Harvard Catalyst Profiles

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Nicholas John Kramer, Ph.D.

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  1. F32GM139244 (KRAMER, NICHOLAS JOHN) Sep 1, 2020 - Aug 31, 2023
    NIH
    Mitonuclear coordination of gene expression across complex cellular states using mitoribosome profiling
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Goodman LD, Prudencio M, Kramer NJ, Martinez-Ramirez LF, Srinivasan AR, Lan M, Parisi MJ, Zhu Y, Chew J, Cook CN, Berson A, Gitler AD, Petrucelli L, Bonini NM. Author Correction: Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD. Nat Neurosci. 2023 Mar; 26(3):528. PMID: 36810653.
    Citations:    Fields:    
  2. Kramer NJ, Prakash G, Choquet K, Soto I, Petrova B, Merens HE, Kanarek N, Churchman LS. Genome-wide screens for mitonuclear co-regulators uncover links between compartmentalized metabolism and mitochondrial gene expression. bioRxiv. 2023 Feb 11. PMID: 36798306; PMCID: PMC9934615.
    Citations:    
  3. Dhungel N, Eleuteri S, Li LB, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields JA, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD. Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on a-Synuclein. Neuron. 2023 Jan 04; 111(1):138. PMID: 36603548; PMCID: PMC9876557.
    Citations:    Fields:    
  4. Rice AJ, Pelton JM, Kramer NJ, Catlin DS, Nair SK, Pogorelov TV, Mitchell DA, Bowers AA. Enzymatic Pyridine Aromatization during Thiopeptide Biosynthesis. J Am Chem Soc. 2022 11 23; 144(46):21116-21124. PMID: 36351243; PMCID: PMC9955758.
    Citations:    Fields:    
  5. Tang R, Murray CW, Linde IL, Kramer NJ, Lyu Z, Tsai MK, Chen LC, Cai H, Gitler AD, Engleman E, Lee W, Winslow MM. A versatile system to record cell-cell interactions. Elife. 2020 10 07; 9. PMID: 33025906.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  6. Cadilla R, Deaton DN, Do Y, Elkins PA, Ennulat D, Guss JH, Holt J, Jeune MR, King AG, Klapwijk JC, Kramer HF, Kramer NJ, Laffan SB, Masuria PI, McDougal AV, Mortenson PN, Musetti C, Peckham GE, Pietrak BL, Poole C, Price DJ, Rendina AR, Sati G, Saxty G, Shearer BG, Shewchuk LM, Sneddon HF, Stewart EL, Stuart JD, Thomas DN, Thomson SA, Ward P, Wilson JW, Xu T, Youngman MA. The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure. Bioorg Med Chem. 2020 12 01; 28(23):115791. PMID: 33059303.
    Citations:    Fields:    Translation:HumansAnimalsCells
  7. Bogart JW, Kramer NJ, Turlik A, Bleich RM, Catlin DS, Schroeder FC, Nair SK, Williamson RT, Houk KN, Bowers AA. Interception of the Bycroft-Gowland Intermediate in the Enzymatic Macrocyclization of Thiopeptides. J Am Chem Soc. 2020 07 29; 142(30):13170-13179. PMID: 32609512.
    Citations: 3     Fields:    Translation:Cells
  8. Yamada SB, Gendron TF, Niccoli T, Genuth NR, Grosely R, Shi Y, Glaria I, Kramer NJ, Nakayama L, Fang S, Dinger TJI, Thoeng A, Rocha G, Barna M, Puglisi JD, Partridge L, Ichida JK, Isaacs AM, Petrucelli L, Gitler AD. RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats. Nat Neurosci. 2019 09; 22(9):1383-1388. PMID: 31358992; PMCID: PMC6713615.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  9. Goodman LD, Prudencio M, Kramer NJ, Martinez-Ramirez LF, Srinivasan AR, Lan M, Parisi MJ, Zhu Y, Chew J, Cook CN, Berson A, Gitler AD, Petrucelli L, Bonini NM. Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD. Nat Neurosci. 2019 06; 22(6):863-874. PMID: 31110321; PMCID: PMC6535128.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  10. Bieri G, Brahic M, Bousset L, Couthouis J, Kramer NJ, Ma R, Nakayama L, Monbureau M, Defensor E, Schüle B, Shamloo M, Melki R, Gitler AD. LRRK2 modifies a-syn pathology and spread in mouse models and human neurons. Acta Neuropathol. 2019 06; 137(6):961-980. PMID: 30927072; PMCID: PMC6531417.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  11. Kramer NJ, Haney MS, Morgens DW, Jovicic A, Couthouis J, Li A, Ousey J, Ma R, Bieri G, Tsui CK, Shi Y, Hertz NT, Tessier-Lavigne M, Ichida JK, Bassik MC, Gitler AD. CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity. Nat Genet. 2018 04; 50(4):603-612. PMID: 29507424; PMCID: PMC5893388.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  12. Kramer NJ, Gitler AD. Raise the Roof: Boosting the Efficacy of a Spinal Muscular Atrophy Therapy. Neuron. 2017 Jan 04; 93(1):3-5. PMID: 28056344.
    Citations: 3     Fields:    Translation:Humans
  13. Kramer NJ, Carlomagno Y, Zhang YJ, Almeida S, Cook CN, Gendron TF, Prudencio M, Van Blitterswijk M, Belzil V, Couthouis J, Paul JW, Goodman LD, Daughrity L, Chew J, Garrett A, Pregent L, Jansen-West K, Tabassian LJ, Rademakers R, Boylan K, Graff-Radford NR, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Boeve BF, Deng N, Feng Y, Cheng TH, Dickson DW, Cohen SN, Bonini NM, Link CD, Gao FB, Petrucelli L, Gitler AD. Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts. Science. 2016 Aug 12; 353(6300):708-12. PMID: 27516603.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  14. Kramer NJ, Gitler AD. Regrowing axons with alternative splicing. Elife. 2016 07 15; 5. PMID: 27420813.
    Citations:    Fields:    Translation:AnimalsCells
  15. Jovicic A, Mertens J, Boeynaems S, Bogaert E, Chai N, Yamada SB, Paul JW, Sun S, Herdy JR, Bieri G, Kramer NJ, Gage FH, Van Den Bosch L, Robberecht W, Gitler AD. Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS. Nat Neurosci. 2015 Sep; 18(9):1226-9. PMID: 26308983; PMCID: PMC4552077.
    Citations: 317     Fields:    Translation:HumansAnimalsCells
  16. Kramer NJ, Wang WL, Reyes EY, Kumar B, Chen CC, Ramakrishna C, Cantin EM, Vonderfecht SL, Taganov KD, Chau N, Boldin MP. Altered lymphopoiesis and immunodeficiency in miR-142 null mice. Blood. 2015 Jun 11; 125(24):3720-30. PMID: 25931583.
    Citations: 61     Fields:    Translation:AnimalsCells
  17. Dhungel N, Eleuteri S, Li LB, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields JA, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD. Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on a-synuclein. Neuron. 2015 Jan 07; 85(1):76-87. PMID: 25533483; PMCID: PMC4289081.
    Citations: 83     Fields:    Translation:Animals
  18. Aby E, Gumps K, Roth A, Sigmon S, Jenkins SE, Kim JJ, Kramer NJ, Parfitt KD, Korey CA. Mutations in palmitoyl-protein thioesterase 1 alter exocytosis and endocytosis at synapses in Drosophila larvae. Fly (Austin). 2013 Oct-Dec; 7(4):267-79. PMID: 24091420.
    Citations: 19     Fields:    Translation:AnimalsCells
  19. Bing Y, Selassie D, Paradise RH, Isborn C, Kramer N, Sadilek M, Kaminsky W, Kahr B. Circular dichroism tensor of a triarylmethyl propeller in sodium chlorate crystals. J Am Chem Soc. 2010 Jun 02; 132(21):7454-65. PMID: 20446684.
    Citations: 3     Fields:    
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© 2023 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.