Harvard Catalyst Profiles

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Tracy Young-Pearse, Ph.D.

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Overview
Young-Pearse lab website:
http://youngpearselab.bwh.harvard.edu/Young-Pearse_Lab/home.html

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21MH118576 (YOUNG-PEARSE, TRACY L) Apr 1, 2019 - Feb 28, 2021
    NIH/NIMH
    Establishing a human cellular model of sex differences in the brain
    Role: Principal Investigator
  2. R01AG055909 (YOUNG-PEARSE, TRACY L) Jul 15, 2018 - Apr 30, 2023
    NIH/NIA
    Probing Heterogeneity of Alzheimer's disease using iPSCs
    Role: Principal Investigator
  3. RF1AG057457 (CHANG, RUI) Sep 15, 2017 - Aug 31, 2020
    NIH/NIA
    Building Novel Predictive Networks for high-throughput, in-silico Key Driver Prioritization to Enhance Drug Target Discovery in AMP-AD and M2OVE-AD
    Role: Co-Principal Investigator
  4. R21AG056011 (YOUNG-PEARSE, TRACY L) Apr 1, 2017 - Mar 31, 2019
    NIH/NIA
    Feasibility of studying vulnerability versus protection to high amyloid load using iPSCs
    Role: Principal Investigator
  5. R21AG053827 (YOUNG-PEARSE, TRACY L) Aug 1, 2016 - May 31, 2018
    NIH/NIA
    Altered APP metabolism triggers changes in tau that cause dementia
    Role: Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
Young-Pearse Laboratory - Antibodies (9), Mouse strains (11) and Plasmids (78)

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Pescosolido MF, Kavanaugh BC, Pochet N, Schmidt M, Jerskey BA, Rogg JM, De Jager PL, Young-Pearse TL, Liu JS, Morrow EM. Complex Neurological Phenotype in Female Carriers of NHE6 Mutations. Mol Neuropsychiatry. 2019 Apr; 5(2):98-108. PMID: 31192222.
    Citations:    
  2. Sullivan SE, Liao M, Smith RV, White C, Lagomarsino VN, Xu J, Taga M, Bennett DA, De Jager PL, Young-Pearse TL. Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in Aß and TAU proteostasis. Hum Mol Genet. 2019 Mar 01; 28(5):718-735. PMID: 30371777.
    Citations:    Fields:    
  3. Klein HU, McCabe C, Gjoneska E, Sullivan SE, Kaskow BJ, Tang A, Smith RV, Xu J, Pfenning AR, Bernstein BE, Meissner A, Schneider JA, Mostafavi S, Tsai LH, Young-Pearse TL, Bennett DA, De Jager PL. Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains. Nat Neurosci. 2019 01; 22(1):37-46. PMID: 30559478.
    Citations:    Fields:    
  4. Srikanth P, Lagomarsino VN, Pearse RV, Liao M, Ghosh S, Nehme R, Seyfried N, Eggan K, Young-Pearse TL. Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression. Transl Psychiatry. 2018 11 08; 8(1):245. PMID: 30410030.
    Citations:    Fields:    
  5. Raj T, Li YI, Wong G, Humphrey J, Wang M, Ramdhani S, Wang YC, Ng B, Gupta I, Haroutunian V, Schadt EE, Young-Pearse T, Mostafavi S, Zhang B, Sklar P, Bennett DA, De Jager PL. Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility. Nat Genet. 2018 11; 50(11):1584-1592. PMID: 30297968.
    Citations:    Fields:    
  6. Jin M, O'Nuallain B, Hong W, Boyd J, Lagomarsino VN, O'Malley TT, Liu W, Vanderburg CR, Frosch MP, Young-Pearse T, Selkoe DJ, Walsh DM. An in vitro paradigm to assess potential anti-Aß antibodies for Alzheimer's disease. Nat Commun. 2018 07 11; 9(1):2676. PMID: 29992960.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  7. Yu L, Petyuk VA, Gaiteri C, Mostafavi S, Young-Pearse T, Shah RC, Buchman AS, Schneider JA, Piehowski PD, Sontag RL, Fillmore TL, Shi T, Smith RD, De Jager PL, Bennett DA. Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia. Ann Neurol. 2018 Jul; 84(1):78-88. PMID: 29908079.
    Citations: 1     Fields:    
  8. Mostafavi S, Gaiteri C, Sullivan SE, White CC, Tasaki S, Xu J, Taga M, Klein HU, Patrick E, Komashko V, McCabe C, Smith R, Bradshaw EM, Root DE, Regev A, Yu L, Chibnik LB, Schneider JA, Young-Pearse TL, Bennett DA, De Jager PL. A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease. Nat Neurosci. 2018 06; 21(6):811-819. PMID: 29802388.
    Citations: 3     Fields:    
  9. Srikanth P, Lagomarsino VN, Muratore CR, Ryu SC, He A, Taylor WM, Zhou C, Arellano M, Young-Pearse TL. Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids. Transl Psychiatry. 2018 04 12; 8(1):77. PMID: 29643329.
    Citations: 1     Fields:    Translation:HumansCells
  10. Guix FX, Corbett GT, Cha DJ, Mustapic M, Liu W, Mengel D, Chen Z, Aikawa E, Young-Pearse T, Kapogiannis D, Selkoe DJ, Walsh DM. Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles. Int J Mol Sci. 2018 Feb 27; 19(3). PMID: 29495441.
    Citations: 1     Fields:    Translation:HumansCells
  11. Muratore CR, Zhou C, Liao M, Fernandez MA, Taylor WM, Lagomarsino VN, Pearse RV, Rice HC, Negri JM, He A, Srikanth P, Callahan DG, Shin T, Zhou M, Bennett DA, Noggle S, Love JC, Selkoe DJ, Young-Pearse TL. Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability. Stem Cell Reports. 2017 12 12; 9(6):1868-1884. PMID: 29153990.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  12. Wang Z, Jackson RJ, Hong W, Taylor WM, Corbett GT, Moreno A, Liu W, Li S, Frosch MP, Slutsky I, Young-Pearse TL, Spires-Jones TL, Walsh DM. Human Brain-Derived Aß Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP. J Neurosci. 2017 12 06; 37(49):11947-11966. PMID: 29101243.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  13. Sato Y, Uchida Y, Hu J, Young-Pearse TL, Niikura T, Mukouyama YS. Soluble APP functions as a vascular niche signal that controls adult neural stem cell number. Development. 2017 08 01; 144(15):2730-2736. PMID: 28694255.
    Citations: 2     Fields:    Translation:AnimalsCells
  14. Callahan DG, Taylor WM, Tilearcio M, Cavanaugh T, Selkoe DJ, Young-Pearse TL. Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortex. Dev Biol. 2017 04 15; 424(2):138-146. PMID: 28284905.
    Citations: 2     Fields:    Translation:AnimalsCells
  15. Liao MC, Muratore CR, Gierahn TM, Sullivan SE, Srikanth P, De Jager PL, Love JC, Young-Pearse TL. Single-Cell Detection of Secreted Aß and sAPPa from Human IPSC-Derived Neurons and Astrocytes. J Neurosci. 2016 Feb 03; 36(5):1730-46. PMID: 26843653.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  16. Young-Pearse TL, Morrow EM. Modeling developmental neuropsychiatric disorders with iPSC technology: challenges and opportunities. Curr Opin Neurobiol. 2016 Feb; 36:66-73. PMID: 26517284.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  17. Sullivan SE, Young-Pearse TL. Induced pluripotent stem cells as a discovery tool for Alzheimer?s disease. Brain Res. 2017 02 01; 1656:98-106. PMID: 26459988.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  18. Srikanth P, Han K, Callahan DG, Makovkina E, Muratore CR, Lalli MA, Zhou H, Boyd JD, Kosik KS, Selkoe DJ, Young-Pearse TL. Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate. Cell Rep. 2015 Sep 01; 12(9):1414-29. PMID: 26299970.
    Citations: 23     Fields:    Translation:HumansCells
  19. Kanmert D, Cantlon A, Muratore CR, Jin M, O'Malley TT, Lee G, Young-Pearse TL, Selkoe DJ, Walsh DM. C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death. J Neurosci. 2015 Jul 29; 35(30):10851-65. PMID: 26224867.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  20. Muratore CR, Srikanth P, Callahan DG, Young-Pearse TL. Comparison and optimization of hiPSC forebrain cortical differentiation protocols. PLoS One. 2014; 9(8):e105807. PMID: 25165848.
    Citations: 23     Fields:    Translation:HumansCells
  21. Preitner N, Quan J, Nowakowski DW, Hancock ML, Shi J, Tcherkezian J, Young-Pearse TL, Flanagan JG. APC is an RNA-binding protein, and its interactome provides a link to neural development and microtubule assembly. Cell. 2014 Jul 17; 158(2):368-382. PMID: 25036633.
    Citations: 40     Fields:    Translation:AnimalsCells
  22. Srikanth P, Young-Pearse TL. Stem cells on the brain: modeling neurodevelopmental and neurodegenerative diseases using human induced pluripotent stem cells. J Neurogenet. 2014 Mar-Jun; 28(1-2):5-29. PMID: 24628482.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  23. Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, Young-Pearse TL. The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. Hum Mol Genet. 2014 Jul 01; 23(13):3523-36. PMID: 24524897.
    Citations: 61     Fields:    Translation:HumansCells
  24. Rice HC, Young-Pearse TL, Selkoe DJ. Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein. Biochemistry. 2013 May 14; 52(19):3264-77. PMID: 23597280.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  25. Rice HC, Townsend M, Bai J, Suth S, Cavanaugh W, Selkoe DJ, Young-Pearse TL. Pancortins interact with amyloid precursor protein and modulate cortical cell migration. Development. 2012 Nov; 139(21):3986-96. PMID: 22992957.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  26. Taniguchi Y, Young-Pearse T, Sawa A, Kamiya A. In utero electroporation as a tool for genetic manipulation in vivo to study psychiatric disorders: from genes to circuits and behaviors. Neuroscientist. 2012 Apr; 18(2):169-79. PMID: 21551077.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  27. Rice H, Suth S, Cavanaugh W, Bai J, Young-Pearse TL. In utero electroporation followed by primary neuronal culture for studying gene function in subset of cortical neurons. J Vis Exp. 2010 Oct 08; (44). PMID: 20972409.
    Citations: 10     Fields:    Translation:AnimalsCells
  28. Young-Pearse TL, Suth S, Luth ES, Sawa A, Selkoe DJ. Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development. J Neurosci. 2010 Aug 04; 30(31):10431-40. PMID: 20685985.
    Citations: 43     Fields:    Translation:AnimalsCells
  29. Young-Pearse TL, Chen AC, Chang R, Marquez C, Selkoe DJ. Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1. Neural Dev. 2008 Jun 23; 3:15. PMID: 18573216.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  30. Young-Pearse TL, Bai J, Chang R, Zheng JB, LoTurco JJ, Selkoe DJ. A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference. J Neurosci. 2007 Dec 26; 27(52):14459-69. PMID: 18160654.
    Citations: 137     Fields:    Translation:AnimalsCells
  31. Young-Pearse TL, Ivic L, Kriegstein AR, Cepko CL. Characterization of mice with targeted deletion of glycine receptor alpha 2. Mol Cell Biol. 2006 Aug; 26(15):5728-34. PMID: 16847326.
    Citations: 26     Fields:    Translation:Animals
  32. Young TL, Matsuda T, Cepko CL. The noncoding RNA taurine upregulated gene 1 is required for differentiation of the murine retina. Curr Biol. 2005 Mar 29; 15(6):501-12. PMID: 15797018.
    Citations: 120     Fields:    Translation:AnimalsCells
  33. Rowan S, Chen CM, Young TL, Fisher DE, Cepko CL. Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10. Development. 2004 Oct; 131(20):5139-52. PMID: 15459106.
    Citations: 50     Fields:    Translation:Animals
  34. Young TL, Cepko CL. A role for ligand-gated ion channels in rod photoreceptor development. Neuron. 2004 Mar 25; 41(6):867-79. PMID: 15046720.
    Citations: 44     Fields:    Translation:AnimalsCells
  35. Livesey FJ, Young TL, Cepko CL. An analysis of the gene expression program of mammalian neural progenitor cells. Proc Natl Acad Sci U S A. 2004 Feb 03; 101(5):1374-9. PMID: 14734810.
    Citations: 26     Fields:    Translation:AnimalsCells
  36. Belliveau MJ, Young TL, Cepko CL. Late retinal progenitor cells show intrinsic limitations in the production of cell types and the kinetics of opsin synthesis. J Neurosci. 2000 Mar 15; 20(6):2247-54. PMID: 10704500.
    Citations: 31     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.