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Jakob Wollborn, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Binneboessel S, Bruno RR, Wernly B, Masyuk M, Flaatten H, Fjølner J, Wolff G, Kelm M, Beil M, Sviri S, Szczeklik W, Leaver S, De Lange DW, Guidet B, Jung C. Cytokine absorption in critically ill old COVID-19 patients with renal failure: A retrospective analysis of 503 intensive care unit patients. Clin Hemorheol Microcirc. 2022 Oct 15. PMID: 36278342.
    Citations:    Fields:    
  2. Wolff G, Wernly B, Flaatten H, Fjølner J, Bruno RR, Artigas A, Pinto BB, Schefold JC, Kelm M, Binneboessel S, Baldia P, Beil M, Sivri S, van Heerden PV, Szczeklik W, Elhadi M, Joannidis M, Oeyen S, Flamm M, Zafeiridis T, Marsh B, Andersen FH, Moreno R, Boumendil A, De Lange DW, Guidet B, Leaver S, Jung C. Sex-specific treatment characteristics and 30-day mortality outcomes of critically ill COVID-19 patients over 70 years of age-results from the prospective COVIP study. Can J Anaesth. 2022 11; 69(11):1390-1398. PMID: 35945477; PMCID: PMC9363137.
    Citations:    Fields:    Translation:HumansPHPublic Health
  3. Polok K, Fronczek J, Artigas A, Flaatten H, Guidet B, De Lange DW, Fjølner J, Leaver S, Beil M, Sviri S, Bruno RR, Wernly B, Bollen Pinto B, Schefold JC, Studzinska D, Joannidis M, Oeyen S, Marsh B, Andersen FH, Moreno R, Cecconi M, Jung C, Szczeklik W. Noninvasive ventilation in COVID-19 patients aged?=?70 years-a prospective multicentre cohort study. Crit Care. 2022 07 22; 26(1):224. PMID: 35869557; PMCID: PMC9305028.
    Citations:    Fields:    Translation:HumansPHPublic Health
  4. Wollborn J, Karamnov S, Fields KG, Yeh T, Muehlschlegel JD. COVID-19 increases the risk for the onset of atrial fibrillation in hospitalized patients. Sci Rep. 2022 07 14; 12(1):12014. PMID: 35835807; PMCID: PMC9281233.
    Citations:    Fields:    Translation:HumansCells
  5. Scheid S, Goeller M, Baar W, Wollborn J, Buerkle H, Schlunck G, Lagrèze W, Goebel U, Ulbrich F. Inhalative as well as Intravenous Administration of H2S Provides Neuroprotection after Ischemia and Reperfusion Injury in the Rats' Retina. Int J Mol Sci. 2022 May 15; 23(10). PMID: 35628328; PMCID: PMC9143628.
    Citations:    Fields:    Translation:Animals
  6. Wernly B, Rezar R, Flaatten H, Beil M, Fjølner J, Bruno RR, Artigas A, Pinto BB, Schefold JC, Kelm M, Sigal S, van Heerden PV, Szczeklik W, Elhadi M, Joannidis M, Oeyen S, Wolff G, Marsh B, Andersen FH, Moreno R, Leaver S, Wernly S, Boumendil A, De Lange DW, Guidet B, Jung C. Variations in end-of-life care practices in older critically ill patients with COVID-19 in Europe. J Intern Med. 2022 09; 292(3):438-449. PMID: 35398948; PMCID: PMC9115222.
    Citations: 1     Fields:    Translation:Humans
  7. Wollborn J, Goebel U. Reply to: Scoring the capillary leak syndrome: towards an individualized gradation of the vascular barrier injury. Ann Intensive Care. 2022 Mar 24; 12(1):28. PMID: 35325317; PMCID: PMC8948307.
    Citations:    
  8. Bruno RR, Wernly B, Flaatten H, Fjølner J, Artigas A, Baldia PH, Binneboessel S, Bollen Pinto B, Schefold JC, Wolff G, Kelm M, Beil M, Sviri S, van Heerden PV, Szczeklik W, Elhadi M, Joannidis M, Oeyen S, Kondili E, Marsh B, Wollborn J, Andersen FH, Moreno R, Leaver S, Boumendil A, De Lange DW, Guidet B, Jung C. The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19. Ann Intensive Care. 2022 Mar 18; 12(1):26. PMID: 35303201; PMCID: PMC8931579.
    Citations:    
  9. Bruno RR, Wernly B, Wolff G, Fjølner J, Artigas A, Bollen Pinto B, Schefold JC, Kindgen-Milles D, Baldia PH, Kelm M, Beil M, Sviri S, van Heerden PV, Szczeklik W, Topeli A, Elhadi M, Joannidis M, Oeyen S, Kondili E, Marsh B, Andersen FH, Moreno R, Leaver S, Boumendil A, De Lange DW, Guidet B, Flaatten H, Jung C. Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19. ESC Heart Fail. 2022 06; 9(3):1756-1765. PMID: 35274490; PMCID: PMC9065875.
    Citations: 1     Fields:    Translation:Humans
  10. Guidet B, Jung C, Flaatten H, Fjølner J, Artigas A, Pinto BB, Schefold JC, Beil M, Sigal S, van Heerden PV, Szczeklik W, Joannidis M, Oeyen S, Kondili E, Marsh B, Andersen FH, Moreno R, Cecconi M, Leaver S, De Lange DW, Boumendil A. Increased 30-day mortality in very old ICU patients with COVID-19 compared to patients with respiratory failure without COVID-19. Intensive Care Med. 2022 04; 48(4):435-447. PMID: 35218366; PMCID: PMC8881896.
    Citations: 7     Fields:    Translation:HumansCells
  11. Burkard N, Baar W, Flemming S, Schlegel N, Wollborn J, Schneider R, Brock RW, Wunder C, Schick MA. Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury. J Vis Exp. 2022 02 15; (180). PMID: 35253793.
    Citations:    Fields:    Translation:HumansAnimals
  12. Soliman IW, Leaver S, Flaatten H, Fjølner J, Wernly B, Bruno RR, Artigas A, Bollen Pinto B, Schefold JC, Beil M, Sviri S, van Heerden PV, Szczeklik W, Elhadi M, Joannidis M, Oeyen S, Zafeiridis T, Wollborn J, Banzo MJA, Fuest K, Marsh B, Andersen FH, Moreno R, Boumendil A, Guidet B, Jung C, De Lange DW. Health-related quality of life in older patients surviving ICU treatment for COVID-19: results from an international observational study of patients older than 70 years. Age Ageing. 2022 02 02; 51(2). PMID: 35136896; PMCID: PMC8825757.
    Citations:    Fields:    Translation:HumansCells
  13. Wollborn J, Mizuguchi KA, Ulbrich F, Brovman EY. Cardiac Anesthesiologists' and Intensivists' Impact on the Treatment of Patients at Advanced Heart Failure Centers. J Cardiothorac Vasc Anesth. 2022 05; 36(5):1228-1230. PMID: 35063348.
    Citations:    Fields:    Translation:Humans
  14. Wollborn J, Hassenzahl LO, Reker D, Staehle HF, Omlor AM, Baar W, Kaufmann KB, Ulbrich F, Wunder C, Utzolino S, Buerkle H, Kalbhenn J, Heinrich S, Goebel U. Diagnosing capillary leak in critically ill patients: development of an innovative scoring instrument for non-invasive detection. Ann Intensive Care. 2021 Dec 15; 11(1):175. PMID: 34910264; PMCID: PMC8674404.
    Citations: 3     
  15. Polok K, Fronczek J, van Heerden PV, Flaatten H, Guidet B, De Lange DW, Fjølner J, Leaver S, Beil M, Sviri S, Bruno RR, Wernly B, Artigas A, Pinto BB, Schefold JC, Studzinska D, Joannidis M, Oeyen S, Marsh B, Andersen FH, Moreno R, Cecconi M, Jung C, Szczeklik W. Association between tracheostomy timing and outcomes for older critically ill COVID-19 patients: prospective observational study in European intensive care units. Br J Anaesth. 2022 03; 128(3):482-490. PMID: 34955167; PMCID: PMC8627864.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  16. Campbell NG, Wollborn J, Fields KG, Lip GYH, Ruetzler K, Muehlschlegel JD, O'Brien B. Inconsistent Methodology as a Barrier to Meaningful Research Outputs From Studies of Atrial Fibrillation After Cardiac Surgery. J Cardiothorac Vasc Anesth. 2022 03; 36(3):739-745. PMID: 34763979.
    Citations:    Fields:    Translation:Humans
  17. Jung C, Wernly B, Fjølner J, Bruno RR, Dudzinski D, Artigas A, Bollen Pinto B, Schefold JC, Wolff G, Kelm M, Beil M, Sigal S, van Heerden PV, Szczeklik W, Czuczwar M, Elhadi M, Joannidis M, Oeyen S, Zafeiridis T, Marsh B, Andersen FH, Moreno R, Cecconi M, Leaver S, Boumendil A, De Lange DW, Guidet B, Flaatten H. Steroid use in elderly critically ill COVID-19 patients. Eur Respir J. 2021 Oct; 58(4). PMID: 34172464.
    Citations: 15     Fields:    Translation:HumansCells
  18. Jung C, Fjølner J, Bruno RR, Wernly B, Artigas A, Bollen Pinto B, Schefold JC, Wolff G, Kelm M, Beil M, Sviri S, van Heerden PV, Szczeklik W, Czuczwar M, Joannidis M, Oeyen S, Zafeiridis T, Andersen FH, Moreno R, Leaver S, Boumendil A, De Lange DW, Guidet B, Flaatten H. Differences in mortality in critically ill elderly patients during the second COVID-19 surge in Europe. Crit Care. 2021 09 23; 25(1):344. PMID: 34556171.
    Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
  19. Scheid S, Goeller M, Baar W, Wollborn J, Buerkle H, Schlunck G, Lagrèze W, Goebel U, Ulbrich F. Hydrogen Sulfide Reduces Ischemia and Reperfusion Injury in Neuronal Cells in a Dose- and Time-Dependent Manner. Int J Mol Sci. 2021 Sep 18; 22(18). PMID: 34576259.
    Citations: 3     Fields:    Translation:AnimalsCells
  20. Bruno RR, Wernly B, Flaatten H, Fjølner J, Artigas A, Bollen Pinto B, Schefold JC, Binnebössel S, Baldia PH, Kelm M, Beil M, Sigal S, van Heerden PV, Szczeklik W, Elhadi M, Joannidis M, Oeyen S, Zafeiridis T, Wollborn J, Arche Banzo MJ, Fuest K, Marsh B, Andersen FH, Moreno R, Leaver S, Boumendil A, De Lange DW, Guidet B, Jung C. Lactate is associated with mortality in very old intensive care patients suffering from COVID-19: results from an international observational study of 2860 patients. Ann Intensive Care. 2021 Aug 21; 11(1):128. PMID: 34417919.
    Citations: 12     
  21. Jung C, Flaatten H, Fjølner J, Bruno RR, Wernly B, Artigas A, Bollen Pinto B, Schefold JC, Wolff G, Kelm M, Beil M, Sviri S, van Heerden PV, Szczeklik W, Czuczwar M, Elhadi M, Joannidis M, Oeyen S, Zafeiridis T, Marsh B, Andersen FH, Moreno R, Cecconi M, Leaver S, Boumendil A, De Lange DW, Guidet B. The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study. Crit Care. 2021 04 19; 25(1):149. PMID: 33874987.
    Citations: 29     Fields:    Translation:Humans
  22. Hopper CP, Zambrana PN, Goebel U, Wollborn J. A brief history of carbon monoxide and its therapeutic origins. Nitric Oxide. 2021 06 01; 111-112:45-63. PMID: 33838343.
    Citations: 3     Fields:    Translation:HumansAnimals
  23. Jung C, Bruno RR, Wernly B, Joannidis M, Oeyen S, Zafeiridis T, Marsh B, Andersen FH, Moreno R, Fernandes AM, Artigas A, Pinto BB, Schefold J, Wolff G, Kelm M, De Lange DW, Guidet B, Flaatten H, Fjølner J. Inhibitors of the renin-angiotensin-aldosterone system and COVID-19 in critically ill elderly patients. Eur Heart J Cardiovasc Pharmacother. 2021 01 16; 7(1):76-77. PMID: 32645153.
    Citations: 12     Fields:    Translation:HumansCells
  24. Goebel U, Scheid S, Spassov S, Schallner N, Wollborn J, Buerkle H, Ulbrich F. Argon reduces microglial activation and inflammatory cytokine expression in retinal ischemia/reperfusion injury. Neural Regen Res. 2021 Jan; 16(1):192-198. PMID: 32788476.
    Citations: 7     
  25. Bruno RR, Wernly B, Hornemann J, Flaatten H, FjØlner J, Artigas A, Bollen Pinto B, Schefold JC, Wolff G, Baldia PH, Binneboessel S, Kelm M, Beil M, Sviri S, van Heerden PV, Szczeklik W, Elhadi M, Joannidis M, Oeyen S, Kondili E, Wollborn J, Marsh B, Andersen FH, Moreno R, Leaver S, Boumendil A, De Lange DW, Guidet B, Jung C. Early evaluation of organ failure using MELD-XI in critically ill elderly COVID-19 patients. Clin Hemorheol Microcirc. 2021; 79(1):109-120. PMID: 34487039.
    Citations: 2     Fields:    Translation:HumansCells
  26. Hopper CP, De La Cruz LK, Lyles KV, Wareham LK, Gilbert JA, Eichenbaum Z, Magierowski M, Poole RK, Wollborn J, Wang B. Role of Carbon Monoxide in Host-Gut Microbiome Communication. Chem Rev. 2020 12 23; 120(24):13273-13311. PMID: 33089988.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  27. Wollborn J, Jung C, Göbel U, Bruno RR. [Evaluation of the microcirculation in critically ill patients : Relevance, practical possibilities and scientific evidence]. Anaesthesist. 2020 10; 69(10):753-757. PMID: 32803320.
    Citations:    Fields:    Translation:Humans
  28. Watchorn JC, Fargaly H, Gilani M, Assadi J, Deitchman AR, Naumann DN, Wollborn J, Goebel U, McCurdy MT, Hutchings SD. The Reproducibility of the Point of Care Microcirculation (POEM) Score When Used to Assess Critically Ill Patients: A Multicenter Prospective Observational Study. Shock. 2020 07; 54(1):15-20. PMID: 31764623.
    Citations: 1     Fields:    Translation:Humans
  29. Wollborn J, Steiger C, Doostkam S, Schallner N, Schroeter N, Kari FA, Meinel L, Buerkle H, Schick MA, Goebel U. Carbon Monoxide Exerts Functional Neuroprotection After Cardiac Arrest Using Extracorporeal Resuscitation in Pigs. Crit Care Med. 2020 04; 48(4):e299-e307. PMID: 32205620.
    Citations:    Fields:    Translation:Animals
  30. Schmidt J, Wenzel C, Spassov S, Borgmann S, Lin Z, Wollborn J, Weber J, Haberstroh J, Meckel S, Eiden S, Wirth S, Schumann S. Flow-Controlled Ventilation Attenuates Lung Injury in a Porcine Model of Acute Respiratory Distress Syndrome: A Preclinical Randomized Controlled Study. Crit Care Med. 2020 03; 48(3):e241-e248. PMID: 31856000; PMCID: PMC7017946.
    Citations: 13     Fields:    Translation:Animals
  31. Goebel U, Wollborn J. Carbon monoxide in intensive care medicine-time to start the therapeutic application?! Intensive Care Med Exp. 2020 Jan 09; 8(1):2. PMID: 31919605; PMCID: PMC6952485.
    Citations: 15     
  32. Bruno RR, Schemmelmann M, Wollborn J, Kelm M, Jung C. Evaluation of a shorter algorithm in an automated analysis of sublingual microcirculation. Clin Hemorheol Microcirc. 2020; 76(2):287-297. PMID: 32925005.
    Citations: 1     Fields:    Translation:Humans
  33. Wollborn J, Steiger C, Ruetten E, Benk C, Kari FA, Wunder C, Meinel L, Buerkle H, Schick MA, Goebel U. Carbon monoxide improves haemodynamics during extracorporeal resuscitation in pigs. Cardiovasc Res. 2020 01 01; 116(1):158-170. PMID: 30873524.
    Citations: 1     Fields:    Translation:AnimalsCells
  34. Kaiser S, Frase S, Selzner L, Lieberum JL, Wollborn J, Niesen WD, Foit NA, Heiland DH, Schallner N. Neuroprotection after Hemorrhagic Stroke Depends on Cerebral Heme Oxygenase-1. Antioxidants (Basel). 2019 Oct 19; 8(10). PMID: 31635102; PMCID: PMC6827088.
    Citations: 10     
  35. Wollborn J, Schlueter B, Steiger C, Hermann C, Wunder C, Schmidt J, Diel P, Meinel L, Buerkle H, Goebel U, Schick MA. Extracorporeal resuscitation with carbon monoxide improves renal function by targeting inflammatory pathways in cardiac arrest in pigs. Am J Physiol Renal Physiol. 2019 12 01; 317(6):F1572-F1581. PMID: 31482730.
    Citations: 3     Fields:    Translation:Animals
  36. Hopper CP, Wollborn J. Delivery of carbon monoxide via halogenated ether anesthetics. Nitric Oxide. 2019 08 01; 89:93-95. PMID: 31125687.
    Citations: 2     Fields:    Translation:Humans
  37. Wollborn J, Siemering S, Steiger C, Buerkle H, Goebel U, Schick MA. Phosphodiesterase-4 inhibition reduces ECLS-induced vascular permeability and improves microcirculation in a rodent model of extracorporeal resuscitation. Am J Physiol Heart Circ Physiol. 2019 03 01; 316(3):H751-H761. PMID: 30681364.
    Citations: 5     Fields:    Translation:AnimalsCells
  38. Maier S, Goebel U, Krause S, Benk C, Schick MA, Buerkle H, Beyersdorf F, Kari FA, Wollborn J. Somatosensory and transcranial motor evoked potential monitoring in a porcine model for experimental procedures. PLoS One. 2018; 13(10):e0205410. PMID: 30296297.
    Citations: 1     Fields:    Translation:HumansAnimals
  39. Wollborn J, Hermann C, Goebel U, Merget B, Wunder C, Maier S, Schäfer T, Heuler D, Müller-Buschbaum K, Buerkle H, Meinel L, Schick MA, Steiger C. Overcoming safety challenges in CO therapy - Extracorporeal CO delivery under precise feedback control of systemic carboxyhemoglobin levels. J Control Release. 2018 06 10; 279:336-344. PMID: 29655987.
    Citations: 5     Fields:    Translation:Animals
  40. Wollborn J, Ruetten E, Schlueter B, Haberstroh J, Goebel U, Schick MA. Standardized model of porcine resuscitation using a custom-made resuscitation board results in optimal hemodynamic management. Am J Emerg Med. 2018 10; 36(10):1738-1744. PMID: 29395757.
    Citations: 4     Fields:    Translation:HumansAnimals
  41. Wollborn J, Schlegel N, Schick MA. [Phosphodiesterase 4 inhibition for treatment of endothelial barrier and microcirculation disorders in sepsis]. Anaesthesist. 2017 May; 66(5):347-352. PMID: 28429038.
    Citations: 2     Fields:    Translation:HumansAnimals
  42. Rosenbaum C, Schick MA, Wollborn J, Heider A, Scholz CJ, Cecil A, Niesler B, Hirrlinger J, Walles H, Metzger M. Activation of Myenteric Glia during Acute Inflammation In Vitro and In Vivo. PLoS One. 2016; 11(3):e0151335. PMID: 26964064.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  43. Steiger C, Wollborn J, Gutmann M, Zehe M, Wunder C, Meinel L. Controlled therapeutic gas delivery systems for quality-improved transplants. Eur J Pharm Biopharm. 2015 Nov; 97(Pt A):96-106. PMID: 26527426.
    Citations: 2     Fields:    Translation:AnimalsCells
  44. Schick MA, Baar W, Bruno RR, Wollborn J, Held C, Schneider R, Flemming S, Schlegel N, Roewer N, Neuhaus W, Wunder C. Balanced Hydroxyethylstarch (HES 130/0.4) Impairs Kidney Function In-Vivo without Inflammation. PLoS One. 2015; 10(9):e0137247. PMID: 26340751; PMCID: PMC4560431.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  45. Wollborn J, Wunder C, Stix J, Neuhaus W, Bruno RR, Baar W, Flemming S, Roewer N, Schlegel N, Schick MA. Phosphodiesterase-4 inhibition with rolipram attenuates hepatocellular injury in hyperinflammation in vivo and in vitro without influencing inflammation and HO-1 expression. J Pharmacol Pharmacother. 2015 Jan-Mar; 6(1):13-23. PMID: 25709347; PMCID: PMC4319242.
    Citations: 5     
  46. Schick MA, Baar W, Flemming S, Schlegel N, Wollborn J, Held C, Schneider R, Brock RW, Roewer N, Wunder C. Sepsis-induced acute kidney injury by standardized colon ascendens stent peritonitis in rats - a simple, reproducible animal model. Intensive Care Med Exp. 2014 Dec; 2(1):34. PMID: 26266931; PMCID: PMC4513002.
    Citations: 6     
  47. Flemming S, Schlegel N, Wunder C, Meir M, Baar W, Wollborn J, Roewer N, Germer CT, Schick MA. Phosphodiesterase 4 inhibition dose dependently stabilizes microvascular barrier functions and microcirculation in a rodent model of polymicrobial sepsis. Shock. 2014 Jun; 41(6):537-45. PMID: 24569506.
    Citations: 14     Fields:    Translation:Animals
  48. Schick MA, Wunder C, Wollborn J, Roewer N, Waschke J, Germer CT, Schlegel N. Phosphodiesterase-4 inhibition as a therapeutic approach to treat capillary leakage in systemic inflammation. J Physiol. 2012 Jun 01; 590(11):2693-708. PMID: 22495586.
    Citations: 26     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.