Harvard Catalyst Profiles

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Caleb Randall Glassman, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Caveney NA, Saxton RA, Waghray D, Glassman CR, Tsutsumi N, Hubbard SR, Garcia KC. Structural basis of Janus kinase trans-activation. Cell Rep. 2023 Mar 01; 42(3):112201. PMID: 36867534.
    Citations:    Fields:    
  2. Saxton RA, Glassman CR, Garcia KC. Emerging principles of cytokine pharmacology and therapeutics. Nat Rev Drug Discov. 2023 01; 22(1):21-37. PMID: 36131080.
    Citations: 1     Fields:    Translation:HumansCells
  3. Caveney NA, Glassman CR, Jude KM, Tsutsumi N, Garcia KC. Structure of the IL-27 quaternary receptor signaling complex. Elife. 2022 05 17; 11. PMID: 35579417; PMCID: PMC9142143.
    Citations: 4     Fields:    Translation:HumansCells
  4. Yen M, Ren J, Liu Q, Glassman CR, Sheahan TP, Picton LK, Moreira FR, Rustagi A, Jude KM, Zhao X, Blish CA, Baric RS, Su LL, Garcia KC. Facile discovery of surrogate cytokine agonists. Cell. 2022 04 14; 185(8):1414-1430.e19. PMID: 35325595; PMCID: PMC9021867.
    Citations: 8     Fields:    Translation:HumansCells
  5. Glassman CR, Tsutsumi N, Saxton RA, Lupardus PJ, Jude KM, Garcia KC. Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation. Science. 2022 04 08; 376(6589):163-169. PMID: 35271300; PMCID: PMC9306331.
    Citations: 10     Fields:    Translation:HumansCells
  6. Mo F, Yu Z, Li P, Oh J, Spolski R, Zhao L, Glassman CR, Yamamoto TN, Chen Y, Golebiowski FM, Hermans D, Majri-Morrison S, Picton LK, Liao W, Ren M, Zhuang X, Mitra S, Lin JX, Gattinoni L, Powell JD, Restifo NP, Garcia KC, Leonard WJ. An engineered IL-2 partial agonist promotes CD8+ T cell stemness. Nature. 2021 09; 597(7877):544-548. PMID: 34526724; PMCID: PMC9172917.
    Citations: 26     Fields:    Translation:AnimalsCells
  7. Baek M, DiMaio F, Anishchenko I, Dauparas J, Ovchinnikov S, Lee GR, Wang J, Cong Q, Kinch LN, Schaeffer RD, Millán C, Park H, Adams C, Glassman CR, DeGiovanni A, Pereira JH, Rodrigues AV, van Dijk AA, Ebrecht AC, Opperman DJ, Sagmeister T, Buhlheller C, Pavkov-Keller T, Rathinaswamy MK, Dalwadi U, Yip CK, Burke JE, Garcia KC, Grishin NV, Adams PD, Read RJ, Baker D. Accurate prediction of protein structures and interactions using a three-track neural network. Science. 2021 08 20; 373(6557):871-876. PMID: 34282049; PMCID: PMC7612213.
    Citations: 655     Fields:    Translation:Cells
  8. Glassman CR, Su L, Majri-Morrison SS, Winkelmann H, Mo F, Li P, Pérez-Cruz M, Ho PP, Koliesnik I, Nagy N, Hnizdilova T, Picton LK, Kovar M, Bollyky P, Steinman L, Meyer E, Piehler J, Leonard WJ, Garcia KC. Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist. Elife. 2021 05 18; 10. PMID: 34003116; PMCID: PMC8131104.
    Citations: 4     Fields:    Translation:AnimalsCells
  9. Glassman CR, Mathiharan YK, Jude KM, Su L, Panova O, Lupardus PJ, Spangler JB, Ely LK, Thomas C, Skiniotis G, Garcia KC. Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells. Cell. 2021 02 18; 184(4):983-999.e24. PMID: 33606986; PMCID: PMC7899134.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  10. Fernandes RA, Li C, Wang G, Yang X, Savvides CS, Glassman CR, Dong S, Luxenberg E, Sibener LV, Birnbaum ME, Benoist C, Mathis D, Garcia KC. Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo. Elife. 2020 08 10; 9. PMID: 32773038; PMCID: PMC7440915.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  11. De Paula VS, Jude KM, Nerli S, Glassman CR, Garcia KC, Sgourakis NG. Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch. Proc Natl Acad Sci U S A. 2020 03 31; 117(13):7183-7192. PMID: 32184322; PMCID: PMC7132253.
    Citations: 9     Fields:    Translation:AnimalsCells
  12. Gee MH, Sibener LV, Birnbaum ME, Jude KM, Yang X, Fernandes RA, Mendoza JL, Glassman CR, Garcia KC. Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro. Proc Natl Acad Sci U S A. 2018 07 31; 115(31):E7369-E7378. PMID: 30021852; PMCID: PMC6077720.
    Citations: 10     Fields:    Translation:HumansCells
  13. Glassman CR, Parrish HL, Lee MS, Kuhns MS. Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex. Cell Rep. 2018 01 30; 22(5):1263-1275. PMID: 29386113; PMCID: PMC5813697.
    Citations: 12     Fields:    Translation:AnimalsCells
  14. Glassman CR, Parrish HL, Deshpande NR, Kuhns MS. The CD4 and CD3de Cytosolic Juxtamembrane Regions Are Proximal within a Compact TCR-CD3-pMHC-CD4 Macrocomplex. J Immunol. 2016 06 01; 196(11):4713-22. PMID: 27183595; PMCID: PMC4875830.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  15. Parrish HL, Glassman CR, Keenen MM, Deshpande NR, Bronnimann MP, Kuhns MS. Correction: A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization. PLoS One. 2016; 11(3):e0150876. PMID: 26930656; PMCID: PMC4773146.
    Citations:    Fields:    
  16. Lee MS, Glassman CR, Deshpande NR, Badgandi HB, Parrish HL, Uttamapinant C, Stawski PS, Ting AY, Kuhns MS. A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3??. Immunity. 2015 Aug 18; 43(2):227-39. PMID: 26231119; PMCID: PMC4545397.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  17. Parrish HL, Glassman CR, Keenen MM, Deshpande NR, Bronnimann MP, Kuhns MS. A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization. PLoS One. 2015; 10(7):e0132333. PMID: 26147390; PMCID: PMC4493003.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.