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Le Qiu, Ph.D.

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2012 - 2012
Advanced Imaging Concept Development Awards

My career in the field of medical physics and biotechnology started in 2004 when I came to Boston to pursue my Ph.D. degree. Years of physics studies provided me with a solid background in optics and engineering and interactions with clinicians and researchers at BIDMC have inspired my interest in applying this knowledge to medicine and biology.
During my postdoctoral and Ph.D. training in Prof. Perelman's laboratory I successfully worked on two exciting projects.

1. Confocal light absorption and scattering spectroscopic (CLASS) microscopy. The idea of CLASS microscopy, technique I have been working on recently, is based on light scattering spectroscopy developed by my advisor, Prof. Perelman, and his colleagues at MIT and Harvard. Light scattering spectroscopy enables non-invasive detection of disease in various organs of human body without the need for exogenous contrast agents, with hundreds of groups around the world working in this new field of medical imaging now. CLASS microscopy represents a breakthrough in the ability to observe the functions of subcellular organelles in living cells nondestructively with resolution approaching the spatial resolution of electron microscopy. This is accomplished without the need for exogenous contrast agents that could interfere with inherent cell functioning. It provides a novel way to use optical imaging techniques for non-invasive monitoring of embryonic cells on the submicron scale with no exogenous labels. The human embryo development and response to environmental factors could be monitored progressively at all critical stages using CLASS microscopy. For example, when cells are in metaphase, CLASS could provide information concerning the number and shape of chromosomes present. Since the CLASS measurement is nondestructive and requires no exogenous chemicals, a given embryo in vitro could be monitored over time before implantation. These kinds of progression studies are not possible with the techniques currently available. Another important application of CLASS microscopy is imaging gold nanoparticles in cells and tissue. Gold nanoparticles have been recently employed as extremely bright and stable molecular markers. By studying single gold nanorods with CLASS microscopy we observed extremely narrow plasmon scattering spectral lines. Those lines are significantly narrower than lines observed previously in the nanorod ensamples and can be used for imaging multiple molecular targets. We are now applying CLASS microscopy in such diverse areas as reproductive biology, early cancer detection, etc.

2. Endoscopic polarized scanning biopsy guidance technique. The purpose of this project is to develop an optical system which can perform rapid optical scanning and multispectral imaging of the entire epithelial surface of various organs in reproductive and gastrointestinal tracts and present a diagnosis in near real time. This approach is vastly superior to the present strategies of performing random biopsies. Thus, it will provide a powerful tool for screening large populations of patients for early precancerous changes. In its pilot clinical test in the esophagus at BIDMC this instrument, for the first time in the world, successfully guided biopsy detecting and mapping sites of invisible dysplasia missed by the current standard-of-care. A paper describing this work, where I am a first author, has recently been published in Nature Medicine. Also, I have recently been working on applying polarized light scattering spectroscopy to early detection
of ovarian cancer. In collaboration with gynecologic oncologists, surgeons and pathologists, we are in the process of developing a spectroscopic imaging instrument which will enable a physician to survey ovaries in patients with high levels of CA-125, BRCA mutations, and/or a family history of ovarian cancer in a minimally invasive fashion and determine with high probability the presence of early cancer.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Coughlan MF, Sawhney MS, Pleskow DK, Khan U, Silva-Santisteban A, Ahmed A, Zhang X, Glyavina M, Chen L, Upputuri PK, Zakharov YN, Zhang L, Qiu L, Perelman LT. Biopsy channel of the endoscope as a potential source of infectious droplets during gastrointestinal endoscopy. Gastrointest Endosc. 2022 Jun 17. PMID: 35724696.
    Citations:    Fields:    
  2. Liu D, Li G, Dang P, Zhang Q, Wei Y, Qiu L, Molokeev MS, Lian H, Shang M, Lin J. Highly efficient Fe3+-doped A2BB'O6 (A = Sr2+, Ca2+; B, B' = In3+, Sb5+, Sn4+) broadband near-infrared-emitting phosphors for spectroscopic analysis. Light Sci Appl. 2022 Apr 27; 11(1):112. PMID: 35478191; PMCID: PMC9046267.
    Citations: 1     
  3. Zhu HH, Ma YF, Yu K, Ouyang GF, Luo WD, Pei RZ, Xu WQ, Hu HX, Mo SP, Xu XH, Lan JP, Shen JP, Shou LH, Qian SX, Feng WY, Zhao P, Jiang JH, Hu BL, Zhang J, Qian SY, Wu GQ, Wu WP, Qiu L, Li LJ, Lang XH, Chen S, Chen LL, Guo JB, Cao LH, Jiang HF, Xia YM, Le J, Zhao JZ, Huang J, Zhang YF, Lv YL, Hua JS, Hong YW, Zheng CP, Wang JX, Hu BF, Chen XH, Zhang LM, Tao S, Xie BS, Kuang YM, Luo WJ, Su P, Guo J, Wu X, Jiang W, Zhang HQ, Zhang Y, Chen CM, Xu XF, Guo Y, Tu JM, Hu S, Yan XY, Yao C, Lou YJ, Jin J. Early Death and Survival of Patients With Acute Promyelocytic Leukemia in ATRA Plus Arsenic Era: A Population-Based Study. Front Oncol. 2021; 11:762653. PMID: 34868978.
  4. Pettinato G, Coughlan MF, Zhang X, Chen L, Khan U, Glyavina M, Sheil CJ, Upputuri PK, Zakharov YN, Vitkin E, D'Assoro AB, Fisher RA, Itzkan I, Zhang L, Qiu L, Perelman LT. Spectroscopic label-free microscopy of changes in live cell chromatin and biochemical composition in transplantable organoids. Sci Adv. 2021 08; 7(34). PMID: 34407934; PMCID: PMC8373132.
    Citations: 3     Fields:    Translation:HumansCells
  5. Qiu L, Zhang L, Horowitz GL, Turzhitsky V, Coughlan MF, Glyavina M, Khan U, Zakharov YN, Vitkin E, Itzkan I, Perelman LT. Rapid detection and identification of bacteria directly from whole blood with light scattering spectroscopy based biosensor. Sens Actuators B Chem. 2021 Nov 01; 346. PMID: 34483482.
  6. Coughlan MF, Sawhney MS, Pleskow DK, Sheil CJ, Qiu L, Perelman LT. Measuring Droplets Expelled During Endoscopy to Investigate COVID-19 Transmission Risk. Gastroenterology. 2021 11; 161(5):1702-1704.e3. PMID: 34280387; PMCID: PMC8284060.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  7. Pleskow DK, Zhang L, Turzhitsky V, Coughlan MF, Khan U, Zhang X, Sheil CJ, Glyavina M, Chen L, Shinagare S, Zakharov YN, Vitkin E, Itzkan I, Perelman LT, Qiu L. Coherent confocal light scattering spectroscopic microscopy evaluates cancer progression and aggressiveness in live cells and tissue. ACS Photonics. 2021 Jul 21; 8(7):2050-2059. PMID: 34485615; PMCID: PMC8411902.
    Citations: 1     
  8. Sheil CJ, Khan U, Zakharov YN, Coughlan MF, Pleskow DK, Sawhney MS, Berzin TM, Cohen JM, Glyavina M, Zhang L, Itzkan I, Perelman LT, Qiu L. Two-photon polymerization nanofabrication of ultracompact light scattering spectroscopic probe for detection of pre-cancer in pancreatic cyst. Opt Lasers Eng. 2021 Jul; 142. PMID: 34305200; PMCID: PMC8294208.
  9. Yu DN, Qiu L, Ning SY, Guo LX. Evaluation of efficacy and safety of DPP-4 inhibitors for Chinese elderly patients with type 2 diabetes mellitus. Diabetol Metab Syndr. 2020; 12:35. PMID: 32368255; PMCID: PMC7189465.
  10. Tao C, Seyfried WE, Lowell RP, Liu Y, Liang J, Guo Z, Ding K, Zhang H, Liu J, Qiu L, Egorov I, Liao S, Zhao M, Zhou J, Deng X, Li H, Wang H, Cai W, Zhang G, Zhou H, Lin J, Li W. Deep high-temperature hydrothermal circulation in a detachment faulting system on the ultra-slow spreading ridge. Nat Commun. 2020 Mar 10; 11(1):1300. PMID: 32157084; PMCID: PMC7064610.
    Citations: 4     Fields:    
  11. Turzhitsky V, Zhang L, Horowitz GL, Vitkin E, Khan U, Zakharov Y, Qiu L, Itzkan I, Perelman LT. Picoanalysis of Drugs in Biofluids with Quantitative Label-Free Surface-Enhanced Raman Spectroscopy. Small. 2018 11; 14(47):e1802392. PMID: 30369072; PMCID: PMC6389872.
    Citations: 8     Fields:    
  12. Qiu L, Zhang L, Turzhitsky V, Khan U, Zakharov Y, Kantekure K, Vitkin E, Itzkan I, Pleskow DK, Sawhney M, Berzin TM, Goldsmith JD, Perelman LT. Multispectral Endoscopy with Light Gating for Early Cancer Detection. IEEE J Sel Top Quantum Electron. 2019 Jan-Feb; 25(1). PMID: 31244520; PMCID: PMC6594557.
    Citations: 1     
  13. Qiu L, Chuttani R, Pleskow DK, Turzhitsky V, Khan U, Zakharov YN, Zhang L, Berzin TM, Yee EU, Sawhney MS, Li Y, Vitkin E, Goldsmith JD, Itzkan I, Perelman LT. Multispectral light scattering endoscopic imaging of esophageal precancer. Light Sci Appl. 2018; 7:17174. PMID: 30839534; PMCID: PMC6060057.
    Citations: 8     
  14. Zhang L, Pleskow DK, Turzhitsky V, Yee EU, Berzin TM, Sawhney M, Shinagare S, Vitkin E, Zakharov Y, Khan U, Wang F, Goldsmith JD, Goldberg S, Chuttani R, Itzkan I, Qiu L, Perelman LT. Light scattering spectroscopy identifies the malignant potential of pancreatic cysts during endoscopy. Nat Biomed Eng. 2017; 1. PMID: 29057146.
    Citations: 17     Fields:    
  15. Melo SA, Sugimoto H, O'Connell JT, Kato N, Villanueva A, Vidal A, Qiu L, Vitkin E, Perelman LT, Melo CA, Lucci A, Ivan C, Calin GA, Kalluri R. Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis. Cancer Cell. 2014 Nov 10; 26(5):707-21. PMID: 25446899; PMCID: PMC4254633.
    Citations: 675     Fields:    Translation:HumansAnimalsCells
  16. Turzhitsky V, Qiu L, Itzkan I, Novikov AA, Kotelev MS, Getmanskiy M, Vinokurov VA, Muradov AV, Perelman LT. Spectroscopy of scattered light for the characterization of micro and nanoscale objects in biology and medicine. Appl Spectrosc. 2014; 68(2):133-54. PMID: 24480270.
    Citations: 5     Fields:    
  17. Qiu L, Turzhitsky V, Chuttani R, Pleskow D, Goldsmith JD, Guo L, Vitkin E, Itzkan I, Hanlon EB, Perelman LT. Spectral Imaging with Scattered Light: From Early Cancer Detection to Cell Biology. IEEE J Sel Top Quantum Electron. 2012 May; 18(3):1073-1083. PMID: 23087592.
    Citations: 10     
  18. Vitkin E, Turzhitsky V, Qiu L, Guo L, Itzkan I, Hanlon EB, Perelman LT. Photon diffusion near the point-of-entry in anisotropically scattering turbid media. Nat Commun. 2011 Dec 13; 2:587. PMID: 22158442.
    Citations: 17     Fields:    Translation:HumansCells
  19. Qiu L, Pleskow DK, Chuttani R, Vitkin E, Leyden J, Ozden N, Itani S, Guo L, Sacks A, Goldsmith JD, Modell MD, Hanlon EB, Itzkan I, Perelman LT. Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett's esophagus. Nat Med. 2010 May; 16(5):603-6, 1p following 606. PMID: 20383155.
    Citations: 64     Fields:    Translation:Humans
  20. Lim KH, Salahuddin S, Qiu L, Fang H, Vitkin E, Ghiran IC, Modell MD, Takoudes T, Itzkan I, Hanlon EB, Sachs BP, Perelman LT. Light-scattering spectroscopy differentiates fetal from adult nucleated red blood cells: may lead to noninvasive prenatal diagnosis. Opt Lett. 2009 May 01; 34(9):1483-5. PMID: 19412313.
    Citations: 1     Fields:    Translation:HumansCells
  21. Qiu L, Chuttani R, Zhang S, Feng J, Itani S, Fang H, Pleskow D, Sawhney MS, Salahuddin S, Modell MD, Vitkin E, Hanlon EB, Itzkan I, Perelman LT. Diagnostic imaging of esophageal epithelium with clinical endoscopic polarized scanning spectroscopy instrument. Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:1997-2000. PMID: 19964032.
    Citations: 1     Fields:    Translation:HumansCells
  22. Itzkan I, Qiu L, Fang H, Zaman MM, Vitkin E, Ghiran IC, Salahuddin S, Modell M, Andersson C, Kimerer LM, Cipolloni PB, Lim KH, Freedman SD, Bigio I, Sachs BP, Hanlon EB, Perelman LT. Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17255-60. PMID: 17956980.
    Citations: 49     Fields:    Translation:HumansCells
  23. Fang H, Qiu L, Vitkin E, Zaman MM, Andersson C, Salahuddin S, Kimerer LM, Cipolloni PB, Modell MD, Turner BS, Keates SE, Bigio I, Itzkan I, Freedman SD, Bansil R, Hanlon EB, Perelman LT. Confocal light absorption and scattering spectroscopic microscopy. Appl Opt. 2007 Apr 01; 46(10):1760-9. PMID: 17356619.
    Citations: 17     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.