Harvard Catalyst Profiles

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Henry Lu, Ph.D.

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Biography
The University of British Columbia, Vancouver, BCBSc05/2016Integrated Sciences
The University of British Columbia, Vancouver, BCPhD10/2020Experimental Medicine
2021
Outstanding Achievement by a Doctoral Student
2020 - 2023
Frederick Banting and Charles Best Canada Graduate Scholarships Doctoral Award
2019 - 2020
BC Children's Hospital Research Institute Sue Carruthers Graduate Studentship
2019 - 2020
Friedman Award for Scholars in Health
2019 - 2020
Killam Doctoral Scholarship
2018
Richard A Robertson Memorial Service Award in Medicine
2018 - 2021
4 Year Doctoral Fellowship
2017 - 2018
Theodore E Arnold Fellowship
2017 - 2018
Shaughnessy Hospital Volunteer Society Fellowship in Healthcare
2018 - 2020
Faculty of Medicine Graduate Award

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 2918 (Henry Y. Lu) Feb 28, 2019 - Feb 28, 2020
    Rare Disease Foundation
    Defining the Pathogenesis of a Novel CARD11 Mutation Causing Profound Combined Immunodeficiency and Inflammatory Gastrointestinal Disease
    Role: Principal Applicant
  2. 2174 (Henry Y. Lu) Nov 1, 2017 - Nov 1, 2018
    Rare Disease Foundation
    Defining the Role of a Novel BCL11b Variant in Atopy and Immune Dysregulation
    Role: Principal Applicant

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sharma M, Fu MP, Lu HY, Sharma AA, Modi BP, Michalski C, Lin S, Dalmann J, Salman A, Del Bel KL, Waqas M, Terry J, Setiadi A, Lavoie PM, Wasserman WW, Mwenifumbo J, Kobor MS, Lee AF, Kuchenbauer F, Lehman A, Cheng S, Cooper A, Patel MS, Turvey SE. Human complete NFAT1 deficiency causes a triad of joint contractures, osteochondromas, and B-cell malignancy. Blood. 2022 10 27; 140(17):1858-1874. PMID: 35789258.
    Citations:    Fields:    Translation:Humans
  2. Bell PA, Scheuermann S, Renner F, Pan CL, Lu HY, Turvey SE, Bornancin F, Régnier CH, Overall CM. Integrating knowledge of protein sequence with protein function for the prediction and validation of new MALT1 substrates. Comput Struct Biotechnol J. 2022; 20:4717-4732. PMID: 36147669; PMCID: PMC9463181.
    Citations:    
  3. Lu HY, Sertori R, Contreras AV, Hamer M, Messing M, Del Bel KL, Lopez-Rangel E, Chan ES, Rehmus W, Milner JD, McNagny KM, Lehman A, Wiest DL, Turvey SE. A Novel Germline Heterozygous BCL11B Variant Causing Severe Atopic Disease and Immune Dysregulation. Front Immunol. 2021; 12:788278. PMID: 34887873.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. Fung SY, Lu HY, Sharma M, Sharma AA, Saferali A, Jia A, Abraham L, Klein T, Gold MR, Noterangelo LD, Overall CM, Turvey SE. MALT1-Dependent Cleavage of HOIL1 Modulates Canonical NF-?B Signaling and Inflammatory Responsiveness. Front Immunol. 2021; 12:749794. PMID: 34721419; PMCID: PMC8552041.
    Citations:    Fields:    Translation:HumansCells
  5. Vaseghi-Shanjani M, Smith KL, Sara RJ, Modi BP, Branch A, Sharma M, Lu HY, James EL, Hildebrand KJ, Biggs CM, Turvey SE. Inborn errors of immunity manifesting as atopic disorders. J Allergy Clin Immunol. 2021 11; 148(5):1130-1139. PMID: 34428518.
    Citations: 4     Fields:    Translation:Humans
  6. Lu HY, Sharma M, Sharma AA, Lacson A, Szpurko A, Luider J, Dharmani-Khan P, Shameli A, Bell PA, Guilcher GMT, Lewis VA, Vasquez MR, Desai S, McGonigle L, Murguia-Favela L, Wright NAM, Sergi C, Wine E, Overall CM, Suresh S, Turvey SE. Mechanistic understanding of the combined immunodeficiency in complete human CARD11 deficiency. J Allergy Clin Immunol. 2021 12; 148(6):1559-1574.e13. PMID: 33872653.
    Citations: 8     Fields:    Translation:HumansCells
  7. Lu HY, Turvey SE. Human MALT1 deficiency and predisposition to infections. Curr Opin Immunol. 2021 10; 72:1-12. PMID: 33714841.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  8. Blanchard-Rohner G, Ragotte RJ, Junker AK, Sharma M, Del Bel KL, Lu HY, Erdle S, Chomyn A, Gill H, Tucker LB, Schreiber RA, Rozmus J, Biggs CM, Hildebrand KJ, Wu J, Stockler-Ipsiroglu S, Turvey SE. Idiopathic splenomegaly in childhood and the spectrum of RAS-associated lymphoproliferative disease: a case report. BMC Pediatr. 2021 01 21; 21(1):45. PMID: 33472608.
    Citations: 1     Fields:    Translation:Humans
  9. Jia A, James E, Lu HY, Sharma M, Modi BP, Biggs CM, Hildebrand KJ, Chomyn A, Erdle S, Kular H, Turvey SE. Clinical IRAK4 deficiency caused by homozygosity for the novel IRAK4 (c.1049delG, p.Gly350Glufs*15) variant. Cold Spring Harb Mol Case Stud. 2020 06; 6(3). PMID: 32532880.
    Citations: 1     Fields:    Translation:Humans
  10. Novice T, Kariminia A, Del Bel KL, Lu H, Sharma M, Lim CJ, Read J, Lugt MV, Hannibal MC, O'Dwyer D, Hosler M, Scharnitz T, Rizzo JM, Zacur J, Priatel J, Abdossamadi S, Bohm A, Junker A, Turvey SE, Schultz KR, Rozmus J. A Germline Mutation in the C2 Domain of PLC?2 Associated with Gain-of-Function Expands the Phenotype for PLCG2-Related Diseases. J Clin Immunol. 2020 02; 40(2):267-276. PMID: 31853824.
    Citations: 9     Fields:    Translation:HumansCells
  11. Lu HY, Biggs CM, Blanchard-Rohner G, Fung SY, Sharma M, Turvey SE. Germline CBM-opathies: From immunodeficiency to atopy. J Allergy Clin Immunol. 2019 05; 143(5):1661-1673. PMID: 31060714.
    Citations: 19     Fields:    Translation:HumansCells
  12. Gao W, Wang Y, Xiong Y, Sun L, Wang L, Wang K, Lu HY, Bao A, Turvey SE, Li Q, Yang H. Size-dependent anti-inflammatory activity of a peptide-gold nanoparticle hybrid in vitro and in a mouse model of acute lung injury. Acta Biomater. 2019 02; 85:203-217. PMID: 30597258.
    Citations: 18     Fields:    Translation:Animals
  13. Lu HY, Bauman BM, Arjunaraja S, Dorjbal B, Milner JD, Snow AL, Turvey SE. The CBM-opathies-A Rapidly Expanding Spectrum of Human Inborn Errors of Immunity Caused by Mutations in the CARD11-BCL10-MALT1 Complex. Front Immunol. 2018; 9:2078. PMID: 30283440.
    Citations: 36     Fields:    Translation:HumansCells
  14. Lu HY, Sharma M, Biggs CM, Huang YH, Shopsowitz KE, Frosk P, Priatel JJ, Rubin TS, Turvey SE. The importance of functional validation after next-generation sequencing: evaluation of a novel CARD11 variant. Pediatr Allergy Immunol. 2018 09; 29(6):663-668. PMID: 29808493.
    Citations: 1     Fields:    Translation:Humans
  15. Tang AC, Rahavi SM, Fung SY, Lu HY, Yang H, Lim CJ, Reid GS, Turvey SE. Combination therapy with proteasome inhibitors and TLR agonists enhances tumour cell death and IL-1ß production. Cell Death Dis. 2018 02 07; 9(2):162. PMID: 29415982.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  16. Lu HY, Turvey SE. UNC93B1 Deficiency. Encyclopedia of Medical Immunology: Immunodeficiency Diseases. 2018. View Publication.
  17. Lu HY, Turvey SE. TRAF3 Deficiency. Encyclopedia of Medical Immunology: Immunodeficiency Diseases. 2018. View Publication.
  18. Lu HY, Turvey SE. TRIF Deficiency. Encyclopedia of Medical Immunology: Immunodeficiency Diseases. 2018. View Publication.
  19. Lu HY, Turvey SE. TLR3 Deficiency. Encyclopedia of Medical Immunology: Immunodeficiency Diseases. 2018. View Publication.
  20. Lu HY, Turvey SE. TBK1 Deficiency. Encyclopedia of Medical Immunology: Immunodeficiency Diseases. 2018. View Publication.
  21. Lu HY, Turvey SE. IRF3 Deficiency. Encyclopedia of Medical Immunology: Immunodeficiency Diseases. 2018. View Publication.
  22. Abraham L, Lu HY, Falcão RC, Scurll J, Jou T, Irwin B, Tafteh R, Gold MR, Coombs D. Limitations of Qdot labelling compared to directly-conjugated probes for single particle tracking of B cell receptor mobility. Sci Rep. 2017 09 12; 7(1):11379. PMID: 28900238.
    Citations: 9     Fields:    Translation:Cells
  23. Biggs CM, Lu HY, Turvey SE. Monogenic immune disorders and severe atopic disease. Nat Genet. 2017 Jul 27; 49(8):1162-1163. PMID: 28747751.
    Citations: 4     Fields:    Translation:Humans
  24. Tafteh R, Abraham L, Seo D, Lu HY, Gold MR, Chou KC. Real-time 3D stabilization of a super-resolution microscope using an electrically tunable lens. Opt Express. 2016 Oct 03; 24(20):22959-22970. PMID: 27828362.
    Citations: 6     Fields:    
  25. Wu J, Meng F, Lu H, Kong L, Bornmann W, Peng Z, Talpaz M, Donato NJ. Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. Blood. 2008 Apr 01; 111(7):3821-9. PMID: 18235045; PMCID: PMC2275035.
    Citations: 51     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.