Harvard Catalyst Profiles

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Kamill Maksymilian Prondzynski, Ph.D.


University Medical Center Hamburg-Eppendorf, Hamburg02/2019Disease Modeling with Human Induced Pluripotent Stem Cells
University of Hamburg, HamburgPhD07/2018Biology
Fraunhofer Institute for Molecular Biology and Applied Ecology IME, ScreeningPort, Hamburg12/2014Assay Development, Stem Cells
University of Hamburg, HamburgMSc09/2014Molecular Life Sciences
Beiersdorf AG, Hamburg02/2012Microbiology
University of Hamburg, HamburgBSc08/2011Microbiology
Wilhem P. Winterstein Prize
Young Investigator Award
Poster Award

Featured Content

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bezzerides VJ, Prondzynski M, Carrier L, Pu WT. Gene therapy for inherited arrhythmias. Cardiovasc Res. 2020 07 15; 116(9):1635-1650. PMID: 32321160.
    Citations: 3     Fields:    Translation:HumansAnimals
  2. Lemme M, Braren I, Prondzynski M, Aksehirlioglu B, Ulmer BM, Schulze ML, Ismaili D, Meyer C, Hansen A, Christ T, Lemoine MD, Eschenhagen T. Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue. Cardiovasc Res. 2020 07 01; 116(8):1487-1499. PMID: 31598634.
    Citations: 11     Fields:    Translation:HumansCells
  3. Horváth A, Christ T, Koivumäki JT, Prondzynski M, Zech ATL, Spohn M, Saleem U, Mannhardt I, Ulmer B, Girdauskas E, Meyer C, Hansen A, Eschenhagen T, Lemoine MD. Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes-An Artifact by Big Conductance Calcium Activated Potassium Current (Ibk,Ca). Cells. 2020 01 20; 9(1). PMID: 31968557.
    Citations: 2     Fields:    Translation:HumansCells
  4. Prondzynski M, Lemoine MD, Zech AT, Horváth A, Di Mauro V, Koivumäki JT, Kresin N, Busch J, Krause T, Krämer E, Schlossarek S, Spohn M, Friedrich FW, Münch J, Laufer SD, Redwood C, Volk AE, Hansen A, Mearini G, Catalucci D, Meyer C, Christ T, Patten M, Eschenhagen T, Carrier L. Disease modeling of a mutation in a-actinin 2 guides clinical therapy in hypertrophic cardiomyopathy. EMBO Mol Med. 2019 12; 11(12):e11115. PMID: 31680489.
    Citations: 23     Fields:    Translation:HumansAnimals
  5. Breckwoldt K, Brenière-Letuffe D, Mannhardt I, Schulze T, Ulmer B, Werner T, Benzin A, Klampe B, Reinsch MC, Laufer S, Shibamiya A, Prondzynski M, Mearini G, Schade D, Fuchs S, Neuber C, Krämer E, Saleem U, Schulze ML, Rodriguez ML, Eschenhagen T, Hansen A. Author Correction: Differentiation of cardiomyocytes and generation of human engineered heart tissue. Nat Protoc. 2019 Sep; 14(9):2748. PMID: 31384055.
    Citations:    Fields:    
  6. Morhenn K, Quentin T, Wichmann H, Steinmetz M, Prondzynski M, Söhren KD, Christ T, Geertz B, Schröder S, Schöndube FA, Hasenfuss G, Schlossarek S, Zimmermann WH, Carrier L, Eschenhagen T, Cardinaux JR, Lutz S, Oetjen E. Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy. J Mol Cell Cardiol. 2019 02; 127:31-43. PMID: 30521840.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  7. Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M, Harmer SC, Tinker A, Smith JGW, Carrier L, Williams PM, Gaffney D, Eschenhagen T, Hansen A, Denning C. CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy. Eur Heart J. 2018 11 14; 39(43):3879-3892. PMID: 29741611.
    Citations: 54     Fields:    Translation:HumansCells
  8. Prondzynski M, Mearini G, Carrier L. Gene therapy strategies in the treatment of hypertrophic cardiomyopathy. Pflugers Arch. 2019 05; 471(5):807-815. PMID: 29971600.
    Citations: 9     Fields:    Translation:HumansAnimals
  9. Lemoine MD, Krause T, Koivumäki JT, Prondzynski M, Schulze ML, Girdauskas E, Willems S, Hansen A, Eschenhagen T, Christ T. Human Induced Pluripotent Stem Cell-Derived Engineered Heart Tissue as a Sensitive Test System for QT Prolongation and Arrhythmic Triggers. Circ Arrhythm Electrophysiol. 2018 07; 11(7):e006035. PMID: 29925535.
    Citations: 17     Fields:    Translation:HumansCells
  10. Singh SR, Zech ATL, Geertz B, Reischmann-Düsener S, Osinska H, Prondzynski M, Krämer E, Meng Q, Redwood C, van der Velden J, Robbins J, Schlossarek S, Carrier L. Activation of Autophagy Ameliorates Cardiomyopathy in Mybpc3-Targeted Knockin Mice. Circ Heart Fail. 2017 Oct; 10(10). PMID: 29021349.
    Citations: 18     Fields:    Translation:HumansAnimals
  11. Lemoine MD, Mannhardt I, Breckwoldt K, Prondzynski M, Flenner F, Ulmer B, Hirt MN, Neuber C, Horváth A, Kloth B, Reichenspurner H, Willems S, Hansen A, Eschenhagen T, Christ T. Human iPSC-derived cardiomyocytes cultured in 3D engineered heart tissue show physiological upstroke velocity and sodium current density. Sci Rep. 2017 07 14; 7(1):5464. PMID: 28710467.
    Citations: 51     Fields:    Translation:HumansCells
  12. Mannhardt I, Eder A, Dumotier B, Prondzynski M, Krämer E, Traebert M, Söhren KD, Flenner F, Stathopoulou K, Lemoine MD, Carrier L, Christ T, Eschenhagen T, Hansen A. Blinded Contractility Analysis in hiPSC-Cardiomyocytes in Engineered Heart Tissue Format: Comparison With Human Atrial Trabeculae. Toxicol Sci. 2017 07 01; 158(1):164-175. PMID: 28453742.
    Citations: 19     Fields:    Translation:HumansCells
  13. Prondzynski M, Krämer E, Laufer SD, Shibamiya A, Pless O, Flenner F, Müller OJ, Münch J, Redwood C, Hansen A, Patten M, Eschenhagen T, Mearini G, Carrier L. Evaluation of MYBPC3 trans-Splicing and Gene Replacement as Therapeutic Options in Human iPSC-Derived Cardiomyocytes. Mol Ther Nucleic Acids. 2017 Jun 16; 7:475-486. PMID: 28624223.
    Citations: 20     
  14. Breckwoldt K, Letuffe-Brenière D, Mannhardt I, Schulze T, Ulmer B, Werner T, Benzin A, Klampe B, Reinsch MC, Laufer S, Shibamiya A, Prondzynski M, Mearini G, Schade D, Fuchs S, Neuber C, Krämer E, Saleem U, Schulze ML, Rodriguez ML, Eschenhagen T, Hansen A. Differentiation of cardiomyocytes and generation of human engineered heart tissue. Nat Protoc. 2017 Jun; 12(6):1177-1197. PMID: 28492526.
    Citations: 58     Fields:    Translation:HumansCells
  15. Theis T, Mishra B, von der Ohe M, Loers G, Prondzynski M, Pless O, Blackshear PJ, Schachner M, Kleene R. Functional role of the interaction between polysialic acid and myristoylated alanine-rich C kinase substrate at the plasma membrane. J Biol Chem. 2013 Mar 01; 288(9):6726-42. PMID: 23329829.
    Citations: 16     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.