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Renato Umeton, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lamberti G, Spurr LF, Li Y, Ricciuti B, Recondo G, Umeton R, Nishino M, Sholl LM, Meyerson ML, Cherniack AD, Awad MM. Clinicopathological and genomic correlates of programmed cell death ligand 1 (PD-L1) expression in nonsquamous non-small-cell lung cancer. Ann Oncol. 2020 Apr 27. PMID: 32171752.
    Citations:    
  2. Ricciuti B, Recondo G, Spurr LF, Li YY, Lamberti G, Venkatraman D, Umeton R, Cherniack AD, Nishino M, Sholl LM, Shapiro GI, Awad MM, Cheng ML. Impact of DNA Damage Response and Repair (DDR) Gene Mutations on Efficacy of PD-(L)1 Immune Checkpoint Inhibition in Non-Small Cell Lung Cancer. Clin Cancer Res. 2020 Aug 01; 26(15):4135-4142. PMID: 32332016.
    Citations:    
  3. Waring J, Lindvall C, Umeton R. Automated machine learning: Review of the state-of-the-art and opportunities for healthcare. Artif Intell Med. 2020 04; 104:101822. PMID: 32499001.
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  4. Recondo G, Bahcall M, Spurr LF, Che J, Ricciuti B, Leonardi GC, Lo YC, Li YY, Lamberti G, Nguyen T, Milan MSD, Venkatraman D, Umeton R, Paweletz CP, Albayrak A, Cherniack AD, Price KS, Fairclough SR, Nishino M, Sholl LM, Oxnard GR, Jänne PA, Awad MM. Molecular Mechanisms of Acquired Resistance to MET Tyrosine Kinase Inhibitors in Patients with MET Exon 14-Mutant NSCLC. Clin Cancer Res. 2020 Jun 01; 26(11):2615-2625. PMID: 32034073.
    Citations:    
  5. Barroso-Sousa R, Keenan TE, Pernas S, Exman P, Jain E, Garrido-Castro AC, Hughes M, Bychkovsky B, Umeton R, Files JL, Lindeman NI, MacConaill LE, Hodi FS, Krop IE, Dillon D, Winer EP, Wagle N, Lin NU, Mittendorf EA, Van Allen EM, Tolaney SM. Tumor Mutational Burden and PTEN Alterations as Molecular Correlates of Response to PD-1/L1 Blockade in Metastatic Triple-Negative Breast Cancer. Clin Cancer Res. 2020 Jun 01; 26(11):2565-2572. PMID: 32019858.
    Citations:    
  6. Mechelli R, Umeton R, Manfrè G, Romano S, Buscarinu MC, Rinaldi V, Bellucci G, Bigi R, Ferraldeschi M, Salvetti M, Ristori G. Reworking GWAS Data to Understand the Role of Nongenetic Factors in MS Etiopathogenesis. Genes (Basel). 2020 01 14; 11(1). PMID: 31947683.
    Citations:    
  7. Vokes NI, Liu D, Ricciuti B, Jimenez-Aguilar E, Rizvi H, Dietlein F, He MX, Margolis CA, Elmarakeby HA, Girshman J, Adeni A, Sanchez-Vega F, Schultz N, Dahlberg S, Zehir A, Jänne PA, Nishino M, Umeton R, Sholl LM, Van Allen EM, Hellmann MD, Awad MM. Harmonization of Tumor Mutational Burden Quantification and Association With Response to Immune Checkpoint Blockade in Non-Small-Cell Lung Cancer. JCO Precis Oncol. 2019; 3. PMID: 31832578.
    Citations:    
  8. Ricciuti B, Kravets S, Dahlberg SE, Umeton R, Albayrak A, Subegdjo SJ, Johnson BE, Nishino M, Sholl LM, Awad MM. Use of targeted next generation sequencing to characterize tumor mutational burden and efficacy of immune checkpoint inhibition in small cell lung cancer. J Immunother Cancer. 2019 03 28; 7(1):87. PMID: 30922388.
    Citations:    
  9. La Starza S, Ferraldeschi M, Buscarinu MC, Romano S, Fornasiero A, Mechelli R, Umeton R, Ristori G, Salvetti M. Genome-Wide Multiple Sclerosis Association Data and Coagulation. Front Neurol. 2019; 10:95. PMID: 30837932.
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  10. Nassar AH, Umeton R, Kim J, Lundgren K, Harshman L, Van Allen EM, Preston M, Dong F, Bellmunt J, Mouw KW, Choueiri TK, Sonpavde G, Kwiatkowski DJ. Mutational Analysis of 472 Urothelial Carcinoma Across Grades and Anatomic Sites. Clin Cancer Res. 2019 04 15; 25(8):2458-2470. PMID: 30593515.
    Citations:    Fields:    
  11. Dunn IF, Du Z, Touat M, Sisti MB, Wen PY, Umeton R, Dubuc AM, Ducar M, Canoll PD, Severson E, Elvin JA, Ramkissoon SH, Lin JR, Cabrera L, Acevedo B, Sorger PK, Ligon KL, Santagata S, Reardon DA. Mismatch repair deficiency in high-grade meningioma: a rare but recurrent event associated with dramatic immune activation and clinical response to PD-1 blockade. JCO Precis Oncol. 2018; 2018. PMID: 30801050.
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  12. Sabari JK, Leonardi GC, Shu CA, Umeton R, Montecalvo J, Ni A, Chen R, Dienstag J, Mrad C, Bergagnini I, Lai WV, Offin M, Arbour KC, Plodkowski AJ, Halpenny DF, Paik PK, Li BT, Riely GJ, Kris MG, Rudin CM, Sholl LM, Nishino M, Hellmann MD, Rekhtman N, Awad MM, Drilon A. PD-L1 expression, tumor mutational burden, and response to immunotherapy in patients with MET exon 14 altered lung cancers. Ann Oncol. 2018 10 01; 29(10):2085-2091. PMID: 30165371.
    Citations:    Fields:    
  13. Annibali V, Umeton R, Palermo A, Severa M, Etna MP, Giglio S, Romano S, Ferraldeschi M, Buscarinu MC, Vecchione A, Annese A, Policano C, Mechelli R, Pizzolato Umeton R, Fornasiero A, Angelini DF, Guerrera G, Battistini L, Coccia EM, Salvetti M, Ristori G. Analysis of coding and non-coding transcriptome of peripheral B cells reveals an altered interferon response factor (IRF)-1 pathway in multiple sclerosis patients. J Neuroimmunol. 2018 11 15; 324:165-171. PMID: 30270021.
    Citations:    
  14. Buscarinu MC, Romano S, Mechelli R, Pizzolato Umeton R, Ferraldeschi M, Fornasiero A, Reniè R, Cerasoli B, Morena E, Romano C, Loizzo ND, Umeton R, Salvetti M, Ristori G. Intestinal Permeability in Relapsing-Remitting Multiple Sclerosis. Neurotherapeutics. 2018 01; 15(1):68-74. PMID: 29119385.
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  15. Busch EL, Hornick JL, Umeton R, Albayrak A, Lindeman NI, MacConaill LE, Garcia EP, Ducar M, Rebbeck TR. Somatic mutations in CDH1 and CTNNB1 in primary carcinomas at 13 anatomic sites. Oncotarget. 2017 Oct 17; 8(49):85680-85691. PMID: 29156750.
    Citations: 1     Fields:    
  16. Eleuteri C, Olla S, Veroni C, Umeton R, Mechelli R, Romano S, Buscarinu MC, Ferrari F, Calò G, Ristori G, Salvetti M, Agresti C. A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials. Sci Rep. 2017 04 07; 7:45780. PMID: 28387380.
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  17. Buscarinu MC, Cerasoli B, Annibali V, Policano C, Lionetto L, Capi M, Mechelli R, Romano S, Fornasiero A, Mattei G, Piras E, Angelini DF, Battistini L, Simmaco M, Umeton R, Salvetti M, Ristori G. Altered intestinal permeability in patients with relapsing-remitting multiple sclerosis: A pilot study. Mult Scler. 2017 Mar; 23(3):442-446. PMID: 27270497.
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  18. Cavallari M, Stamile C, Umeton R, Calimeri F, Orzi F. Novel Method for Automated Analysis of Retinal Images: Results in Subjects with Hypertensive Retinopathy and CADASIL. Biomed Res Int. 2015; 2015:752957. PMID: 26167496.
    Citations: 3     Fields:    Translation:Humans
  19. Mechelli R, Manzari C, Policano C, Annese A, Picardi E, Umeton R, Fornasiero A, D'Erchia AM, Buscarinu MC, Agliardi C, Annibali V, Serafini B, Rosicarelli B, Romano S, Angelini DF, Ricigliano VA, Buttari F, Battistini L, Centonze D, Guerini FR, D'Alfonso S, Pesole G, Salvetti M, Ristori G. Epstein-Barr virus genetic variants are associated with multiple sclerosis. Neurology. 2015 Mar 31; 84(13):1362-8. PMID: 25740864.
    Citations:    
  20. Bordi I, Ricigliano VA, Umeton R, Ristori G, Grassi F, Crisanti A, Sutera A, Salvetti M. Noise in multiple sclerosis: unwanted and necessary. Ann Clin Transl Neurol. 2014 Jul; 1(7):502-11. PMID: 25356421.
    Citations:    
  21. Ricigliano VA, Umeton R, Germinario L, Alma E, Briani M, Di Segni N, Montesanti D, Pierelli G, Cancrini F, Lomonaco C, Grassi F, Palmieri G, Salvetti M. Contribution of genome-wide association studies to scientific research: a pragmatic approach to evaluate their impact. PLoS One. 2013; 8(8):e71198. PMID: 23967165.
    Citations:    
  22. Koo A, Nordsletten D, Umeton R, Yankama B, Ayyadurai S, García-Cardeña G, Dewey CF. In silico modeling of shear-stress-induced nitric oxide production in endothelial cells through systems biology. Biophys J. 2013 May 21; 104(10):2295-306. PMID: 23708369.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  23. Mechelli R, Umeton R, Policano C, Annibali V, Coarelli G, Ricigliano VA, Vittori D, Fornasiero A, Buscarinu MC, Romano S, Salvetti M, Ristori G. A "candidate-interactome" aggregate analysis of genome-wide association data in multiple sclerosis. PLoS One. 2013; 8(5):e63300. PMID: 23696811.
    Citations:    
  24. Bordi I, Umeton R, Ricigliano VA, Annibali V, Mechelli R, Ristori G, Grassi F, Salvetti M, Sutera A. A mechanistic, stochastic model helps understand multiple sclerosis course and pathogenesis. Int J Genomics. 2013; 2013:910321. PMID: 23671846.
    Citations:    
  25. Carapezza G, Umeton R, Costanza J, Angione C, Stracquadanio G, Papini A, Lió P, Nicosia G. Efficient behavior of photosynthetic organelles via Pareto optimality, identifiability, and sensitivity analysis. ACS Synth Biol. 2013 May 17; 2(5):274-88. PMID: 23654280.
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  26. Umeton R, Nicosia G, Dewey CF. OREMPdb: a semantic dictionary of computational pathway models. BMC Bioinformatics. 2012 Mar 28; 13 Suppl 4:S6. PMID: 22536973.
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  27. Umeton R, Stracquadanio G, Papini A, Costanza J, Liò P, Nicosia G. Identification of sensitive enzymes in the photosynthetic carbon metabolism. Adv Exp Med Biol. 2012; 736:441-59. PMID: 22161345.
    Citations:    
  28. Nordsletten DA, Yankama B, Umeton R, Ayyadurai VA, Dewey CF. Multiscale mathematical modeling to support drug development. IEEE Trans Biomed Eng. 2011 Dec; 58(12):3508-12. PMID: 22042123.
    Citations:    
  29. Calabrese R, Zampieri M, Mechelli R, Annibali V, Guastafierro T, Ciccarone F, Coarelli G, Umeton R, Salvetti M, Caiafa P. Methylation-dependent PAD2 upregulation in multiple sclerosis peripheral blood. Mult Scler. 2012 Mar; 18(3):299-304. PMID: 21878453.
    Citations:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.