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Nikolaos Patikas, Ph.D.

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University of Cambridge, United KingdomPhD10/2023Clinical Neuroscience
University of Ioannina, GreeceMeng07/2017Computer Science and Engineering

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My work utilizes single-cell technologies to elucidate the genetic regulation mechanisms of the human genome. Specifically, I am interested in understanding how human neurons regulate their gene expression to maintain cellular homeostasis and how these mechanisms are perturbed in neurodegenerative disorders. My work spans both experimental aspects of genetic screening and stem cell models as well as computational method development for genomic datasets. To this end, I seek to combine high-throughput CRISPR genetic screening in stem cell models of neurodegeneration and develop the necessary computational frameworks to analyze and integrate large volumes of single-cell datasets.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.