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Patrick David Wilkinson, Ph.D.

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Biography
Saint Vincent College, Latrobe, PennsylvaniaBS05/2014Biology
Saint Vincent College, Latrobe, PennsylvaniaCert05/2014Biotechnology
University of Pittsburgh, Pittsburgh, PennsylvaniaPhD08/2019Cellular and Molecular Pathology
2019
ASIP Experimental Pathologist in Graduate Training Merit Award
2018
Award for Selected Oral Presentation at the FASEB Liver Science Research Conference
2017
ASIP Gold Poster Award
2014
Award for Academic Excellence in Field of Study for Biology
2014
Alpha Lambda Delta Maria Leonard Senior Book Award
2010 - 2014
Fr. Maximilian G. Duman Biology Scholarship

Overview
Patrick completed his Ph.D. in Cellular and Molecular Pathology at the University of Pittsburgh in 2019 under the direction of Dr. Andrew Duncan. His doctoral thesis focused on studying the role of polyploidy in liver regeneration and aneuploidy-mediated adaptation to chronic liver disease. He joined the lab of Dr. Wolfram Goessling in 2019 as a postdoctoral fellow to study developmental biology, with a focus on the endoderm. Patrick's research is focused on utilizing CRSIPR/Cas9-generated zebrafish models, combined with diet challenges and RNAseq analyses, to determine how lipid metabolism influences liver growth and development, and whether modulation of early lipid metabolism affects fatty liver disease susceptibility.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Delgado ER, Stahl EC, Roy N, Wilkinson PD, Duncan AW. The Liver: Biology and Pathobiology. Polyploidy in Liver Function, Mitochondrial Metabolism, and Cancer. 2020. View Publication.
  2. Stahl EC, Delgado ER, Alencastro F, LoPresti ST, Wilkinson PD, Roy N, Haschak MJ, Skillen CD, Monga SP, Duncan AW, Brown BN. Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by CCR2. Am J Pathol. 2020 02; 190(2):372-387. PMID: 31843499.
    Citations:    
  3. Wilkinson PD, Alencastro F, Delgado ER, Leek MP, Weirich MP, Otero PA, Roy N, Brown WK, Oertel M, Duncan AW. Polyploid Hepatocytes Facilitate Adaptation and Regeneration to Chronic Liver Injury. Am J Pathol. 2019 06; 189(6):1241-1255. PMID: 30928253.
    Citations:    
  4. Wilkinson PD, Delgado ER, Alencastro F, Leek MP, Roy N, Weirich MP, Stahl EC, Otero PA, Chen MI, Brown WK, Duncan AW. The Polyploid State Restricts Hepatocyte Proliferation and Liver Regeneration in Mice. Hepatology. 2019 03; 69(3):1242-1258. PMID: 30244478.
    Citations:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.