Harvard Catalyst Profiles

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Sven M Lange, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kalogeropulou AF, Purlyte E, Tonelli F, Lange SM, Wightman M, Prescott AR, Padmanabhan S, Sammler E, Alessi DR. Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding. Biochem J. 2022 09 16; 479(17):1759-1783. PMID: 35950872; PMCID: PMC9472821.
    Citations: 1     Fields:    Translation:HumansCells
  2. Millrine D, Cummings T, Matthews SP, Peter JJ, Magnussen HM, Lange SM, Macartney T, Lamoliatte F, Knebel A, Kulathu Y. Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation. Cell Rep. 2022 08 02; 40(5):111168. PMID: 35926457; PMCID: PMC9638016.
    Citations: 1     Fields:    Translation:HumansCells
  3. Lange SM, Kulathu Y. Purification, crystallization and drug screening of the IRAK pseudokinases. Methods Enzymol. 2022; 667:101-121. PMID: 35525539.
    Citations:    Fields:    Translation:Cells
  4. Lange SM, Armstrong LA, Kulathu Y. Deubiquitinases: From mechanisms to their inhibition by small molecules. Mol Cell. 2022 01 06; 82(1):15-29. PMID: 34813758.
    Citations: 18     Fields:    Translation:HumansCells
  5. Abdul Rehman SA, Armstrong LA, Lange SM, Kristariyanto YA, Gräwert TW, Knebel A, Svergun DI, Kulathu Y. Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2. Mol Cell. 2021 10 21; 81(20):4176-4190.e6. PMID: 34529927; PMCID: PMC8550791.
    Citations: 3     Fields:    Translation:HumansCells
  6. Lange SM, Kulathu Y. Linking K29-Ub chains to biology. Nat Chem Biol. 2021 08; 17(8):843-844. PMID: 34239126.
    Citations:    Fields:    Translation:Cells
  7. Armstrong LA, Lange SM, Dee Cesare V, Matthews SP, Nirujogi RS, Cole I, Hope A, Cunningham F, Toth R, Mukherjee R, Bojkova D, Gruber F, Gray D, Wyatt PG, Cinatl J, Dikic I, Davies P, Kulathu Y. Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies. PLoS One. 2021; 16(7):e0253364. PMID: 34270554; PMCID: PMC8284666.
    Citations: 17     Fields:    Translation:HumansCells
  8. Lange SM, Nelen MI, Cohen P, Kulathu Y. Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation. Structure. 2021 03 04; 29(3):238-251.e4. PMID: 33238146; PMCID: PMC7955167.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  9. Lokaj M, Kösling SK, Koerner C, Lange SM, van Beersum SE, van Reeuwijk J, Roepman R, Horn N, Ueffing M, Boldt K, Wittinghofer A. The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function. Structure. 2015 Nov 03; 23(11):2122-32. PMID: 26455799; PMCID: PMC4635315.
    Citations: 13     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.