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Gregory D Lewis, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL151841 (LEWIS, GREGORY DYER) Apr 1, 2020 - Mar 31, 2024
    NIH/NHLBI
    Characterization of Molecular and Physiologic Signatures of Impaired Multi-Organ System Reserve Capacity During Exercise in Heart Failure with Preserved Ejection Fraction
    Role: Principal Investigator
  2. R01HL131029 (LEWIS, GREGORY DYER) Jan 1, 2016 - Dec 31, 2019
    NIH/NHLBI
    Comprehensive Metabolic Profiling of Exercise to Predict Cardiometabolic Risk
    Role: Principal Investigator
  3. R01HL119154 (LEWIS, GREGORY DYER) Sep 18, 2013 - Jun 30, 2017
    NIH/NHLBI
    PITCH HF Right Ventricular Pulmonary Vascular Reserve Ancillary Study
    Role: Principal Investigator
  4. U10HL110337 (LEWIS, GREGORY DYER) Jan 1, 2012 - Dec 31, 2018
    NIH/NHLBI
    Harvard Regional Clinical Center of the NHLBI Heart Failure Network
    Role: Principal Investigator
  5. K23HL091106 (LEWIS, GREGORY DYER) Sep 22, 2008 - Jul 31, 2013
    NIH/NHLBI
    Metabolic Profiling of Acute Myocardial Injury in Humans
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Nayor M, Shah RV, Miller PE, Blodgett JB, Tanguay M, Pico AR, Murthy VL, Malhotra R, Houstis NE, Deik A, Pierce KA, Bullock K, Dailey L, Velagaleti RS, Moore SA, Ho JE, Baggish AL, Clish CB, Larson MG, Vasan RS, Lewis GD. Metabolic Architecture of Acute Exercise Response in Middle-Aged Adults in the Community. Circulation. 2020 Sep 15. PMID: 32927962.
    Citations:    
  2. Reddy YNV, Obokata M, Jones AD, Lewis GD, Shah SJ, Abouezzedine OF, Fudim M, Alhanti B, Stevenson LW, Redfield MM, Borlaug BA. Characterization of the Progression From Ambulatory to Hospitalized Heart Failure With Preserved Ejection Fraction. J Card Fail. 2020 Aug 19. PMID: 32827644.
    Citations:    
  3. Michelhaugh SA, Camacho A, Ibrahim NE, Gaggin H, D'Alessandro D, Coglianese E, Lewis GD, Januzzi JL. Proteomic Signatures During Treatment in Different Stages of Heart Failure. Circ Heart Fail. 2020 Aug; 13(8):e006794. PMID: 32809875.
    Citations:    
  4. Moonsamy P, Axtell AL, Ibrahim NE, Funamoto M, Tolis G, Lewis GD, D'Alessandro DA, Villavicencio MA. Survival After Heart Transplantation in Patients Bridged With Mechanical Circulatory Support. J Am Coll Cardiol. 2020 Jun 16; 75(23):2892-2905. PMID: 32527398.
    Citations:    
  5. Nayor M, Houstis NE, Namasivayam M, Rouvina J, Hardin C, Shah RV, Ho JE, Malhotra R, Lewis GD. Impaired Exercise Tolerance in Heart Failure With Preserved Ejection Fraction: Quantification of Multiorgan System Reserve Capacity. JACC Heart Fail. 2020 Aug; 8(8):605-617. PMID: 32535122.
    Citations:    
  6. Mann DL, Greene SJ, Givertz MM, Vader JM, Starling RC, Ambrosy AP, Shah P, McNulty SE, Mahr C, Gupta D, Redfield MM, Lala A, Lewis GD, Mohammed SF, Gilotra NA, DeVore AD, Gorodeski EZ, Desvigne-Nickens P, Hernandez AF, Braunwald E. Sacubitril/Valsartan in Advanced Heart Failure With Reduced Ejection Fraction: Rationale and Design of the LIFE Trial. JACC Heart Fail. 2020 Jun 10. PMID: 32641226.
    Citations:    
  7. Ho JE, Lewis GD. Reply: Does PAP/CO Ratio Have a Linear Relationship? J Am Coll Cardiol. 2020 May 26; 75(20):2647. PMID: 32439017.
    Citations:    
  8. Nayor M, Xanthakis V, Tanguay M, Blodgett JB, Shah RV, Schoenike M, Sbarbaro J, Farrell R, Malhotra R, Houstis NE, Velagaleti RS, Moore SA, Baggish AL, O'Connor GT, Ho JE, Larson MG, Vasan RS, Lewis GD. Clinical and Hemodynamic Associations and Prognostic Implications of Ventilatory Efficiency in Patients With Preserved Left Ventricular Systolic Function. Circ Heart Fail. 2020 May; 13(5):e006729. PMID: 32362167.
    Citations:    
  9. Churchill TW, Groezinger E, Kim JH, Loomer G, Guseh JS, Wasfy MM, Isselbacher EM, Lewis GD, Weiner RB, Schmied C, Baggish AL. Association of Ascending Aortic Dilatation and Long-term Endurance Exercise Among Older Masters-Level Athletes. JAMA Cardiol. 2020 May 01; 5(5):522-531. PMID: 32101252.
    Citations:    
  10. Rothman AMK, Vachiery JL, Howard LS, Mikhail GW, Lang IM, Jonas M, Kiely DG, Shav D, Shabtay O, Avriel A, Lewis GD, Rosenzweig EB, Kirtane AJ, Kim NH, Mahmud E, McLaughlain VV, Chetcuti S, Leon MB, Ben-Yehuda O, Rubin LJ. Intravascular Ultrasound Pulmonary Artery Denervation to Treat Pulmonary Arterial Hypertension (TROPHY1): Multicenter, Early Feasibility Study. JACC Cardiovasc Interv. 2020 Apr 27; 13(8):989-999. PMID: 32327095.
    Citations:    
  11. Pierson RN, Burdorf L, Madsen JC, Lewis GD, D'Alessandro DA. Pig-to-human heart transplantation: Who goes first? Am J Transplant. 2020 Apr 17. PMID: 32301262.
    Citations:    
  12. Lim K, Ting SMS, Hamborg T, McGregor G, Oxborough D, Tomkins C, Xu D, Thadhani R, Lewis G, Bland R, Banerjee P, Fletcher S, Krishnan NS, Higgins R, Zehnder D, Hiemstra TF. Cardiovascular Functional Reserve Before and After Kidney Transplant. JAMA Cardiol. 2020 Apr 01; 5(4):420-429. PMID: 32022839.
    Citations:    
  13. Ton VK, Lewis GD. Does Chronotropic Incompetence in HFpEF Cause or Result From Exercise Intolerance? Circ Heart Fail. 2020 03; 13(3):e006872. PMID: 32164432.
    Citations:    
  14. Reddy YNV, Rikhi A, Obokata M, Shah SJ, Lewis GD, AbouEzzedine OF, Dunlay S, McNulty S, Chakraborty H, Stevenson LW, Redfield MM, Borlaug BA. Quality of life in heart failure with preserved ejection fraction: importance of obesity, functional capacity, and physical inactivity. Eur J Heart Fail. 2020 Jun; 22(6):1009-1018. PMID: 32150314.
    Citations:    
  15. Murthy VL, Xia R, Baldridge AS, Carnethon MR, Sidney S, Bouchard C, Sarzynski MA, Lima JAC, Lewis GD, Shah SJ, Fornage M, Shah RV. Polygenic Risk, Fitness, and Obesity in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. JAMA Cardiol. 2020 Mar 01; 5(3):40-48. PMID: 31913407.
    Citations:    
  16. Udelson JE, Lewis GD, Shah SJ, Zile MR, Redfield MM, Burnett J, Mittleman RS, Profy AT, Seferovic JP, Reasner D, Konstam MA. Rationale and design for a multicenter, randomized, double-blind, placebo-controlled, phase 2 study evaluating the safety and efficacy of the soluble guanylate cyclase stimulator praliciguat over 12 weeks in patients with heart failure with preserved ejection fraction (CAPACITY HFpEF). Am Heart J. 2020 04; 222:183-190. PMID: 32105984.
    Citations:    
  17. Honigberg MC, Lau ES, Jones AD, Coles A, Redfield MM, Lewis GD, Givertz MM. Sex Differences in Exercise Capacity and Quality of Life in Heart Failure With Preserved Ejection Fraction: A Secondary Analysis of the RELAX and NEAT-HFpEF Trials. J Card Fail. 2020 Mar; 26(3):276-280. PMID: 31945458.
    Citations:    
  18. Ho JE, Zern EK, Lau ES, Wooster L, Bailey CS, Cunningham T, Eisman AS, Hardin KM, Farrell R, Sbarbaro JA, Schoenike MW, Houstis NE, Baggish AL, Shah RV, Nayor M, Malhotra R, Lewis GD. Exercise Pulmonary Hypertension Predicts Clinical Outcomes in Patients With Dyspnea on Effort. J Am Coll Cardiol. 2020 01 07; 75(1):17-26. PMID: 31918830.
    Citations:    
  19. Lau ES, Cunningham T, Hardin KM, Liu E, Malhotra R, Nayor M, Lewis GD, Ho JE. Sex Differences in Cardiometabolic Traits and Determinants of Exercise Capacity in Heart Failure With Preserved Ejection Fraction. JAMA Cardiol. 2020 Jan 01; 5(1):30-37. PMID: 31664435.
    Citations:    
  20. Axelsson Raja A, Shi L, Day SM, Russell M, Zahka K, Lever H, Colan SD, Margossian R, Hall EK, Becker J, Jefferies JL, Patel AR, Choudhury L, Murphy AM, Canter C, Bach R, Taylor M, Mestroni L, Wheeler MT, Benson L, Owens AT, Rossano J, Lin KY, Pahl E, Pereira AC, Bundgaard H, Lewis GD, Vargas JD, Cirino AL, McMurray JJV, MacRae CA, Solomon SD, Orav EJ, Braunwald E, Ho CY. Baseline Characteristics of the VANISH Cohort. Circ Heart Fail. 2019 12; 12(12):e006231. PMID: 31813281.
    Citations:    
  21. Fudim M, Kelly JP, Jones AD, AbouEzzeddine OF, Ambrosy AP, Greene SJ, Reddy YNV, Anstrom KJ, Alhanti B, Lewis GD, Hernandez AF, Felker GM. Are existing and emerging biomarkers associated with cardiorespiratory fitness in patients with chronic heart failure? Am Heart J. 2020 02; 220:97-107. PMID: 31805424.
    Citations:    
  22. Reddy YNV, Obokata M, Testani JM, Felker GM, Tang WHW, Abou-Ezzeddine OF, Sun JL, Chakrabothy H, McNulty S, Shah SJ, Lewis GD, Stevenson LW, Redfield MM, Borlaug BA. Adverse Renal Response to Decongestion in the Obese Phenotype of Heart Failure With Preserved Ejection Fraction. J Card Fail. 2020 02; 26(2):101-107. PMID: 31618698.
    Citations:    
  23. Bethea ED, Gaj K, Gustafson JL, Axtell A, Lebeis T, Schoenike M, Turvey K, Coglianese E, Thomas S, Newton-Cheh C, Ibrahim N, Carlson W, Ho JE, Shah R, Nayor M, Gift T, Shao S, Dugal A, Markmann J, Elias N, Yeh H, Andersson K, Pratt D, Bhan I, Safa K, Fishman J, Kotton C, Myoung P, Villavicencio MA, D'Alessandro D, Chung RT, Lewis GD. Pre-emptive pangenotypic direct acting antiviral therapy in donor HCV-positive to recipient HCV-negative heart transplantation: an open-label study. Lancet Gastroenterol Hepatol. 2019 10; 4(10):771-780. PMID: 31353243.
    Citations:    
  24. Qualls DA, Lewis GD, Sanchorawala V, Staron A. Orthotopic heart transplant rejection in association with immunomodulatory therapy for AL amyloidosis: A case series and review of the literature. Am J Transplant. 2019 11; 19(11):3185-3190. PMID: 31207062.
    Citations:    
  25. Reddy YNV, Lewis GD, Shah SJ, Obokata M, Abou-Ezzedine OF, Fudim M, Sun JL, Chakraborty H, McNulty S, LeWinter MM, Mann DL, Stevenson LW, Redfield MM, Borlaug BA. Characterization of the Obese Phenotype of Heart Failure With Preserved Ejection Fraction: A RELAX Trial Ancillary Study. Mayo Clin Proc. 2019 07; 94(7):1199-1209. PMID: 31272568.
    Citations:    
  26. Ison MG, Lebeis TA, Barros N, Lewis GD, Massoth LR. Case 20-2019: A 52-Year-Old Woman with Fever and Rash after Heart Transplantation. N Engl J Med. 2019 Jun 27; 380(26):2564-2573. PMID: 31242366.
    Citations:    
  27. Axtell AL, Fiedler AG, Lewis G, Melnitchouk S, Tolis G, D'Alessandro DA, Villavicencio MA. Reoperative sternotomy is associated with increased early mortality after cardiac transplantation. Eur J Cardiothorac Surg. 2019 Jun 01; 55(6):1136-1143. PMID: 30649307.
    Citations:    Fields:    
  28. Ho JE, Zern EK, Wooster L, Bailey CS, Cunningham T, Eisman AS, Hardin KM, Zampierollo GA, Jarolim P, Pappagianopoulos PP, Malhotra R, Nayor M, Lewis GD. Differential Clinical Profiles, Exercise Responses, and Outcomes Associated With Existing HFpEF Definitions. Circulation. 2019 07 30; 140(5):353-365. PMID: 31132875.
    Citations:    
  29. Lewis GD, Houstis NE. The Upsurge in Exercise Hemodynamic Measurements in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2019 04; 7(4):333-335. PMID: 30922509.
    Citations:    
  30. Ambrosy AP, Lewis GD, Malhotra R, Jones AD, Greene SJ, Fudim M, Coles A, Butler J, Sharma A, Hernandez AF, Mentz RJ. Identifying responders to oral iron supplementation in heart failure with a reduced ejection fraction: a post-hoc analysis of the IRONOUT-HF trial. J Cardiovasc Med (Hagerstown). 2019 Apr; 20(4):223-225. PMID: 30540649.
    Citations:    
  31. Shah RV, Das S, Lewis GD. Circulating MicroRNAs: New Avenues for Heart Failure Classification? J Am Coll Cardiol. 2019 03 26; 73(11):1314-1316. PMID: 30898207.
    Citations:    
  32. Churchill TW, Disanto M, Singh TK, Groezinger E, Loomer G, Contursi M, DiCarli M, Michaud-Finch J, Stewart KM, Hutter AM, Lewis GD, Weiner RB, Baggish AL, Wasfy MM. Diagnostic Yield of Customized Exercise Provocation Following Routine Testing. Am J Cardiol. 2019 06 15; 123(12):2044-2050. PMID: 30982540.
    Citations:    
  33. Yeri A, Murphy RA, Marron MM, Clish C, Harris TB, Lewis GD, Newman AB, Murthy VL, Shah RV. Metabolite Profiles of Healthy Aging Index Are Associated With Cardiovascular Disease in African Americans: The Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2019 01 01; 74(1):68-72. PMID: 29253112.
    Citations:    Fields:    
  34. Borlaug BA, Anstrom KJ, Lewis GD, Shah SJ, Levine JA, Koepp GA, Givertz MM, Felker GM, LeWinter MM, Mann DL, Margulies KB, Smith AL, Tang WHW, Whellan DJ, Chen HH, Davila-Roman VG, McNulty S, Desvigne-Nickens P, Hernandez AF, Braunwald E, Redfield MM. Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial. JAMA. 2018 11 06; 320(17):1764-1773. PMID: 30398602.
    Citations:    
  35. Axtell AL, Fiedler AG, Chang DC, Yeh H, Lewis GD, Villavicencio MA, D'Alessandro DA. The effect of donor age on posttransplant mortality in a cohort of adult cardiac transplant recipients aged 18-45. Am J Transplant. 2019 03; 19(3):876-883. PMID: 30106231.
    Citations:    Fields:    
  36. Shah RV, Rong J, Larson MG, Yeri A, Ziegler O, Tanriverdi K, Murthy V, Liu X, Xiao C, Pico AR, Huan T, Levy D, Lewis GD, Rosenzweig A, Vasan RS, Das S, Freedman JE. Associations of Circulating Extracellular RNAs With Myocardial Remodeling and Heart Failure. JAMA Cardiol. 2018 09 01; 3(9):871-876. PMID: 30090932.
    Citations:    Fields:    
  37. Parikh KS, Sharma K, Fiuzat M, Surks HK, George JT, Honarpour N, Depre C, Desvigne-Nickens P, Nkulikiyinka R, Lewis GD, Gomberg-Maitland M, O'Connor CM, Stockbridge N, Califf RM, Konstam MA, Januzzi JL, Solomon SD, Borlaug BA, Shah SJ, Redfield MM, Felker GM. Heart Failure With Preserved Ejection Fraction Expert Panel Report: Current Controversies and Implications for Clinical Trials. JACC Heart Fail. 2018 08; 6(8):619-632. PMID: 30071950.
    Citations:    Fields:    
  38. DeFaria Yeh D, Stefanescu Schmidt AC, Eisman AS, Serfas JD, Naqvi M, Youniss MA, Ryfa AD, Khan AA, Safi L, Tabtabai SR, Bhatt AB, Lewis GD. Impaired right ventricular reserve predicts adverse cardiac outcomes in adults with congenital right heart disease. Heart. 2018 12; 104(24):2044-2050. PMID: 30030334.
    Citations:    Fields:    
  39. Eisman AS, Shah RV, Dhakal BP, Pappagianopoulos PP, Wooster L, Bailey C, Cunningham TF, Hardin KM, Baggish AL, Ho JE, Malhotra R, Lewis GD. Pulmonary Capillary Wedge Pressure Patterns During Exercise Predict Exercise Capacity and Incident Heart Failure. Circ Heart Fail. 2018 05; 11(5):e004750. PMID: 29695381.
    Citations:    Fields:    
  40. Bailey CS, Wooster LT, Buswell M, Patel S, Pappagianopoulos PP, Bakken K, White C, Tanguay M, Blodgett JB, Baggish AL, Malhotra R, Lewis GD. Post-Exercise Oxygen Uptake Recovery Delay: A Novel Index of Impaired Cardiac Reserve Capacity in Heart Failure. JACC Heart Fail. 2018 04; 6(4):329-339. PMID: 29525330.
    Citations: 1     Fields:    
  41. Pandey A, Khera R, Park B, Haykowsky M, Borlaug BA, Lewis GD, Kitzman DW, Butler J, Berry JD. Relative Impairments in Hemodynamic Exercise Reserve Parameters in Heart Failure With Preserved Ejection Fraction: A Study-Level Pooled Analysis. JACC Heart Fail. 2018 02; 6(2):117-126. PMID: 29413366.
    Citations:    Fields:    
  42. Wasfy MM, Bibbo CF, Brown M, DeLuca JR, Wang F, Berkstresser B, Weiner RB, Lewis GD, Hutter AM, Picard MH, Di Carli MF, Baggish AL. Myocardial Metabolism in Endurance Exercise-Induced Left Ventricular Hypertrophy. JACC Cardiovasc Imaging. 2018 06; 11(6):928-930. PMID: 29248660.
    Citations:    Fields:    
  43. Pedlar CR, Brown MG, Shave RE, Otto JM, Drane A, Michaud-Finch J, Contursi M, Wasfy MM, Hutter A, Picard MH, Lewis GD, Baggish AL. Cardiovascular response to prescribed detraining among recreational athletes. J Appl Physiol (1985). 2018 04 01; 124(4):813-820. PMID: 29212672.
    Citations:    Fields:    
  44. Kovacs G, Herve P, Barbera JA, Chaouat A, Chemla D, Condliffe R, Garcia G, Grünig E, Howard L, Humbert M, Lau E, Laveneziana P, Lewis GD, Naeije R, Peacock A, Rosenkranz S, Saggar R, Ulrich S, Vizza D, Vonk Noordegraaf A, Olschewski H. An official European Respiratory Society statement: pulmonary haemodynamics during exercise. Eur Respir J. 2017 11; 50(5). PMID: 29167297.
    Citations: 6     Fields:    Translation:Humans
  45. Berger KI, Burton BK, Lewis GD, Tarnopolsky M, Harmatz PR, Mitchell JJ, Muschol N, Jones SA, Sutton VR, Pastores GM, Lau H, Sparkes R, Shaywitz AJ. Cardiopulmonary Exercise Testing Reflects Improved Exercise Capacity in Response to Treatment in Morquio A Patients: Results of a 52-Week Pilot Study of Two Different Doses of Elosulfase Alfa. JIMD Rep. 2018; 42:9-17. PMID: 29159458.
    Citations:    
  46. Shah R, Murthy VL, Colangelo LA, Reis JP, Carr JJ, Sidney S, Siddique J, Lewis CE, Lima JAC, Lewis GD. Submaximal Blood Pressure Responses to Exercise in Young Adulthood and Long-Term Cardiovascular Health. J Am Coll Cardiol. 2017 10 10; 70(15):1941-1943. PMID: 28982510.
    Citations:    Fields:    
  47. Houstis NE, Eisman AS, Pappagianopoulos PP, Wooster L, Bailey CS, Wagner PD, Lewis GD. Exercise Intolerance in Heart Failure With Preserved Ejection Fraction: Diagnosing and Ranking Its Causes Using Personalized O2 Pathway Analysis. Circulation. 2018 01 09; 137(2):148-161. PMID: 28993402.
    Citations: 3     Fields:    
  48. Shah R, Yeri A, Das A, Courtright-Lim A, Ziegler O, Gervino E, Ocel J, Quintero-Pinzon P, Wooster L, Bailey CS, Tanriverdi K, Beaulieu LM, Freedman JE, Ghiran I, Lewis GD, Van Keuren-Jensen K, Das S. Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic health: brief report. Am J Physiol Heart Circ Physiol. 2017 Dec 01; 313(6):H1162-H1167. PMID: 28916639.
    Citations: 1     Fields:    Translation:HumansAnimals
  49. Lewis GD, Malhotra R, Hernandez AF, McNulty SE, Smith A, Felker GM, Tang WHW, LaRue SJ, Redfield MM, Semigran MJ, Givertz MM, Van Buren P, Whellan D, Anstrom KJ, Shah MR, Desvigne-Nickens P, Butler J, Braunwald E. Effect of Oral Iron Repletion on Exercise Capacity in Patients With Heart Failure With Reduced Ejection Fraction and Iron Deficiency: The IRONOUT HF Randomized Clinical Trial. JAMA. 2017 May 16; 317(19):1958-1966. PMID: 28510680.
    Citations: 11     Fields:    Translation:HumansCTClinical Trials
  50. Reddy YNV, Lewis GD, Shah SJ, LeWinter M, Semigran M, Davila-Roman VG, Anstrom K, Hernandez A, Braunwald E, Redfield MM, Borlaug BA. INDIE-HFpEF (Inorganic Nitrite Delivery to Improve Exercise Capacity in Heart Failure With Preserved Ejection Fraction): Rationale and Design. Circ Heart Fail. 2017 May; 10(5). PMID: 28476756.
    Citations: 5     Fields:    Translation:Humans
  51. Lin J, Wang F, Weiner RB, DeLuca JR, Wasfy MM, Berkstresser B, Lewis GD, Hutter AM, Picard MH, Baggish AL. The Authors Reply. JACC Cardiovasc Imaging. 2017 04; 10(4):496-497. PMID: 28385261.
    Citations:    Fields:    
  52. Steiner J, Wiafe S, Camuso J, Milley K, Wooster LT, Bailey CS, Thomas SS, D'Alessandro DA, Garcia JP, Lewis GD. Predicting Success: Left Ventricular Assist Device Explantation Evaluation Protocol Using Comprehensive Cardiopulmonary Exercise Testing. Circ Heart Fail. 2017 01; 10(1). PMID: 27998882.
    Citations:    Fields:    Translation:Humans
  53. Lin J, Wang F, Weiner RB, DeLuca JR, Wasfy MM, Berkstresser B, Lewis GD, Hutter AM, Picard MH, Baggish AL. Blood Pressure and LV Remodeling Among American-Style Football Players. JACC Cardiovasc Imaging. 2016 12; 9(12):1367-1376. PMID: 27931524.
    Citations: 6     Fields:    Translation:Humans
  54. Chaudhry S, Kumar N, Behbahani H, Bagai A, Singh BK, Menasco N, Lewis GD, Sperling L, Myers J. Abnormal heart-rate response during cardiopulmonary exercise testing identifies cardiac dysfunction in symptomatic patients with non-obstructive coronary artery disease. Int J Cardiol. 2017 Feb 01; 228:114-121. PMID: 27863351.
    Citations:    Fields:    Translation:Humans
  55. Abbasi SA, Shah RV, McNulty SE, Hernandez AF, Semigran MJ, Lewis GD, Jerosch-Herold M, Kim RJ, Redfield MM, Kwong RY. Left Atrial Structure and Function in Heart Failure with Preserved Ejection Fraction: A RELAX Substudy. PLoS One. 2016; 11(11):e0164914. PMID: 27812147.
    Citations: 1     Fields:    Translation:Humans
  56. Shapero K, Deluca J, Contursi M, Wasfy M, Weiner RB, Lewis GD, Hutter A, Baggish AL. Cardiovascular Risk and Disease Among Masters Endurance Athletes: Insights from the Boston MASTER (Masters Athletes Survey To Evaluate Risk) Initiative. Sports Med Open. 2016 Dec; 2(1):29. PMID: 27747784.
    Citations:    
  57. Shapero K, Deluca J, Contursi M, Wasfy M, Weiner RB, Lewis GD, Hutter A, Baggish AL. Cardiovascular Risk and Disease Among Masters Endurance Athletes: Insights from the Boston MASTER (Masters Athletes Survey To Evaluate Risk) Initiative. Sports Med Open. 2016 Dec; 2:29. PMID: 27547715.
    Citations: 3     
  58. Malhotra R, Bakken K, D'Elia E, Lewis GD. Cardiopulmonary Exercise Testing in Heart Failure. JACC Heart Fail. 2016 08; 4(8):607-16. PMID: 27289406.
    Citations: 12     Fields:    Translation:Humans
  59. Malhotra R, Dhakal BP, Eisman AS, Pappagianopoulos PP, Dress A, Weiner RB, Baggish AL, Semigran MJ, Lewis GD. Pulmonary Vascular Distensibility Predicts Pulmonary Hypertension Severity, Exercise Capacity, and Survival in Heart Failure. Circ Heart Fail. 2016 06; 9(6). PMID: 27301469.
    Citations: 6     Fields:    Translation:Humans
  60. Spartano NL, Lyass A, Larson MG, Lewis GD, Vasan RS. Submaximal Exercise Systolic Blood Pressure and Heart Rate at 20 Years of Follow-up: Correlates in the Framingham Heart Study. J Am Heart Assoc. 2016 05 27; 5(6). PMID: 27233297.
    Citations: 1     Fields:    Translation:Humans
  61. Lewis GD, Semigran MJ, Givertz MM, Malhotra R, Anstrom KJ, Hernandez AF, Shah MR, Braunwald E. Oral Iron Therapy for Heart Failure With Reduced Ejection Fraction: Design and Rationale for Oral Iron Repletion Effects on Oxygen Uptake in Heart Failure. Circ Heart Fail. 2016 05; 9(5). PMID: 27140203.
    Citations: 9     Fields:    Translation:Humans
  62. Chatterjee NA, Lewis GD. Heart Rate Modulation in Heart Failure: Time to Slow Down? J Am Coll Cardiol. 2016 Apr 26; 67(16):1897-900. PMID: 27102505.
    Citations:    Fields:    Translation:Humans
  63. Durand ML, Ennis SC, Baker JN, Camuso JM, McEachern KM, Kotton CN, Lewis GD, Garcia JP, MacGillivray TE. Topical Polymyxin-Trimethoprim Prophylaxis May Decrease the Incidence of Driveline Infections in Patients With Continuous-Flow Left Ventricular Assist Devices. Artif Organs. 2017 Feb; 41(2):169-175. PMID: 27098102.
    Citations:    Fields:    Translation:Humans
  64. Hussain I, Mohammed SF, Forfia PR, Lewis GD, Borlaug BA, Gallup DS, Redfield MM. Impaired Right Ventricular-Pulmonary Arterial Coupling and Effect of Sildenafil in Heart Failure With Preserved Ejection Fraction: An Ancillary Analysis From the Phosphodiesterase-5 Inhibition to Improve Clinical Status And Exercise Capacity in Diastolic Heart Failure (RELAX) Trial. Circ Heart Fail. 2016 Apr; 9(4):e002729. PMID: 27072860.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  65. Dhakal BP, Lewis GD. Exercise oscillatory ventilation: Mechanisms and prognostic significance. World J Cardiol. 2016 Mar 26; 8(3):258-66. PMID: 27022457.
    Citations:    
  66. Brittain EL, Talati M, Fessel JP, Zhu H, Penner N, Calcutt MW, West JD, Funke M, Lewis GD, Gerszten RE, Hamid R, Pugh ME, Austin ED, Newman JH, Hemnes AR. Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension. Circulation. 2016 May 17; 133(20):1936-44. PMID: 27006481.
    Citations: 15     Fields:    Translation:HumansAnimals
  67. Oldham WM, Lewis GD, Opotowsky AR, Waxman AB, Systrom DM. Unexplained exertional dyspnea caused by low ventricular filling pressures: results from clinical invasive cardiopulmonary exercise testing. Pulm Circ. 2016 Mar; 6(1):55-62. PMID: 27162614.
    Citations: 4     
  68. Spartano NL, Himali JJ, Beiser AS, Lewis GD, DeCarli C, Vasan RS, Seshadri S. Midlife exercise blood pressure, heart rate, and fitness relate to brain volume 2 decades later. Neurology. 2016 Apr 05; 86(14):1313-1319. PMID: 26865519.
    Citations: 3     Fields:    Translation:Humans
  69. Melman YF, Shah R, Danielson K, Xiao J, Simonson B, Barth A, Chakir K, Lewis GD, Lavender Z, Truong QA, Kleber A, Das R, Rosenzweig A, Wang Y, Kass D, Singh JP, Das S. Response to Letter Regarding Article, "Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study". Circulation. 2016 Feb 09; 133(6):e389-e390. PMID: 26858296.
    Citations:    Fields:    Translation:HumansAnimalsCells
  70. Lewis GD, Ngo D, Hemnes AR, Farrell L, Domos C, Pappagianopoulos PP, Dhakal BP, Souza A, Shi X, Pugh ME, Beloiartsev A, Sinha S, Clish CB, Gerszten RE. Metabolic Profiling of Right Ventricular-Pulmonary Vascular Function Reveals Circulating Biomarkers of Pulmonary Hypertension. J Am Coll Cardiol. 2016 Jan 19; 67(2):174-189. PMID: 26791065.
    Citations: 12     Fields:    Translation:HumansAnimals
  71. Shah RV, Murthy VL, Colangelo LA, Reis J, Venkatesh BA, Sharma R, Abbasi SA, Goff DC, Carr JJ, Rana JS, Terry JG, Bouchard C, Sarzynski MA, Eisman A, Neilan T, Das S, Jerosch-Herold M, Lewis CE, Carnethon M, Lewis GD, Lima JA. Association of Fitness in Young Adulthood With Survival and Cardiovascular Risk: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. JAMA Intern Med. 2016 Jan; 176(1):87-95. PMID: 26618471.
    Citations: 13     Fields:    Translation:Humans
  72. Weiner RB, DeLuca JR, Wang F, Lin J, Wasfy MM, Berkstresser B, Stöhr E, Shave R, Lewis GD, Hutter AM, Picard MH, Baggish AL. Exercise-Induced Left Ventricular Remodeling Among Competitive Athletes: A Phasic Phenomenon. Circ Cardiovasc Imaging. 2015 Dec; 8(12). PMID: 26666381.
    Citations: 10     Fields:    Translation:Humans
  73. Maron BA, Stephens TE, Farrell LA, Oldham WM, Loscalzo J, Leopold JA, Lewis GD. Elevated pulmonary arterial and systemic plasma aldosterone levels associate with impaired cardiac reserve capacity during exercise in left ventricular systolic heart failure patients: A pilot study. J Heart Lung Transplant. 2016 Mar; 35(3):342-351. PMID: 26586488.
    Citations: 4     Fields:    Translation:Humans
  74. Wasfy MM, Weiner RB, Wang F, Berkstresser B, Lewis GD, DeLuca JR, Hutter AM, Picard MH, Baggish AL. Endurance Exercise-Induced Cardiac Remodeling: Not All Sports Are Created Equal. J Am Soc Echocardiogr. 2015 Dec; 28(12):1434-40. PMID: 26361851.
    Citations: 6     Fields:    Translation:Humans
  75. Carroll BJ, Shah RV, Murthy V, McCullough SA, Reza N, Thomas SS, Song TH, Newton-Cheh CH, Camuso JM, MacGillivray T, Sundt TM, Semigran MJ, Lewis GD, Baker JN, Garcia JP. Clinical Features and outcomes in adults with cardiogenic shock supported by extracorporeal membrane oxygenation. Am J Cardiol. 2015 Nov 15; 116(10):1624-30. PMID: 26443560.
    Citations:    Fields:    Translation:Humans
  76. Borlaug BA, Chen H, Lin G, Redfield MM, Lewis GD, Semigran MJ, McNulty SE, LeWinter M, Deswal A, Margulies KB. Response to Letter Regarding Article, “Effects of Sildenafil on Ventricular and Vascular Function in Heart Failure With Preserved Ejection Fraction”. Circ Heart Fail. 2015 Jul; 8(4):840. PMID: 26405727.
    Citations:    Fields:    Translation:Humans
  77. Burton BK, Berger KI, Lewis GD, Tarnopolsky M, Treadwell M, Mitchell JJ, Muschol N, Jones SA, Sutton VR, Pastores GM, Lau H, Sparkes R, Genter F, Shaywitz AJ, Harmatz P. Safety and physiological effects of two different doses of elosulfase alfa in patients with morquio a syndrome: A randomized, double-blind, pilot study. Am J Med Genet A. 2015 Oct; 167A(10):2272-81. PMID: 26069231.
    Citations: 6     Fields:    Translation:Humans
  78. Niehaus ED, Malhotra R, Cocca-Spofford D, Semigran M, Lewis GD. Repletion of Iron Stores With the Use of Oral Iron Supplementation in Patients With Systolic Heart Failure. J Card Fail. 2015 Aug; 21(8):694-7. PMID: 26028263.
    Citations: 3     Fields:    Translation:Humans
  79. Melman YF, Shah R, Danielson K, Xiao J, Simonson B, Barth A, Chakir K, Lewis GD, Lavender Z, Truong QA, Kleber A, Das R, Rosenzweig A, Wang Y, Kass D, Singh JP, Das S. Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study. Circulation. 2015 Jun 23; 131(25):2202-2216. PMID: 25995320.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  80. Degani-Costa LH, Levarge B, Digumarthy SR, Eisman AS, Harris RS, Lewis GD. Pulmonary vascular response patterns during exercise in interstitial lung disease. Eur Respir J. 2015 Sep; 46(3):738-49. PMID: 25976688.
    Citations: 2     Fields:    Translation:Humans
  81. Borlaug BA, Lewis GD, McNulty SE, Semigran MJ, LeWinter M, Chen H, Lin G, Deswal A, Margulies KB, Redfield MM. Effects of sildenafil on ventricular and vascular function in heart failure with preserved ejection fraction. Circ Heart Fail. 2015 May; 8(3):533-41. PMID: 25782985.
    Citations: 12     Fields:    Translation:Humans
  82. Sharma AK, Vegh E, Orencole M, Miller A, Blendea D, Moore S, Lewis GD, Singh JP, Parks KA, Heist EK. Association of hypothyroidism with adverse events in patients with heart failure receiving cardiac resynchronization therapy. Am J Cardiol. 2015 May 01; 115(9):1249-53. PMID: 25743211.
    Citations: 4     Fields:    Translation:Humans
  83. Zilinski JL, Contursi ME, Isaacs SK, Deluca JR, Lewis GD, Weiner RB, Hutter AM, d'Hemecourt PA, Troyanos C, Dyer KS, Baggish AL. Myocardial adaptations to recreational marathon training among middle-aged men. Circ Cardiovasc Imaging. 2015 Feb; 8(2):e002487. PMID: 25673646.
    Citations: 7     Fields:    Translation:Humans
  84. Nathan AS, Loukas B, Moko L, Wu F, Rhodes J, Rathod RH, Systrom DM, Ubeda Tikkanen A, Shafer K, Lewis GD, Landzberg MJ, Opotowsky AR. Exercise oscillatory ventilation in patients with Fontan physiology. Circ Heart Fail. 2015 Mar; 8(2):304-11. PMID: 25550441.
    Citations: 3     Fields:    Translation:Humans
  85. Chatterjee NA, Steiner J, Lewis GD. It is time to look at heart failure with preserved ejection fraction from the right side. Circulation. 2014 Dec 23; 130(25):2272-7. PMID: 25391521.
    Citations: 3     Fields:    Translation:Humans
  86. Chatterjee NA, Lewis GD. Characterization of pulmonary hypertension in heart failure using the diastolic pressure gradient: limitations of a solitary measurement. JACC Heart Fail. 2015 Jan; 3(1):17-21. PMID: 25453537.
    Citations: 3     Fields:    Translation:Humans
  87. Dhakal BP, Malhotra R, Murphy RM, Pappagianopoulos PP, Baggish AL, Weiner RB, Houstis NE, Eisman AS, Hough SS, Lewis GD. Mechanisms of exercise intolerance in heart failure with preserved ejection fraction: the role of abnormal peripheral oxygen extraction. Circ Heart Fail. 2015 Mar; 8(2):286-94. PMID: 25344549.
    Citations: 39     Fields:    Translation:Humans
  88. Ho JE, Arora P, Walford GA, Ghorbani A, Guanaga DP, Dhakal BP, Nathan DI, Buys ES, Florez JC, Newton-Cheh C, Lewis GD, Wang TJ. Effect of phosphodiesterase inhibition on insulin resistance in obese individuals. J Am Heart Assoc. 2014 Sep 11; 3(5):e001001. PMID: 25213566.
    Citations: 7     Fields:    Translation:HumansCells
  89. Wasfy MM, DeLuca J, Wang F, Berkstresser B, Ackerman KE, Eisman A, Lewis GD, Hutter AM, Weiner RB, Baggish AL. ECG findings in competitive rowers: normative data and the prevalence of abnormalities using contemporary screening recommendations. Br J Sports Med. 2015 Feb; 49(3):200-6. PMID: 25202138.
    Citations: 5     Fields:    Translation:Humans
  90. Lewis GD. The emerging role of metabolomics in the development of biomarkers for pulmonary hypertension and other cardiovascular diseases (2013 Grover Conference series). Pulm Circ. 2014 Sep; 4(3):417-23. PMID: 25621155.
    Citations: 4     
  91. Lindman BR, Dávila-Román VG, Mann DL, McNulty S, Semigran MJ, Lewis GD, de las Fuentes L, Joseph SM, Vader J, Hernandez AF, Redfield MM. Cardiovascular phenotype in HFpEF patients with or without diabetes: a RELAX trial ancillary study. J Am Coll Cardiol. 2014 Aug 12; 64(6):541-9. PMID: 25104521.
    Citations: 24     Fields:    Translation:Humans
  92. Houstis NE, Lewis GD. Causes of exercise intolerance in heart failure with preserved ejection fraction: searching for consensus. J Card Fail. 2014 Oct; 20(10):762-778. PMID: 25108084.
    Citations: 5     Fields:    Translation:Humans
  93. Turer AT, Lewis GD, O'Sullivan JF, Elmariah S, Mega JL, Addo TA, Sabatine MS, de Lemos JA, Gerszten RE. Increases in myocardial workload induced by rapid atrial pacing trigger alterations in global metabolism. PLoS One. 2014; 9(6):e99058. PMID: 24932507.
    Citations: 2     Fields:    Translation:HumansCells
  94. Mohammed SF, Borlaug BA, McNulty S, Lewis GD, Lin G, Zakeri R, Semigran MJ, LeWinter M, Hernandez AF, Braunwald E, Redfield MM. Resting ventricular-vascular function and exercise capacity in heart failure with preserved ejection fraction: a RELAX trial ancillary study. Circ Heart Fail. 2014 Jul; 7(4):580-9. PMID: 24833648.
    Citations: 9     Fields:    Translation:Humans
  95. Chatterjee NA, Upadhyay GA, Singal G, Parks KA, Dec GW, Singh JP, Lewis GD. Pre-capillary pulmonary hypertension and right ventricular dilation predict clinical outcome in cardiac resynchronization therapy. JACC Heart Fail. 2014 Jun; 2(3):230-7. PMID: 24952689.
    Citations: 5     Fields:    Translation:Humans
  96. Roberts LD, Boström P, O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee YK, Palma MJ, Calhoun S, Georgiadi A, Chen MH, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, Cowan CA, Spiegelman BM, Gerszten RE. ß-Aminoisobutyric acid induces browning of white fat and hepatic ß-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 2014 Jan 07; 19(1):96-108. PMID: 24411942.
    Citations: 85     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  97. Stefanescu A, Macklin EA, Lin E, Dudzinski DM, Johnson J, Kennedy KF, Jacoby D, DeFaria Yeh D, Lewis GD, Yeh RW, Liberthson R, Lui G, Bhatt AB. Usefulness of the Seattle Heart Failure Model to identify adults with congenital heart disease at high risk of poor outcome. Am J Cardiol. 2014 Mar 01; 113(5):865-70. PMID: 24411285.
    Citations: 2     Fields:    Translation:Humans
  98. Zakeri R, Borlaug BA, McNulty SE, Mohammed SF, Lewis GD, Semigran MJ, Deswal A, LeWinter M, Hernandez AF, Braunwald E, Redfield MM. Impact of atrial fibrillation on exercise capacity in heart failure with preserved ejection fraction: a RELAX trial ancillary study. Circ Heart Fail. 2014 Jan; 7(1):123-30. PMID: 24162898.
    Citations: 28     Fields:    Translation:Humans
  99. Lewis GD, Bossone E, Naeije R, Grünig E, Saggar R, Lancellotti P, Ghio S, Varga J, Rajagopalan S, Oudiz R, Rubenfire M. Pulmonary vascular hemodynamic response to exercise in cardiopulmonary diseases. Circulation. 2013 Sep 24; 128(13):1470-9. PMID: 24060943.
    Citations: 42     Fields:    Translation:HumansAnimals
  100. Chatterjee NA, Murphy RM, Malhotra R, Dhakal BP, Baggish AL, Pappagianopoulos PP, Hough SS, Semigran MJ, Lewis GD. Prolonged mean VO2 response time in systolic heart failure: an indicator of impaired right ventricular-pulmonary vascular function. Circ Heart Fail. 2013 May; 6(3):499-507. PMID: 23572493.
    Citations: 2     Fields:    Translation:Humans
  101. Naeije R, Vanderpool R, Dhakal BP, Saggar R, Saggar R, Vachiery JL, Lewis GD. Exercise-induced pulmonary hypertension: physiological basis and methodological concerns. Am J Respir Crit Care Med. 2013 Mar 15; 187(6):576-83. PMID: 23348976.
    Citations: 31     Fields:    Translation:Humans
  102. Magnusson M, Lewis GD, Ericson U, Orho-Melander M, Hedblad B, Engström G, Ostling G, Clish C, Wang TJ, Gerszten RE, Melander O. A diabetes-predictive amino acid score and future cardiovascular disease. Eur Heart J. 2013 Jul; 34(26):1982-9. PMID: 23242195.
    Citations: 56     Fields:    Translation:Humans
  103. Fujimoto N, Borlaug BA, Lewis GD, Hastings JL, Shafer KM, Bhella PS, Carrick-Ranson G, Levine BD. Hemodynamic responses to rapid saline loading: the impact of age, sex, and heart failure. Circulation. 2013 Jan 01; 127(1):55-62. PMID: 23172838.
    Citations: 24     Fields:    Translation:HumansCTClinical Trials
  104. Bishu K, Deswal A, Chen HH, LeWinter MM, Lewis GD, Semigran MJ, Borlaug BA, McNulty S, Hernandez AF, Braunwald E, Redfield MM. Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction. Am Heart J. 2012 Nov; 164(5):763-770.e3. PMID: 23137508.
    Citations: 21     Fields:    Translation:Humans
  105. Dhakal BP, Murphy RM, Lewis GD. Exercise oscillatory ventilation in heart failure. Trends Cardiovasc Med. 2012 Oct; 22(7):185-91. PMID: 23062973.
    Citations: 5     Fields:    Translation:Humans
  106. Fang JC, DeMarco T, Givertz MM, Borlaug BA, Lewis GD, Rame JE, Gomberg-Maitland M, Murali S, Frantz RP, McGlothlin D, Horn EM, Benza RL. World Health Organization Pulmonary Hypertension group 2: pulmonary hypertension due to left heart disease in the adult--a summary statement from the Pulmonary Hypertension Council of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2012 Sep; 31(9):913-33. PMID: 22884380.
    Citations: 30     Fields:    Translation:Humans
  107. Weiner RB, Wang F, Berkstresser B, Kim J, Wang TJ, Lewis GD, Hutter AM, Picard MH, Baggish AL. Regression of "gray zone" exercise-induced concentric left ventricular hypertrophy during prescribed detraining. J Am Coll Cardiol. 2012 May 29; 59(22):1992-4. PMID: 22624842.
    Citations: 4     Fields:    Translation:Humans
  108. Altman RK, Parks KA, Schlett CL, Orencole M, Park MY, Truong QA, Deeprasertkul P, Moore SA, Barrett CD, Lewis GD, Das S, Upadhyay GA, Heist EK, Picard MH, Singh JP. Multidisciplinary care of patients receiving cardiac resynchronization therapy is associated with improved clinical outcomes. Eur Heart J. 2012 Sep; 33(17):2181-8. PMID: 22613342.
    Citations: 14     Fields:    Translation:Humans
  109. Cheng S, Rhee EP, Larson MG, Lewis GD, McCabe EL, Shen D, Palma MJ, Roberts LD, Dejam A, Souza AL, Deik AA, Magnusson M, Fox CS, O'Donnell CJ, Vasan RS, Melander O, Clish CB, Gerszten RE, Wang TJ. Metabolite profiling identifies pathways associated with metabolic risk in humans. Circulation. 2012 May 08; 125(18):2222-31. PMID: 22496159.
    Citations: 124     Fields:    Translation:HumansAnimals
  110. Januzzi JL, Rehman SU, Mohammed AA, Bhardwaj A, Barajas L, Barajas J, Kim HN, Baggish AL, Weiner RB, Chen-Tournoux A, Marshall JE, Moore SA, Carlson WD, Lewis GD, Shin J, Sullivan D, Parks K, Wang TJ, Gregory SA, Uthamalingam S, Semigran MJ. Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction. J Am Coll Cardiol. 2011 Oct 25; 58(18):1881-9. PMID: 22018299.
    Citations: 52     Fields:    Translation:Humans
  111. Chatterjee NA, Lewis GD. What is the prognostic significance of pulmonary hypertension in heart failure? Circ Heart Fail. 2011 Sep; 4(5):541-5. PMID: 21934090.
    Citations: 3     Fields:    Translation:Humans
  112. Murphy RM, Shah RV, Malhotra R, Pappagianopoulos PP, Hough SS, Systrom DM, Semigran MJ, Lewis GD. Exercise oscillatory ventilation in systolic heart failure: an indicator of impaired hemodynamic response to exercise. Circulation. 2011 Sep 27; 124(13):1442-51. PMID: 21875912.
    Citations: 17     Fields:    Translation:Humans
  113. Baggish AL, Hale A, Weiner RB, Lewis GD, Systrom D, Wang F, Wang TJ, Chan SY. Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training. J Physiol. 2011 Aug 15; 589(Pt 16):3983-94. PMID: 21690193.
    Citations: 97     Fields:    Translation:Humans
  114. Addona TA, Shi X, Keshishian H, Mani DR, Burgess M, Gillette MA, Clauser KR, Shen D, Lewis GD, Farrell LA, Fifer MA, Sabatine MS, Gerszten RE, Carr SA. A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease. Nat Biotechnol. 2011 Jun 19; 29(7):635-43. PMID: 21685905.
    Citations: 77     Fields:    Translation:Humans
  115. Turer AT, Addo TA, Martin JL, Sabatine MS, Lewis GD, Gerszten RE, Keeley EC, Cigarroa JE, Lange RA, Hillis LD, de Lemos JA. Myocardial ischemia induced by rapid atrial pacing causes troponin T release detectable by a highly sensitive assay: insights from a coronary sinus sampling study. J Am Coll Cardiol. 2011 Jun 14; 57(24):2398-405. PMID: 21658559.
    Citations: 24     Fields:    Translation:Humans
  116. Malhotra R, Hess D, Lewis GD, Bloch KD, Waxman AB, Semigran MJ. Vasoreactivity to inhaled nitric oxide with oxygen predicts long-term survival in pulmonary arterial hypertension. Pulm Circ. 2011 Apr; 1(2):250-258. PMID: 22020367.
    Citations: 11     
  117. Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, Lewis GD, Fox CS, Jacques PF, Fernandez C, O'Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A, Melander O, Clish CB, Gerszten RE. Metabolite profiles and the risk of developing diabetes. Nat Med. 2011 Apr; 17(4):448-53. PMID: 21423183.
    Citations: 617     Fields:    Translation:Humans
  118. Rhee EP, Cheng S, Larson MG, Walford GA, Lewis GD, McCabe E, Yang E, Farrell L, Fox CS, O'Donnell CJ, Carr SA, Vasan RS, Florez JC, Clish CB, Wang TJ, Gerszten RE. Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. J Clin Invest. 2011 Apr; 121(4):1402-11. PMID: 21403394.
    Citations: 136     Fields:    Translation:HumansCells
  119. Lewis GD, Murphy RM, Shah RV, Pappagianopoulos PP, Malhotra R, Bloch KD, Systrom DM, Semigran MJ. Pulmonary vascular response patterns during exercise in left ventricular systolic dysfunction predict exercise capacity and outcomes. Circ Heart Fail. 2011 May; 4(3):276-85. PMID: 21292991.
    Citations: 24     Fields:    Translation:Humans
  120. Chen-Tournoux A, Khan AM, Baggish AL, Castro VM, Semigran MJ, McCabe EL, Moukarbel G, Reingold J, Durrani S, Lewis GD, Newton-Cheh C, Scherrer-Crosbie M, Kaplan LM, Wang TJ. Effect of weight loss after weight loss surgery on plasma N-terminal pro-B-type natriuretic peptide levels. Am J Cardiol. 2010 Nov 15; 106(10):1450-5. PMID: 21059435.
    Citations: 18     Fields:    Translation:Humans
  121. Chaudhry S, Arena RA, Hansen JE, Lewis GD, Myers JN, Sperling LS, Labudde BD, Wasserman K. The utility of cardiopulmonary exercise testing to detect and track early-stage ischemic heart disease. Mayo Clin Proc. 2010 Oct; 85(10):928-32. PMID: 20884826.
    Citations: 1     Fields:    Translation:Humans
  122. Lewis GD, Farrell L, Wood MJ, Martinovic M, Arany Z, Rowe GC, Souza A, Cheng S, McCabe EL, Yang E, Shi X, Deo R, Roth FP, Asnani A, Rhee EP, Systrom DM, Semigran MJ, Vasan RS, Carr SA, Wang TJ, Sabatine MS, Clish CB, Gerszten RE. Metabolic signatures of exercise in human plasma. Sci Transl Med. 2010 May 26; 2(33):33ra37. PMID: 20505214.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  123. Baumgartner C, Lewis GD, Netzer M, Pfeifer B, Gerszten RE. A new data mining approach for profiling and categorizing kinetic patterns of metabolic biomarkers after myocardial injury. Bioinformatics. 2010 Jul 15; 26(14):1745-51. PMID: 20483816.
    Citations: 8     Fields:    Translation:Humans
  124. Rhee EP, Souza A, Farrell L, Pollak MR, Lewis GD, Steele DJ, Thadhani R, Clish CB, Greka A, Gerszten RE. Metabolite profiling identifies markers of uremia. J Am Soc Nephrol. 2010 Jun; 21(6):1041-1051. PMID: 20378825.
    Citations: 49     Fields:    Translation:Humans
  125. Lewis GD, Gerszten RE. Toward metabolomic signatures of cardiovascular disease. Circ Cardiovasc Genet. 2010 Apr; 3(2):119-21. PMID: 20407099.
    Citations: 12     Fields:    Translation:Humans
  126. Deo RC, Hunter L, Lewis GD, Pare G, Vasan RS, Chasman D, Wang TJ, Gerszten RE, Roth FP. Interpreting metabolomic profiles using unbiased pathway models. PLoS Comput Biol. 2010 Feb 26; 6(2):e1000692. PMID: 20195502.
    Citations: 27     Fields:    Translation:HumansCells
  127. Lewis GD. The role of the pulmonary vasculature in heart failure with preserved ejection fraction. J Am Coll Cardiol. 2009 Mar 31; 53(13):1127-9. PMID: 19324257.
    Citations: 1     Fields:    Translation:Humans
  128. Chaudhry S, Arena R, Wasserman K, Hansen JE, Lewis GD, Myers J, Belardinelli R, LaBudde B, Menasco N, Boden WE. The utility of cardiopulmonary exercise testing in the assessment of suspected microvascular ischemia. Int J Cardiol. 2011 Apr 01; 148(1):e7-9. PMID: 19233492.
    Citations: 3     Fields:    Translation:Humans
  129. Chaudhry S, Arena R, Wasserman K, Hansen JE, Lewis GD, Myers J, Chronos N, Boden WE. Exercise-induced myocardial ischemia detected by cardiopulmonary exercise testing. Am J Cardiol. 2009 Mar 01; 103(5):615-9. PMID: 19231322.
    Citations: 11     Fields:    Translation:Humans
  130. Lewis GD, Shah RV, Pappagianopolas PP, Systrom DM, Semigran MJ. Determinants of ventilatory efficiency in heart failure: the role of right ventricular performance and pulmonary vascular tone. Circ Heart Fail. 2008 Nov; 1(4):227-33. PMID: 19808296.
    Citations: 26     Fields:    Translation:Humans
  131. Lewis GD, Wei R, Liu E, Yang E, Shi X, Martinovic M, Farrell L, Asnani A, Cyrille M, Ramanathan A, Shaham O, Berriz G, Lowry PA, Palacios IF, Tasan M, Roth FP, Min J, Baumgartner C, Keshishian H, Addona T, Mootha VK, Rosenzweig A, Carr SA, Fifer MA, Sabatine MS, Gerszten RE. Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury. J Clin Invest. 2008 Oct; 118(10):3503-12. PMID: 18769631.
    Citations: 77     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  132. Shaham O, Wei R, Wang TJ, Ricciardi C, Lewis GD, Vasan RS, Carr SA, Thadhani R, Gerszten RE, Mootha VK. Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity. Mol Syst Biol. 2008; 4:214. PMID: 18682704.
    Citations: 127     Fields:    Translation:HumansCells
  133. Lewis GD, Asnani A, Gerszten RE. Application of metabolomics to cardiovascular biomarker and pathway discovery. J Am Coll Cardiol. 2008 Jul 08; 52(2):117-23. PMID: 18598890.
    Citations: 52     Fields:    Translation:Humans
  134. Lewis GD, Gona P, Larson MG, Plehn JF, Benjamin EJ, O'Donnell CJ, Levy D, Vasan RS, Wang TJ. Exercise blood pressure and the risk of incident cardiovascular disease (from the Framingham Heart Study). Am J Cardiol. 2008 Jun 01; 101(11):1614-20. PMID: 18489939.
    Citations: 20     Fields:    Translation:Humans
  135. Lewis GD, Shah R, Shahzad K, Camuso JM, Pappagianopoulos PP, Hung J, Tawakol A, Gerszten RE, Systrom DM, Bloch KD, Semigran MJ. Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension. Circulation. 2007 Oct 02; 116(14):1555-62. PMID: 17785618.
    Citations: 119     Fields:    Translation:Humans
  136. Lewis GD, Holmes CB, Holmvang G, Butterton JR. Case records of the Massachusetts General Hospital. Case 8-2007. A 48-year-old man with chest pain followed by cardiac arrest. N Engl J Med. 2007 Mar 15; 356(11):1153-62. PMID: 17360994.
    Citations: 8     Fields:    Translation:HumansCells
  137. Lewis GD, Lachmann J, Camuso J, Lepore JJ, Shin J, Martinovic ME, Systrom DM, Bloch KD, Semigran MJ. Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure. Circulation. 2007 Jan 02; 115(1):59-66. PMID: 17179022.
    Citations: 83     Fields:    Translation:Humans
  138. Lewis GD, Semigran MJ. The emerging role for type 5 phosphodiesterase inhibition in heart failure. Curr Heart Fail Rep. 2006 Sep; 3(3):123-8. PMID: 16914104.
    Citations: 5     Fields:    Translation:Humans
  139. Lewis GD, Witzke C, Colon-Hernandez P, Guerrero JL, Bloch KD, Semigran MJ. Sildenafil improves coronary artery patency in a canine model of platelet-mediated cyclic coronary occlusion after thrombolysis. J Am Coll Cardiol. 2006 Apr 04; 47(7):1471-7. PMID: 16580539.
    Citations: 3     Fields:    Translation:Animals
  140. Lewis GD, Semigran MJ. Type 5 phosphodiesterase inhibition in heart failure and pulmonary hypertension. Curr Heart Fail Rep. 2004 Dec; 1(4):183-9. PMID: 16036043.
    Citations: 10     Fields:    Translation:HumansAnimals
  141. Lewis GD, Bloch KD, Semigran MJ. Pulmonary thromboembolism superimposed on a congenital ventricular septal defect in a 50-year-old man inhaled nitric oxide and sildenafil to the rescue. Cardiol Rev. 2004 Jul-Aug; 12(4):188-90. PMID: 15191635.
    Citations: 2     Fields:    Translation:Humans
  142. Andela VB, Gordon AH, Zotalis G, Rosier RN, Goater JJ, Lewis GD, Schwarz EM, Puzas JE, O'Keefe RJ. NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone. Clin Orthop Relat Res. 2003 Oct; (415 Suppl):S75-85. PMID: 14600595.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  143. Agus DB, Akita RW, Fox WD, Lewis GD, Higgins B, Pisacane PI, Lofgren JA, Tindell C, Evans DP, Maiese K, Scher HI, Sliwkowski MX. Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth. Cancer Cell. 2002 Aug; 2(2):127-37. PMID: 12204533.
    Citations: 228     Fields:    Translation:HumansAnimalsCells
  144. Greening GE, Hewitt J, Lewis GD. Evaluation of integrated cell culture-PCR (C-PCR) for virological analysis of environmental samples. J Appl Microbiol. 2002; 93(5):745-50. PMID: 12392518.
    Citations: 16     Fields:    Translation:CellsPHPublic Health
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.