowitz MA, Bonventre JV, Alessandrini A. Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11569-74. PMID: 11504919.
    Citations: 99     Fields:    Translation:AnimalsCells
  28. Yehia G, Schlotter F, Razavi R, Alessandrini A, Molina CA. Mitogen-activated protein kinase phosphorylates and targets inducible cAMP early repressor to ubiquitin-mediated destruction. J Biol Chem. 2001 Sep 21; 276(38):35272-9. PMID: 11466319.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  29. Haq S, Choukroun G, Kang ZB, Ranu H, Matsui T, Rosenzweig A, Molkentin JD, Alessandrini A, Woodgett J, Hajjar R, Michael A, Force T. Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy. J Cell Biol. 2000 Oct 02; 151(1):117-30. PMID: 11018058.
    Citations: 108     Fields:    Translation:AnimalsCells
  30. Namura S, Nagata I, Kikuchi H, Andreucci M, Alessandrini A. Serine-threonine protein kinase Akt does not mediate ischemic tolerance after global ischemia in the gerbil. J Cereb Blood Flow Metab. 2000 Sep; 20(9):1301-5. PMID: 10994851.
    Citations: 15     Fields:    Translation:AnimalsCells
  31. Welch DR, Sakamaki T, Pioquinto R, Leonard TO, Goldberg SF, Hon Q, Erikson RL, Rieber M, Rieber MS, Hicks DJ, Bonventre JV, Alessandrini A. Transfection of constitutively active mitogen-activated protein/extracellular signal-regulated kinase kinase confers tumorigenic and metastatic potentials to NIH3T3 cells. Cancer Res. 2000 Mar 15; 60(6):1552-6. PMID: 10749122.
    Citations: 17     Fields:    Translation:AnimalsCells
  32. Alessandrini A, Namura S, Moskowitz MA, Bonventre JV. MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12866-9. PMID: 10536014.
    Citations: 114     Fields:    Translation:AnimalsCells
  33. Wilson DJ, Alessandrini A, Budd RC. MEK1 activation rescues Jurkat T cells from Fas-induced apoptosis. Cell Immunol. 1999 May 25; 194(1):67-77. PMID: 10357882.
    Citations: 6     Fields:    Translation:HumansCells
  34. Murray B, Alessandrini A, Cole AJ, Yee AG, Furshpan EJ. Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11975-80. PMID: 9751775.
    Citations: 35     Fields:    Translation:AnimalsCells
  35. Alessandrini A, Brott BK, Erikson RL. Differential expression of MEK1 and MEK2 during mouse development. Cell Growth Differ. 1997 May; 8(5):505-11. PMID: 9149902.
    Citations: 6     Fields:    Translation:Animals
  36. Alessandrini A, Chiaur DS, Pagano M. Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation. Leukemia. 1997 Mar; 11(3):342-5. PMID: 9067571.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  37. Alessandrini A, Greulich H, Huang W, Erikson RL. Mek1 phosphorylation site mutants activate Raf-1 in NIH 3T3 cells. J Biol Chem. 1996 Dec 06; 271(49):31612-8. PMID: 8940180.
    Citations: 21     Fields:    Translation:AnimalsCells
  38. Huang W, Alessandrini A, Crews CM, Erikson RL. Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation. Proc Natl Acad Sci U S A. 1993 Dec 01; 90(23):10947-51. PMID: 8248196.
    Citations: 28     Fields:    Translation:AnimalsCells
  39. Brott BK, Alessandrini A, Largaespada DA, Copeland NG, Jenkins NA, Crews CM, Erikson RL. MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues. Cell Growth Differ. 1993 Nov; 4(11):921-9. PMID: 8297798.
    Citations: 17     Fields:    Translation:AnimalsCells
  40. Crews CM, Alessandrini A, Erikson RL. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science. 1992 Oct 16; 258(5081):478-80. PMID: 1411546.
    Citations: 209     Fields:    Translation:AnimalsCells
  41. Alessandrini A, Crews CM, Erikson RL. Phorbol ester stimulates a protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product. Proc Natl Acad Sci U S A. 1992 Sep 01; 89(17):8200-4. PMID: 1518847.
    Citations: 31     Fields:    Translation:AnimalsCells
  42. Crews CM, Alessandrini A, Erikson RL. Erks: their fifteen minutes has arrived. Cell Growth Differ. 1992 Feb; 3(2):135-42. PMID: 1504018.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  43. Crews CM, Alessandrini AA, Erikson RL. Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential to phosphorylate tyrosine. Proc Natl Acad Sci U S A. 1991 Oct 01; 88(19):8845-9. PMID: 1717989.
    Citations: 36     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.