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profileMarjorie Ann Oettinger, Ph.D.

TitleProfessor of Genetics
InstitutionMassachusetts General Hospital
DepartmentGenetics
AddressMassachusetts General Hospital
Simches Research Ctr CPZN# 7240
185 Cambridge St
Boston MA 02114
Phone617/726-5967
Fax617/726-5949
vCardDownload vCard (login for email)

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01AI083510     (OETTINGER, MARJORIE A)Dec 15, 2009 - May 31, 2015
NIH/NIAID
Functional role of RAG2 H3K4me3 interaction in V(D)J recombination
Role: Principal Investigator

R56AI083510     (OETTINGER, MARJORIE A)Jun 5, 2009 - Nov 30, 2009
NIH/NIAID
Functional role of RAG2 H3K4me3 interaction in V(D)J recombination
Role: Principal Investigator

R01DK082711     (OETTINGER, MARJORIE A)Sep 30, 2008 - Aug 31, 2011
NIH/NIDDK
Is symmetrical dimethylation of Arginine 2 of Histone H3 used as an epigenetic si
Role: Principal Investigator

R01GM048026     (OETTINGER, MARJORIE A)Aug 1, 1992 - Feb 28, 2011
NIH/NIGMS
V(D)J Recombination Activating Genes-Functional Analysis
Role: Principal Investigator

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Pulivarthy SR, Lion M, Kuzu G, Matthews AG, Borowsky ML, Morris J, Kingston RE, Dennis JH, Tolstorukov MY, Oettinger MA. Regulated large-scale nucleosome density patterns and precise nucleosome positioning correlate with V(D)J recombination. Proc Natl Acad Sci U S A. 2016 Oct 18; 113(42):E6427-E6436. PMID: 27698124.
    View in: PubMed
  2. Matthews AG, Briggs CE, Yamanaka K, Small TN, Mooster JL, Bonilla FA, Oettinger MA, Butte MJ. Compound heterozygous mutation of Rag1 leading to Omenn syndrome. PLoS One. 2015; 10(4):e0121489. PMID: 25849362; PMCID: PMC4388548.
  3. Balter BB, Ciccone DN, Oettinger MA, Selsing E. Mice lacking Sµ tandem repeats maintain RNA polymerase patterns but exhibit histone modification pattern shifts linked to class switch site locations. Mol Immunol. 2012 Aug; 52(1):1-8. PMID: 22580346; PMCID: PMC3361635.
  4. Yuan CC, Matthews AG, Jin Y, Chen CF, Chapman BA, Ohsumi TK, Glass KC, Kutateladze TG, Borowsky ML, Struhl K, Oettinger MA. Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes. Cell Rep. 2012 Feb 23; 1(2):83-90. PMID: 22720264; PMCID: PMC3377377.
  5. Matthews AG, Oettinger MA. RAG: a recombinase diversified. Nat Immunol. 2009 Aug; 10(8):817-21. PMID: 19621044; PMCID: PMC3773180.
  6. Matthews AG, Oettinger MA. Regulation of RAG transposition. Adv Exp Med Biol. 2009; 650:16-31. PMID: 19731798.
    View in: PubMed
  7. Schatz DG, Oettinger MA, Baltimore D. Pillars article: the V(D)J recombination activating gene, RAG-1. 1989. J Immunol. 2008 Jan 01; 180(1):5-18. PMID: 18096996.
    View in: PubMed
  8. Matthews AG, Kuo AJ, Ramón-Maiques S, Han S, Champagne KS, Ivanov D, Gallardo M, Carney D, Cheung P, Ciccone DN, Walter KL, Utz PJ, Shi Y, Kutateladze TG, Yang W, Gozani O, Oettinger MA. RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature. 2007 Dec 13; 450(7172):1106-10. PMID: 18033247; PMCID: PMC2988437.
  9. Ramón-Maiques S, Kuo AJ, Carney D, Matthews AG, Oettinger MA, Gozani O, Yang W. The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. Proc Natl Acad Sci U S A. 2007 Nov 27; 104(48):18993-8. PMID: 18025461; PMCID: PMC2141896.
  10. Elkin SK, Ivanov D, Ewalt M, Ferguson CG, Hyberts SG, Sun ZY, Prestwich GD, Yuan J, Wagner G, Oettinger MA, Gozani OP. A PHD finger motif in the C terminus of RAG2 modulates recombination activity. J Biol Chem. 2005 Aug 05; 280(31):28701-10. PMID: 15964836.
    View in: PubMed
  11. Dai Y, Wong B, Yen YM, Oettinger MA, Kwon J, Johnson RC. Determinants of HMGB proteins required to promote RAG1/2-recombination signal sequence complex assembly and catalysis during V(D)J recombination. Mol Cell Biol. 2005 Jun; 25(11):4413-25. PMID: 15899848; PMCID: PMC1140611.
  12. Clatworthy AE, Valencia-Burton MA, Haber JE, Oettinger MA. The MRE11-RAD50-XRS2 complex, in addition to other non-homologous end-joining factors, is required for V(D)J joining in yeast. J Biol Chem. 2005 May 27; 280(21):20247-52. PMID: 15757898.
    View in: PubMed
  13. Oettinger MA. Molecular biology: hairpins at split ends in DNA. Nature. 2004 Dec 23; 432(7020):960-1. PMID: 15616542.
    View in: PubMed
  14. Oettinger MA. How to keep V(D)J recombination under control. Immunol Rev. 2004 Aug; 200:165-81. PMID: 15242404.
    View in: PubMed
  15. Patenge N, Elkin SK, Oettinger MA. ATP-dependent remodeling by SWI/SNF and ISWI proteins stimulates V(D)J cleavage of 5 S arrays. J Biol Chem. 2004 Aug 20; 279(34):35360-7. PMID: 15201272.
    View in: PubMed
  16. Matthews AG, Elkin SK, Oettinger MA. Ordered DNA release and target capture in RAG transposition. EMBO J. 2004 Mar 10; 23(5):1198-206. PMID: 14988730; PMCID: PMC380985.
  17. Ciccone DN, Morshead KB, Oettinger MA. Chromatin immunoprecipitation in the analysis of large chromatin domains across murine antigen receptor loci. Methods Enzymol. 2004; 376:334-48. PMID: 14975316.
    View in: PubMed
  18. Ciccone D, Oettinger M. Chromatin modifications as clues to the regulation of antigen receptor assembly. Novartis Found Symp. 2004; 259:146-58; discussion 158-69. PMID: 15171252.
    View in: PubMed
  19. Park EJ, Chan DW, Park JH, Oettinger MA, Kwon J. DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner. Nucleic Acids Res. 2003 Dec 01; 31(23):6819-27. PMID: 14627815; PMCID: PMC290281.
  20. Montalbano A, Ogwaro KM, Tang A, Matthews AG, Larijani M, Oettinger MA, Feeney AJ. V(D)J recombination frequencies can be profoundly affected by changes in the spacer sequence. J Immunol. 2003 Nov 15; 171(10):5296-304. PMID: 14607931.
    View in: PubMed
  21. Morshead KB, Ciccone DN, Taverna SD, Allis CD, Oettinger MA. Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11577-82. PMID: 14500909; PMCID: PMC208800.
  22. Clatworthy AE, Valencia MA, Haber JE, Oettinger MA. V(D)J recombination and RAG-mediated transposition in yeast. Mol Cell. 2003 Aug; 12(2):489-99. PMID: 14536087.
    View in: PubMed
  23. Elkin SK, Matthews AG, Oettinger MA. The C-terminal portion of RAG2 protects against transposition in vitro. EMBO J. 2003 Apr 15; 22(8):1931-8. PMID: 12682025; PMCID: PMC154476.
  24. Dai Y, Kysela B, Hanakahi LA, Manolis K, Riballo E, Stumm M, Harville TO, West SC, Oettinger MA, Jeggo PA. Nonhomologous end joining and V(D)J recombination require an additional factor. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2462-7. PMID: 12604777; PMCID: PMC151363.
  25. Ng HH, Ciccone DN, Morshead KB, Oettinger MA, Struhl K. Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1820-5. PMID: 12574507; PMCID: PMC149917.
  26. Akamatsu Y, Monroe R, Dudley DD, Elkin SK, Gartner F, Talukder SR, Takahama Y, Alt FW, Bassing CH, Oettinger MA. Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):1209-14. PMID: 12531919; PMCID: PMC298752.
  27. Mundy CL, Patenge N, Matthews AG, Oettinger MA. Assembly of the RAG1/RAG2 synaptic complex. Mol Cell Biol. 2002 Jan; 22(1):69-77. PMID: 11739723; PMCID: PMC134220.
  28. O'Driscoll M, Cerosaletti KM, Girard PM, Dai Y, Stumm M, Kysela B, Hirsch B, Gennery A, Palmer SE, Seidel J, Gatti RA, Varon R, Oettinger MA, Neitzel H, Jeggo PA, Concannon P. DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Mol Cell. 2001 Dec; 8(6):1175-85. PMID: 11779494.
    View in: PubMed
  29. Riballo E, Doherty AJ, Dai Y, Stiff T, Oettinger MA, Jeggo PA, Kysela B. Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity. J Biol Chem. 2001 Aug 17; 276(33):31124-32. PMID: 11349135.
    View in: PubMed
  30. Baldwin AS, Oettinger M, Struhl K. Methylation and uracil interference assays for analysis of protein-DNA interactions. Curr Protoc Mol Biol. 2001 May; Chapter 12:Unit 12.3. PMID: 18265086.
    View in: PubMed
  31. Kwon J, Morshead KB, Guyon JR, Kingston RE, Oettinger MA. Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA. Mol Cell. 2000 Nov; 6(5):1037-48. PMID: 11106743.
    View in: PubMed
  32. Kim DR, Park SJ, Oettinger MA. V(D)J recombination: site-specific cleavage and repair. Mol Cells. 2000 Aug 31; 10(4):367-74. PMID: 10987131.
    View in: PubMed
  33. Kim DR, Dai Y, Mundy CL, Yang W, Oettinger MA. Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase. Genes Dev. 1999 Dec 01; 13(23):3070-80. PMID: 10601033; PMCID: PMC317176.
  34. Oettinger MA. V(D)J recombination: on the cutting edge. Curr Opin Cell Biol. 1999 Jun; 11(3):325-9. PMID: 10395566.
    View in: PubMed
  35. Steen SB, Han JO, Mundy C, Oettinger MA, Roth DB. Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination. Mol Cell Biol. 1999 Apr; 19(4):3010-7. PMID: 10082568; PMCID: PMC84095.
  36. Kwon J, Imbalzano AN, Matthews A, Oettinger MA. Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1. Mol Cell. 1998 Dec; 2(6):829-39. PMID: 9885570.
    View in: PubMed
  37. Kirch SA, Rathbun GA, Oettinger MA. Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly. EMBO J. 1998 Aug 17; 17(16):4881-6. PMID: 9707447; PMCID: PMC1170817.
  38. Akamatsu Y, Oettinger MA. Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences. Mol Cell Biol. 1998 Aug; 18(8):4670-8. PMID: 9671477; PMCID: PMC109053.
  39. Kim DR, Oettinger MA. Functional analysis of coordinated cleavage in V(D)J recombination. Mol Cell Biol. 1998 Aug; 18(8):4679-88. PMID: 9671478; PMCID: PMC109054.
  40. Cuomo CA, Mundy CL, Oettinger MA. DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences. Mol Cell Biol. 1996 Oct; 16(10):5683-90. PMID: 8816481; PMCID: PMC231568.
  41. Kirch SA, Sudarsanam P, Oettinger MA. Regions of RAG1 protein critical for V(D)J recombination. Eur J Immunol. 1996 Apr; 26(4):886-91. PMID: 8625984.
    View in: PubMed
  42. Oettinger MA. Cutting apart V(D)J recombination. Curr Opin Genet Dev. 1996 Apr; 6(2):141-5. PMID: 8722168.
    View in: PubMed
  43. Gallay P, Stitt V, Mundy C, Oettinger M, Trono D. Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import. J Virol. 1996 Feb; 70(2):1027-32. PMID: 8551560; PMCID: PMC189908.
  44. McBlane JF, van Gent DC, Ramsden DA, Romeo C, Cuomo CA, Gellert M, Oettinger MA. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell. 1995 Nov 03; 83(3):387-95. PMID: 8521468.
    View in: PubMed
  45. Kirchgessner CU, Patil CK, Evans JW, Cuomo CA, Fried LM, Carter T, Oettinger MA, Brown JM. DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science. 1995 Feb 24; 267(5201):1178-83. PMID: 7855601.
    View in: PubMed
  46. Cuomo CA, Kirch SA, Gyuris J, Brent R, Oettinger MA. Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein. Proc Natl Acad Sci U S A. 1994 Jun 21; 91(13):6156-60. PMID: 8016130; PMCID: PMC44157.
  47. Cuomo CA, Oettinger MA. Analysis of regions of RAG-2 important for V(D)J recombination. Nucleic Acids Res. 1994 May 25; 22(10):1810-4. PMID: 8208604; PMCID: PMC308078.
  48. Oettinger MA. Activation of V(D)J recombination by RAG1 and RAG2. Trends Genet. 1992 Dec; 8(12):413-6. PMID: 1492366.
    View in: PubMed
  49. Schatz DG, Oettinger MA, Schlissel MS. V(D)J recombination: molecular biology and regulation. Annu Rev Immunol. 1992; 10:359-83. PMID: 1590991.
    View in: PubMed
  50. Oettinger MA, Stanger B, Schatz DG, Glaser T, Call K, Housman D, Baltimore D. The recombination activating genes, RAG 1 and RAG 2, are on chromosome 11p in humans and chromosome 2p in mice. Immunogenetics. 1992; 35(2):97-101. PMID: 1735560.
    View in: PubMed
  51. Turka LA, Schatz DG, Oettinger MA, Chun JJ, Gorka C, Lee K, McCormack WT, Thompson CB. Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking. Science. 1991 Aug 16; 253(5021):778-81. PMID: 1831564.
    View in: PubMed
  52. Hendrickson EA, Qin XQ, Bump EA, Schatz DG, Oettinger M, Weaver DT. A link between double-strand break-related repair and V(D)J recombination: the scid mutation. Proc Natl Acad Sci U S A. 1991 May 15; 88(10):4061-5. PMID: 1709732; PMCID: PMC51597.
  53. Carlson LM, Oettinger MA, Schatz DG, Masteller EL, Hurley EA, McCormack WT, Baltimore D, Thompson CB. Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion. Cell. 1991 Jan 11; 64(1):201-8. PMID: 1986866.
    View in: PubMed
  54. Chun JJ, Schatz DG, Oettinger MA, Jaenisch R, Baltimore D. The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system. Cell. 1991 Jan 11; 64(1):189-200. PMID: 1986864.
    View in: PubMed
  55. Oettinger MA, Schatz DG, Gorka C, Baltimore D. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science. 1990 Jun 22; 248(4962):1517-23. PMID: 2360047.
    View in: PubMed
  56. Schatz DG, Oettinger MA, Baltimore D. The V(D)J recombination activating gene, RAG-1. Cell. 1989 Dec 22; 59(6):1035-48. PMID: 2598259.
    View in: PubMed
  57. Oettinger MA, Struhl K. Suppressors of Saccharomyces cerevisiae his3 promoter mutations lacking the upstream element. Mol Cell Biol. 1985 Aug; 5(8):1901-9. PMID: 3018536; PMCID: PMC366906.
  58. Struhl K, Chen W, Hill DE, Hope IA, Oettinger MA. Constitutive and coordinately regulated transcription of yeast genes: promoter elements, positive and negative regulatory sites, and DNA binding proteins. Cold Spring Harb Symp Quant Biol. 1985; 50:489-503. PMID: 3913566.
    View in: PubMed
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