Harvard Catalyst Profiles

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Jyoti Chauhan, Ph.D.

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Harvard Medical School, BostonPostdoctoral Reseach FellowOrganic and Medicinal Chemistry
Brigham Women's Hospital, BostonPostdoctoral Reseach FellowOrganic and Medicinal Chemistry
Northeastern University, BostonPostdoctoral Reseach Associate02/2023Organic and Medicinal Chemistry
Shiv Nadar University, Delhi, IndiaPh.D.07/2020Organic Chemistry

My research has focused on the identification and early optimization of compounds (synthetic and medicinally), most significantly for discoveries and translation of medicine from Engineering in Medicine against cancer diseases. I dedicated all my career efforts to development as an organic and medicinal chemist. Throughout my career, I gained experience in various aspects of drug discovery: from hit discovery, to hit-to-lead optimization, to the design and optimization of pre-scale-up syntheses. I have spent ten years working for drug discovery and medicinal chemistry. With a background in drug discovery, I have a strong desire to see scientific innovations translated into successful treatments to benefit patients in need. I have developed a strong experience of working in diversity-oriented synthesis strategy for generating libraries of molecules, carbohydrate chemistry and metal-mediated C-H activation reactions, radical chemistry. Besides that, I handled in vitro screening of compounds and biochemical assays against cancer cell lines and have hand-on experience on in vitro ADME and DMPK studies. I have extensively learned characterization techniques which are required for organic chemistry.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.