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Anna Aldovini, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI140914 (ALDOVINI, ANNA) Jun 1, 2018 - May 31, 2021
    NIH
    Macrophage lineage SIV persistence and latency during suppressive ART in Macaques
    Role: Principal Investigator
  2. R56AI120723 (ALDOVINI, ANNA) Aug 11, 2016 - Dec 31, 2018
    NIH
    Role of the GI microbiome in immune responses to oral SIV-DNA+SIV-polio Vaccine
    Role: Principal Investigator
  3. R01DE026325 (ALDOVINI, ANNA) Aug 1, 2016 - Jun 30, 2021
    NIH
    Prophylactic oral vaccination for SIV and SHIV infections and AIDS prevention
    Role: Principal Investigator
  4. R01AI110293 (ALDOVINI, ANNA) Mar 1, 2014 - Feb 29, 2020
    NIH
    Role of p38 MAPK activation in AIDS pathogenesis
    Role: Principal Investigator
  5. R21AI106540 (ALDOVINI, ANNA) Aug 8, 2013 - Jul 31, 2016
    NIH
    In vivo suppression of SIV-mediated immune activation
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Agostinis P, Vianello V, Dereani E, Caruso G, Montessoro B, Taurian M, Di Chiara A, Patruno V, Cavallin F, Fadini GP, Aldovini A, Baritussio A, Curcio F, Tascini C, Baritussio A. Response to a massive SARS-CoV-2 infection in a nursing home transformed into a caring center. Aging Clin Exp Res. 2021 Feb; 33(2):443-450. PMID: 33506312.
    Citations:    Fields:    Translation:Humans
  2. Chaudhary O, Wang L, Bose D, Narayan V, Yeh MT, Carville A, Clements JD, Andino R, Kozlowski PA, Aldovini A. Comparative Evaluation of Prophylactic SIV Vaccination Modalities Administered to the Oral Cavity. AIDS Res Hum Retroviruses. 2020 12; 36(12):984-997. PMID: 32962398.
    Citations:    Fields:    
  3. Kozlowski PA, Aldovini A. Mucosal Vaccine Approaches for Prevention of HIV and SIV Transmission. Curr Immunol Rev. 2019; 15(1):102-122. PMID: 31452652.
    Citations: 7     
  4. Chaudhary O, Narayan V, Lelis F, Linz B, Watkins M, Veazey R, Aldovini A. Inhibition of p38 MAPK in combination with ART reduces SIV-induced immune activation and provides additional protection from immune system deterioration. PLoS Pathog. 2018 08; 14(8):e1007268. PMID: 30161247.
    Citations:    Fields:    Translation:AnimalsCells
  5. Aldovini A. Mucosal Vaccination for Prevention of HIV Infection and AIDS. Curr HIV Res. 2016; 14(3):247-59. PMID: 26957199.
    Citations: 5     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  6. Kukkonen S, Martinez-Viedma Mdel P, Kim N, Manrique M, Aldovini A. HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells. Retrovirology. 2014 Apr 17; 11:30. PMID: 24742347.
    Citations: 11     Fields:    Translation:HumansCells
  7. Manrique M, Kozlowski PA, Cobo-Molinos A, Wang SW, Wilson RL, Martinez-Viedma Mdel P, Montefiori DC, Carville A, Aldovini A. Resistance to infection, early and persistent suppression of simian immunodeficiency virus SIVmac251 viremia, and significant reduction of tissue viral burden after mucosal vaccination in female rhesus macaques. J Virol. 2014 Jan; 88(1):212-24. PMID: 24155376.
    Citations: 14     Fields:    Translation:AnimalsCells
  8. Kim N, Kukkonen S, Martinez-Viedma Mdel P, Gupta S, Aldovini A. Tat engagement of p38 MAP kinase and IRF7 pathways leads to activation of interferon-stimulated genes in antigen-presenting cells. Blood. 2013 May 16; 121(20):4090-100. PMID: 23535064.
    Citations: 14     Fields:    Translation:HumansCells
  9. Manrique M, Kozlowski PA, Cobo-Molinos A, Wang SW, Wilson RL, Montefiori DC, Carville A, Aldovini A. Immunogenicity of a vaccine regimen composed of simian immunodeficiency virus DNA, rMVA, and viral particles administered to female rhesus macaques via four different mucosal routes. J Virol. 2013 Apr; 87(8):4738-50. PMID: 23408627.
    Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
  10. Manrique M, Kozlowski PA, Cobo-Molinos A, Wang SW, Wilson RL, Montefiori DC, Mansfield KG, Carville A, Aldovini A. Long-term control of simian immunodeficiency virus mac251 viremia to undetectable levels in half of infected female rhesus macaques nasally vaccinated with simian immunodeficiency virus DNA/recombinant modified vaccinia virus Ankara. J Immunol. 2011 Mar 15; 186(6):3581-93. PMID: 21317390.
    Citations: 23     Fields:    Translation:AnimalsCells
  11. Kim N, Kukkonen S, Gupta S, Aldovini A. Association of Tat with promoters of PTEN and PP2A subunits is key to transcriptional activation of apoptotic pathways in HIV-infected CD4+ T cells. PLoS Pathog. 2010 Sep 16; 6(9):e1001103. PMID: 20862322.
    Citations: 30     Fields:    Translation:HumansCells
  12. Manrique M, Kozlowski PA, Wang SW, Wilson RL, Micewicz E, Montefiori DC, Mansfield KG, Carville A, Aldovini A. Nasal DNA-MVA SIV vaccination provides more significant protection from progression to AIDS than a similar intramuscular vaccination. Mucosal Immunol. 2009 Nov; 2(6):536-50. PMID: 19741603.
    Citations: 43     Fields:    Translation:AnimalsCells
  13. Abbadessa G, Accolla R, Aiuti F, Albini A, Aldovini A, Alfano M, Antonelli G, Bartholomew C, Bentwich Z, Bertazzoni U, Berzofsky JA, Biberfeld P, Boeri E, Buonaguro L, Buonaguro FM, Bukrinsky M, Burny A, Caruso A, Cassol S, Chandra P, Ceccherini-Nelli L, Chieco-Bianchi L, Clerici M, Colombini-Hatch S, de Giuli Morghen C, de Maria A, de Rossi A, Dierich M, Della-Favera R, Dolei A, Douek D, Erfle V, Felber B, Fiorentini S, Franchini G, Gershoni JM, Gotch F, Green P, Greene WC, Hall W, Haseltine W, Jacobson S, Kallings LO, Kalyanaraman VS, Katinger H, Khalili K, Klein G, Klein E, Klotman M, Klotman P, Kotler M, Kurth R, Lafeuillade A, La Placa M, Lewis J, Lillo F, Lisziewicz J, Lomonico A, Lopalco L, Lori F, Lusso P, Macchi B, Malim M, Margolis L, Markham PD, McClure M, Miller N, Mingari MC, Moretta L, Noonan D, O'Brien S, Okamoto T, Pal R, Palese P, Panet A, Pantaleo G, Pavlakis G, Pistello M, Plotkin S, Poli G, Pomerantz R, Radaelli A, Robertguroff M, Roederer M, Sarngadharan MG, Schols D, Secchiero P, Shearer G, Siccardi A, Stevenson M, Svoboda J, Tartaglia J, Torelli G, Tornesello ML, Tschachler E, Vaccarezza M, Vallbracht A, van Lunzen J, Varnier O, Vicenzi E, von Melchner H, Witz I, Zagury D, Zagury JF, Zauli G, Zipeto D. Unsung hero Robert C. Gallo. Science. 2009 Jan 09; 323(5911):206-7. PMID: 19131607.
    Citations:    Fields:    Translation:HumansCells
  14. Dabrowska A, Kim N, Aldovini A. Tat-induced FOXO3a is a key mediator of apoptosis in HIV-1-infected human CD4+ T lymphocytes. J Immunol. 2008 Dec 15; 181(12):8460-77. PMID: 19050264.
    Citations: 33     Fields:    Translation:HumansCells
  15. Manrique M, Micewicz E, Kozlowski PA, Wang SW, Aurora D, Wilson RL, Ghebremichael M, Mazzara G, Montefiori D, Carville A, Mansfield KG, Aldovini A. DNA-MVA vaccine protection after X4 SHIV challenge in macaques correlates with day-of-challenge antiviral CD4+ cell-mediated immunity levels and postchallenge preservation of CD4+ T cell memory. AIDS Res Hum Retroviruses. 2008 Mar; 24(3):505-19. PMID: 18373436.
    Citations: 19     Fields:    Translation:AnimalsCells
  16. Kim N, Dabrowska A, Jenner RG, Aldovini A. Human and simian immunodeficiency virus-mediated upregulation of the apoptotic factor TRAIL occurs in antigen-presenting cells from AIDS-susceptible but not from AIDS-resistant species. J Virol. 2007 Jul; 81(14):7584-97. PMID: 17494085.
    Citations: 23     Fields:    Translation:AnimalsCells
  17. Wang SW, Bertley FM, Kozlowski PA, Herrmann L, Manson K, Mazzara G, Piatak M, Johnson RP, Carville A, Mansfield K, Aldovini A. An SHIV DNA/MVA rectal vaccination in macaques provides systemic and mucosal virus-specific responses and protection against AIDS. AIDS Res Hum Retroviruses. 2004 Aug; 20(8):846-59. PMID: 15320989.
    Citations: 21     Fields:    Translation:AnimalsCells
  18. Bertley FM, Kozlowski PA, Wang SW, Chappelle J, Patel J, Sonuyi O, Mazzara G, Montefiori D, Carville A, Mansfield KG, Aldovini A. Control of simian/human immunodeficiency virus viremia and disease progression after IL-2-augmented DNA-modified vaccinia virus Ankara nasal vaccination in nonhuman primates. J Immunol. 2004 Mar 15; 172(6):3745-57. PMID: 15004179.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  19. Wang SW, Noonan K, Aldovini A. Nucleocapsid-RNA interactions are essential to structural stability but not to assembly of retroviruses. J Virol. 2004 Jan; 78(2):716-23. PMID: 14694103.
    Citations: 24     Fields:    Translation:HumansCells
  20. Patel J, Wang SW, Izmailova E, Aldovini A. The simian immunodeficiency virus 5' untranslated leader sequence plays a role in intracellular viral protein accumulation and in RNA packaging. J Virol. 2003 Jun; 77(11):6284-92. PMID: 12743285.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  21. Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A. HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. Nat Med. 2003 Feb; 9(2):191-7. PMID: 12539042.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  22. Wang SW, Aldovini A. RNA incorporation is critical for retroviral particle integrity after cell membrane assembly of Gag complexes. J Virol. 2002 Dec; 76(23):11853-65. PMID: 12414928.
    Citations: 32     Fields:    Translation:HumansCells
  23. Izmailova E, Aldovini A. Functional analysis of the murine sarcoma virus RNA packaging sequence. J Virol. 2002 May; 76(9):4643-8. PMID: 11932430.
    Citations: 1     Fields:    Translation:AnimalsCells
  24. Krogstad P, Geng YZ, Rey O, Canon J, Ibarrondo FJ, Ackerson B, Patel J, Aldovini A. Human immunodeficiency virus nucleocapsid protein polymorphisms modulate the infectivity of RNA packaging mutants. Virology. 2002 Mar 15; 294(2):282-8. PMID: 12009869.
    Citations: 2     Fields:    Translation:HumansCells
  25. Migliore G, Rossi E, Aldovini A, Mudu P, Alderisio M, Giovagnoli MR, Fabiano A, Morosini PL, Branca M. Variation in the assessment of adequacy in cervical smears. Cytopathology. 2001 Dec; 12(6):377-82. PMID: 11843939.
    Citations:    Fields:    Translation:HumansPHPublic Health
  26. Branca M, Rossi E, Cedri C, Migliore G, Cedri S, Aldovini A, Leoncini L, Bonelli L, Montanari G, Navone R. [Personnel training for a population screening program for cervical carcinoma]. Pathologica. 2001 Jun; 93(3):233-41. PMID: 11433619.
    Citations:    Fields:    Translation:HumansPHPublic Health
  27. Wang SW, Kozlowski PA, Schmelz G, Manson K, Wyand MS, Glickman R, Montefiori D, Lifson JD, Johnson RP, Neutra MR, Aldovini A. Effective induction of simian immunodeficiency virus-specific systemic and mucosal immune responses in primates by vaccination with proviral DNA producing intact but noninfectious virions. J Virol. 2000 Nov; 74(22):10514-22. PMID: 11044096.
    Citations: 25     Fields:    Translation:AnimalsCellsPHPublic Health
  28. Jabbar IA, Fernando GJ, Saunders N, Aldovini A, Young R, Malcolm K, Frazer IH. Immune responses induced by BCG recombinant for human papillomavirus L1 and E7 proteins. Vaccine. 2000 May 08; 18(22):2444-53. PMID: 10738102.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  29. Leung NJ, Aldovini A, Young R, Jarvis MA, Smith JM, Meyer D, Anderson DE, Carlos MP, Gardner MB, Torres JV. The kinetics of specific immune responses in rhesus monkeys inoculated with live recombinant BCG expressing SIV Gag, Pol, Env, and Nef proteins. Virology. 2000 Mar 01; 268(1):94-103. PMID: 10683331.
    Citations: 8     Fields:    Translation:AnimalsCellsPHPublic Health
  30. Poon DT, Li G, Aldovini A. Nucleocapsid and matrix protein contributions to selective human immunodeficiency virus type 1 genomic RNA packaging. J Virol. 1998 Mar; 72(3):1983-93. PMID: 9499052.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  31. Coggi G, Bulfamante G, Romeo M, Falleni M, Aldovini A, Cirillo G, Federico D, Roncalli M. Impact of the Pathfinder in a cytology laboratory. Acta Cytol. 1997 Jan-Feb; 41(1):166-72. PMID: 9022740.
    Citations:    Fields:    Translation:HumansPHPublic Health
  32. Poon DT, Wu J, Aldovini A. Charged amino acid residues of human immunodeficiency virus type 1 nucleocapsid p7 protein involved in RNA packaging and infectivity. J Virol. 1996 Oct; 70(10):6607-16. PMID: 8794295.
    Citations: 87     Fields:    Translation:HumansCells
  33. Murray PJ, Aldovini A, Young RA. Manipulation and potentiation of antimycobacterial immunity using recombinant bacille Calmette-Guérin strains that secrete cytokines. Proc Natl Acad Sci U S A. 1996 Jan 23; 93(2):934-9. PMID: 8570663.
    Citations: 46     Fields:    Translation:AnimalsCells
  34. Tsomides TJ, Aldovini A, Johnson RP, Walker BD, Young RA, Eisen HN. Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1. J Exp Med. 1994 Oct 01; 180(4):1283-93. PMID: 7523570.
    Citations: 74     Fields:    Translation:HumansCells
  35. O'Donnell MA, Aldovini A, Duda RB, Yang H, Szilvasi A, Young RA, DeWolf WC. Recombinant Mycobacterium bovis BCG secreting functional interleukin-2 enhances gamma interferon production by splenocytes. Infect Immun. 1994 Jun; 62(6):2508-14. PMID: 8188376.
    Citations: 35     Fields:    Translation:AnimalsCells
  36. Aldovini A, Husson RN, Young RA. The uraA locus and homologous recombination in Mycobacterium bovis BCG. J Bacteriol. 1993 Nov; 175(22):7282-9. PMID: 8226675.
    Citations: 26     Fields:    Translation:Cells
  37. Aldovini A, Young RA. Humoral and cell-mediated immune responses to live recombinant BCG-HIV vaccines. Nature. 1991 Jun 06; 351(6326):479-82. PMID: 2046750.
    Citations: 84     Fields:    Translation:AnimalsCellsPHPublic Health
  38. Aldovini A, Young RA, Palker TJ. New AIDS vaccine candidates: antigen delivery and design. AIDS. 1991; 5 Suppl 2:S151-8. PMID: 1845045.
    Citations:    Fields:    Translation:Cells
  39. Aldovini A, Young RA. Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus. J Virol. 1990 May; 64(5):1920-6. PMID: 2109098.
    Citations: 258     Fields:    Translation:AnimalsCells
  40. Yamamoto H, Miller MD, Tsubota H, Watkins DI, Mazzara GP, Stallard V, Panicali DL, Aldovini A, Young RA, Letvin NL. Studies of cloned simian immunodeficiency virus-specific T lymphocytes. gag-specific cytotoxic T lymphocytes exhibit a restricted epitope specificity. J Immunol. 1990 May 01; 144(9):3385-91. PMID: 1691757.
    Citations: 15     Fields:    Translation:AnimalsCells
  41. Aldovini A, Young RA. Development of a BCG recombinant vehicle for candidate AIDS vaccines. Int Rev Immunol. 1990; 7(1):79-83. PMID: 2132881.
    Citations: 3     Fields:    Translation:Cells
  42. Walker BD, Flexner C, Birch-Limberger K, Fisher L, Paradis TJ, Aldovini A, Young R, Moss B, Schooley RT. Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type 1. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9514-8. PMID: 2480604.
    Citations: 97     Fields:    Translation:HumansCells
  43. Gurgo C, Guo HG, Franchini G, Aldovini A, Collalti E, Farrell K, Wong-Staal F, Gallo RC, Reitz MS. Envelope sequences of two new United States HIV-1 isolates. Virology. 1988 Jun; 164(2):531-6. PMID: 3369091.
    Citations: 52     Fields:    Translation:Cells
  44. Franchini G, Robert-Guroff M, Aldovini A, Kan NC, Wong-Staal F. Spectrum of natural antibodies against five HTLV-III antigens in infected individuals: correlation of antibody prevalence with clinical status. Blood. 1987 Feb; 69(2):437-41. PMID: 3467797.
    Citations: 11     Fields:    Translation:HumansCells
  45. Feinberg MB, Jarrett RF, Aldovini A, Gallo RC, Wong-Staal F. HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA. Cell. 1986 Sep 12; 46(6):807-17. PMID: 3638988.
    Citations: 288     Fields:    Translation:AnimalsCells
  46. Aldovini A, Debouck C, Feinberg MB, Rosenberg M, Arya SK, Wong-Staal F. Synthesis of the complete trans-activation gene product of human T-lymphotropic virus type III in Escherichia coli: demonstration of immunogenicity in vivo and expression in vitro. Proc Natl Acad Sci U S A. 1986 Sep; 83(18):6672-6. PMID: 3018743.
    Citations: 27     Fields:    Translation:HumansCells
  47. De Rossi A, Franchini G, Aldovini A, Del Mistro A, Chieco-Bianchi L, Gallo RC, Wong-Staal F. Differential response to the cytopathic effects of human T-cell lymphotropic virus type III (HTLV-III) superinfection in T4+ (helper) and T8+ (suppressor) T-cell clones transformed by HTLV-I. Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4297-301. PMID: 2424024.
    Citations: 22     Fields:    Translation:HumansCells
  48. Fisher AG, Feinberg MB, Josephs SF, Harper ME, Marselle LM, Reyes G, Gonda MA, Aldovini A, Debouk C, Gallo RC, et al. The trans-activator gene of HTLV-III is essential for virus replication. Nature. 1986 Mar 27-Apr 2; 320(6060):367-71. PMID: 3007995.
    Citations: 215     Fields:    Translation:Cells
  49. Del Mistro A, De Rossi A, Aldovini A, Salmi R, Chieco-Bianchi L. Immortalization of human T lymphocytes by HTLV-I: phenotypic characteristics of target cells and kinetics of virus integration and expression. Leuk Res. 1986; 10(9):1109-20. PMID: 3020320.
    Citations: 2     Fields:    Translation:HumansCells
  50. Aldovini A, De Rossi A, Feinberg MB, Wong-Staal F, Franchini G. Molecular analysis of a deletion mutant provirus of type I human T-cell lymphotropic virus: evidence for a doubly spliced x-lor mRNA. Proc Natl Acad Sci U S A. 1986 Jan; 83(1):38-42. PMID: 3001724.
    Citations: 13     Fields:    Translation:Cells
  51. Sodroski JG, Goh WC, Rosen CA, Salahuddin SZ, Aldovini A, Franchini G, Wong-Staal F, Gallo RC, Sugamura K, Hinuma Y, et al. trans-Activation of the human T-cell leukemia virus long terminal repeat correlates with expression of the x-lor protein. J Virol. 1985 Sep; 55(3):831-5. PMID: 2991599.
    Citations: 15     Fields:    Translation:Cells
  52. de Rossi A, Aldovini A, Franchini G, Mann D, Gallo RC, Wong-Staal F. Clonal selection of T lymphocytes infected by cell-free human T-cell leukemia/lymphoma virus type I: parameters of virus integration and expression. Virology. 1985 Jun; 143(2):640-5. PMID: 2998031.
    Citations: 16     Fields:    Translation:HumansCells
  53. Chieco-Bianchi L, Aldovini A, Ronchese F, De Rossi A, Majone F, Montaldi A, Levis AG. Short- and long-term studies on chemical carcinogenesis in BALB/Mo mice. Toxicol Pathol. 1984; 12(4):361-8. PMID: 6335923.
    Citations:    Fields:    Translation:AnimalsCells
  54. Aldovini A, Ronchese F. Different susceptibility of BALB/Mo and BALB/c mice to cytogenetic damage induced by urethan. Tumori. 1983 Oct 31; 69(5):387-90. PMID: 6649067.
    Citations:    Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.