Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

HMS faculty, help us improve the algorithms in Profiles by uploading your CV!

Renato Umeton, Ph.D.

Title
Institution
Department
Address

Overview
Affiliate, Dana-Farber Cancer Institute
Affiliate, Massachusetts Institute of Technology
Affiliate, Harvard T.H. Chan School of Public Health
Affiliate, Weill Cornell Medical

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ricciuti B, Wang X, Alessi JV, Rizvi H, Mahadevan NR, Li YY, Polio A, Lindsay J, Umeton R, Sinha R, Vokes NI, Recondo G, Lamberti G, Lawrence M, Vaz VR, Leonardi GC, Plodkowski AJ, Gupta H, Cherniack AD, Tolstorukov MY, Sharma B, Felt KD, Gainor JF, Ravi A, Getz G, Schalper KA, Henick B, Forde P, Anagnostou V, Jänne PA, Van Allen EM, Nishino M, Sholl LM, Christiani DC, Lin X, Rodig SJ, Hellmann MD, Awad MM. Association of High Tumor Mutation Burden in Non-Small Cell Lung Cancers With Increased Immune Infiltration and Improved Clinical Outcomes of PD-L1 Blockade Across PD-L1 Expression Levels. JAMA Oncol. 2022 08 01; 8(8):1160-1168. PMID: 35708671; PMCID: PMC9204620.
    Citations:    Fields:    
  2. Gray TF, Kwok A, Do KM, Zeng S, Moseley ET, Dbeis YM, Umeton R, Tulsky JA, El-Jawahri A, Lindvall C. Associations Between Family Member Involvement and Outcomes of Patients Admitted to the Intensive Care Unit: Retrospective Cohort Study. JMIR Med Inform. 2022 Jun 15; 10(6):e33921. PMID: 35704362; PMCID: PMC9244649.
    Citations:    
  3. Bychkovsky BL, Li T, Sotelo J, Tayob N, Mercado J, Gomy I, Chittenden A, Kane S, Stokes S, Hughes ME, Kim JS, Umeton R, Awad MM, Konstantinopoulos PA, Yurgelun MB, Wolpin BM, Taplin ME, Newmark RE, Johnson BE, Lindeman NI, MacConaill LE, Garber JE, Lin NU. Identification and Management of Pathogenic Variants in BRCA1, BRCA2, and PALB2 in a Tumor-Only Genomic Testing Program. Clin Cancer Res. 2022 06 01; 28(11):2349-2360. PMID: 35363308; PMCID: PMC9167798.
    Citations:    Fields:    Translation:Humans
  4. Lindvall C, Deng CY, Agaronnik ND, Kwok A, Samineni S, Umeton R, Mackie-Jenkins W, Kehl KL, Tulsky JA, Enzinger AC. Deep Learning for Cancer Symptoms Monitoring on the Basis of Electronic Health Record Unstructured Clinical Notes. JCO Clin Cancer Inform. 2022 06; 6:e2100136. PMID: 35714301; PMCID: PMC9232368.
    Citations:    Fields:    Translation:Humans
  5. Umeton R, Bellucci G, Bigi R, Romano S, Buscarinu MC, Reniè R, Rinaldi V, Pizzolato Umeton R, Morena E, Romano C, Mechelli R, Salvetti M, Ristori G. Multiple sclerosis genetic and non-genetic factors interact through the transient transcriptome. Sci Rep. 2022 05 09; 12(1):7536. PMID: 35534508; PMCID: PMC9085834.
    Citations:    Fields:    Translation:HumansCells
  6. Rosenthal J, Carelli R, Omar M, Brundage D, Halbert E, Nyman J, Hari SN, Van Allen EM, Marchionni L, Umeton R, Loda M. Building Tools for Machine Learning and Artificial Intelligence in Cancer Research: Best Practices and a Case Study with the PathML Toolkit for Computational Pathology. Mol Cancer Res. 2022 02; 20(2):202-206. PMID: 34880124; PMCID: PMC9127877.
    Citations: 1     Fields:    Translation:Humans
  7. Ferraldeschi M, Romano S, Giglio S, Romano C, Morena E, Mechelli R, Annibali V, Ubaldi M, Buscarinu MC, Umeton R, Sani G, Vecchione A, Salvetti M, Ristori G. Circulating hsa-miR-323b-3p in Huntington's Disease: A Pilot Study. Front Neurol. 2021; 12:657973. PMID: 34025560.
    Citations: 1     
  8. Penney KL, Tyekucheva S, Rosenthal J, El Fandy H, Carelli R, Borgstein S, Zadra G, Fanelli GN, Stefanizzi L, Giunchi F, Pomerantz M, Peisch S, Coulson H, Lis R, Kibel AS, Fiorentino M, Umeton R, Loda M. Metabolomics of Prostate Cancer Gleason Score in Tumor Tissue and Serum. Mol Cancer Res. 2021 03; 19(3):475-484. PMID: 33168599; PMCID: PMC8369519.
    Citations: 3     Fields:    Translation:Humans
  9. Albayrak A, Garrido-Castro AC, Giannakis M, Umeton R, Manam MD, Stover EH, Porter RL, Johnson BE, Liaw KL, Amonkar M, Church AJ, Janeway KA, Nowak JA, Sholl L, Lin NU, Johnson JM. Clinical Pan-Cancer Assessment of Mismatch Repair Deficiency Using Tumor-Only, Targeted Next-Generation Sequencing. JCO Precis Oncol. 2020 Nov; 4:1084-1097. PMID: 35050773.
    Citations: 1     Fields:    
  10. Lamberti G, Spurr LF, Li Y, Ricciuti B, Recondo G, Umeton R, Nishino M, Sholl LM, Meyerson ML, Cherniack AD, Awad MM. Clinicopathological and genomic correlates of programmed cell death ligand 1 (PD-L1) expression in nonsquamous non-small-cell lung cancer. Ann Oncol. 2020 06; 31(6):807-814. PMID: 32171752.
    Citations: 25     Fields:    Translation:Humans
  11. Ricciuti B, Recondo G, Spurr LF, Li YY, Lamberti G, Venkatraman D, Umeton R, Cherniack AD, Nishino M, Sholl LM, Shapiro GI, Awad MM, Cheng ML. Impact of DNA Damage Response and Repair (DDR) Gene Mutations on Efficacy of PD-(L)1 Immune Checkpoint Inhibition in Non-Small Cell Lung Cancer. Clin Cancer Res. 2020 08 01; 26(15):4135-4142. PMID: 32332016.
    Citations: 41     Fields:    Translation:HumansCells
  12. Waring J, Lindvall C, Umeton R. Automated machine learning: Review of the state-of-the-art and opportunities for healthcare. Artif Intell Med. 2020 04; 104:101822. PMID: 32499001.
    Citations: 57     Fields:    Translation:Humans
  13. Recondo G, Bahcall M, Spurr LF, Che J, Ricciuti B, Leonardi GC, Lo YC, Li YY, Lamberti G, Nguyen T, Milan MSD, Venkatraman D, Umeton R, Paweletz CP, Albayrak A, Cherniack AD, Price KS, Fairclough SR, Nishino M, Sholl LM, Oxnard GR, Jänne PA, Awad MM. Molecular Mechanisms of Acquired Resistance to MET Tyrosine Kinase Inhibitors in Patients with MET Exon 14-Mutant NSCLC. Clin Cancer Res. 2020 06 01; 26(11):2615-2625. PMID: 32034073.
    Citations: 41     Fields:    Translation:Humans
  14. Barroso-Sousa R, Keenan TE, Pernas S, Exman P, Jain E, Garrido-Castro AC, Hughes M, Bychkovsky B, Umeton R, Files JL, Lindeman NI, MacConaill LE, Hodi FS, Krop IE, Dillon D, Winer EP, Wagle N, Lin NU, Mittendorf EA, Van Allen EM, Tolaney SM. Tumor Mutational Burden and PTEN Alterations as Molecular Correlates of Response to PD-1/L1 Blockade in Metastatic Triple-Negative Breast Cancer. Clin Cancer Res. 2020 06 01; 26(11):2565-2572. PMID: 32019858.
    Citations: 51     Fields:    Translation:Humans
  15. Mechelli R, Umeton R, Manfrè G, Romano S, Buscarinu MC, Rinaldi V, Bellucci G, Bigi R, Ferraldeschi M, Salvetti M, Ristori G. Reworking GWAS Data to Understand the Role of Nongenetic Factors in MS Etiopathogenesis. Genes (Basel). 2020 01 14; 11(1). PMID: 31947683.
    Citations: 2     Fields:    Translation:Humans
  16. Vokes NI, Liu D, Ricciuti B, Jimenez-Aguilar E, Rizvi H, Dietlein F, He MX, Margolis CA, Elmarakeby HA, Girshman J, Adeni A, Sanchez-Vega F, Schultz N, Dahlberg S, Zehir A, Jänne PA, Nishino M, Umeton R, Sholl LM, Van Allen EM, Hellmann MD, Awad MM. Harmonization of Tumor Mutational Burden Quantification and Association With Response to Immune Checkpoint Blockade in Non-Small-Cell Lung Cancer. JCO Precis Oncol. 2019; 3. PMID: 31832578; PMCID: PMC6907021.
    Citations: 24     Fields:    
  17. Ricciuti B, Kravets S, Dahlberg SE, Umeton R, Albayrak A, Subegdjo SJ, Johnson BE, Nishino M, Sholl LM, Awad MM. Use of targeted next generation sequencing to characterize tumor mutational burden and efficacy of immune checkpoint inhibition in small cell lung cancer. J Immunother Cancer. 2019 03 28; 7(1):87. PMID: 30922388.
    Citations: 27     Fields:    Translation:Humans
  18. La Starza S, Ferraldeschi M, Buscarinu MC, Romano S, Fornasiero A, Mechelli R, Umeton R, Ristori G, Salvetti M. Genome-Wide Multiple Sclerosis Association Data and Coagulation. Front Neurol. 2019; 10:95. PMID: 30837932; PMCID: PMC6383413.
    Citations: 3     
  19. Nassar AH, Umeton R, Kim J, Lundgren K, Harshman L, Van Allen EM, Preston M, Dong F, Bellmunt J, Mouw KW, Choueiri TK, Sonpavde G, Kwiatkowski DJ. Mutational Analysis of 472 Urothelial Carcinoma Across Grades and Anatomic Sites. Clin Cancer Res. 2019 04 15; 25(8):2458-2470. PMID: 30593515.
    Citations: 32     Fields:    Translation:Humans
  20. Dunn IF, Du Z, Touat M, Sisti MB, Wen PY, Umeton R, Dubuc AM, Ducar M, Canoll PD, Severson E, Elvin JA, Ramkissoon SH, Lin JR, Cabrera L, Acevedo B, Sorger PK, Ligon KL, Santagata S, Reardon DA. Mismatch repair deficiency in high-grade meningioma: a rare but recurrent event associated with dramatic immune activation and clinical response to PD-1 blockade. JCO Precis Oncol. 2018; 2018. PMID: 30801050; PMCID: PMC6383717.
    Citations: 18     Fields:    
  21. Sabari JK, Leonardi GC, Shu CA, Umeton R, Montecalvo J, Ni A, Chen R, Dienstag J, Mrad C, Bergagnini I, Lai WV, Offin M, Arbour KC, Plodkowski AJ, Halpenny DF, Paik PK, Li BT, Riely GJ, Kris MG, Rudin CM, Sholl LM, Nishino M, Hellmann MD, Rekhtman N, Awad MM, Drilon A. PD-L1 expression, tumor mutational burden, and response to immunotherapy in patients with MET exon 14 altered lung cancers. Ann Oncol. 2018 10 01; 29(10):2085-2091. PMID: 30165371.
    Citations: 79     Fields:    Translation:Humans
  22. Annibali V, Umeton R, Palermo A, Severa M, Etna MP, Giglio S, Romano S, Ferraldeschi M, Buscarinu MC, Vecchione A, Annese A, Policano C, Mechelli R, Pizzolato Umeton R, Fornasiero A, Angelini DF, Guerrera G, Battistini L, Coccia EM, Salvetti M, Ristori G. Analysis of coding and non-coding transcriptome of peripheral B cells reveals an altered interferon response factor (IRF)-1 pathway in multiple sclerosis patients. J Neuroimmunol. 2018 11 15; 324:165-171. PMID: 30270021.
    Citations: 1     Fields:    Translation:HumansCells
  23. Buscarinu MC, Romano S, Mechelli R, Pizzolato Umeton R, Ferraldeschi M, Fornasiero A, Reniè R, Cerasoli B, Morena E, Romano C, Loizzo ND, Umeton R, Salvetti M, Ristori G. Intestinal Permeability in Relapsing-Remitting Multiple Sclerosis. Neurotherapeutics. 2018 01; 15(1):68-74. PMID: 29119385.
    Citations: 21     Fields:    Translation:HumansAnimals
  24. Busch EL, Hornick JL, Umeton R, Albayrak A, Lindeman NI, MacConaill LE, Garcia EP, Ducar M, Rebbeck TR. Somatic mutations in CDH1 and CTNNB1 in primary carcinomas at 13 anatomic sites. Oncotarget. 2017 Oct 17; 8(49):85680-85691. PMID: 29156750.
    Citations: 6     Fields:    
  25. Eleuteri C, Olla S, Veroni C, Umeton R, Mechelli R, Romano S, Buscarinu MC, Ferrari F, Calò G, Ristori G, Salvetti M, Agresti C. A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials. Sci Rep. 2017 04 07; 7:45780. PMID: 28387380.
    Citations: 15     Fields:    Translation:AnimalsCells
  26. Buscarinu MC, Cerasoli B, Annibali V, Policano C, Lionetto L, Capi M, Mechelli R, Romano S, Fornasiero A, Mattei G, Piras E, Angelini DF, Battistini L, Simmaco M, Umeton R, Salvetti M, Ristori G. Altered intestinal permeability in patients with relapsing-remitting multiple sclerosis: A pilot study. Mult Scler. 2017 Mar; 23(3):442-446. PMID: 27270497.
    Citations: 43     Fields:    Translation:Humans
  27. Cavallari M, Stamile C, Umeton R, Calimeri F, Orzi F. Novel Method for Automated Analysis of Retinal Images: Results in Subjects with Hypertensive Retinopathy and CADASIL. Biomed Res Int. 2015; 2015:752957. PMID: 26167496.
    Citations: 5     Fields:    Translation:Humans
  28. Mechelli R, Manzari C, Policano C, Annese A, Picardi E, Umeton R, Fornasiero A, D'Erchia AM, Buscarinu MC, Agliardi C, Annibali V, Serafini B, Rosicarelli B, Romano S, Angelini DF, Ricigliano VA, Buttari F, Battistini L, Centonze D, Guerini FR, D'Alfonso S, Pesole G, Salvetti M, Ristori G. Epstein-Barr virus genetic variants are associated with multiple sclerosis. Neurology. 2015 Mar 31; 84(13):1362-8. PMID: 25740864; PMCID: PMC4388746.
    Citations: 21     Fields:    Translation:HumansCells
  29. Bordi I, Ricigliano VA, Umeton R, Ristori G, Grassi F, Crisanti A, Sutera A, Salvetti M. Noise in multiple sclerosis: unwanted and necessary. Ann Clin Transl Neurol. 2014 Jul; 1(7):502-11. PMID: 25356421.
    Citations: 3     Fields:    
  30. Ricigliano VA, Umeton R, Germinario L, Alma E, Briani M, Di Segni N, Montesanti D, Pierelli G, Cancrini F, Lomonaco C, Grassi F, Palmieri G, Salvetti M. Contribution of genome-wide association studies to scientific research: a pragmatic approach to evaluate their impact. PLoS One. 2013; 8(8):e71198. PMID: 23967165.
    Citations: 4     Fields:    Translation:Humans
  31. Koo A, Nordsletten D, Umeton R, Yankama B, Ayyadurai S, García-Cardeña G, Dewey CF. In silico modeling of shear-stress-induced nitric oxide production in endothelial cells through systems biology. Biophys J. 2013 May 21; 104(10):2295-306. PMID: 23708369.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  32. Mechelli R, Umeton R, Policano C, Annibali V, Coarelli G, Ricigliano VA, Vittori D, Fornasiero A, Buscarinu MC, Romano S, Salvetti M, Ristori G. A "candidate-interactome" aggregate analysis of genome-wide association data in multiple sclerosis. PLoS One. 2013; 8(5):e63300. PMID: 23696811.
    Citations: 14     Fields:    Translation:HumansCells
  33. Bordi I, Umeton R, Ricigliano VA, Annibali V, Mechelli R, Ristori G, Grassi F, Salvetti M, Sutera A. A mechanistic, stochastic model helps understand multiple sclerosis course and pathogenesis. Int J Genomics. 2013; 2013:910321. PMID: 23671846.
    Citations: 9     
  34. Carapezza G, Umeton R, Costanza J, Angione C, Stracquadanio G, Papini A, Lió P, Nicosia G. Efficient behavior of photosynthetic organelles via Pareto optimality, identifiability, and sensitivity analysis. ACS Synth Biol. 2013 May 17; 2(5):274-88. PMID: 23654280.
    Citations: 3     Fields:    Translation:AnimalsCells
  35. Umeton R, Nicosia G, Dewey CF. OREMPdb: a semantic dictionary of computational pathway models. BMC Bioinformatics. 2012 Mar 28; 13 Suppl 4:S6. PMID: 22536973.
    Citations: 4     Fields:    
  36. Umeton R, Stracquadanio G, Papini A, Costanza J, Liò P, Nicosia G. Identification of sensitive enzymes in the photosynthetic carbon metabolism. Adv Exp Med Biol. 2012; 736:441-59. PMID: 22161345.
    Citations: 1     Fields:    Translation:AnimalsCells
  37. Nordsletten DA, Yankama B, Umeton R, Ayyadurai VA, Dewey CF. Multiscale mathematical modeling to support drug development. IEEE Trans Biomed Eng. 2011 Dec; 58(12):3508-12. PMID: 22042123.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  38. Calabrese R, Zampieri M, Mechelli R, Annibali V, Guastafierro T, Ciccarone F, Coarelli G, Umeton R, Salvetti M, Caiafa P. Methylation-dependent PAD2 upregulation in multiple sclerosis peripheral blood. Mult Scler. 2012 Mar; 18(3):299-304. PMID: 21878453.
    Citations: 24     Fields:    Translation:HumansCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: SPH faculty should contact Faculty Affairs at facultyaffairshsph.harvard.edu).
Umeton's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (142)
Explore
_
Co-Authors (77)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.