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Ethan Arthur Lerner, M.D.,Ph.D.

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Mechanisms of Itch [login at prompt]
Available: 03/30/22, Expires: 12/31/24

Itch is the most common symptom in dermatology yet there are few specific treatments. The impact of itch on quality of life matches that of pain. We pair fundamental techniques to gain mechanistic insights with clinical research to identify genetic variants that contribute to itch. We use advanced in vivo imaging and deep sequencing to examine the neuroanatomy and biology of sensory fibers. We use CRISPR to make humanized mice in order to model itch. We welcome the opportunity to generate mice in which skin is genetically labeled, akin to Brainbow mice, to examine interactions between neurons and other skin cells. We are particularly interested in deciphering the role of mas-related G-protein coupled receptors in basic models and in humans. Clinical studies can also be undertaken. These include the itch associated with burns and the use of fractionated laser or cold to treat itch. Writing of in-depth of an in-depth review is welcome.


Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R21AR067399 (LERNER, ETHAN A) Feb 1, 2015 - Jan 31, 2017
    NIH
    The role of Mrgprs in substance P-induced itch
    Role: Principal Investigator
  2. R13AR065371 (LERNER, ETHAN A) Aug 20, 2013 - Jul 31, 2014
    NIH
    7th World Congress on Itch (WCI)
    Role: Principal Investigator
  3. R01AR057744 (LERNER, ETHAN A) Aug 1, 2010 - Jun 30, 2016
    NIH
    Itch, proteases and protease-activated receptors
    Role: Principal Investigator
  4. U01AI061420 (LERNER, ETHAN A) Jul 1, 2004 - Jun 30, 2008
    NIH
    G-protein coupled receptors for bioagent detection
    Role: Principal Investigator
  5. R01AR044510 (LERNER, ETHAN A) Sep 30, 1998 - Aug 31, 2004
    NIH
    CUTANEOUS BIOLOGY OF NITRIC OXIDE
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Moradi Tuchayi S, Wang Y, Khodorova A, Pence IJ, Evans CL, Anderson RR, Lerner EA, Woolf CJ, Garibyan L. Cryoneurolysis with Injectable Ice Slurry Modulates Mechanical Skin Pain. J Invest Dermatol. 2023 01; 143(1):134-141.e1. PMID: 35985498.
    Citations: 1     Fields:    Translation:Animals
  2. Miron Y, Miller PE, Hughes C, Indersmitten T, Lerner EA, Cevikbas F. Mechanistic insights into the antipruritic effects of lebrikizumab, an anti-IL-13 mAb. J Allergy Clin Immunol. 2022 09; 150(3):690-700. PMID: 35240144.
    Citations: 2     Fields:    
  3. Dondalska A, Rönnberg E, Ma H, Pålsson SA, Magnusdottir E, Gao T, Adam L, Lerner EA, Nilsson G, Lagerström M, Spetz AL. Amelioration of Compound 48/80-Mediated Itch and LL-37-Induced Inflammation by a Single-Stranded Oligonucleotide. Front Immunol. 2020; 11:559589. PMID: 33101278.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  4. Vernal S, De Paula NA, Bollela VR, Lerner EA, Roselino AM. Pemphigus foliaceus and sand fly bites: assessing the humoral immune response to the salivary proteins maxadilan and LJM11. Br J Dermatol. 2020 11; 183(5):958-960. PMID: 32407578.
    Citations: 1     Fields:    Translation:HumansAnimals
  5. Cevikbas F, Lerner EA. Physiology and Pathophysiology of Itch. Physiol Rev. 2020 07 01; 100(3):945-982. PMID: 31869278.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  6. Lerner EA. Why do we itch? Exp Dermatol. 2019 12; 28(12):1474-1475. PMID: 31299113.
    Citations:    Fields:    Translation:HumansAnimals
  7. Lerner EA. Is the Nervous System More Important Than the Immune System in Itch and Atopic Dermatitis? J Investig Dermatol Symp Proc. 2018 Dec; 19(2):S94. PMID: 30471764.
    Citations: 1     Fields:    
  8. Lee MS, Lerner EA. Targeting PAR2 with Pepducins. J Invest Dermatol. 2019 02; 139(2):282-284. PMID: 30471839.
    Citations:    Fields:    Translation:Humans
  9. Lerner EA. Pathophysiology of Itch. Dermatol Clin. 2018 Jul; 36(3):175-177. PMID: 29929590.
    Citations: 3     Fields:    Translation:HumansCells
  10. Steinhoff M, Buddenkotte J, Lerner EA. Role of mast cells and basophils in pruritus. Immunol Rev. 2018 03; 282(1):248-264. PMID: 29431207.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  11. Lerner E. Why Do Wounds Itch? Wounds. 2018 Jan; 30(1):1-3. PMID: 29406291.
    Citations: 1     Fields:    Translation:HumansCells
  12. Reddy VB, Azimi E, Chu L, Lerner EA. Mas-Related G-Protein Coupled Receptors and Cowhage-Induced Itch. J Invest Dermatol. 2018 02; 138(2):461-464. PMID: 28988117; PMCID: PMC5794532.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  13. Carstens E, Schmelz M, Hunter HJA, Lerner EA, Misery L, Steinhoff M, Yosipovitch G, Ständer S. FRT - FONDATION RENE TOURAINE: An International Foundation For Dermatology. Exp Dermatol. 2017 10; 26(10):972-985. PMID: 28952194.
    Citations:    Fields:    Translation:HumansAnimals
  14. Reddy VB, Lerner EA. Activation of mas-related G-protein-coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation. J Biol Chem. 2017 10 20; 292(42):17399-17406. PMID: 28768771.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  15. Reddy VB, Graham TA, Azimi E, Lerner EA. A single amino acid in MRGPRX2 necessary for binding and activation by pruritogens. J Allergy Clin Immunol. 2017 12; 140(6):1726-1728. PMID: 28689793; PMCID: PMC5723232.
    Citations: 14     Fields:    Translation:HumansCells
  16. Haddadi NS, Foroutan A, Ostadhadi S, Azimi E, Rahimi N, Nateghpour M, Lerner EA, Dehpour AR. Peripheral NMDA Receptor/NO System Blockage Inhibits Itch Responses Induced by Chloroquine in Mice. Acta Derm Venereol. 2017 May 08; 97(5):571-577. PMID: 28119997; PMCID: PMC5524132.
    Citations: 2     Fields:    Translation:AnimalsCells
  17. Azimi E, Reddy VB, Lerner EA. Brief communication: MRGPRX2, atopic dermatitis and red man syndrome. Itch (Phila). 2017 Mar; 2(1). PMID: 28367504; PMCID: PMC5375112.
    Citations: 20     
  18. Pereira PJS, Lerner EA. Gate Control Theory Springs a Leak. Neuron. 2017 Feb 22; 93(4):723-724. PMID: 28231458.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  19. Azimi E, Reddy VB, Pereira PJS, Talbot S, Woolf CJ, Lerner EA. Substance P activates Mas-related G protein-coupled receptors to induce itch. J Allergy Clin Immunol. 2017 Aug; 140(2):447-453.e3. PMID: 28219706; PMCID: PMC5546940.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  20. Aires J, Casanova C, Vernal S, Nascimento M, Rodrigues S, Lerner EA, Roselino AM. Maxadilan-simile expression in Nyssomyia neivai, a sandfly vector in an endemic region of Brazil, and its immunogenicity in patients with American tegumentary leishmaniasis. Mem Inst Oswaldo Cruz. 2017 Feb; 112(2):116-122. PMID: 28177045; PMCID: PMC5293120.
    Citations: 1     Fields:    Translation:HumansAnimalsPHPublic Health
  21. Azimi E, Lerner EA. Implications of MRGPRX2 in human and experimental cardiometabolic diseases. Nat Rev Cardiol. 2017 02; 14(2):124. PMID: 28054574.
    Citations: 4     Fields:    Translation:HumansCells
  22. Azimi E, Reddy VB, Shade KC, Anthony RM, Talbot S, Pereira PJS, Lerner EA. Dual action of neurokinin-1 antagonists on Mas-related GPCRs. JCI Insight. 2016 Oct 06; 1(16):e89362. PMID: 27734033.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  23. Azimi E, Xia J, Lerner EA. Peripheral Mechanisms of Itch. Curr Probl Dermatol. 2016; 50:18-23. PMID: 27578066; PMCID: PMC5540324.
    Citations: 13     Fields:    Translation:HumansCells
  24. Ostadhadi S, Azimi E, Lerner EA, Dehpour AR. Are itch and scratching the nausea and vomiting of skin? Exp Dermatol. 2016 05; 25(5):340-3. PMID: 26739556; PMCID: PMC5445905.
    Citations: 2     Fields:    Translation:HumansAnimals
  25. Pereira PJ, Machado GD, Danesi GM, Canevese FF, Reddy VB, Pereira TC, Bogo MR, Cheng YC, Laedermann C, Talbot S, Lerner EA, Campos MM. GRPR/PI3K?: Partners in Central Transmission of Itch. J Neurosci. 2015 Dec 09; 35(49):16272-81. PMID: 26658875; PMCID: PMC4682789.
    Citations: 9     Fields:    Translation:AnimalsCells
  26. Napadow V, Li A, Loggia ML, Kim J, Mawla I, Desbordes G, Schalock PC, Lerner EA, Tran TN, Ring J, Rosen BR, Kaptchuk TJ, Pfab F. The imagined itch: brain circuitry supporting nocebo-induced itch in atopic dermatitis patients. Allergy. 2015 Nov; 70(11):1485-92. PMID: 26280659.
    Citations: 18     Fields:    Translation:Humans
  27. Reddy VB, Sun S, Azimi E, Elmariah SB, Dong X, Lerner EA. Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs. Nat Commun. 2015 Jul 28; 6:7864. PMID: 26216096.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  28. Garibyan L, Cornelissen L, Sipprell W, Pruessner J, Elmariah S, Luo T, Lerner EA, Jung Y, Evans C, Zurakowski D, Berde CB, Rox Anderson R. Transient Alterations of Cutaneous Sensory Nerve Function by Noninvasive Cryolipolysis. J Invest Dermatol. 2015 Nov; 135(11):2623-2631. PMID: 26099028; PMCID: PMC4640987.
    Citations: 5     Fields:    Translation:HumansCells
  29. Azimi E, Lerner EA, Elmariah SB. Altered manifestations of skin disease at sites affected by neurological deficit. Br J Dermatol. 2015 Apr; 172(4):988-93. PMID: 25132518.
    Citations: 7     Fields:    Translation:Humans
  30. Akiyama T, Lerner EA, Carstens E. Protease-activated receptors and itch. Handb Exp Pharmacol. 2015; 226:219-35. PMID: 25861783; PMCID: PMC5540334.
    Citations: 15     Fields:    Translation:HumansAnimals
  31. Desbordes G, Li A, Loggia ML, Kim J, Schalock PC, Lerner E, Tran TN, Ring J, Rosen BR, Kaptchuk TJ, Pfab F, Napadow V. Evoked itch perception is associated with changes in functional brain connectivity. Neuroimage Clin. 2015; 7:213-21. PMID: 25610783.
    Citations: 8     Fields:    Translation:Humans
  32. Azimi E, Lerner EA. The 7th World Congress on Itch. J Invest Dermatol. 2014 Jul; 134(7):1786-1788. PMID: 24924756.
    Citations:    Fields:    Translation:HumansAnimals
  33. Elmariah SB, Reddy VB, Lerner EA. Cathepsin S signals via PAR2 and generates a novel tethered ligand receptor agonist. PLoS One. 2014; 9(6):e99702. PMID: 24964046.
    Citations: 27     Fields:    Translation:HumansCells
  34. Pereira PJ, Lerner EA. Interneurons scratch an itch. Neuron. 2014 May 07; 82(3):503-5. PMID: 24811374.
    Citations:    Fields:    Translation:AnimalsCells
  35. Elmariah SB, Lerner EA. The missing link between itch and inflammation in atopic dermatitis. Cell. 2013 Oct 10; 155(2):267-9. PMID: 24120126.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  36. Olivry T, Bizikova P, Paps JS, Dunston S, Lerner EA, Yosipovitch G. Cowhage can induce itch in the atopic dog. Exp Dermatol. 2013 Jun; 22(6):435-7. PMID: 23711071.
    Citations:    Fields:    Translation:AnimalsCells
  37. Garibyan L, Rheingold CG, Lerner EA. Understanding the pathophysiology of itch. Dermatol Ther. 2013 Mar-Apr; 26(2):84-91. PMID: 23551365.
    Citations: 20     Fields:    Translation:Humans
  38. Napadow V, Li A, Loggia ML, Kim J, Schalock PC, Lerner E, Tran TN, Ring J, Rosen BR, Kaptchuk TJ, Pfab F. The brain circuitry mediating antipruritic effects of acupuncture. Cereb Cortex. 2014 Apr; 24(4):873-82. PMID: 23222890.
    Citations: 26     Fields:    Translation:HumansCTClinical Trials
  39. Inglott MA, Lerner EA, Pilowsky PM, Farnham MM. Activation of PAC(1) and VPAC receptor subtypes elicits differential physiological responses from sympathetic preganglionic neurons in the anaesthetized rat. Br J Pharmacol. 2012 Nov; 167(5):1089-98. PMID: 22612450.
    Citations: 4     Fields:    Translation:AnimalsCells
  40. Svensjö E, Saraiva EM, Amendola RS, Barja-Fidalgo C, Bozza MT, Lerner EA, Teixeira MM, Scharfstein J. Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1-CXCR1/2-pathway. Microvasc Res. 2012 Mar; 83(2):185-93. PMID: 22036674.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  41. Elmariah SB, Lerner EA. Topical therapies for pruritus. Semin Cutan Med Surg. 2011 Jun; 30(2):118-26. PMID: 21767774.
    Citations: 17     Fields:    Translation:Humans
  42. Lauenstein HD, Quarcoo D, Plappert L, Schleh C, Nassimi M, Pilzner C, Rochlitzer S, Brabet P, Welte T, Hoymann HG, Krug N, Müller M, Lerner EA, Braun A, Groneberg DA. Pituitary adenylate cyclase-activating peptide receptor 1 mediates anti-inflammatory effects in allergic airway inflammation in mice. Clin Exp Allergy. 2011 Apr; 41(4):592-601. PMID: 21059121.
    Citations: 14     Fields:    Translation:AnimalsCells
  43. Reddy VB, Lerner EA. Plant cysteine proteases that evoke itch activate protease-activated receptors. Br J Dermatol. 2010 Sep; 163(3):532-5. PMID: 20491769.
    Citations: 19     Fields:    Translation:HumansCells
  44. Lerner EA, Yosipovitch G. A tribute to Walter Shelley, a pioneer itch researcher (1917-2009). Arch Dermatol. 2010 Jul; 146(7):788. PMID: 20644043.
    Citations:    Fields:    Translation:Humans
  45. Reddy VB, Shimada SG, Sikand P, Lamotte RH, Lerner EA. Cathepsin S elicits itch and signals via protease-activated receptors. J Invest Dermatol. 2010 May; 130(5):1468-70. PMID: 20072136.
    Citations: 40     Fields:    Translation:HumansCellsCTClinical Trials
  46. Yang K, Trepanier CH, Li H, Beazely MA, Lerner EA, Jackson MF, MacDonald JF. Vasoactive intestinal peptide acts via multiple signal pathways to regulate hippocampal NMDA receptors and synaptic transmission. Hippocampus. 2009 Sep; 19(9):779-89. PMID: 19173226.
    Citations: 15     Fields:    Translation:AnimalsCells
  47. Iuga A, Lerner E, Shedd TR, van der Schalie WH. Rapid responses of a melanophore cell line to chemical contaminants in water. J Appl Toxicol. 2009 May; 29(4):346-9. PMID: 19213008.
    Citations: 3     Fields:    Translation:AnimalsCells
  48. Svensjö E, Saraiva EM, Bozza MT, Oliveira SM, Lerner EA, Scharfstein J. Salivary gland homogenates of Lutzomyia longipalpis and its vasodilatory peptide maxadilan cause plasma leakage via PAC1 receptor activation. J Vasc Res. 2009; 46(5):435-46. PMID: 19176972.
    Citations: 7     Fields:    Translation:Animals
  49. Jiang Q, Ko WK, Lerner EA, Chan KM, Wong AO. Grass carp somatolactin: I. Evidence for PACAP induction of somatolactin-alpha and -beta gene expression via activation of pituitary PAC-I receptors. Am J Physiol Endocrinol Metab. 2008 Aug; 295(2):E463-76. PMID: 18523122.
    Citations: 7     Fields:    Translation:AnimalsCells
  50. Reddy VB, Li Y, Lerner EA. Maxadilan, the PAC1 receptor, and leishmaniasis. J Mol Neurosci. 2008 Nov; 36(1-3):241-4. PMID: 18509762.
    Citations: 4     Fields:    Translation:Animals
  51. Reddy VB, Iuga AO, Shimada SG, LaMotte RH, Lerner EA. Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors. J Neurosci. 2008 Apr 23; 28(17):4331-5. PMID: 18434511.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  52. Yamashita T, Akita H, Astner S, Miyakawa M, Lerner EA, González S. In vivo assessment of pigmentary and vascular compartments changes in UVA exposed skin by reflectance-mode confocal microscopy. Exp Dermatol. 2007 Nov; 16(11):905-11. PMID: 17927573.
    Citations: 3     Fields:    Translation:HumansCells
  53. Lerner E. Aaron B. Lerner, 1920-2007. J Invest Dermatol. 2007 Sep; 127(9):2077-9. PMID: 17700610.
    Citations:    Fields:    Translation:Humans
  54. Iuga AO, Lerner EA. TRP-ing up melanophores: TRPM7, melanin synthesis, and pigment cell survival. J Invest Dermatol. 2007 Aug; 127(8):1855-6. PMID: 17632567.
    Citations: 4     Fields:    Translation:AnimalsCells
  55. Lerner EA, Iuga AO, Reddy VB. Maxadilan, a PAC1 receptor agonist from sand flies. Peptides. 2007 Sep; 28(9):1651-4. PMID: 17681401.
    Citations: 19     Fields:    Translation:AnimalsCellsPHPublic Health
  56. Reddy VB, Iuga AO, Kounga K, Lerner EA. Functional analysis of recombinant mutants of maxadilan with a PAC1 receptor-expressing melanophore cell line. J Biol Chem. 2006 Jun 16; 281(24):16197-201. PMID: 16569645.
    Citations: 3     Fields:    Translation:AnimalsCells
  57. Iuga AO, Reddy VB, Lerner EA. Identification of novel hexapeptide agonists at the Xenopus laevis melanophore melanocortin receptor. Peptides. 2005 Nov; 26(11):2124-8. PMID: 16269347.
    Citations: 2     Fields:    Translation:AnimalsCells
  58. Iuga AO, Qureshi AA, Lerner EA. Nitric oxide is toxic to melanocytes in vitro. Pigment Cell Res. 2004 Jun; 17(3):302-6. PMID: 15140077.
    Citations: 1     Fields:    Translation:AnimalsCells
  59. Gower WR, Dietz JR, McCuen RW, Fabri PJ, Lerner EA, Schubert ML. Regulation of atrial natriuretic peptide secretion by cholinergic and PACAP neurons of the gastric antrum. Am J Physiol Gastrointest Liver Physiol. 2003 Jan; 284(1):G68-74. PMID: 12488235.
    Citations: 5     Fields:    Translation:AnimalsCells
  60. Pereira P, Reddy VB, Kounga K, Bello Y, Lerner E. Maxadilan activates PAC1 receptors expressed in Xenopus laevis xelanophores. Pigment Cell Res. 2002 Dec; 15(6):461-6. PMID: 12453189.
    Citations: 5     Fields:    Translation:AnimalsCells
  61. Karlsson AM, Bjuhr K, Testorf M, Oberg PA, Lerner E, Lundstrom I, Svensson SP. Biosensing of opioids using frog melanophores. Biosens Bioelectron. 2002 Apr; 17(4):331-5. PMID: 11849930.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  62. Choi CM, Lerner EA. Leishmaniasis: recognition and management with a focus on the immunocompromised patient. Am J Clin Dermatol. 2002; 3(2):91-105. PMID: 11893221.
    Citations: 11     Fields:    Translation:HumansPHPublic Health
  63. Choi CM, Lerner EA. Leishmaniasis as an emerging infection. J Investig Dermatol Symp Proc. 2001 Dec; 6(3):175-82. PMID: 11924824.
    Citations: 23     Fields:    Translation:Humans
  64. Juarranz MG, Bolaños O, Gutiérrez-Cañas I, Lerner EA, Robberecht P, Carmena MJ, Prieto JC, Rodríguez-Henche N. Neuroendocrine differentiation of the LNCaP prostate cancer cell line maintains the expression and function of VIP and PACAP receptors. Cell Signal. 2001 Dec; 13(12):887-94. PMID: 11728828.
    Citations: 8     Fields:    Translation:HumansCells
  65. O'Sullivan RL, Mansueto CS, Lerner EA, Miguel EC. Characterization of trichotillomania. A phenomenological model with clinical relevance to obsessive-compulsive spectrum disorders. Psychiatr Clin North Am. 2000 Sep; 23(3):587-604. PMID: 10986729.
    Citations: 18     Fields:    Translation:HumansAnimals
  66. Reddy VB, Kounga K, Mariano F, Lerner EA. Chrysoptin is a potent glycoprotein IIb/IIIa fibrinogen receptor antagonist present in salivary gland extracts of the deerfly. J Biol Chem. 2000 May 26; 275(21):15861-7. PMID: 10821849.
    Citations: 8     Fields:    Translation:AnimalsCells
  67. Lerner LH, Qureshi AA, Reddy BV, Lerner EA. Nitric oxide synthase in toxic epidermal necrolysis and Stevens-Johnson syndrome. J Invest Dermatol. 2000 Jan; 114(1):196-9. PMID: 10620138.
    Citations: 8     Fields:    Translation:Humans
  68. Moro O, Wakita K, Ohnuma M, Denda S, Lerner EA, Tajima M. Functional characterization of structural alterations in the sequence of the vasodilatory peptide maxadilan yields a pituitary adenylate cyclase-activating peptide type 1 receptor-specific antagonist. J Biol Chem. 1999 Aug 13; 274(33):23103-10. PMID: 10438479.
    Citations: 20     Fields:    Translation:AnimalsCells
  69. Eggenberger M, Born W, Zimmermann U, Lerner EA, Fischer JA, Muff R. Maxadilan interacts with receptors for pituitary adenylyl cyclase activating peptide in human SH-SY5Y and SK-N-MC neuroblastoma cells. Neuropeptides. 1999 Apr; 33(2):107-14. PMID: 10657479.
    Citations: 4     Fields:    Translation:HumansCells
  70. O'Sullivan RL, Lipper G, Lerner EA. The neuro-immuno-cutaneous-endocrine network: relationship of mind and skin. Arch Dermatol. 1998 Nov; 134(11):1431-5. PMID: 9828880.
    Citations: 14     Fields:    Translation:Humans
  71. Kaminuma T, Shimizu H, Ahmad I, Ochiai N, Ehama R, Ohnuma M, Banba T, Watabe K, Lerner EA, Imaizumi S, Tajima M, Yoshimoto T. Prevention of cerebral vasospasm by vasodilatory peptide maxadilan following subarachnoid hemorrhage in rabbits. J Control Release. 1998 Mar 02; 52(1-2):71-80. PMID: 9685937.
    Citations: 2     Fields:    Translation:Animals
  72. Lerner LH, Lerner EA, Bello YM. Co-existence of cutaneous and presumptive pulmonary alternariosis. Int J Dermatol. 1997 Apr; 36(4):285-8. PMID: 9169329.
    Citations:    Fields:    Translation:HumansAnimals
  73. Biedrzycki LM, Lerner E, Levy RJ, Schoen FJ. Differential calcification of cusps and aortic wall of failed stented porcine bioprosthetic valves. J Biomed Mater Res. 1997 Mar 15; 34(4):411-5. PMID: 9054525.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  74. Moro O, Lerner EA. Maxadilan, the vasodilator from sand flies, is a specific pituitary adenylate cyclase activating peptide type I receptor agonist. J Biol Chem. 1997 Jan 10; 272(2):966-70. PMID: 8995389.
    Citations: 37     Fields:    Translation:AnimalsCells
  75. Qureshi AA, Hosoi J, Xu S, Takashima A, Granstein RD, Lerner EA. Langerhans cells express inducible nitric oxide synthase and produce nitric oxide. J Invest Dermatol. 1996 Dec; 107(6):815-21. PMID: 8941667.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  76. Moro O, Tajima M, Lerner EA. Receptors for the vasodilator maxadilan are expressed on selected neural crest and smooth muscle-derived cells. Insect Biochem Mol Biol. 1996 Dec; 26(10):1019-25. PMID: 9035385.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  77. Jackson TS, Lerner E, Weisbrod RM, Tajima M, Loscalzo J, Keaney JF. Vasodilatory properties of recombinant maxadilan. Am J Physiol. 1996 Sep; 271(3 Pt 2):H924-30. PMID: 8853326.
    Citations: 5     Fields:    Translation:Animals
  78. Qureshi AA, Lerner LH, Lerner EA. From bedside to the bench and back. Nitric oxide and the cutis. Arch Dermatol. 1996 Aug; 132(8):889-93. PMID: 8712838.
    Citations: 3     Fields:    Translation:Humans
  79. Qureshi AA, Asahina A, Ohnuma M, Tajima M, Granstein RD, Lerner EA. Immunomodulatory properties of maxadilan, the vasodilator peptide from sand fly salivary gland extracts. Am J Trop Med Hyg. 1996 Jun; 54(6):665-71. PMID: 8686790.
    Citations: 20     Fields:    Translation:AnimalsCells
  80. Grevelink SA, Lerner EA. Leishmaniasis. J Am Acad Dermatol. 1996 Feb; 34(2 Pt 1):257-72. PMID: 8642091.
    Citations: 28     Fields:    Translation:HumansAnimalsPHPublic Health
  81. Yoshida S, Takamatsu T, Denda S, Ohnuma M, Tajima M, Lerner EA, Kanda F. Structural characterization and location of disulphide linkages of a potent vasodilatory peptide, recombinant maxadilan, by a multiple mass spectrometric approach. Rapid Commun Mass Spectrom. 1996; 10(6):641-8. PMID: 8624417.
    Citations:    Fields:    Translation:Cells
  82. Moro O, Tsomides TJ, Tajima M, Lerner EA. Maxadilan binds to membrane fractions of brain tissue. Biochem Biophys Res Commun. 1995 Nov 02; 216(1):234-41. PMID: 7488094.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  83. Asahina A, Moro O, Hosoi J, Lerner EA, Xu S, Takashima A, Granstein RD. Specific induction of cAMP in Langerhans cells by calcitonin gene-related peptide: relevance to functional effects. Proc Natl Acad Sci U S A. 1995 Aug 29; 92(18):8323-7. PMID: 7667288; PMCID: PMC41149.
    Citations: 24     Fields:    Translation:AnimalsCells
  84. Grevelink SA, Osborne J, Loscalzo J, Lerner EA. Vasorelaxant and second messenger effects of maxadilan. J Pharmacol Exp Ther. 1995 Jan; 272(1):33-7. PMID: 7815348.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  85. Lima HC, Vasconcelos AW, David JR, Lerner EA. American cutaneous leishmaniasis: in situ characterization of the cellular immune response with time. Am J Trop Med Hyg. 1994 Jun; 50(6):743-7. PMID: 8024068.
    Citations: 4     Fields:    Translation:HumansAnimals
  86. Grevelink SA, Youssef DE, Loscalzo J, Lerner EA. Salivary gland extracts from the deerfly contain a potent inhibitor of platelet aggregation. Proc Natl Acad Sci U S A. 1993 Oct 01; 90(19):9155-8. PMID: 8415671; PMCID: PMC47520.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  87. Hosoi J, Murphy GF, Egan CL, Lerner EA, Grabbe S, Asahina A, Granstein RD. Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide. Nature. 1993 May 13; 363(6425):159-63. PMID: 8483499.
    Citations: 116     Fields:    Translation:HumansAnimalsCells
  88. Dunn DA, Gadenne AS, Simha S, Lerner EA, Bigby M, Bleicher PA. T-cell receptor V beta expression in normal human skin. Proc Natl Acad Sci U S A. 1993 Feb 15; 90(4):1267-71. PMID: 7679496; PMCID: PMC45853.
    Citations: 11     Fields:    Translation:HumansCells
  89. Lerner EA, Shoemaker CB. Maxadilan. Cloning and functional expression of the gene encoding this potent vasodilator peptide. J Biol Chem. 1992 Jan 15; 267(2):1062-6. PMID: 1730635.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  90. Lerner EA, Ribeiro JM, Nelson RJ, Lerner MR. Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis. J Biol Chem. 1991 Jun 15; 266(17):11234-6. PMID: 2040631.
    Citations: 53     Fields:    Translation:Animals
  91. Samuelson J, Lerner E, Tesh R, Titus R. A mouse model of Leishmania braziliensis braziliensis infection produced by coinjection with sand fly saliva. J Exp Med. 1991 Jan 01; 173(1):49-54. PMID: 1985126; PMCID: PMC2118755.
    Citations: 46     Fields:    Translation:AnimalsCells
  92. Lerner EA, Sober AJ. Chemical and pharmacologic agents that cause hyperpigmentation or hypopigmentation of the skin. Dermatol Clin. 1988 Apr; 6(2):327-37. PMID: 3288388.
    Citations: 2     Fields:    Translation:Humans
  93. Lerner EA, Kibbi AG, Haas A. Calf ulcer in an immunocompromised host. Cryptococcosis. Arch Dermatol. 1988 Mar; 124(3):430-1, 433-4. PMID: 3345094.
    Citations:    Fields:    Translation:Humans
  94. Lerner EA, Lerner MR. Whither the ANA? Arch Dermatol. 1987 Mar; 123(3):358-62. PMID: 2434034.
    Citations:    Fields:    Translation:HumansCells
  95. Lerner EA, Dover JS. Malignant pyoderma: a manifestation of Wegener's granulomatosis? J Am Acad Dermatol. 1986 Nov; 15(5 Pt 1):1051-2. PMID: 3782521.
    Citations: 2     Fields:    Translation:Humans
  96. Janeway CA, Conrad PJ, Lerner EA, Babich J, Wettstein P, Murphy DB. Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: possible role of T cellbound Ia antigens as targets of immunoregulatory T cells. J Immunol. 1984 Feb; 132(2):662-7. PMID: 6228596.
    Citations: 64     Fields:    Translation:AnimalsCells
  97. Matis LA, Hedrick SM, Hannum C, Ultee ME, Lebwohl D, Margoliash E, Solinger AM, Lerner EA, Schwartz RH. The T lymphocyte response to cytochrome C. III. Relationship of the fine specificity of antigen recognition to major histocompatibility complex genotype. J Immunol. 1982 Jun; 128(6):2439-46. PMID: 6176634.
    Citations: 11     Fields:    Translation:AnimalsCells
  98. Matis LA, Jones PP, Murphy DB, Hedrick SM, Lerner EA, Janeway CA, McNicholas JM, Schwartz RH. Immune response gene function correlates with the expression of an Ia antigen. II. A quantitative deficiency in Ae:E alpha complex expression causes a corresponding defect in antigen-presenting cell function. J Exp Med. 1982 Feb 01; 155(2):508-23. PMID: 6173457; PMCID: PMC2186585.
    Citations: 29     Fields:    Translation:AnimalsCells
  99. McNicholas JM, Murphy DB, Matis LA, Schwartz RH, Lerner EA, Janeway CA, Jones PP. Immune response gene function correlates with the expression of an Ia antigen. I. Preferential association of certain Ae and E alpha chains results in a quantitative deficiency in expression of an Ae:E alpha complex. J Exp Med. 1982 Feb 01; 155(2):490-507. PMID: 6799608; PMCID: PMC2186583.
    Citations: 28     Fields:    Translation:Animals
  100. Lerner EA, Lerner MR, Janeway CA, Steitz JA. Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease. Proc Natl Acad Sci U S A. 1981 May; 78(5):2737-41. PMID: 6789322; PMCID: PMC319432.
    Citations: 346     Fields:    Translation:AnimalsCells
  101. Sredni B, Matis LA, Lerner EA, Paul WE, Schwartz RH. Antigen-specific T cell clones restricted to unique F1 major histocompatibility complex determinants. Inhibition of proliferation with monoclonal anti-Ia antibody. J Exp Med. 1981 Mar 01; 153(3):677-93. PMID: 6166704; PMCID: PMC2186099.
    Citations: 13     Fields:    Translation:AnimalsCells
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