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Yuta Takagaki, Ph.D., M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Miura S, Niida Y, Hashizume C, Fujii A, Takagaki Y, Kusama K, Akazawa S, Minami T, Mukai T, Furuichi K, Tsuchishima M, Ueda N, Takamura H, Koya D, Ito T. Novel PKD2 Missense Mutation p.Ile424Ser in an Individual with Multiple Hepatic Cysts: A Case Report. Medicines (Basel). 2022 Mar 29; 9(4). PMID: 35447873; PMCID: PMC9031803.
  2. Shimada K, Kanasaki K, Kato M, Ogura Y, Takagaki Y, Monno I, Hirai T, Kitada M, Koya D. Adenosine/adenosine type?1 receptor signaling pathway did not play dominant roles on the influence of sodium-glucose cotransporter?2 inhibitor in the kidney of bovine serum albumin-overloaded streptozotocin-induced diabetic mice. J Diabetes Investig. 2022 Jun; 13(6):955-964. PMID: 35098679; PMCID: PMC9153834.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  3. Srivastava SP, Li J, Takagaki Y, Kitada M, Goodwin JE, Kanasaki K, Koya D. Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneys. iScience. 2021 May 21; 24(5):102390. PMID: 33981977; PMCID: PMC8086030.
    Citations: 17     
  4. Hirai T, Kitada M, Monno I, Oda E, Hayashi Y, Shimada K, Takagaki Y, Ogura Y, Fujii M, Konishi K, Sakurai M, Nakagawa A, Koya D. Sodium-glucose cotransporter 2 inhibitors in type 2 diabetes patients with renal function impairment slow the annual renal function decline, in a real clinical practice. J Diabetes Investig. 2021 Sep; 12(9):1577-1585. PMID: 33417741; PMCID: PMC8409862.
    Citations: 3     Fields:    Translation:Humans
  5. Takagaki Y, Kanasaki K. Classical molecule in diabetic kidney hypertrophy is linked to defects in self-eating through fine-tuning. J Diabetes Investig. 2021 05; 12(5):686-688. PMID: 33455088; PMCID: PMC8088996.
    Citations:    Fields:    Translation:Humans
  6. Liu H, Takagaki Y, Kumagai A, Kanasaki K, Koya D. The PKM2 activator TEPP-46 suppresses kidney fibrosis via inhibition of the EMT program and aberrant glycolysis associated with suppression of HIF-1a accumulation. J Diabetes Investig. 2021 May; 12(5):697-709. PMID: 33314682; PMCID: PMC8089020.
    Citations: 16     Fields:    Translation:AnimalsCells
  7. Kawakita E, Yang F, Kumagai A, Takagaki Y, Kitada M, Yoshitomi Y, Ikeda T, Nakamura Y, Ishigaki Y, Kanasaki K, Koya D. Metformin Mitigates DPP-4 Inhibitor-Induced Breast Cancer Metastasis via Suppression of mTOR Signaling. Mol Cancer Res. 2021 01; 19(1):61-73. PMID: 32994182.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  8. Mizunuma Y, Kanasaki K, Nitta K, Nakamura Y, Ishigaki Y, Takagaki Y, Kitada M, Li S, Liu H, Li J, Usui I, Aso Y, Koya D. CD-1db/db mice: A novel type 2 diabetic mouse model with progressive kidney fibrosis. J Diabetes Investig. 2020 Nov; 11(6):1470-1481. PMID: 32472621; PMCID: PMC7610117.
    Citations: 2     Fields:    Translation:Animals
  9. Li J, Liu H, Takagi S, Nitta K, Kitada M, Srivastava SP, Takagaki Y, Kanasaki K, Koya D. Renal protective effects of empagliflozin via inhibition of EMT and aberrant glycolysis in proximal tubules. JCI Insight. 2020 03 26; 5(6). PMID: 32134397; PMCID: PMC7213787.
    Citations: 47     Fields:    Translation:AnimalsCells
  10. Hirai T, Kitada M, Hayashi Y, Monno I, Takagaki Y, Shimada K, Ogura Y, Fujii M, Konishi K, Nakagawa A, Koya D. Case report of superior mesenteric artery syndrome that developed in a lean type 2 diabetes patient and was associated with rapid body weight loss after sodium-glucose cotransporter 2 inhibitor administration. J Diabetes Investig. 2020 Sep; 11(5):1359-1362. PMID: 32020751; PMCID: PMC7477529.
    Citations: 2     Fields:    Translation:Humans
  11. Takagaki Y, Lee SM, Dongqing Z, Kitada M, Kanasaki K, Koya D. Endothelial autophagy deficiency induces IL6 - dependent endothelial mesenchymal transition and organ fibrosis. Autophagy. 2020 10; 16(10):1905-1914. PMID: 31965901; PMCID: PMC8386622.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  12. Takagaki Y, Shi S, Katoh M, Kitada M, Kanasaki K, Koya D. Dipeptidyl peptidase-4 plays a pathogenic role in BSA-induced kidney injury in diabetic mice. Sci Rep. 2019 05 17; 9(1):7519. PMID: 31101909; PMCID: PMC6525172.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  13. Yang F, Takagaki Y, Yoshitomi Y, Ikeda T, Li J, Kitada M, Kumagai A, Kawakita E, Shi S, Kanasaki K, Koya D. Inhibition of Dipeptidyl Peptidase-4 Accelerates Epithelial-Mesenchymal Transition and Breast Cancer Metastasis via the CXCL12/CXCR4/mTOR Axis. Cancer Res. 2019 02 15; 79(4):735-746. PMID: 30584072.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  14. Kawakita E, Kanasaki K, Hirai T, Tsuda SI, Watanabe A, Nitta K, Kitada M, Ogura Y, Takagaki Y, Fujii M, Nagai T, Shimada K, Takagi S, Mizunuma Y, Monno I, Shino F, Minato H, Miyatake N, Nakagawa A, Koya D. Severe electrolytes disorders with the interstitial kidney alterations in the patient with the history of total thyroidectomy and parathyroidectomy: possible role of vitamin D deficiency. Clin Case Rep. 2018 Jun; 6(6):983-989. PMID: 29881548; PMCID: PMC5986046.
  15. Takagi S, Li J, Takagaki Y, Kitada M, Nitta K, Takasu T, Kanasaki K, Koya D. Ipragliflozin improves mitochondrial abnormalities in renal tubules induced by a high-fat diet. J Diabetes Investig. 2018 Sep; 9(5):1025-1032. PMID: 29352520; PMCID: PMC6123054.
    Citations: 49     Fields:    Translation:AnimalsCells
  16. Takagaki Y, Koya D, Kanasaki K. Dipeptidyl peptidase-4 inhibition and renoprotection: the role of antifibrotic effects. Curr Opin Nephrol Hypertens. 2017 01; 26(1):56-66. PMID: 27820706.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  17. Tanaka Y, Taguchi S, Yoshida S, Hori S, Takagaki Y. [Effects of veterinary drugs on beta-hexosaminidase release from rat basophilic leukemia cells (RBL-2H3)]. Shokuhin Eiseigaku Zasshi. 2002 Oct; 43(5):306-11. PMID: 12607930.
    Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.