Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Yves Boucher, Ph.D.

Co-Author

This page shows the publications co-authored by Yves Boucher and Rakesh Jain.
Connection Strength

8.154
  1. Bevacizumab improves tumor infiltration of mature dendritic cells and effector T-cells in triple-negative breast cancer patients. NPJ Precis Oncol. 2021 Jun 29; 5(1):62.
    View in: PubMed
    Score: 0.979
  2. Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy. Proc Natl Acad Sci U S A. 2019 05 28; 116(22):10674-10680.
    View in: PubMed
    Score: 0.211
  3. Intratumoral infusion of fluid: estimation of hydraulic conductivity and implications for the delivery of therapeutic agents. Br J Cancer. 1998 Dec; 78(11):1442-8.
    View in: PubMed
    Score: 0.205
  4. Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2. Sci Transl Med. 2018 03 14; 10(432).
    View in: PubMed
    Score: 0.195
  5. Use of Angiotensin System Inhibitors Is Associated with Immune Activation and Longer Survival in Nonmetastatic Pancreatic Ductal Adenocarcinoma. Clin Cancer Res. 2017 Oct 01; 23(19):5959-5969.
    View in: PubMed
    Score: 0.185
  6. Interstitial fluid pressure in intracranial tumours in patients and in rodents. Br J Cancer. 1997; 75(6):829-36.
    View in: PubMed
    Score: 0.179
  7. Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity. Cold Spring Harb Perspect Med. 2016 Dec 01; 6(12).
    View in: PubMed
    Score: 0.178
  8. Corrigendum: Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity. Cold Spring Harb Perspect Med. 2016 12 01; 6(12).
    View in: PubMed
    Score: 0.178
  9. Solid stress and elastic energy as measures of tumour mechanopathology. Nat Biomed Eng. 2016; 1.
    View in: PubMed
    Score: 0.178
  10. Tumor angiogenesis and interstitial hypertension. Cancer Res. 1996 Sep 15; 56(18):4264-6.
    View in: PubMed
    Score: 0.176
  11. Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy. Cancer Discov. 2016 08; 6(8):852-69.
    View in: PubMed
    Score: 0.172
  12. Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):14325-30.
    View in: PubMed
    Score: 0.165
  13. Lack of general correlation between interstitial fluid pressure and oxygen partial pressure in solid tumors. Microvasc Res. 1995 Sep; 50(2):175-82.
    View in: PubMed
    Score: 0.163
  14. Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy. J Natl Cancer Inst. 2015 Apr; 107(4).
    View in: PubMed
    Score: 0.158
  15. Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. Cancer Cell. 2014 Jul 14; 26(1):14-5.
    View in: PubMed
    Score: 0.151
  16. Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels. Nat Commun. 2013; 4:2516.
    View in: PubMed
    Score: 0.136
  17. Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse. Cancer Res. 1992 Sep 15; 52(18):5110-4.
    View in: PubMed
    Score: 0.133
  18. Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors. Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):15101-8.
    View in: PubMed
    Score: 0.133
  19. Effects of sorafenib on intra-tumoral interstitial fluid pressure and circulating biomarkers in patients with refractory sarcomas (NCI protocol 6948). PLoS One. 2012; 7(2):e26331.
    View in: PubMed
    Score: 0.128
  20. Interstitial hypertension in superficial metastatic melanomas in humans. Cancer Res. 1991 Dec 15; 51(24):6691-4.
    View in: PubMed
    Score: 0.126
  21. Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev. 2011 Jul; 91(3):1071-121.
    View in: PubMed
    Score: 0.122
  22. Safety, Efficacy, and Biomarker Exploration in a Phase II Study of Bevacizumab, Oxaliplatin, and Gemcitabine in Recurrent Müllerian Carcinoma. Clin Ovarian Cancer Other Gynecol Malig. 2011 Jun; 4(1):26-33.
    View in: PubMed
    Score: 0.122
  23. Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors. Cancer Res. 2011 Jul 01; 71(13):4527-38.
    View in: PubMed
    Score: 0.121
  24. Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2909-14.
    View in: PubMed
    Score: 0.119
  25. Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies. Annu Rev Chem Biomol Eng. 2011; 2:281-98.
    View in: PubMed
    Score: 0.118
  26. Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy. Cancer Res. 1990 Aug 01; 50(15):4478-84.
    View in: PubMed
    Score: 0.115
  27. Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo. Biophys J. 2009 Jul 08; 97(1):330-6.
    View in: PubMed
    Score: 0.107
  28. Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. J Clin Oncol. 2009 Jun 20; 27(18):3020-6.
    View in: PubMed
    Score: 0.106
  29. Mathematical modeling of herpes simplex virus distribution in solid tumors: implications for cancer gene therapy. Clin Cancer Res. 2009 Apr 01; 15(7):2352-60.
    View in: PubMed
    Score: 0.105
  30. In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts. Nat Methods. 2009 Feb; 6(2):143-5.
    View in: PubMed
    Score: 0.103
  31. Correlation of blood and physiologic markers with effect of bevacizumab (BV) with chemoradiation therapy in rectal cancer (RC). J Clin Oncol. 2008 May 20; 26(15_suppl):4096.
    View in: PubMed
    Score: 0.099
  32. Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors. Cancer Res. 2008 May 15; 68(10):3795-802.
    View in: PubMed
    Score: 0.099
  33. Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus. Cancer Res. 2007 Nov 15; 67(22):10664-8.
    View in: PubMed
    Score: 0.095
  34. Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors. Cancer Res. 2007 Jun 01; 67(11):5076-82.
    View in: PubMed
    Score: 0.092
  35. Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer. Nat Clin Pract Oncol. 2007 May; 4(5):316-21.
    View in: PubMed
    Score: 0.092
  36. Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice. Semin Oncol. 2006 Oct; 33(5 Suppl 10):S35-40.
    View in: PubMed
    Score: 0.088
  37. Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector. Cancer Res. 2006 Mar 01; 66(5):2509-13.
    View in: PubMed
    Score: 0.085
  38. Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line. Cancer Res. 2005 Jul 01; 65(13):5674-82.
    View in: PubMed
    Score: 0.081
  39. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res. 2004 Jun 01; 64(11):3731-6.
    View in: PubMed
    Score: 0.075
  40. Measurement of macromolecular diffusion coefficients in human tumors. Microvasc Res. 2004 May; 67(3):231-6.
    View in: PubMed
    Score: 0.075
  41. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med. 2004 Feb; 10(2):145-7.
    View in: PubMed
    Score: 0.073
  42. Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors. Nat Med. 2004 Feb; 10(2):203-7.
    View in: PubMed
    Score: 0.073
  43. Correspondence re: S. Maula et al., intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinoma of the head and neck. Cancer Res., 63: 1920-1926, 2003. Cancer Res. 2003 Dec 01; 63(23):8555-6; author reply 8558.
    View in: PubMed
    Score: 0.072
  44. Irradiation reduces interstitial fluid transport and increases the collagen content in tumors. Clin Cancer Res. 2003 Nov 15; 9(15):5508-13.
    View in: PubMed
    Score: 0.072
  45. Solid stress generated by spheroid growth estimated using a linear poroelasticity model. Microvasc Res. 2003 Nov; 66(3):204-12.
    View in: PubMed
    Score: 0.072
  46. Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation. Nat Med. 2003 Jun; 9(6):796-800.
    View in: PubMed
    Score: 0.070
  47. Diffusion and convection in collagen gels: implications for transport in the tumor interstitium. Biophys J. 2002 Sep; 83(3):1650-60.
    View in: PubMed
    Score: 0.066
  48. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science. 2002 Jun 07; 296(5574):1883-6.
    View in: PubMed
    Score: 0.065
  49. Solid stress facilitates spheroid formation: potential involvement of hyaluronan. Br J Cancer. 2002 Mar 18; 86(6):947-53.
    View in: PubMed
    Score: 0.064
  50. LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis. Cancer Res. 2001 Nov 15; 61(22):8079-84.
    View in: PubMed
    Score: 0.063
  51. Decorin inhibits endothelial migration and tube-like structure formation: role of thrombospondin-1. Microvasc Res. 2001 Jul; 62(1):26-42.
    View in: PubMed
    Score: 0.061
  52. Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4628-33.
    View in: PubMed
    Score: 0.060
  53. Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res. 2000 Oct 01; 60(19):5565-70.
    View in: PubMed
    Score: 0.058
  54. Oncotic pressure in solid tumors is elevated. Cancer Res. 2000 Aug 01; 60(15):4251-5.
    View in: PubMed
    Score: 0.057
  55. Mechanics of interstitial-lymphatic fluid transport: theoretical foundation and experimental validation. J Biomech. 1999 Dec; 32(12):1297-307.
    View in: PubMed
    Score: 0.055
  56. Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor beta1. Nat Med. 1999 Oct; 5(10):1203-8.
    View in: PubMed
    Score: 0.054
  57. Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications. Cancer Res. 1999 Aug 01; 59(15):3776-82.
    View in: PubMed
    Score: 0.054
  58. Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial. JAMA Oncol. 2019 Jul 01; 5(7):1020-1027.
    View in: PubMed
    Score: 0.053
  59. FOLFOX plus ziv-aflibercept or placebo in first-line metastatic esophagogastric adenocarcinoma: A double-blind, randomized, multicenter phase 2 trial. Cancer. 2019 07 01; 125(13):2213-2221.
    View in: PubMed
    Score: 0.052
  60. Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3137-42.
    View in: PubMed
    Score: 0.052
  61. Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases. Sci Transl Med. 2016 10 12; 8(360):360ra135.
    View in: PubMed
    Score: 0.044
  62. Noninvasive Assessment of Losartan-Induced Increase in Functional Microvasculature and Drug Delivery in Pancreatic Ductal Adenocarcinoma. Transl Oncol. 2016 Oct; 9(5):431-437.
    View in: PubMed
    Score: 0.044
  63. Reduction of interstitial fluid pressure after TNF-alpha treatment of three human melanoma xenografts. Br J Cancer. 1996 Aug; 74(4):533-6.
    View in: PubMed
    Score: 0.044
  64. Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity. Microvasc Res. 1996 Jul; 52(1):27-46.
    View in: PubMed
    Score: 0.043
  65. Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft. Cancer Res. 1996 Mar 01; 56(5):964-68.
    View in: PubMed
    Score: 0.042
  66. Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery. Cancer Res. 1995 Nov 15; 55(22):5451-8.
    View in: PubMed
    Score: 0.041
  67. Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: network analysis and mechanistic interpretation. Microvasc Res. 1995 Nov; 50(3):429-43.
    View in: PubMed
    Score: 0.041
  68. Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows. Cancer Res. 1994 Sep 01; 54(17):4564-8.
    View in: PubMed
    Score: 0.038
  69. A phase 1/2 and biomarker study of preoperative short course chemoradiation with proton beam therapy and capecitabine followed by early surgery for resectable pancreatic ductal adenocarcinoma. Int J Radiat Oncol Biol Phys. 2014 Jul 15; 89(4):830-8.
    View in: PubMed
    Score: 0.037
  70. Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline. Br J Cancer. 1994 Mar; 69(3):492-6.
    View in: PubMed
    Score: 0.037
  71. Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft. Cancer Res. 1993 Oct 15; 53(20):4764-6.
    View in: PubMed
    Score: 0.036
  72. Effect of angiotensin II induced hypertension on tumor blood flow and interstitial fluid pressure. Cancer Res. 1993 Jun 01; 53(11):2466-8.
    View in: PubMed
    Score: 0.035
  73. Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. Cancer Res. 1992 Dec 01; 52(23):6553-60.
    View in: PubMed
    Score: 0.034
  74. Interstitial hypertension in human breast and colorectal tumors. Cancer Res. 1992 Nov 15; 52(22):6371-4.
    View in: PubMed
    Score: 0.034
  75. TGF-ß blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):16618-23.
    View in: PubMed
    Score: 0.033
  76. Nicotinamide can lower tumor interstitial fluid pressure: mechanistic and therapeutic implications. Cancer Res. 1992 Jun 01; 52(11):3237-40.
    View in: PubMed
    Score: 0.033
  77. Mechanical compression drives cancer cells toward invasive phenotype. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):911-6.
    View in: PubMed
    Score: 0.032
  78. Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response. Cancer Res. 1991 Dec 15; 51(24):6695-8.
    View in: PubMed
    Score: 0.032
  79. Do the dietary supplements epigallocatechin gallate or vitamin e cause a radiomodifying response on tumors in vivo? A pilot study with murine breast carcinoma. J Soc Integr Oncol. 2007; 5(1):11-7.
    View in: PubMed
    Score: 0.022
  80. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. J Clin Oncol. 2005 Nov 01; 23(31):8136-9.
    View in: PubMed
    Score: 0.021
  81. Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts. Cancer Res. 2001 Jan 01; 61(1):39-44.
    View in: PubMed
    Score: 0.015
  82. Effects of needle insertion in tumors on interstitial fluid pressure. Microvasc Res. 1997 Sep; 54(2):174-7.
    View in: PubMed
    Score: 0.012
  83. Effect of hemodilution and resuscitation on tumor interstitial fluid pressure, blood flow, and oxygenation. Microvasc Res. 1994 Jul; 48(1):1-12.
    View in: PubMed
    Score: 0.009
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.