Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Christoph Lange, Ph.D.

Co-Author

This page shows the publications co-authored by Christoph Lange and Edwin Silverman.
Connection Strength

4.253
  1. Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain. Genet Epidemiol. 2021 10; 45(7):685-693.
    View in: PubMed
    Score: 0.243
  2. Unsupervised cluster analysis of SARS-CoV-2 genomes indicates that recent (June 2020) cases in Beijing are from a genetic subgroup that consists of mostly European and South(east) Asian samples, of which the latter are the most recent. bioRxiv. 2020 Jun 30.
    View in: PubMed
    Score: 0.227
  3. A flexible and nearly optimal sequential testing approach to randomized testing: QUICK-STOP. Genet Epidemiol. 2020 03; 44(2):139-147.
    View in: PubMed
    Score: 0.217
  4. Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. Am J Respir Crit Care Med. 2019 09 15; 200(6):677-690.
    View in: PubMed
    Score: 0.215
  5. On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows. Genet Epidemiol. 2017 05; 41(4):332-340.
    View in: PubMed
    Score: 0.181
  6. Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. J Cachexia Sarcopenia Muscle. 2017 Jun; 8(3):428-436.
    View in: PubMed
    Score: 0.178
  7. On the simultaneous association analysis of large genomic regions: a massive multi-locus association test. Bioinformatics. 2014 Jan 15; 30(2):157-64.
    View in: PubMed
    Score: 0.143
  8. 'Location, Location, Location': a spatial approach for rare variant analysis and an application to a study on non-syndromic cleft lip with or without cleft palate. Bioinformatics. 2012 Dec 01; 28(23):3027-33.
    View in: PubMed
    Score: 0.133
  9. On the follow-up of genome-wide association studies: an overall test for the most promising SNPs. Genet Epidemiol. 2011 Jul; 35(5):303-9.
    View in: PubMed
    Score: 0.119
  10. Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet. 2010 Mar; 42(3):200-2.
    View in: PubMed
    Score: 0.111
  11. On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies. PLoS Genet. 2009 Nov; 5(11):e1000741.
    View in: PubMed
    Score: 0.109
  12. Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. Am J Hum Genet. 2009 Oct; 85(4):493-502.
    View in: PubMed
    Score: 0.108
  13. On the replication of genetic associations: timing can be everything! Am J Hum Genet. 2008 Apr; 82(4):849-58.
    View in: PubMed
    Score: 0.097
  14. Testing and estimating gene-environment interactions in family-based association studies. Biometrics. 2008 Jun; 64(2):458-67.
    View in: PubMed
    Score: 0.094
  15. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Aug; 3(6):502.
    View in: PubMed
    Score: 0.086
  16. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet. 2006 Feb; 78(2):253-64.
    View in: PubMed
    Score: 0.083
  17. Genomic screening and replication using the same data set in family-based association testing. Nat Genet. 2005 Jul; 37(7):683-91.
    View in: PubMed
    Score: 0.080
  18. Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Am J Respir Cell Mol Biol. 2005 Jul; 33(1):71-8.
    View in: PubMed
    Score: 0.079
  19. Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004 Dec 15; 170(12):1294-301.
    View in: PubMed
    Score: 0.076
  20. A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects. Stat Appl Genet Mol Biol. 2004; 3:Article17.
    View in: PubMed
    Score: 0.075
  21. The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet. 2004 Aug 01; 13(15):1649-56.
    View in: PubMed
    Score: 0.074
  22. PBAT: tools for family-based association studies. Am J Hum Genet. 2004 Feb; 74(2):367-9.
    View in: PubMed
    Score: 0.073
  23. Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program. J Allergy Clin Immunol. 2003 Nov; 112(5):870-6.
    View in: PubMed
    Score: 0.071
  24. Using the noninformative families in family-based association tests: a powerful new testing strategy. Am J Hum Genet. 2003 Oct; 73(4):801-11.
    View in: PubMed
    Score: 0.071
  25. A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics. 2003 Apr; 4(2):195-206.
    View in: PubMed
    Score: 0.069
  26. A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies. Hum Hered. 2003; 56(1-3):10-7.
    View in: PubMed
    Score: 0.067
  27. locStra: Fast analysis of regional/global stratification in whole-genome sequencing studies. Genet Epidemiol. 2021 02; 45(1):82-98.
    View in: PubMed
    Score: 0.058
  28. metaFARVAT: An Efficient Tool for Meta-Analysis of Family-Based, Case-Control, and Population-Based Rare Variant Association Studies. Front Genet. 2019; 10:572.
    View in: PubMed
    Score: 0.053
  29. Whole-Genome Sequencing in Severe Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2018 11; 59(5):614-622.
    View in: PubMed
    Score: 0.051
  30. Whole exome sequencing analysis in severe chronic obstructive pulmonary disease. Hum Mol Genet. 2018 11 01; 27(21):3801-3812.
    View in: PubMed
    Score: 0.051
  31. Gene-based segregation method for identifying rare variants in family-based sequencing studies. Genet Epidemiol. 2017 05; 41(4):309-319.
    View in: PubMed
    Score: 0.045
  32. Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 06 15; 193(12):1353-63.
    View in: PubMed
    Score: 0.043
  33. Utilizing the Jaccard index to reveal population stratification in sequencing data: a simulation study and an application to the 1000 Genomes Project. Bioinformatics. 2016 05 01; 32(9):1366-72.
    View in: PubMed
    Score: 0.042
  34. A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. BMC Genet. 2015 Dec 03; 16:138.
    View in: PubMed
    Score: 0.041
  35. Using Network Methodology to Infer Population Substructure. PLoS One. 2015; 10(6):e0130708.
    View in: PubMed
    Score: 0.040
  36. Integrating Multiple Correlated Phenotypes for Genetic Association Analysis by Maximizing Heritability. Hum Hered. 2015; 79(2):93-104.
    View in: PubMed
    Score: 0.040
  37. Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2014 Nov; 51(5):678-87.
    View in: PubMed
    Score: 0.038
  38. Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci. Hum Mol Genet. 2015 Feb 15; 24(4):1200-10.
    View in: PubMed
    Score: 0.038
  39. Beyond GWAS in COPD: probing the landscape between gene-set associations, genome-wide associations and protein-protein interaction networks. Hum Hered. 2014; 78(3-4):131-9.
    View in: PubMed
    Score: 0.038
  40. Quantitative computed tomography measures of pectoralis muscle area and disease severity in chronic obstructive pulmonary disease. A cross-sectional study. Ann Am Thorac Soc. 2014 Mar; 11(3):326-34.
    View in: PubMed
    Score: 0.037
  41. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med. 2014 Mar; 2(3):214-25.
    View in: PubMed
    Score: 0.036
  42. Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility. Hum Genet. 2013 Apr; 132(4):431-41.
    View in: PubMed
    Score: 0.034
  43. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet. 2012 Feb 15; 21(4):947-57.
    View in: PubMed
    Score: 0.031
  44. Association of SERPINE2 with asthma. Chest. 2011 Sep; 140(3):667-674.
    View in: PubMed
    Score: 0.030
  45. Combining disease models to test for gene-environment interaction in nuclear families. Biometrics. 2011 Dec; 67(4):1260-70.
    View in: PubMed
    Score: 0.030
  46. Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):304-10.
    View in: PubMed
    Score: 0.029
  47. Asthma-susceptibility variants identified using probands in case-control and family-based analyses. BMC Med Genet. 2010 Aug 10; 11:122.
    View in: PubMed
    Score: 0.029
  48. Stronger evidence for replication of NPPA using genome-wide genotyping data. Am J Respir Crit Care Med. 2010 Jan 01; 181(1):96.
    View in: PubMed
    Score: 0.027
  49. MMP12, lung function, and COPD in high-risk populations. N Engl J Med. 2009 Dec 31; 361(27):2599-608.
    View in: PubMed
    Score: 0.027
  50. Parsing the effects of individual SNPs in candidate genes with family data. Hum Hered. 2010; 69(2):91-103.
    View in: PubMed
    Score: 0.027
  51. Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet. 2009 May; 84(5):581-93.
    View in: PubMed
    Score: 0.026
  52. Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. Am J Respir Crit Care Med. 2009 Jun 15; 179(12):1084-90.
    View in: PubMed
    Score: 0.026
  53. Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood. J Allergy Clin Immunol. 2007 Jul; 120(1):84-90.
    View in: PubMed
    Score: 0.023
  54. The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet. 2007 Apr 27; 3(4):e61.
    View in: PubMed
    Score: 0.023
  55. Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes. Am J Respir Crit Care Med. 2005 Sep 15; 172(6):687-92.
    View in: PubMed
    Score: 0.020
  56. The IL12B gene is associated with asthma. Am J Hum Genet. 2004 Oct; 75(4):709-15.
    View in: PubMed
    Score: 0.019
  57. Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med. 2004 Nov 15; 170(10):1057-65.
    View in: PubMed
    Score: 0.019
  58. TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples. Am J Respir Crit Care Med. 2004 Sep 15; 170(6):594-600.
    View in: PubMed
    Score: 0.019
  59. ADAM33 polymorphisms and phenotype associations in childhood asthma. J Allergy Clin Immunol. 2004 Jun; 113(6):1071-8.
    View in: PubMed
    Score: 0.019
  60. IL10 gene polymorphisms are associated with asthma phenotypes in children. Genet Epidemiol. 2004 Feb; 26(2):155-65.
    View in: PubMed
    Score: 0.018
  61. Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes. Hum Mol Genet. 2003 Aug 15; 12(16):1973-9.
    View in: PubMed
    Score: 0.018
  62. Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program. Genet Epidemiol. 2002 Nov; 23(4):335-48.
    View in: PubMed
    Score: 0.017
  63. Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes. Am J Respir Crit Care Med. 2002 Dec 01; 166(11):1449-56.
    View in: PubMed
    Score: 0.017
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.