Harvard Catalyst Profiles

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Pamela Barraza-Flores, Ph.D.


Available: 01/10/22, Expires: 01/01/23

We focus on the discovery and description of genes that cause congenital myopathies. The main project you would be involved with is in describing the mitochondrial involvement in SEPN1-related myopathy. We need help handling zebrafish experiments as well as other molecular biology experiments in the lab. Basic lab skills such as pipetting are preferred but not required. You will learn how to keep zebrafish husbandry and perform functional studies, as well as basic molecular biology such as RTqPCR, Western Blot and DNA sequencing. You will also be involved in the experimental design and data analysis. You will be able to take this project and present it at conferences or presentations assigned to you. We hope to find someone that can commit to work between 10-20 hours, this is a wide range of hours, meaning we are willing to negotiate this part. You will be directly mentored by a postdoc who will guide you throughout the job. If you are interested, please apply to a fellowships or register for a research course credit. However, if these are not an option and you are still interested, please reach out to us to the email provided. Send your CV along with a statement with your reason for wanting to join our group and your future plans regarding research to staff member Pamela Barraza, pamela.barraza-flores@childrens.harvard.edu .

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bugiardini E, Nunes AM, Oliveira-Santos A, Dagda M, Fontelonga TM, Barraza-Flores P, Pittman AM, Morrow JM, Parton M, Houlden H, Elliott PM, Syrris P, Maas RP, Akhtar MM, Küsters B, Raaphorst J, Schouten M, Kamsteeg EJ, van Engelen B, Hanna MG, Phadke R, Lopes LR, Matthews E, Burkin DJ. Integrin a7 Mutations Are Associated With Adult-Onset Cardiac Dysfunction in Humans and Mice. J Am Heart Assoc. 2022 Dec 06; 11(23):e026494. PMID: 36444867.
    Citations:    Fields:    
  2. Luna AJ, Sterk RT, Griego-Fisher AM, Chung JY, Berggren KL, Bondu V, Barraza-Flores P, Cowan AT, Gan GN, Yilmaz E, Cho H, Kim JH, Hewitt SM, Bauman JE, Ozbun MA. MEK/ERK signaling is a critical regulator of high-risk human papillomavirus oncogene expression revealing therapeutic targets for HPV-induced tumors. PLoS Pathog. 2021 01; 17(1):e1009216. PMID: 33481911.
    Citations: 1     Fields:    Translation:HumansCells
  3. Barraza-Flores P, Bukovec KE, Dagda M, Conner BW, Oliveira-Santos A, Grange RW, Burkin DJ. Laminin-111 protein therapy after disease onset slows muscle disease in a mouse model of laminin-a2 related congenital muscular dystrophy. Hum Mol Genet. 2020 08 03; 29(13):2162-2170. PMID: 32472139.
    Citations: 1     Fields:    Translation:HumansAnimals
  4. Barraza-Flores P, Hermann HJ, Bates CR, Allen TG, Grunert TT, Burkin DJ. Human laminin-111 and laminin-211 protein therapy prevents muscle disease progression in an immunodeficient mouse model of LAMA2-CMD. Skelet Muscle. 2020 06 04; 10(1):18. PMID: 32498713.
    Citations:    Fields:    Translation:HumansAnimals
  5. Jones TI, Chew GL, Barraza-Flores P, Schreier S, Ramirez M, Wuebbles RD, Burkin DJ, Bradley RK, Jones PL. Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severity. Skelet Muscle. 2020 04 11; 10(1):8. PMID: 32278354.
    Citations: 18     Fields:    Translation:AnimalsCells
  6. Barraza-Flores P, Bates CR, Oliveira-Santos A, Burkin DJ. Laminin and Integrin in LAMA2-Related Congenital Muscular Dystrophy: From Disease to Therapeutics. Front Mol Neurosci. 2020; 13:1. PMID: 32116540; PMCID: PMC7026472.
    Citations: 6     
  7. Barraza-Flores P, Fontelonga TM, Wuebbles RD, Hermann HJ, Nunes AM, Kornegay JN, Burkin DJ. Laminin-111 protein therapy enhances muscle regeneration and repair in the GRMD dog model of Duchenne muscular dystrophy. Hum Mol Genet. 2019 08 15; 28(16):2686-2695. PMID: 31179490; PMCID: PMC6687953.
    Citations: 11     Fields:    Translation:Animals
  8. Fontelonga TM, Jordan B, Nunes AM, Barraza-Flores P, Bolden N, Wuebbles RD, Griner LM, Hu X, Ferrer M, Marugan J, Southall N, Burkin DJ. Sunitinib promotes myogenic regeneration and mitigates disease progression in the mdx mouse model of Duchenne muscular dystrophy. Hum Mol Genet. 2019 07 01; 28(13):2120-2132. PMID: 30806670; PMCID: PMC6586148.
    Citations: 5     Fields:    Translation:AnimalsCells
  9. Wuebbles RD, Cruz V, Van Ry P, Barraza-Flores P, Brewer PD, Jones P, Burkin DJ. Human Galectin-1 Improves Sarcolemma Stability and Muscle Vascularization in the mdx Mouse Model of Duchenne Muscular Dystrophy. Mol Ther Methods Clin Dev. 2019 Jun 14; 13:145-153. PMID: 30788383; PMCID: PMC6369265.
    Citations: 5     
  10. Nunes AM, Barraza-Flores P, Smith CR, Burkin DJ. Integrin a7: a major driver and therapeutic target for glioblastoma malignancy. Stem Cell Investig. 2017; 4:97. PMID: 29359136; PMCID: PMC5763033.
    Citations: 2     
  11. Van Ry PM, Fontelonga TM, Barraza-Flores P, Sarathy A, Nunes AM, Burkin DJ. ECM-Related Myopathies and Muscular Dystrophies: Pros and Cons of Protein Therapies. Compr Physiol. 2017 Sep 12; 7(4):1519-1536. PMID: 28915335.
    Citations: 4     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.