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profileGewei Lian, Ph.D.

TitleInstructor in Neurology
InstitutionBeth Israel Deaconess Medical Center
DepartmentNeurology
AddressBeth Israel Deaconess Medical Center
Neurology, HIM 8
330 Brookline Ave
Boston MA 02215
Phone617/667-0882
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  1. Lian G, Wong T, Lu J, Hu J, Zhang J, Sheen V. Cytoskeletal Associated Filamin A and RhoA Affect Neural Progenitor Specification During Mitosis. Cereb Cortex. 2018 Feb 16. PMID: 29462287.
    View in: PubMed
  2. Lian G, Kanaujia S, Wong T, Sheen V. FilaminA and Formin2 regulate skeletal, muscular, and intestinal formation through mesenchymal progenitor proliferation. PLoS One. 2017; 12(12):e0189285. PMID: 29240780.
    View in: PubMed
  3. Hu J, Lu J, Goyal A, Wong T, Lian G, Zhang J, Hecht JL, Feng Y, Sheen VL. Opposing FlnA and FlnB interactions regulate RhoA activation in guiding dynamic actin stress fiber formation and cell spreading. Hum Mol Genet. 2017 04 01; 26(7):1294-1304. PMID: 28175289.
    View in: PubMed
  4. Lian G, Dettenhofer M, Lu J, Downing M, Chenn A, Wong T, Sheen V. Filamin A- and formin 2-dependent endocytosis regulates proliferation via the canonical Wnt pathway. Development. 2016 12 01; 143(23):4509-4520. PMID: 27789627.
    View in: PubMed
  5. Lu J, Mccarter M, Lian G, Esposito G, Capoccia E, Delli-Bovi LC, Hecht J, Sheen V. Global hypermethylation in fetal cortex of Down syndrome due to DNMT3L overexpression. Hum Mol Genet. 2016 05 01; 25(9):1714-27. PMID: 26911678; PMCID: PMC4986328 [Available on 05/01/17].
  6. Lian G, Sheen VL. Cytoskeletal proteins in cortical development and disease: actin associated proteins in periventricular heterotopia. Front Cell Neurosci. 2015; 9:99. PMID: 25883548; PMCID: PMC4381626.
  7. Hu J, Lu J, Lian G, Ferland RJ, Dettenhofer M, Sheen VL. Formin 1 and filamin B physically interact to coordinate chondrocyte proliferation and differentiation in the growth plate. Hum Mol Genet. 2014 Sep 01; 23(17):4663-73. PMID: 24760772; PMCID: PMC4119417.
  8. Hu J, Lu J, Lian G, Zhang J, Hecht JL, Sheen VL. Filamin B regulates chondrocyte proliferation and differentiation through Cdk1 signaling. PLoS One. 2014; 9(2):e89352. PMID: 24551245; PMCID: PMC3925234.
  9. Zhang J, Neal J, Lian G, Hu J, Lu J, Sheen V. Filamin A regulates neuronal migration through brefeldin A-inhibited guanine exchange factor 2-dependent Arf1 activation. J Neurosci. 2013 Oct 02; 33(40):15735-46. PMID: 24089482; PMCID: PMC3787497.
  10. Zhang J, Neal J, Lian G, Shi B, Ferland RJ, Sheen V. Brefeldin A-inhibited guanine exchange factor 2 regulates filamin A phosphorylation and neuronal migration. J Neurosci. 2012 Sep 05; 32(36):12619-29. PMID: 22956851; PMCID: PMC3478955.
  11. Lian G, Lu J, Hu J, Zhang J, Cross SH, Ferland RJ, Sheen VL. Filamin a regulates neural progenitor proliferation and cortical size through Wee1-dependent Cdk1 phosphorylation. J Neurosci. 2012 May 30; 32(22):7672-84. PMID: 22649246; PMCID: PMC3368379.
  12. Lu J, Lian G, Zhou H, Esposito G, Steardo L, Delli-Bovi LC, Hecht JL, Lu QR, Sheen V. OLIG2 over-expression impairs proliferation of human Down syndrome neural progenitors. Hum Mol Genet. 2012 May 15; 21(10):2330-40. PMID: 22343408; PMCID: PMC3335315.
  13. Ferland RJ, Batiz LF, Neal J, Lian G, Bundock E, Lu J, Hsiao YC, Diamond R, Mei D, Banham AH, Brown PJ, Vanderburg CR, Joseph J, Hecht JL, Folkerth R, Guerrini R, Walsh CA, Rodriguez EM, Sheen VL. Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopia. Hum Mol Genet. 2009 Feb 01; 18(3):497-516. PMID: 18996916; PMCID: PMC2722192.
  14. Lu J, Lian G, Lenkinski R, De Grand A, Vaid RR, Bryce T, Stasenko M, Boskey A, Walsh C, Sheen V. Filamin B mutations cause chondrocyte defects in skeletal development. Hum Mol Genet. 2007 Jul 15; 16(14):1661-75. PMID: 17510210.
    View in: PubMed
  15. Lian G, Sheen V. Cerebral developmental disorders. Curr Opin Pediatr. 2006 Dec; 18(6):614-20. PMID: 17099359.
    View in: PubMed
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