Harvard Catalyst Profiles

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Ching Ting Loke, Ph.D., M.B.,B.Ch.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. O'Connor D, Loke J, Brown M, Stanworth SJ, Young A, Prue G. Non-pharmacological supportive-care interventions in acute myeloid leukaemia: a review of randomised controlled trials. Br J Haematol. 2021 10; 195(1):e97-e113. PMID: 34159579.
    Citations:    Fields:    Translation:Humans
  2. Loke J, Cockerill PN. Unravelling the apoptotic machinery in CMML. Blood. 2021 06 17; 137(24):3321-3322. PMID: 34137844.
    Citations:    Fields:    Translation:Humans
  3. Loke J, Buka R, Craddock C. Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia: Who, When, and How? Front Immunol. 2021; 12:659595. PMID: 34012445; PMCID: PMC8126705.
    Citations: 6     Fields:    Translation:Humans
  4. Loke J, Vyas H, Craddock C. Optimizing Transplant Approaches and Post-Transplant Strategies for Patients With Acute Myeloid Leukemia. Front Oncol. 2021; 11:666091. PMID: 33937080.
    Citations: 1     
  5. Craddock C, Jackson A, Loke J, Siddique S, Hodgkinson A, Mason J, Andrew G, Nagra S, Malladi R, Peniket A, Gilleece M, Salim R, Tholouli E, Potter V, Crawley C, Wheatley K, Protheroe R, Vyas P, Hunter A, Parker A, Wilson K, Pavlu J, Byrne J, Dillon R, Khan N, McCarthy N, Freeman SD. Augmented Reduced-Intensity Regimen Does Not Improve Postallogeneic Transplant Outcomes in Acute Myeloid Leukemia. J Clin Oncol. 2021 03 01; 39(7):768-778. PMID: 33373276; PMCID: PMC8078252.
    Citations: 17     Fields:    Translation:HumansCTClinical Trials
  6. Majothi S, Adams D, Loke J, Stevens SP, Wheatley K, Wilson JS. FLT3 inhibitors in acute myeloid leukaemia: assessment of clinical effectiveness, adverse events and future research-a systematic review and meta-analysis. Syst Rev. 2020 12 07; 9(1):285. PMID: 33287892.
    Citations: 5     Fields:    Translation:Humans
  7. Loke J, Labopin M, Craddock C, Niederwieser D, Cornelissen J, Afansayev B, Jindra P, Maertens J, Blaise D, Boriskina K, Gramatzki M, Ganser A, Savani B, Mohty M, Nagler A. Impact of patient: donor HLA disparity on reduced-intensity-conditioned allogeneic stem cell transplants from HLA mismatched unrelated donors for AML: from the ALWP of the EBMT. Bone Marrow Transplant. 2021 03; 56(3):614-621. PMID: 33009514.
    Citations: 1     Fields:    Translation:Humans
  8. Loke J, Lowe DM, Miller LJ, Morton S, Roy NBA, Sekhar M, Stanworth SJ. Supportive care in the management of patients with acute myeloid leukaemia: where are the research needs? Br J Haematol. 2020 08; 190(3):311-313. PMID: 32378733.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  9. Loke J, Malladi R, Moss P, Craddock C. The role of allogeneic stem cell transplantation in the management of acute myeloid leukaemia: a triumph of hope and experience. Br J Haematol. 2020 01; 188(1):129-146. PMID: 31823351; PMCID: PMC6972492.
    Citations: 24     Fields:    Translation:Humans
  10. Assi SA, Imperato MR, Coleman DJL, Pickin A, Potluri S, Ptasinska A, Chin PS, Blair H, Cauchy P, James SR, Zacarias-Cabeza J, Gilding LN, Beggs A, Clokie S, Loke JC, Jenkin P, Uddin A, Delwel R, Richards SJ, Raghavan M, Griffiths MJ, Heidenreich O, Cockerill PN, Bonifer C. Subtype-specific regulatory network rewiring in acute myeloid leukemia. Nat Genet. 2019 01; 51(1):151-162. PMID: 30420649; PMCID: PMC6330064.
    Citations: 53     Fields:    Translation:HumansCells
  11. Loke J, Chin PS, Keane P, Pickin A, Assi SA, Ptasinska A, Imperato MR, Cockerill PN, Bonifer C. C/EBPa overrides epigenetic reprogramming by oncogenic transcription factors in acute myeloid leukemia. Blood Adv. 2018 02 13; 2(3):271-284. PMID: 29431622.
    Citations: 6     Fields:    Translation:HumansCells
  12. Loke J, Assi SA, Imperato MR, Ptasinska A, Cauchy P, Grabovska Y, Soria NM, Raghavan M, Delwel HR, Cockerill PN, Heidenreich O, Bonifer C. RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML. Cell Rep. 2017 05 23; 19(8):1654-1668. PMID: 28538183.
    Citations: 23     Fields:    Translation:HumansCells
  13. Malaker SA, Penny SA, Steadman LG, Myers PT, Loke JC, Raghavan M, Bai DL, Shabanowitz J, Hunt DF, Cobbold M. Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia. Cancer Immunol Res. 2017 05; 5(5):376-384. PMID: 28314751.
    Citations: 45     Fields:    Translation:HumansCells
  14. Cauchy P, James SR, Zacarias-Cabeza J, Ptasinska A, Imperato MR, Assi SA, Piper J, Canestraro M, Hoogenkamp M, Raghavan M, Loke J, Akiki S, Clokie SJ, Richards SJ, Westhead DR, Griffiths MJ, Ott S, Bonifer C, Cockerill PN. Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature. Cell Rep. 2015 Aug 04; 12(5):821-36. PMID: 26212328.
    Citations: 34     Fields:    Translation:HumansCells
  15. Loke JC, Akiki S, Borrow J, Ewing J, Bokhari SW, Chandra D, Arrazi J, Hazlewood P, Arthur K, Walsh J, Membwange Y, Wandroo FA, Watts A, Borg A, Brock K, Ferguson P, Craddock C, Griffiths M, Raghavan M. Acquired isodisomy on chromosome 13 at diagnosis results in impaired overall survival in patients with FLT3-ITD mutant acute myeloid leukaemia. Leukemia. 2015 Dec; 29(12):2404-7. PMID: 26172402.
    Citations:    Fields:    Translation:HumansCells
  16. Mussai F, Egan S, Higginbotham-Jones J, Perry T, Beggs A, Odintsova E, Loke J, Pratt G, U KP, Lo A, Ng M, Kearns P, Cheng P, De Santo C. Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target. Blood. 2015 Apr 09; 125(15):2386-96. PMID: 25710880; PMCID: PMC4416943.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  17. Loke J, Khan JN, Wilson JS, Craddock C, Wheatley K. Mylotarg has potent anti-leukaemic effect: a systematic review and meta-analysis of anti-CD33 antibody treatment in acute myeloid leukaemia. Ann Hematol. 2015 Mar; 94(3):361-73. PMID: 25284166.
    Citations: 26     Fields:    Translation:Humans
  18. Goodyear OC, Dennis M, Jilani NY, Loke J, Siddique S, Ryan G, Nunnick J, Khanum R, Raghavan M, Cook M, Snowden JA, Griffiths M, Russell N, Yin J, Crawley C, Cook G, Vyas P, Moss P, Malladi R, Craddock CF. Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML). Blood. 2012 Apr 05; 119(14):3361-9. PMID: 22234690.
    Citations: 137     Fields:    Translation:HumansCellsCTClinical Trials
  19. Wheeler DW, Thompson AJ, Corletto F, Reckless J, Loke JC, Lapaque N, Grant AJ, Mastroeni P, Grainger DJ, Padgett CL, O'Brien JA, Miller NG, Trowsdale J, Lummis SC, Menon DK, Beech JS. Anaesthetic impairment of immune function is mediated via GABA(A) receptors. PLoS One. 2011 Feb 24; 6(2):e17152. PMID: 21390329; PMCID: PMC3044756.
    Citations: 28     Fields:    Translation:HumansCells
  20. Loke J, Rutter M, Mahadeva R. Tonsillar cyst: an unusual cause of ventilatory failure. JRSM Short Rep. 2010 Oct 26; 1(5):45. PMID: 21103137.
  21. Hughes D, Hafferty J, Fulton L, Friend P, Devaney A, Loke J, Welsh KI, Handa A, Klenerman P. Donor and recipient CMV serostatus and antigenemia after renal transplantation: an analysis of 486 patients. J Clin Virol. 2008 Feb; 41(2):92-5. PMID: 18032098.
    Citations: 9     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.