Harvard Catalyst Profiles

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Herminia Diana Rosas, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS114562 (ROSAS, HERMINIA DIANA) Dec 15, 2020 - Nov 30, 2025
    NIH
    Understanding the contribution of altered cerebrovascular function to the pathology and clinical symptoms of Huntington disease
    Role: Principal Investigator
  2. R01NS106384 (ROSAS, HERMINIA DIANA) Sep 15, 2018 - Jun 30, 2023
    NIH
    Huntington's disease: Learning from Extremes
    Role: Principal Investigator
  3. R21NS098407 (ROSAS, HERMINIA DIANA) Apr 1, 2017 - Sep 30, 2020
    NIH
    Using PET to Map Epigenetic Changes in Huntington's Disease.
    Role: Principal Investigator
  4. R21NS081409 (ROSAS, HERMINIA DIANA) Jul 1, 2013 - Jun 30, 2016
    NIH
    Using High Field MRI to Evaluate Metal Dyshomeostasis in Huntington???s Disease
    Role: Principal Investigator
  5. P01NS058793 (HERSCH, STEVEN M) Jun 9, 2008 - Feb 28, 2014
    NIH
    Biomarkers for Huntington's Disease: Accelerating the Development of Therapies
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lai F, Mercaldo ND, Wang CM, Hersch MS, Hersch GG, Rosas HD. Association between Hypothyroidism Onset and Alzheimer Disease Onset in Adults with Down Syndrome. Brain Sci. 2021 Sep 16; 11(9). PMID: 34573243.
    Citations:    
  2. Hom CL, Kirby KA, Ricks-Oddie J, Keator DB, Krinsky-McHale SJ, Pulsifer MB, Rosas HD, Lai F, Schupf N, Lott IT, Silverman W. Cognitive Function during the Prodromal Stage of Alzheimer's Disease in Down Syndrome: Comparing Models. Brain Sci. 2021 Sep 16; 11(9). PMID: 34573242.
    Citations:    
  3. Fagan AM, Henson RL, Li Y, Boerwinkle AH, Xiong C, Bateman RJ, Goate A, Ances BM, Doran E, Christian BT, Lai F, Rosas HD, Schupf N, Krinsky-McHale S, Silverman W, Lee JH, Klunk WE, Handen BL, Allegri RF, Chhatwal JP, Day GS, Graff-Radford NR, Jucker M, Levin J, Martins RN, Masters CL, Mori H, Mummery CJ, Niimi Y, Ringman JM, Salloway S, Schofield PR, Shoji M, Lott IT. Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study. Lancet Neurol. 2021 08; 20(8):615-626. PMID: 34302786.
    Citations: 1     Fields:    Translation:Humans
  4. Chan ST, Mercaldo ND, Kwong KK, Hersch SM, Rosas HD. Impaired Cerebrovascular Reactivity in Huntington's Disease. Front Physiol. 2021; 12:663898. PMID: 34366879.
    Citations:    
  5. Lai F, Mercaldo N, Wang CM, Hersch GG, Rosas HD. Association between Inflammatory Conditions and Alzheimer's Disease Age of Onset in Down Syndrome. J Clin Med. 2021 Jul 15; 10(14). PMID: 34300282.
    Citations:    
  6. Rosas HD, Lewis LR, Mercaldo ND, Nasr S, Brickman AM, Siless V, Yassa M, Sathishkumar M, Lott I, Schupf N, Silverman W, Lai F. Altered connectivity of the default mode network in cognitively stable adults with Down syndrome: "Accelerated aging" or a prelude to Alzheimer's disease? Alzheimers Dement (Amst). 2021; 13(1):e12105. PMID: 34027014.
    Citations:    
  7. Hendrix JA, Airey DC, Britton A, Burke AD, Capone GT, Chavez R, Chen J, Chicoine B, Costa ACS, Dage JL, Doran E, Esbensen A, Evans CL, Faber KM, Foroud TM, Hart S, Haugen K, Head E, Hendrix S, Hillerstrom H, Kishnani PS, Krell K, Ledesma DL, Lai F, Lott I, Ochoa-Lubinoff C, Mason J, Nicodemus-Johnson J, Proctor NK, Pulsifer MB, Revta C, Rosas HD, Rosser TC, Santoro S, Schafer K, Scheidemantel T, Schmitt F, Skotko BG, Stasko MR, Talboy A, Torres A, Wilmes K, Woodward J, Zimmer JA, Feldman HH, Mobley W. Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer's Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study. J Clin Med. 2021 Apr 28; 10(9). PMID: 33924960.
    Citations: 2     
  8. Brownstein MJ, Simon NG, Long JD, Yankey J, Maibach HT, Cudkowicz M, Coffey C, Conwit RA, Lungu C, Anderson KE, Hersch SM, Ecklund DJ, Damiano EM, Itzkowitz DE, Lu S, Chase MK, Shefner JM, McGarry A, Thornell B, Gladden C, Costigan M, O'Suilleabhain P, Marshall FJ, Chesire AM, Deritis P, Adams JL, Hedera P, Lowen K, Rosas HD, Hiller AL, Quinn J, Keith K, Duker AP, Gruenwald C, Molloy A, Jacob C, Factor S, Sperin E, Bega D, Brown ZR, Seeberger LC, Sung VW, Benge M, Kostyk SK, Daley AM, Perlman S, Suski V, Conlon P, Barrett MJ, Lowenhaupt S, Quigg M, Perlmutter JS, Wright BA, Most E, Schwartz GJ, Lamb J, Chuang RS, Singer C, Marder K, Moran JA, Singleton JR, Zorn M, Wall PV, Dubinsky RM, Gray C, Drazinic C. Safety and Tolerability of SRX246, a Vasopressin 1a Antagonist, in Irritable Huntington's Disease Patients-A Randomized Phase 2 Clinical Trial. J Clin Med. 2020 Nov 16; 9(11). PMID: 33207828.
    Citations:    
  9. Rosas HD, Hsu E, Mercaldo ND, Lai F, Pulsifer M, Keator D, Brickman AM, Price J, Yassa M, Hom C, Krinsky-McHale SJ, Silverman W, Lott I, Schupf N. Alzheimer-related altered white matter microstructural integrity in Down syndrome: A model for sporadic AD? Alzheimers Dement (Amst). 2020; 12(1):e12040. PMID: 33204811.
    Citations:    
  10. Rafii MS, Ances BM, Schupf N, Krinsky-McHale SJ, Mapstone M, Silverman W, Lott I, Klunk W, Head E, Christian B, Lai F, Rosas HD, Zaman S, Petersen ME, Strydom A, Fortea J, Handen B, O'Bryant S. The AT(N) framework for Alzheimer's disease in adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12062. PMID: 33134477.
    Citations: 4     
  11. Chan ST, Mercaldo ND, Ravina B, Hersch SM, Rosas HD. Association of Dilated Perivascular Spaces and Disease Severity in Patients With Huntington Disease. Neurology. 2021 02 09; 96(6):e890-e894. PMID: 33106388.
    Citations: 2     Fields:    Translation:Humans
  12. Lao PJ, Gutierrez J, Keator D, Rizvi B, Banerjee A, Igwe KC, Laing KK, Sathishkumar M, Moni F, Andrews H, Krinsky-McHale S, Head E, Lee JH, Lai F, Yassa MA, Rosas HD, Silverman W, Lott IT, Schupf N, Brickman AM. Alzheimer-Related Cerebrovascular Disease in Down Syndrome. Ann Neurol. 2020 12; 88(6):1165-1177. PMID: 32944999.
    Citations: 8     Fields:    Translation:Humans
  13. Lai F, Mhatre PG, Yang Y, Wang MC, Schupf N, Rosas HD. Sex differences in risk of Alzheimer's disease in adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12084. PMID: 32995462.
    Citations: 2     
  14. Pulsifer MB, Evans CL, Hom C, Krinsky-McHale SJ, Silverman W, Lai F, Lott I, Schupf N, Wen J, Rosas HD. Language skills as a predictor of cognitive decline in adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12080. PMID: 32875055.
    Citations: 4     
  15. Handen BL, Lott IT, Christian BT, Schupf N, OBryant S, Mapstone M, Fagan AM, Lee JH, Tudorascu D, Wang MC, Head E, Klunk W, Ances B, Lai F, Zaman S, Krinsky-McHale S, Brickman AM, Rosas HD, Cohen A, Andrews H, Hartley S, Silverman W. The Alzheimer's Biomarker Consortium-Down Syndrome: Rationale and methodology. Alzheimers Dement (Amst). 2020; 12(1):e12065. PMID: 32775597.
    Citations: 12     
  16. Henson RL, Doran E, Christian BT, Handen BL, Klunk WE, Lai F, Lee JH, Rosas HD, Schupf N, Zaman SH, Lott IT, Fagan AM. Cerebrospinal fluid biomarkers of Alzheimer's disease in a cohort of adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12057. PMID: 32671183.
    Citations: 6     
  17. Petersen ME, Zhang F, Schupf N, Krinsky-McHale SJ, Hall J, Mapstone M, Cheema A, Silverman W, Lott I, Rafii MS, Handen B, Klunk W, Head E, Christian B, Foroud T, Lai F, Rosas HD, Zaman S, Ances BM, Wang MC, Tycko B, Lee JH, O'Bryant S. Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study. Alzheimers Dement (Amst). 2020; 12(1):e12039. PMID: 32626817.
    Citations: 6     
  18. Snyder HM, Bain LJ, Brickman AM, Carrillo MC, Esbensen AJ, Espinosa JM, Fernandez F, Fortea J, Hartley SL, Head E, Hendrix J, Kishnani PS, Lai F, Lao P, Lemere C, Mobley W, Mufson EJ, Potter H, Zaman SH, Granholm AC, Rosas HD, Strydom A, Whitten MS, Rafii MS. Further understanding the connection between Alzheimer's disease and Down syndrome. Alzheimers Dement. 2020 07; 16(7):1065-1077. PMID: 32544310.
    Citations: 6     Fields:    Translation:Humans
  19. Claassen DO, Corey-Bloom J, Dorsey ER, Edmondson M, Kostyk SK, LeDoux MS, Reilmann R, Rosas HD, Walker F, Wheelock V, Svrzikapa N, Longo KA, Goyal J, Hung S, Panzara MA. Genotyping single nucleotide polymorphisms for allele-selective therapy in Huntington disease. Neurol Genet. 2020 Jun; 6(3):e430. PMID: 32548276.
    Citations: 1     
  20. Mengel D, Liu W, Glynn RJ, Selkoe DJ, Strydom A, Lai F, Rosas HD, Torres A, Patsiogiannis V, Skotko B, Walsh DM. Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aß42 decrease with age, whereas NT1 tau and NfL increase. Alzheimers Res Ther. 2020 03 19; 12(1):27. PMID: 32192521.
    Citations: 7     Fields:    Translation:Humans
  21. Nasr S, Rosas HD. Impact of Huntington's Disease on Mental Rotation Performance in Motor Pre-Symptomatic Individuals. J Huntingtons Dis. 2019; 8(3):339-356. PMID: 31306138.
    Citations: 1     Fields:    Translation:Humans
  22. Lois C, González I, Izquierdo-García D, Zürcher NR, Wilkens P, Loggia ML, Hooker JM, Rosas HD. Neuroinflammation in Huntington's Disease: New Insights with 11C-PBR28 PET/MRI. ACS Chem Neurosci. 2018 11 21; 9(11):2563-2571. PMID: 29719953.
    Citations: 13     Fields:    Translation:HumansCells
  23. Stephen CD, Hung J, Schifitto G, Hersch SM, Rosas HD. Electrocardiogram Abnormalities Suggest Aberrant Cardiac Conduction in Huntington's Disease. Mov Disord Clin Pract. 2018 May-Jun; 5(3):306-311. PMID: 30363459.
    Citations: 6     
  24. Rosas HD, Wilkens P, Salat DH, Mercaldo ND, Vangel M, Yendiki AY, Hersch SM. Complex spatial and temporally defined myelin and axonal degeneration in Huntington disease. Neuroimage Clin. 2018; 20:236-242. PMID: 30090698.
    Citations: 12     Fields:    Translation:HumansCells
  25. Hersch SM, Schifitto G, Oakes D, Bredlau AL, Meyers CM, Nahin R, Rosas HD. The CREST-E study of creatine for Huntington disease: A randomized controlled trial. Neurology. 2017 Aug 08; 89(6):594-601. PMID: 28701493.
    Citations: 21     Fields:    Translation:Humans
  26. McGarry A, McDermott M, Kieburtz K, de Blieck EA, Beal F, Marder K, Ross C, Shoulson I, Gilbert P, Mallonee WM, Guttman M, Wojcieszek J, Kumar R, LeDoux MS, Jenkins M, Rosas HD, Nance M, Biglan K, Como P, Dubinsky RM, Shannon KM, O'Suilleabhain P, Chou K, Walker F, Martin W, Wheelock VL, McCusker E, Jankovic J, Singer C, Sanchez-Ramos J, Scott B, Suchowersky O, Factor SA, Higgins DS, Molho E, Revilla F, Caviness JN, Friedman JH, Perlmutter JS, Feigin A, Anderson K, Rodriguez R, McFarland NR, Margolis RL, Farbman ES, Raymond LA, Suski V, Kostyk S, Colcher A, Seeberger L, Epping E, Esmail S, Diaz N, Fung WL, Diamond A, Frank S, Hanna P, Hermanowicz N, Dure LS, Cudkowicz M. A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease. Neurology. 2017 Jan 10; 88(2):152-159. PMID: 27913695.
    Citations: 31     Fields:    Translation:Humans
  27. Coutinho AM, Coutu JP, Lindemer ER, Rosas HD, Rosen BR, Salat DH. Differential associations between systemic markers of disease and cortical thickness in healthy middle-aged and older adults. Neuroimage. 2017 02 01; 146:19-27. PMID: 27847345.
    Citations: 3     Fields:    Translation:Humans
  28. Nasr S, Rosas HD. Impact of Visual Corticostriatal Loop Disruption on Neural Processing within the Parahippocampal Place Area. J Neurosci. 2016 10 05; 36(40):10456-10471. PMID: 27707978.
    Citations: 4     Fields:    Translation:Humans
  29. Ryu CW, Coutu JP, Greka A, Rosas HD, Jahng GH, Rosen BR, Salat DH. Differential associations between systemic markers of disease and white matter tissue health in middle-aged and older adults. J Cereb Blood Flow Metab. 2017 Nov; 37(11):3568-3579. PMID: 27298238.
    Citations: 4     Fields:    Translation:HumansCells
  30. Coutu JP, Goldblatt A, Rosas HD, Salat DH. White Matter Changes are Associated with Ventricular Expansion in Aging, Mild Cognitive Impairment, and Alzheimer's Disease. J Alzheimers Dis. 2016; 49(2):329-42. PMID: 26444767.
    Citations: 10     Fields:    Translation:Humans
  31. Yendiki A, Reuter M, Wilkens P, Rosas HD, Fischl B. Joint reconstruction of white-matter pathways from longitudinal diffusion MRI data with anatomical priors. Neuroimage. 2016 Feb 15; 127:277-286. PMID: 26717853.
    Citations: 15     Fields:    Translation:Humans
  32. Pickhardt PJ, Lauder T, Pooler BD, Muñoz Del Rio A, Rosas H, Bruce RJ, Binkley N. Effect of IV contrast on lumbar trabecular attenuation at routine abdominal CT: correlation with DXA and implications for opportunistic osteoporosis screening. Osteoporos Int. 2016 Jan; 27(1):147-52. PMID: 26153046.
    Citations: 18     Fields:    Translation:HumansPHPublic Health
  33. Rosas HD, Doros G, Bhasin S, Thomas B, Gevorkian S, Malarick K, Matson W, Hersch SM. A systems-level "misunderstanding": the plasma metabolome in Huntington's disease. Ann Clin Transl Neurol. 2015 Jul; 2(7):756-68. PMID: 26273688.
    Citations: 13     Fields:    
  34. Lee SH, Coutu JP, Wilkens P, Yendiki A, Rosas HD, Salat DH. Tract-based analysis of white matter degeneration in Alzheimer's disease. Neuroscience. 2015 Aug 20; 301:79-89. PMID: 26026680.
    Citations: 27     Fields:    Translation:Humans
  35. Narayanan KL, Chopra V, Rosas HD, Malarick K, Hersch S. Rho Kinase Pathway Alterations in the Brain and Leukocytes in Huntington's Disease. Mol Neurobiol. 2016 May; 53(4):2132-40. PMID: 25941073.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  36. Ryu SY, Coutu JP, Rosas HD, Salat DH. Effects of insulin resistance on white matter microstructure in middle-aged and older adults. Neurology. 2014 May 27; 82(21):1862-70. PMID: 24771537.
    Citations: 14     Fields:    Translation:HumansCells
  37. Rosas HD, Doros G, Gevorkian S, Malarick K, Reuter M, Coutu JP, Triggs TD, Wilkens PJ, Matson W, Salat DH, Hersch SM. PRECREST: a phase II prevention and biomarker trial of creatine in at-risk Huntington disease. Neurology. 2014 Mar 11; 82(10):850-7. PMID: 24510496.
    Citations: 30     Fields:    Translation:HumansCTClinical Trials
  38. Coutu JP, Chen JJ, Rosas HD, Salat DH. Non-Gaussian water diffusion in aging white matter. Neurobiol Aging. 2014 Jun; 35(6):1412-21. PMID: 24378085.
    Citations: 22     Fields:    Translation:Humans
  39. Moscovitch-Lopatin M, Goodman RE, Eberly S, Ritch JJ, Rosas HD, Matson S, Matson W, Oakes D, Young AB, Shoulson I, Hersch SM. HTRF analysis of soluble huntingtin in PHAROS PBMCs. Neurology. 2013 Sep 24; 81(13):1134-40. PMID: 23966247.
    Citations: 3     Fields:    Translation:HumansCells
  40. Ramos EM, Latourelle JC, Gillis T, Mysore JS, Squitieri F, Di Pardo A, Di Donato S, Gellera C, Hayden MR, Morrison PJ, Nance M, Ross CA, Margolis RL, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Gusella JF, Lee JM, Alonso I, Sequeiros J, Myers RH, Macdonald ME. Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington's disease motor onset. Neurogenetics. 2013 Nov; 14(3-4):173-9. PMID: 23644918.
    Citations: 3     Fields:    Translation:Humans
  41. Chen JJ, Rosas HD, Salat DH. The relationship between cortical blood flow and sub-cortical white-matter health across the adult age span. PLoS One. 2013; 8(2):e56733. PMID: 23437228.
    Citations: 25     Fields:    Translation:HumansCells
  42. Thomas B, Matson S, Chopra V, Sun L, Sharma S, Hersch S, Rosas HD, Scherzer C, Ferrante R, Matson W. A novel method for detecting 7-methyl guanine reveals aberrant methylation levels in Huntington disease. Anal Biochem. 2013 May 15; 436(2):112-20. PMID: 23416183.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  43. Ramos EM, Latourelle JC, Lee JH, Gillis T, Mysore JS, Squitieri F, Di Pardo A, Di Donato S, Hayden MR, Morrison PJ, Nance M, Ross CA, Margolis RL, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Marder K, Gusella JF, Lee JM, Alonso I, Sequeiros J, Myers RH, Macdonald ME. Population stratification may bias analysis of PGC-1a as a modifier of age at Huntington disease motor onset. Hum Genet. 2012 Dec; 131(12):1833-40. PMID: 22825315.
    Citations: 13     Fields:    Translation:HumansCells
  44. Lee JH, Lee JM, Ramos EM, Gillis T, Mysore JS, Kishikawa S, Hadzi T, Hendricks AE, Hayden MR, Morrison PJ, Nance M, Ross CA, Margolis RL, Squitieri F, Gellera C, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Sequeiros J, Landwehrmeyer GB, Shoulson I, Myers RH, MacDonald ME, Gusella JF. TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease. Biochem Biophys Res Commun. 2012 Aug 03; 424(3):404-8. PMID: 22771793.
    Citations: 6     Fields:    Translation:HumansCells
  45. Rosas HD, Chen YI, Doros G, Salat DH, Chen NK, Kwong KK, Bush A, Fox J, Hersch SM. Alterations in brain transition metals in Huntington disease: an evolving and intricate story. Arch Neurol. 2012 Jul; 69(7):887-93. PMID: 22393169.
    Citations: 45     Fields:    Translation:Humans
  46. Reuter M, Schmansky NJ, Rosas HD, Fischl B. Within-subject template estimation for unbiased longitudinal image analysis. Neuroimage. 2012 Jul 16; 61(4):1402-18. PMID: 22430496.
    Citations: 700     Fields:    Translation:Humans
  47. Lee JM, Gillis T, Mysore JS, Ramos EM, Myers RH, Hayden MR, Morrison PJ, Nance M, Ross CA, Margolis RL, Squitieri F, Griguoli A, Di Donato S, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Sequeiros J, MacDonald ME, Gusella JF. Common SNP-based haplotype analysis of the 4p16.3 Huntington disease gene region. Am J Hum Genet. 2012 Mar 09; 90(3):434-44. PMID: 22387017.
    Citations: 29     Fields:    Translation:HumansCells
  48. Lee JM, Ramos EM, Lee JH, Gillis T, Mysore JS, Hayden MR, Warby SC, Morrison P, Nance M, Ross CA, Margolis RL, Squitieri F, Orobello S, Di Donato S, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Sequeiros J, Paulsen JS, Landwehrmeyer GB, Myers RH, MacDonald ME, Gusella JF. CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion. Neurology. 2012 Mar 06; 78(10):690-5. PMID: 22323755.
    Citations: 121     Fields:    Translation:HumansCells
  49. Hu Y, Chopra V, Chopra R, Locascio JJ, Liao Z, Ding H, Zheng B, Matson WR, Ferrante RJ, Rosas HD, Hersch SM, Scherzer CR. Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):17141-6. PMID: 21969577.
    Citations: 38     Fields:    Translation:HumansAnimalsCTClinical Trials
  50. Chen JJ, Salat DH, Rosas HD. Complex relationships between cerebral blood flow and brain atrophy in early Huntington's disease. Neuroimage. 2012 Jan 16; 59(2):1043-51. PMID: 21945790.
    Citations: 20     Fields:    Translation:Humans
  51. Rosas HD, Reuter M, Doros G, Lee SY, Triggs T, Malarick K, Fischl B, Salat DH, Hersch SM. A tale of two factors: what determines the rate of progression in Huntington's disease? A longitudinal MRI study. Mov Disord. 2011 Aug 01; 26(9):1691-7. PMID: 21611979.
    Citations: 17     Fields:    Translation:HumansCells
  52. Moscovitch-Lopatin M, Weiss A, Rosas HD, Ritch J, Doros G, Kegel KB, Difiglia M, Kuhn R, Bilbe G, Paganetti P, Hersch S. Optimization of an HTRF Assay for the Detection of Soluble Mutant Huntingtin in Human Buffy Coats: A Potential Biomarker in Blood for Huntington Disease. PLoS Curr. 2010 Dec 29; 2:RRN1205. PMID: 21278900.
    Citations: 8     
  53. Chen JJ, Rosas HD, Salat DH. Age-associated reductions in cerebral blood flow are independent from regional atrophy. Neuroimage. 2011 Mar 15; 55(2):468-78. PMID: 21167947.
    Citations: 143     Fields:    Translation:Humans
  54. Weiss A, Grueninger S, Abramowski D, Giorgio FP, Lopatin MM, Rosas HD, Hersch S, Paganetti P. Microtiter plate quantification of mutant and wild-type huntingtin normalized to cell count. Anal Biochem. 2011 Mar 15; 410(2):304-6. PMID: 21134349.
    Citations: 11     Fields:    Translation:HumansCells
  55. Bechtel N, Scahill RI, Rosas HD, Acharya T, van den Bogaard SJ, Jauffret C, Say MJ, Sturrock A, Johnson H, Onorato CE, Salat DH, Durr A, Leavitt BR, Roos RA, Landwehrmeyer GB, Langbehn DR, Stout JC, Tabrizi SJ, Reilmann R. Tapping linked to function and structure in premanifest and symptomatic Huntington disease. Neurology. 2010 Dec 14; 75(24):2150-60. PMID: 21068430.
    Citations: 40     Fields:    Translation:HumansCells
  56. Salat DH, Chen JJ, van der Kouwe AJ, Greve DN, Fischl B, Rosas HD. Hippocampal degeneration is associated with temporal and limbic gray matter/white matter tissue contrast in Alzheimer's disease. Neuroimage. 2011 Feb 01; 54(3):1795-802. PMID: 20965261.
    Citations: 30     Fields:    Translation:HumansCells
  57. Reuter M, Rosas HD, Fischl B. Highly accurate inverse consistent registration: a robust approach. Neuroimage. 2010 Dec; 53(4):1181-96. PMID: 20637289.
    Citations: 415     Fields:    Translation:Humans
  58. Kim J, Amante DJ, Moody JP, Edgerly CK, Bordiuk OL, Smith K, Matson SA, Matson WR, Scherzer CR, Rosas HD, Hersch SM, Ferrante RJ. Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease. Biochim Biophys Acta. 2010 Jul-Aug; 1802(7-8):673-81. PMID: 20460152.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  59. Salat DH, Tuch DS, van der Kouwe AJ, Greve DN, Pappu V, Lee SY, Hevelone ND, Zaleta AK, Growdon JH, Corkin S, Fischl B, Rosas HD. White matter pathology isolates the hippocampal formation in Alzheimer's disease. Neurobiol Aging. 2010 Feb; 31(2):244-56. PMID: 18455835.
    Citations: 131     Fields:    Translation:HumansCells
  60. Rosas HD, Lee SY, Bender AC, Zaleta AK, Vangel M, Yu P, Fischl B, Pappu V, Onorato C, Cha JH, Salat DH, Hersch SM. Altered white matter microstructure in the corpus callosum in Huntington's disease: implications for cortical "disconnection". Neuroimage. 2010 Feb 15; 49(4):2995-3004. PMID: 19850138.
    Citations: 98     Fields:    Translation:HumansCells
  61. Weiss A, Abramowski D, Bibel M, Bodner R, Chopra V, DiFiglia M, Fox J, Kegel K, Klein C, Grueninger S, Hersch S, Housman D, Régulier E, Rosas HD, Stefani M, Zeitlin S, Bilbe G, Paganetti P. Single-step detection of mutant huntingtin in animal and human tissues: a bioassay for Huntington's disease. Anal Biochem. 2009 Dec 01; 395(1):8-15. PMID: 19664996.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  62. Tabrizi SJ, Langbehn DR, Leavitt BR, Roos RA, Durr A, Craufurd D, Kennard C, Hicks SL, Fox NC, Scahill RI, Borowsky B, Tobin AJ, Rosas HD, Johnson H, Reilmann R, Landwehrmeyer B, Stout JC. Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data. Lancet Neurol. 2009 Sep; 8(9):791-801. PMID: 19646924.
    Citations: 317     Fields:    Translation:HumansCTClinical Trials
  63. Salat DH, Lee SY, van der Kouwe AJ, Greve DN, Fischl B, Rosas HD. Age-associated alterations in cortical gray and white matter signal intensity and gray to white matter contrast. Neuroimage. 2009 Oct 15; 48(1):21-8. PMID: 19580876.
    Citations: 106     Fields:    Translation:HumansCells
  64. Brocklebank D, Gayán J, Andresen JM, Roberts SA, Young AB, Snodgrass SR, Penney JB, Ramos-Arroyo MA, Cha JJ, Rosas HD, Hersch SM, Feigin A, Cherny SS, Wexler NS, Housman DE, Cardon LR. Repeat instability in the 27-39 CAG range of the HD gene in the Venezuelan kindreds: Counseling implications. Am J Med Genet B Neuropsychiatr Genet. 2009 Apr 05; 150B(3):425-9. PMID: 18712713.
    Citations: 5     Fields:    Translation:HumansCells
  65. Rosas HD, Salat DH, Lee SY, Zaleta AK, Hevelone N, Hersch SM. Complexity and heterogeneity: what drives the ever-changing brain in Huntington's disease? Ann N Y Acad Sci. 2008 Dec; 1147:196-205. PMID: 19076442.
    Citations: 19     Fields:    Translation:Humans
  66. Liu W, Kennington LA, Rosas HD, Hersch S, Cha JH, Zamore PD, Aronin N. Linking SNPs to CAG repeat length in Huntington's disease patients. Nat Methods. 2008 Nov; 5(11):951-3. PMID: 18931668.
    Citations: 17     Fields:    Translation:HumansCells
  67. Dickerson BC, Bakkour A, Salat DH, Feczko E, Pacheco J, Greve DN, Grodstein F, Wright CI, Blacker D, Rosas HD, Sperling RA, Atri A, Growdon JH, Hyman BT, Morris JC, Fischl B, Buckner RL. The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals. Cereb Cortex. 2009 Mar; 19(3):497-510. PMID: 18632739.
    Citations: 391     Fields:    Translation:Humans
  68. Nectoux J, Bahi-Buisson N, Guellec I, Coste J, De Roux N, Rosas H, Tardieu M, Chelly J, Bienvenu T. The p.Val66Met polymorphism in the BDNF gene protects against early seizures in Rett syndrome. Neurology. 2008 May 27; 70(22 Pt 2):2145-51. PMID: 18434641.
    Citations: 15     Fields:    Translation:Humans
  69. Hersch SM, Rosas HD. Neuroprotection for Huntington's disease: ready, set, slow. Neurotherapeutics. 2008 Apr; 5(2):226-36. PMID: 18394565.
    Citations: 13     Fields:    Translation:Humans
  70. Rosas HD, Salat DH, Lee SY, Zaleta AK, Pappu V, Fischl B, Greve D, Hevelone N, Hersch SM. Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity. Brain. 2008 Apr; 131(Pt 4):1057-68. PMID: 18337273.
    Citations: 166     Fields:    Translation:Humans
  71. Hinds O, Polimeni JR, Rajendran N, Balasubramanian M, Wald LL, Augustinack JC, Wiggins G, Rosas HD, Fischl B, Schwartz EL. The intrinsic shape of human and macaque primary visual cortex. Cereb Cortex. 2008 Nov; 18(11):2586-95. PMID: 18308709.
    Citations: 17     Fields:    Translation:HumansAnimals
  72. Grodstein F, van Oijen M, Irizarry MC, Rosas HD, Hyman BT, Growdon JH, De Vivo I. Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the nurses' health study. PLoS One. 2008 Feb 13; 3(2):e1590. PMID: 18795148.
    Citations: 47     Fields:    Translation:HumansCells
  73. Rosas HD, Tuch DS, Hevelone ND, Zaleta AK, Vangel M, Hersch SM, Salat DH. Diffusion tensor imaging in presymptomatic and early Huntington's disease: Selective white matter pathology and its relationship to clinical measures. Mov Disord. 2006 Sep; 21(9):1317-25. PMID: 16755582.
    Citations: 128     Fields:    Translation:HumansCells
  74. Salat DH, Smith EE, Tuch DS, Benner T, Pappu V, Schwab KM, Gurol ME, Rosas HD, Rosand J, Greenberg SM. White matter alterations in cerebral amyloid angiopathy measured by diffusion tensor imaging. Stroke. 2006 Jul; 37(7):1759-64. PMID: 16763176.
    Citations: 28     Fields:    Translation:Humans
  75. Hersch SM, Gevorkian S, Marder K, Moskowitz C, Feigin A, Cox M, Como P, Zimmerman C, Lin M, Zhang L, Ulug AM, Beal MF, Matson W, Bogdanov M, Ebbel E, Zaleta A, Kaneko Y, Jenkins B, Hevelone N, Zhang H, Yu H, Schoenfeld D, Ferrante R, Rosas HD. Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG. Neurology. 2006 Jan 24; 66(2):250-2. PMID: 16434666.
    Citations: 93     Fields:    Translation:Humans
  76. Salat DH, Tuch DS, Hevelone ND, Fischl B, Corkin S, Rosas HD, Dale AM. Age-related changes in prefrontal white matter measured by diffusion tensor imaging. Ann N Y Acad Sci. 2005 Dec; 1064:37-49. PMID: 16394146.
    Citations: 129     Fields:    Translation:HumansCells
  77. Rosas HD, Hevelone ND, Zaleta AK, Greve DN, Salat DH, Fischl B. Regional cortical thinning in preclinical Huntington disease and its relationship to cognition. Neurology. 2005 Sep 13; 65(5):745-7. PMID: 16157910.
    Citations: 113     Fields:    Translation:HumansCells
  78. Tuch DS, Salat DH, Wisco JJ, Zaleta AK, Hevelone ND, Rosas HD. Choice reaction time performance correlates with diffusion anisotropy in white matter pathways supporting visuospatial attention. Proc Natl Acad Sci U S A. 2005 Aug 23; 102(34):12212-7. PMID: 16103359.
    Citations: 122     Fields:    Translation:Humans
  79. Ryu H, Rosas HD, Hersch SM, Ferrante RJ. The therapeutic role of creatine in Huntington's disease. Pharmacol Ther. 2005 Nov; 108(2):193-207. PMID: 16055197.
    Citations: 17     Fields:    Translation:HumansAnimals
  80. Borovecki F, Lovrecic L, Zhou J, Jeong H, Then F, Rosas HD, Hersch SM, Hogarth P, Bouzou B, Jensen RV, Krainc D. Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):11023-8. PMID: 16043692.
    Citations: 150     Fields:    Translation:HumansCells
  81. Hogarth P, Kayson E, Kieburtz K, Marder K, Oakes D, Rosas D, Shoulson I, Wexler N, Young AB, Zhao H. A study of inter-rater reliability of the motor diagnosis of Huntington’s disease. Movement Disorders. 2005; Dec 6(xx):xx.
  82. Salat DH, Tuch DS, Greve DN, van der Kouwe AJ, Hevelone ND, Zaleta AK, Rosen BR, Fischl B, Corkin S, Rosas HD, Dale AM. Age-related alterations in white matter microstructure measured by diffusion tensor imaging. Neurobiol Aging. 2005 Aug-Sep; 26(8):1215-27. PMID: 15917106.
    Citations: 328     Fields:    Translation:HumansCells
  83. Rosas HD, Feigin AS, Hersch SM. Using advances in neuroimaging to detect, understand, and monitor disease progression in Huntington's disease. NeuroRx. 2004 Apr; 1(2):263-72. PMID: 15717027.
    Citations: 18     Fields:    Translation:Humans
  84. The US-Venezuela Collaborative Research Project . Venezuelan kindreds reveal that genetic and environmental factors modulate Huntingotn’s disease age of onset. Proc Natl Aca Sci USA. 2004; 101(10):3498-503.
  85. Rosas HD, Koroshetz WJ, Chen YI, Skeuse C, Vangel M, Cudkowicz ME, Caplan K, Marek K, Seidman LJ, Makris N, Jenkins BG, Goldstein JM. Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis. Neurology. 2003 May 27; 60(10):1615-20. PMID: 12771251.
    Citations: 144     Fields:    Translation:Humans
  86. Rosas HD, Liu AK, Hersch S, Glessner M, Ferrante RJ, Salat DH, van der Kouwe A, Jenkins BG, Dale AM, Fischl B. Regional and progressive thinning of the cortical ribbon in Huntington's disease. Neurology. 2002 Mar 12; 58(5):695-701. PMID: 11889230.
    Citations: 381     Fields:    Translation:Humans
  87. Sperling R, Greve D, Dale A, Killiany R, Holmes J, Rosas HD, Cocchiarella A, Firth P, Rosen B, Lake S, Lange N, Routledge C, Albert M. Functional MRI detection of pharmacologically induced memory impairment. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):455-60. PMID: 11756667.
    Citations: 60     Fields:    Translation:Humans
  88. Hersch SM, Rosas HD. 10 most commonly asked questions about Huntington's disease. Neurologist. 2001 Nov; 7(6):364-8. PMID: 14649632.
    Citations:    Fields:    
  89. Rosas HD, Goodman J, Chen YI, Jenkins BG, Kennedy DN, Makris N, Patti M, Seidman LJ, Beal MF, Koroshetz WJ. Striatal volume loss in HD as measured by MRI and the influence of CAG repeat. Neurology. 2001 Sep 25; 57(6):1025-8. PMID: 11571328.
    Citations: 54     Fields:    Translation:HumansCells
  90. Hersch SM, Rosas HD. Neuroprotective therapy for Huntington's disease: new prospects and challenges. Expert Rev Neurother. 2001 Sep; 1(1):111-8. PMID: 19811052.
    Citations:    Fields:    
  91. Rosas HD, Koroshetz WJ, Jenkins BG, Chen YI, Hayden DL, Beal MF, Cudkowicz ME. Riluzole therapy in Huntington's disease (HD). Mov Disord. 1999 Mar; 14(2):326-30. PMID: 10091628.
    Citations: 14     Fields:    Translation:HumansCTClinical Trials
  92. Jenkins BG, Chen YI, Kuestermann E, Makris NM, Nguyen TV, Kraft E, Brownell AL, Rosas HD, Kennedy DN, Rosen BR, Koroshetz WJ, Beal MF. An integrated strategy for evaluation of metabolic and oxidative defects in neurodegenerative illness using magnetic resonance techniques. Ann N Y Acad Sci. 1999; 893:214-42. PMID: 10672240.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  93. Counter SA, Buchanan LH, Rosas HD, Ortega F. Neurocognitive effects of chronic lead intoxication in Andean children. J Neurol Sci. 1998 Sep 18; 160(1):47-53. PMID: 9804116.
    Citations: 9     Fields:    Translation:HumansPHPublic Health
  94. Jenkins BG, Rosas HD, Chen YC, Makabe T, Myers R, MacDonald M, Rosen BR, Beal MF, Koroshetz WJ. 1H NMR spectroscopy studies of Huntington's disease: correlations with CAG repeat numbers. Neurology. 1998 May; 50(5):1357-65. PMID: 9595987.
    Citations: 50     Fields:    Translation:HumansCells
  95. Carter BS, Ogilvy CS, Candia GJ, Rosas HD, Buonanno F. One-year outcome after decompressive surgery for massive nondominant hemispheric infarction. Neurosurgery. 1997 Jun; 40(6):1168-75; discussion 1175-6. PMID: 9179889.
    Citations: 38     Fields:    Translation:Humans
  96. Cher LM, Hochberg FH, Teruya J, Nitschke M, Valenzuela RF, Schmahmann JD, Herbert M, Rosas HD, Stowell C. Therapy for paraneoplastic neurologic syndromes in six patients with protein A column immunoadsorption. Cancer. 1995 Apr 01; 75(7):1678-83. PMID: 8826927.
    Citations: 17     Fields:    Translation:Humans
  97. Ruprecht RM, Gama-Sosa MA, Rosas HD. Combination therapy after retroviral inoculation. Lancet. 1988 Jan 30; 1(8579):239-40. PMID: 2893060.
    Citations: 4     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.