Francis W. Luscinskas, Ph.D.
Title Professor of Pathology, Emeritus Institution Brigham and Women's Hospital Address 111 Allerton Road Milton MA 02186
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Biography
1997
Iberdrola Visiting Professor
2000
A.H.A. Established Investigator Award
2007
Excellence in Tutorial Award
Overview
My interests are in the cell biology of leukocytes and vascular endothelial cells and their adhesive interactions in the context of the pathophysiology of the inflammatory response. Prior to closing my lab in December 2021, my lab employed mouse and human models to understand the molecular mechanisms involved leukocyte recruitment and in regulating vascular permeability, focusing on the role of vascular endothelial expressed adhesion molecules (e.g., ICAM-1 and CD47, and the adherens junction protein, Vascular Endothelial-cadherin (VE-cadherin, cadherin-5). My lab team combined expertise in endothelial cell biochemistry, immunology and live cell fluorescence microscopy techniques with my collaborators, Drs. Kevin Croce, Andrew Lichtman, and Tanya Mayadas from BWH (MGB) and Charles Parkos, Chairman of Pathology, University of Michigan, who have significant expertise in intravital microscopy of the microcirculation and have established several in vivo experimental models and in vitro models of inflammation and vascular permeability. My laboratory was located in the Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women’s Hospital (Mass General Brigham).
Mentoring
Role of Endothelial JAM-C in Leukocyte Recruitment Under Shear Flow in vitro
Summer, 05/25/05 - 09/02/05
Research
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R01HL125780
(LUSCINSKAS, FRANCIS W.)
May 1, 2016 - Sep 30, 2020
CD47 Regulation of Leukocyte Integrins during Leukocyte Trafficking
Role: Principal Investigator
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R13CA186413
(LUSCINSKAS, FRANCIS W.)
Apr 24, 2014 - Apr 23, 2015
2014 Annual Meeting of the American Society for Investigative Pathology
Role: Principal Investigator
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R13CA177075
(LUSCINSKAS, FRANCIS W.)
Apr 1, 2013 - Mar 31, 2014
2013 Annual Meeting of the American Society for Investigative Pathology
Role: Principal Investigator
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R01HL065090
(LUSCINSKAS, FRANCIS W.)
Sep 30, 1999 - Jul 31, 2005
ENDOTHELIAL CELL DYSFUNCTION IN CHRONIC IMMUNE DISEASES
Role: Principal Investigator
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R01HL053993
(LUSCINSKAS, FRANCIS W.)
Aug 1, 1996 - Jun 30, 2011
Endothelial Regulation of Leukocyte Transmigration
Role: Principal Investigator
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R29HL047646
(LUSCINSKAS, FRANCIS W.)
Feb 1, 1992 - Jan 31, 1997
ENDOTHELIAL-DEPENDENT LEUKOCYTE ACTIVATION
Role: Principal Investigator
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F32HL007672
(LUSCINSKAS, FRANCIS W.)
Nov 15, 1987
ACTIVATION MECHANISMS IN LEUKOCYTE-ENDOTHELIAL ADHESION
Role: Principal Investigator
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P01HL036028
(LUSCINSKAS, FRANCIS W.)
Jul 1, 1984 - Jun 30, 2015
Pathophysiology of the Endothelium
Role: Principal Investigator
Bibliographic
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