Harvard Catalyst Profiles

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Ethan Arthur Lerner, M.D.,Ph.D.

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Mechanisms of Itch [login at prompt]
Available: 03/30/22, Expires: 12/31/24

Itch is the most common symptom in dermatology yet there are few specific treatments. The impact of itch on quality of life matches that of pain. We pair fundamental techniques to gain mechanistic insights with clinical research to identify genetic variants that contribute to itch. We use advanced in vivo imaging and deep sequencing to examine the neuroanatomy and biology of sensory fibers. We use CRISPR to make humanized mice in order to model itch. We welcome the opportunity to generate mice in which skin is genetically labeled, akin to Brainbow mice, to examine interactions between neurons and other skin cells. We are particularly interested in deciphering the role of mas-related G-protein coupled receptors in basic models and in humans. Clinical studies can also be undertaken. These include the itch associated with burns and the use of fractionated laser or cold to treat itch. Writing of in-depth of an in-depth review is welcome.


Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01AR082401 (LERNER, ETHAN A) Dec 6, 2023 - Nov 30, 2028
    NIH
    Neuronal MRGPR signaling in itch and allergic skin inflammation
    Role: Principal Investigator
  2. R21AR067399 (LERNER, ETHAN A) Feb 1, 2015 - Jan 31, 2017
    NIH
    The role of Mrgprs in substance P-induced itch
    Role: Principal Investigator
  3. R13AR065371 (LERNER, ETHAN A) Aug 20, 2013 - Jul 31, 2014
    NIH
    7th World Congress on Itch (WCI)
    Role: Principal Investigator
  4. R01AR057744 (LERNER, ETHAN A) Aug 1, 2010 - Jun 30, 2016
    NIH
    Itch, proteases and protease-activated receptors
    Role: Principal Investigator
  5. U01AI061420 (LERNER, ETHAN A) Jul 1, 2004 - Jun 30, 2008
    NIH
    G-protein coupled receptors for bioagent detection
    Role: Principal Investigator

Bibliographic
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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© 2024 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.